1 results match your criteria: "Humboldt Universität zu Berlin and Charité Universitätsmedizin Berlin[Affiliation]"
Characterization of Myocardial Microstructure and Function in an Experimental Model of Isolated Subendocardial Damage.
Hypertension
August 2019
From the Charité-Universitätsmedizin Berlin, corporate member of Freie Universitaät Berlin, Humboldt-Universitaät zu Berlin, and Berlin Institute of Health, Institute of Pharmacology, Center for Cardiovascular Research, Berlin, Germany (N.B., A.F.-L., S.B., J.G., Arne Thiele, U.K.).
Article Synopsis
- - The study investigates how subendocardial damage due to hypertension impacts the structure and function of the heart, highlighting early signs of cardiac problems even in asymptomatic individuals.
- - Mice induced with subendocardial scarring showed diastolic dysfunction, changes in myocardial deformation, and increased expression of specific biomarkers, while systolic function remained normal.
- - Advanced imaging techniques indicated that alterations in myocardial microstructure, particularly in subepicardial myofibers, can serve as early indicators for subendocardial fibrosis, with high sensitivity and specificity for predicting cardiac damage.