Icariin targets PDE5A to regulate viability, DNA synthesis and DNA damage of spermatogonial stem cells and improves reproductive capacity.

Icariin is a pure compound derived from Epimedium brevicornu Maxim, and it helps the regulation of male reproduction. Nevertheless, the role and underlying mechanisms of Icariin in mediating male germ cell development remain to be clarified. Here, we have demonstrated that Icariin promoted proliferation and DNA synthesis of mouse spermatogonial stem cells (SSCs).

Cytokine Gene Variants as Predisposing Factors for the Development and Progression of Coronary Artery Disease: A Systematic Review.

Coronary artery disease (CAD) is the most prevalent form of cardiovascular disease. A growing body of research shows that interleukins (ILs), such as IL-8, IL-18 and IL-16, elicit pro-inflammatory responses and may play critical roles in the pathologic process of CAD. Single nucleotide polymorphisms (SNPs), capable of generating functional modifications in IL genes, appear to be associated with CAD risk.

Identification of Three Genotypes in Largemouth Bass () and Their Differential Physiological Responses to Feed Domestication.

Diverse feeding habits in teleosts involve a wide range of appetite-regulating factors. As an appetite-suppressing gene, the polymorphisms of in largemouth bass () were validated via sequencing and high-resolution melting (HRM). The frequency distribution of different genotypes were analyzed in two populations, and physiological responses of different genotypes to feed domestication were investigated.

Neural correlates of social observation and socioeconomic status in influencing environmental donations.

With the increasing urgency of environmental degradation, it is crucial to investigate whether and why individuals from different socioeconomic statuses (SES) engage in environmental donations within social contexts to develop targeted strategies that promote environmental sustainability. However, the psychological mechanisms and neural activities underlying environmental donations across SES in social contexts remain unclear. The current study randomly assigned participants to high (low) SES groups and asked them to complete the environmental donation task in the (non) observable contexts while the electroencephalogram was recorded.

Observation of quantum strong Mpemba effect.

An ancient and counterintuitive phenomenon known as the Mpemba effect (water can cool faster when initially heated up) showcases the critical role of initial conditions in relaxation processes. How to realize and utilize this effect for speeding up relaxation is an important but challenging task in purely quantum system till now. Here, we experimentally study the strong Mpemba effect in a single trapped ion system in which an exponentially accelerated relaxation in time is observed by preparing an optimal quantum initial state with no excitation of the slowest decaying mode.

Unpacking Learners' Global Perspective and Willingness to Communicate in English among Different English Proficiency University Students in China.

The correlation between students' Global Perspective (GP) and Willingness to Communicate in a second language (L2 WTC), particularly in the context of China, remains an under-explored area. Additionally, few studies have compared the GP and WTC among students with varying English proficiency levels or examined whether there are specific similarities and differences among these students. This study aimed to bridge these gaps within the context of traditional and English Medium Instruction (EMI) universities in China.

The circular effects between adolescent anxiety and benign/malicious envy: evidence from a longitudinal study and experience-sampling method.

Background: Prior research has shown a strong association between anxiety and envy (i.e. benign/malicious envy).

A case of nephrocolic fistula presenting primarily with changes in bowel habits.

We report a rare case of nephrocolic fistula in a 56-year-old female presenting with a three-month history of altered bowel habits. Initial colonoscopy revealed a sinus tract in the descending colon. Her hemoglobin was 79 g/L, and she had a history of nephrolithiasis and trauma.

The effects of interactive video games combined with LEGO game therapy on social anxiety in rural left-behind children.

Background: China has a significant population of left-behind children, defined as those whose parents have migrated away from their home for at least six months. This situation arises when one or both parents leave to seek work in urban areas. Among the various challenges faced by left-behind children, social anxiety has emerged as one of the most pressing issues.

Effect of plasma homocysteine on cardiometabolic multimorbidity among Chinese adults: a population-based and real-world evidence study.

Aims: To explore the effect of plasma homocysteine (Hcy) on cardiometabolic multimorbidity (CMM) among Chinses adults.

Methods: This study combined a community-based cross-sectional study with a 1:1 matched case-control study using propensity score method among adults aged over 30 years in six districts randomly selected from Hunan Province, China. We recruited 5,258 people, of whom 4,012 met the study criteria were enrolled.

More envy, more loneliness? not only that: A longitudinal study and daily diary study.

Although cross-sectional studies have explored the correlation between envy and loneliness, few longitudinal studies have investigated the bidirectional association between envy and loneliness at both trait and state levels. Here, through a longitudinal study and a daily diary investigation, we examined the interrelationships between envy and loneliness at both trait and state levels. In study 1, 288 college students answered the Dispositional Envy Scale (DES) and UCLA Loneliness Scale (UCL-8 Scale) twice with a one-year interval.

The bidirectional relationship between perceived social support and moral sensitivity in adolescents: Evidence from longitudinal study and weekly diary method.

Introduction: Moral sensitivity, the ability to perceive moral issues, plays a crucial role in societal development and progress. Previous studies have highlighted the significance of perceived social support as a key factor influencing moral sensitivity.

