General (hetero)polyaryl amine synthesis via multicomponent cycloaromatization of amines.

(Hetero)polyaryl amines are extensively prevalent in pharmaceuticals, fine chemicals, and materials but the intricate and varied nature of their structures severely restricts their synthesis. Here, we present a selective multicomponent cycloaromatization of structurally and functionally diverse amine substrates for the general and modular synthesis of (hetero)polyaryl amines through copper(I)-catalysis. This strategy directly constructs a remarkable range of amino group-functionalized (hetero)polyaryl frameworks (194 examples), including naphthalene, binaphthalene, phenanthren, benzothiophene, dibenzothiophene, benzofuran, dibenzofuran, quinoline, isoquinoline, quinazoline, and others, which are challenging or impossible to obtain using alternative methods.

Rethinking BCC diagnosis: Automating concept-specific detection of BCC in dermatoscopic images.

Background: Basal cell carcinoma (BCC) is a prevalent type of skin cancer in which the inherent subjectivity of dermoscopy poses diagnostic challenges. Existing AI systems, which provide mainly image-level insights, lack the interpretability that is crucial for effective clinical decisions and patient education.

Patients And Methods: Our study developed a refined BCC dataset from the Human‒Machine Adversarial Model (HAM10000), which was annotated by clinicians to identify key diagnostic features.

Constructing an electrochemical sensor with screen-printed electrodes incorporating TiCT-PDA-AgNPs for lactate detection in sweat.

Sweat lactate levels are closely related to an individual's physiological state and serve as critical indicators for assessing exercise intensity, muscle fatigue, and certain pathological conditions. Screen-printed electrodes (SPEs) offer a promising avenue for the development of low-cost, high-performance wearable devices for electrochemical sweat analysis. The material composition of SPEs significantly impacts their detection sensitivity and stability.

Can exercise as a complementary technique manage inflammatory markers in women with breast cancer who are overweight and obese? A systematic review and meta-analysis.

Background: Inflammation can result in the development of breast cancer in women with overweight and obese, and also affects the outcome and prognosis of breast cancer patients, thereby decreasing the cure and survival rates of breast cancer patients. Exercise may benefit breast cancer patients as a supplement to conventional treatments. However, research on the effects of exercise on inflammatory markers in women with breast cancer who are overweight and obese remains incomplete.

The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance.

Induction of autophagy is an ancient function of the cyclic GMP-AMP (cGAMP) synthase (cGAS)-stimulator of interferon genes (STING) pathway through which autophagic cargoes are delivered to lysosomes for degradation. However, whether lysosome function is also modulated by the cGAS-STING pathway remains unknown. Here, we discovered that the cGAS-STING pathway upregulated lysosomal activity by stimulating lysosome biogenesis independently of the downstream protein kinase TANK-binding kinase 1 (TBK1).

Assessment of primary school in Changsha based on AISM method.

To tackle the challenge of a one-size-fits-all and inconsistent approach to evaluating school development across districts, we have zeroed in on five key urban districts in Changsha City. Fourteen secondary indicators, spanning four critical categories - campus environment, teaching facilities, financial investment, and teacher resources - were selected to comprehensively assess the development of elementary schools in 2021. This assessment was conducted using the Advanced Interpretive Structural Model (AISM).

Stronger Empathy and Better Peer Relationship? One-Year Cross-Lagged Panel Analysis in Preschoolers.

The development of empathy and the establishment of peer relationships significantly influence the quality of preschoolers' social lives. Past research consistently demonstrates a strong correlation between empathy and peer relationships. However, debates persist regarding causality.

Ferroptosis and Its Potential Role in the Physiopathology of Skeletal Muscle Atrophy.

Skeletal muscle atrophy is a major health concern, severely affecting the patient's mobility and life quality. In the pathological process of skeletal muscle atrophy, with the progressive decline in muscle quality, strength, and function, the incidence of falling, fracture, and death is greatly increased. Unfortunately, there are no effective treatments for this devastating disease.

Assessing the Environmental Impact of Municipal Waste on Energy Incineration Technology for Power Generation Using Life Cycle Assessment Methodology.

The life cycle assessment methodology is a comprehensive environmental impact evaluation approach rooted in the "cradle-to-grave" concept. This study takes a municipal solid waste incineration power plant in central China as an example to comprehensively explore the potential ecological and environmental impacts of municipal solid waste incineration power generation through life cycle assessment methods. Burning one ton of waste can recover 7342 joules of thermal energy.

Validation study for assessing COVID-19 pneumonia treatments.

This study investigates the effectiveness of Azvudine and nirmatrelvir-ritonavir (Paxlovid) in treating COVID-19 pneumonia through an analysis of real-world clinical data. We retrospectively collected data from COVID-19 patients hospitalized at the Second Xiangya Hospital of Central South University between December 21, 2022, and January 18, 2023. Using kernel density estimation, box-and-whisker plots, and Schoenfeld residual plots, we evaluated the transition of patients to negative status and assessed factors such as age, disease severity, and treatment effects.

Enhancing Epstein-Barr virus detection in IBD patients with XAI and clinical data integration.

Background: There is increasing evidence of a link between Epstein-Barr virus (EBV) and gastrointestinal cancers, particularly in immunocompromised patients and those on thiopurines. Traditional endoscopic techniques have limitations in diagnosing EBV, whereas standard methods for diagnosing EBV have practical challenges in regular clinical settings related to their invasiveness and high costs.

