Functional Outcomes After Transoral Plus Lateral Pharyngotomy Approach for Advanced Oral and Oropharyngeal Tumors.

Objective: The aim of this study was to evaluate our institutional experience with the combined transoral plus lateral pharyngotomy (TO+LP) approach in a subset of patients with advanced or recurrent oral and oropharyngeal malignancy.

Study Design: A retrospective study of procedures utilizing TO+LP for cancer resection between January 2007 and July 2019.

Setting: Tertiary academic medical center.

Quantification of very late xerostomia in head and neck cancer patients after irradiation.

Objective: Radiation therapy (RT) for head and neck cancer (HNC) can result in severe xerostomia, or the subjective feeling of dry mouth. Characterizing xerostomia is critical to designing future clinical trials investigating how to improve HNC patients' quality of life (QoL). Few studies have investigated the very late (>5 years post-RT) effects of RT for HNC.

Is HPV-Associated Oropharyngeal Cancer Becoming More Common in Older Patients?

Objective: To evaluate changing age demographics over a 15-year period for patients with HPV-associated oropharyngeal squamous cell carcinoma (OPSCC).

Study Design: Retrospective review of patients identified with p16-positive OPSCC at our institution over a 15-year timeframe. : p16-positive immunohistochemistry was used as a surrogate for HPV-associated OPSCC.

Vision loss in glioblastoma: Disease mimicking presumed therapeutic toxicity.

Glioblastoma is the most common and lethal form of primary brain cancer. In the recurrent setting, bevacizumab is a common choice for salvage therapy. Loss of vision in patients initially treated with radiation at the time of diagnosis and later treated with bevacizumab at time of recurrence has been reported, and presumed to be a treatment-related optic neuropathy.