NRF1-induced mmu_circ_0001388/hsa_circ_0029470 confers ferroptosis resistance in ischemic acute kidney injury via the miR-193b-3p/TCF4/GPX4 axis.

Aims: Circular RNAs (circRNAs) are critical in the progression of ischemic acute kidney injury (AKI). Nevertheless, the specific functions and regulatory pathways of mmu_circ_0001388 and hsa_circ_0029470 remain elusive.

Methods: Real-time quantitative polymerase chain reaction (RT-qPCR) was utilized to assess the expression patterns of mmu_circ_0001388, hsa_circ_0029470, and miR-139b-3p.

Research on frequency shift signal detection algorithm for jointless track circuits based on improved relaxation algorithm.

The accuracy of ZPW-2000 frequency shift signal demodulation is related to the safety and efficiency of high-speed trains. This paper proposed a kind of ZPW-2000 frequency-shift signal detection algorithm based on improved Relaxation algorithm (ZFSD-IR) to address the issue of low accuracy in detecting ZPW-2000 frequency shift signal under strong noise interference, as the traditional fast Fourier transform (FFT) spectrum analysis methods are susceptible to fence effects and spectrum leakage effects. Firstly, the principle of ZPW-2000 jointless track circuit was analyzed, and then the ideal and simplified models of ZPW-2000 frequency shift signal were established, respectively.

Research on high-precision recognition model for multi-scene asphalt pavement distresses based on deep learning.

Accurate detection of asphalt pavement distress is crucial for road maintenance and traffic safety. However, traditional convolutional neural networks usually struggle with this task due to the varied distress patterns and complex background in the images. To enhance the accuracy of asphalt pavement distress identification across various scenarios, this paper introduces an improved model named SMG-YOLOv8, based on the YOLOv8s framework.

Gut microbiota-derived acetic acids promoted sepsis-induced acute respiratory distress syndrome by delaying neutrophil apoptosis through FABP4.

In patients with sepsis, neutrophil apoptosis tends to be inversely proportional to the severity of sepsis, but its mechanism is not yet clear. This study aimed to explore the mechanism of fatty acid binding protein 4 (FABP4) regulating neutrophil apoptosis through combined analysis of gut microbiota and short-chain fatty acids (SCFAs) metabolism. First, neutrophils from bronchoalveolar lavage fluid (BALF) of patients with sepsis-induced acute respiratory distress syndrome (ARDS) were purified and isolated RNA was applied for sequencing.

Identification of SLC31A1 as a prognostic biomarker and a target for therapeutics in breast cancer.

Copper-induced cell death is regulated through protein lipoylation, which is critical for gene expression and phenotypic regulation. Neverless, the role of Cuproptosis-related genes in breast cancer (BC) remains unknown. This study aimed to construct a prognostic signature based on the expression of Cuproptosis-related genes in order to guide the diagnosis and treatment for BC.

N4BP3 facilitates NOD2-MAPK/NF-κB pathway in inflammatory bowel disease through mediating K63-linked RIPK2 ubiquitination.

The NOD2 signaling pathway, which plays an important role in the mechanisms of inflammatory bowel disease (IBD) development, has been closely associated with ubiquitination. It was revealed in this study that NOD2 receptor activation could obviously affect the expression of 19 ubiquitination-related genes, with N4BP3 being the most prominently expressed and upregulated. In addition, N4BP3 knockdown was found to reduce the mRNA levels of MDP-induced inflammatory factors, while N4BP3 overexpression elevated their mRNA levels as well as the levels of phospho-ERK1/2, phospho-JNK, phospho-P38 and phospho-NF-κB P65 proteins.

Ultra-Tough Dynamic Supramolecular Ion-Conducting Elastomer Induced Uniform Li Transport and Stabilizes Interphase Ensures Dendrite-Free Lithium Metal Anodes.

Artificial polymer solid electrolyte interphases (SEIs) with microphase-separated structures provide promising solutions to the inhomogeneity and cracking issues of natural SEIs in lithium metal batteries (LMBs). However, achieving homogeneous ionic conductivity, excellent mechanical properties, and superior interfacial stability remains challenging due to interference from hard-phase domains in ion transport and solid-solid interface issues with lithium metal. Herein, we present a dynamic supramolecular ion-conducting poly (urethane-urea) interphase (DSIPI) that achieves these three properties through modulating the hard-phase domains and constructing a composite SEI in situ.

Multiomics identification of ALDH9A1 as a crucial immunoregulatory molecule involved in calcific aortic valve disease.

Mitochondrial dysfunction and immune cell infiltration play crucial yet incompletely understood roles in the pathogenesis of calcific aortic valve disease (CAVD). This study aimed to identify immune-related mitochondrial genes critical to the pathological process of CAVD using multiomics approaches. The CIBERSORT algorithm was employed to evaluate immune cell infiltration characteristics in CAVD patients.

Scalable fabrication of porous membrane incorporating human extracellular matrix-like collagen for guided bone regeneration.

Guided bone regeneration (GBR) is an extensively used technique for the treatment of maxillofacial bone defects and bone mass deficiency in clinical practice. However, to date, studies on membranes for GBR have not achieved the combination of suitable properties and cost-effective membrane production. Herein, we developed a polycaprolactone/human extracellular matrix-like collagen (PCL/hCol) membrane with an asymmetric porous structure the nonsolvent-induced phase separation (NIPS) method, which is a highly efficient procedure with simple operation, scalable fabrication and low cost.

Atrial tachycardia originating from a right atrial free wall diverticulum: case report.

Background: Atrial tachycardia (AT) is an arrhythmic disorder originating from the atrium, independent of the atrioventricular node, and includes various types based on different mechanisms such as abnormal automaticity, triggered activity, and re-entry. These mechanisms are often related to specific anatomical structures. Focal AT, though relatively rare, typically arises from well-known locations in the left and right atria, such as the pulmonary veins, mitral valve annulus, crista terminalis, and coronary sinus ostium.