Method: Based on the conservation of resources theory, this pioneering study investigates the association between perceived social support and moral sensitivity at both trait and state levels, employing a longitudinal study and a weekly diary method.

Exploration of small-molecule inhibitors targeting Hsp110 as novel therapeutics.

The heat shock protein (HSP) 110 family has a key role as a unique class of molecular chaperones maintaining cellular proteostasis in eukaryotes. Abnormal activation of Hsp110 has been implicated in several diseases. Given its important role in pathogenesis, Hsp110 has become a novel drug target for disease diagnosis and targeted therapy.

Short-Chain Chlorinated Paraffins May Induce Ovarian Damage in Mice via AIM2- and NLRP12-PANoptosome.

Humans may intake 0.02 mg/kg/day of short-chain chlorinated paraffins (SCCPs), and no study is available on mammalian ovarian damage caused by low-level SCCPs. In this study, four groups of 5-week-old female Institute of Cancer Research (ICR) mice were orally administered 0, 0.

Effects of functional training on physical and technical performance among the athletic population: a systematic review and narrative synthesis.

Background: The evidence indicates that functional training is beneficial for athletes' physical and technical performance. However, a systematic review of the effects of functional training on athletes' physical and technical performance is lacking. Therefore, this study uses a literature synthesis approach to evaluate the impact of functional training on the physical and technical performance of the athletic population and to extend and deepen the existing body of knowledge.

Novel variants of FSIP2 and SPEF2 cause varying degrees of spermatozoa damage in MMAF patients and favorable ART outcomes.

Purpose: This study identified novel variants of the FSIP2 and SPEF2 genes in multiple morphological abnormalities of the sperm flagella (MMAF) patients and to investigate the potential effect of variations on male infertility and assisted reproductive outcomes.

Methods: Whole-exome sequencing was performed in 106 Chinese MMAF patients. The discovered variants were evaluated in silico and confirmed by Sanger sequencing.

Midterm comparative result of absorbable screws and metal screws in pediatric medial humeral epicondyle fracture.

Backgroud: Medial humeral epicondyle fracture is a prevalent type of upper limb fractures in pediatric patients. This study aims to compare the follow-up clinical results and complications in 30 children with medial epicondyle fractures who were treated with either metal screws or absorbable screws at our hospital.

Methods: A retrospective review was conducted on 30 children with medial humeral epicondyle fractures, who were divided into two groups: Metal group (18 children) underwent fixation using metal screws, while Absorbable group (12 children) received absorbable screws between January 2016 and June 2024.

Arthroscopic treatment of calcific tendinitis of the popliteal tendon: A case report.

Introduction And Importance: Calcific tendinitis occurring in the popliteal tendon is extremely rare and has rarely been reported in the past. This case describes a patient who underwent arthroscopic surgery to remove the calcification of the popliteal tendon and achieved satisfactory results after surgery, providing valuable evidence for the feasibility of arthroscopic treatment of calcific tendinitis of the popliteal tendon.

Case Presentation: The patient was a 55-year-old female who was admitted to the hospital due to right knee pain and limited mobility.

OsNCED5 confers cold stress tolerance through regulating ROS homeostasis in rice.

Cold stress is one of the most serious abiotic stresses that affects the growth and yield in rice. However, the molecular mechanism by which abscisic acid (ABA) regulates plant cold stress tolerance is not yet clear. In this study, we identified a member of the OsNCED (9-cis-epoxycarotenoid dioxygenase) gene family, OsNCED5, which confers cold stress tolerance in rice.

Differential Expression of GABA Receptor-Related Genes in Alzheimer's Disease and the Positive Regulatory Role of Aerobic Exercise-From Genetic Screening to D-gal-induced AD-like Pathology Model.

Alzheimer's disease (AD) is the most common neurodegenerative disorder. The neuropathology of AD appears in the hippocampus. The purpose of this work was to reveal key differentially expressed genes (DEGs) in the hippocampus of AD patients and healthy individuals.

R(3780) Resonance Interpreted as the 1^{3}D_{1}-Wave Dominant State of Charmonium from Precise Measurements of the Cross Section of e^{+}e^{-}→Hadrons.

We report the precise measurements of the cross section of e^{+}e^{-}→hadrons at center-of-mass energies from 3.645 to 3.871 GeV.

[The mechanism of GSK-3β/CREB signaling pathway regulating macrophage pyroptosis and participating in the occurrence and development of diabetic foot ulcer].

Objective To investigate the role and possible mechanism of glycogen synthase kinase-3 beta (GSK-3β)/cAMP response element binding protein (CREB) signaling pathway in regulating macrophage pyroptosis in the pathogenesis and development of diabetic foot ulcer (DFU). Methods Thirty rats were randomly divided into control group, DFU group and GSK-3β inhibited group, with 10 rats in each group. Fasting blood glucose (FBG) was detected by dynamic blood glucose detector.

Enacting an Online Depression Community in China: The Community of Practice Perspective.

The dilemma of disclosing one's illness experiences in real life has led to a proliferation of online health communities. It is worth exploring the nature of such communities. Drawing on the community of practice (CoP) theory, this article explores how members enact online health communities by studying the support group "Philosophical Treatment of Depression," one of the largest online depression communities in China.