Methods: An explainable AI (XAI) model was developed to analyze 1598 endoscopic images from 287 patients with inflammatory bowel disease (IBD), with a focus on detecting EBV infection.

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A dictionary compilation of the important figures in traditional Chinese medicine is very important. contributes greatly to the research of traditional Chinese medicine figures and traditional Chinese medicine history because more than 18,000 traditional Chinese physicians are included, along with rich data and a clear index. However, some problems are still worth discussing.

FetusMapV2: Enhanced fetal pose estimation in 3D ultrasound.

Fetal pose estimation in 3D ultrasound (US) involves identifying a set of associated fetal anatomical landmarks. Its primary objective is to provide comprehensive information about the fetus through landmark connections, thus benefiting various critical applications, such as biometric measurements, plane localization, and fetal movement monitoring. However, accurately estimating the 3D fetal pose in US volume has several challenges, including poor image quality, limited GPU memory for tackling high dimensional data, symmetrical or ambiguous anatomical structures, and considerable variations in fetal poses.

FeO encapsulated in hierarchically porous nitrogen-doped graphitic carbon layers for efficient oxygen reduction reaction: Enhanced intrinsic activity via directional interfacial charge transfer.

Constructing efficient electrocatalysts for the oxygen reduction reaction (ORR) is crucial for the commercialization of metal-air batteries. Iron oxide-based catalysts exhibit promising potential for ORR. However, addressing the issue of inferior catalytic performance is essential, and a comprehensive understanding of the catalytic mechanism of iron oxide-based catalysts is also lacking.

Influence of hair presence on dermoscopic image analysis by AI in skin lesion diagnosis.

The escalating rates of melanoma and non-melanoma skin cancers highlight the urgent need for enhanced diagnostic tools. This study evaluates the effect of hair presence in dermoscopic images on AI-driven skin lesion recognition, using 10,015 images from the HAM10000 collection. Images were categorized based on the extent of hair occlusions to assess their impact on AI performance.

Mortality salience and helping behavior amidst public crisis: cross-sectional evidence during COVID-19.

Background: As a real mortality salience, a public crisis would have a major impact on individual minds, behaviors, and lifestyles. COVID-19 provides us with a stark real-world example to understand these implications. Previous research has revealed that some individuals become more willing to help the infected at the risk of their own lives, while others become more self-centered and indifferent during COVID-19.

Establishment of a dexamethasone-induced zebrafish skeletal muscle atrophy model and exploration of its mechanisms.

Background: Skeletal muscle atrophy is one of the main side effects of high-dose or continuous use of glucocorticoids (such as dexamethasone). However, there are limited studies on dexamethasone-induced skeletal muscle atrophy in zebrafish and even fewer explorations of the underlying molecular mechanisms. This study aimed to construct a model of dexamethasone-induced skeletal muscle atrophy in zebrafish and to investigate the molecular mechanisms.

AI fusion of multisource data identifies key features of vitiligo.

Vitiligo is a skin disorder that is associated with a decreased risk of skin cancer, but it can lead to increased susceptibility to sunburn, psychological distress, and disruptions in daily life, consists of two primary subtypes: segmental and nonsegmental vitiligo, each with distinct underlying mechanisms. However, the reliable identification of diagnostic markers and the ability to differentiate between these subtypes have remained elusive challenges. This study aims to pioneer predictive algorithms for vitiligo diagnosis, harnessing the capabilities of AI (Artificial Intelligence) to amalgamate multisource data and uncover essential features for distinguishing vitiligo subtypes.

The benefit of rhythm-based interventions for individuals with autism spectrum disorder: a systematic review and meta-analysis with random controlled trials.

Objective: Individuals with autism spectrum disorder (ASD) exhibit impaired behavior synchronization, which is associated with social deficits. Numerous studies have demonstrated that rhythm-based interventions can effectively mitigate social deficits by promoting behavioral synchronization in individuals with ASD. Therefore, a review of the current literature is warranted in this field.

Environmental Impact of Waste Treatment and Synchronous Hydrogen Production: Based on Life Cycle Assessment Method.

Based on the life cycle assessment methodology, this study systematically analyzes the energy utilization of environmental waste through photocatalytic treatment and simultaneous hydrogen production. Using 10,000 tons of organic wastewater as the functional unit, the study evaluates the material consumption, energy utilization, and environmental impact potential of the photocatalytic waste synchronous hydrogen production system (specifically, the synchronous hydrogen production process of 4-NP wastewater with CDs/CdS/CNU). The findings indicate that potential environmental impacts from the photochemical treatment of environmental waste and synchronous hydrogen production primarily manifest in freshwater ecological toxicity, marine ecological toxicity, terrestrial ecological toxicity, and non-carcinogenic toxicity to humans.

The association of calligraphy activities with peace of mind, stress self-management, and perceived health status in older adults.

Introduction: Calligraphy, as a form of mindful practice, encourages focus, creativity, and relaxation, which collectively contribute to a more peaceful mental state. Through regular engagement in calligraphy, older adults can develop better coping mechanisms for stress, leading to more effective self-management of daily stressors. This enhanced ability to manage stress can reduce the overall burden on their mental and physical health, promoting a more positive outlook on life.