Metal free C-O bond cleavage: a new strategy for the synthesis of substituted oxazoles.

A strategy for the efficient metal-free C-O bond cleavage of ester using amines for the synthesis of substituted oxazoles was developed for the first time. The synthesis proceeded smoothly under metal-free conditions, combining C-O bond cleavage as well as C-N and C-O bond formation in one pot to yield desired products in moderate to excellent yields, and accommodated a wide range of functional groups and substrates.

One new species of Jäger, 2000 from Shennongjia, Central China (Araneae, Sparassidae).

Background: Jäger, 2000 is currently the largest genus in the family Sparassidae Bertkau, 1872, comprising 255 species. Of these, 154 species have been recorded in China, representing 60.4% of the global species.

Intra-muscular extraskeletal myxoid chondrosarcoma of the thigh: a case report.

Soft tissue sarcomas are mesenchymal tumors that account for about 1% of all malignancies. We retrospectively analyzed a rare case of a painful intra-muscular extraskeletal myxoid chondrosarcoma in the thigh of a 35-year-old man, that had undergone excision. Histological and immunohistochemical analysis of the mass revealed extraskeletal myxoid chondrosarcoma.

[Protective effect of salidroside on high fat-induced apoptosis in H9c2 cardiomyocytes through AMPK/mTOR/p70S6K pathway].

The study explored the effect of salidroside(SAL) on high fat-induced apoptosis in H9 c2 cardiomyocytes based on AMPK/mTOR/p70 S6 K pathway.H9 c2 cardiomyocytes were cultured in vitro and the lipotoxicity model of H9 c2 cardiomyocytes was constructed by 0.2 mmol·L~(-1) palmitic acid(PA) treatment for 24 hours.

Radiation-initiated high strength chitosan/lithium sulfonate double network hydrogel/aerogel with porosity and stability for efficient CO capture.

Developing efficient and inexpensive CO capture technologies is a significant way to reduce carbon emissions. In this work, a novel chitosan/lithium sulfonate double network high strength hydrogel is synthesized by electron beam radiation. Due to the electron beam having a wide radiation area and certain penetrating power, the free radical polymerization can be initiated more uniformly and quickly in the hydrogel.

Nitrogen-doped lignin-derived carbon for catalytic reduction of hexavalent chromium HCOOH-mediated hydrogenation.

It is highly desirable to explore efficient catalysts for reducing toxic Cr to benign Cr under mild and eco-friendly conditions. This article describes a facile fabrication of nitrogen doped carbon (N@C-g-CN) as a metal-free catalyst for Cr reduction using lignin as a carbon source and g-CN nanosheets as a nitrogen source. The structural properties of the N@C-g-CN catalyst are characterized by TEM, HR-TEM, XRD, TGA, Raman, EDS-mapping, XPS and BET techniques.

Effects of the direct anterior approach and Orthopadisehe Chirurgie Munchen on early joint function after primary hip arthroplasty in young adults.

Objective: To compare the effect of Direct Anterior Approach (DAA) and Orthopadisehe Chirurgie Munchen (OCM) in the prone position on early joint function after primary hip arthroplasty in young adults.

Methods: In this retrospective analysis, 85 patients who received primary hip arthroplasty between September 2018 and January 2020 were enrolled and divided into the OCM group (43 cases with OCM) and the DAA group (42 cases with DAA) according to the different surgical methods. The general operative conditions, postoperative conditions and imaging manifestations, postoperative pain, changes in WOMAC scale scores, and the occurrence of adverse reactions were compared between the two groups.

[PK2/PKR1 signaling pathway participates in geniposide protection against diabetic nephropathy in mice].

This study aimed to investigate the effects of geniposide(GP) on the expression of prokineticin(PK2) and prokineticin receptor 1(PKR1) in db/db mice with diabetic nephropathy(DN), so as to explore how the PK2 signaling pathway participated in the pathological changes of DN and whether GP exerted the therapeutic effect through this signaling pathway. Male mice were randomly divided into four groups, namely db/m, db/db, db/db+GP, and db/m+GP groups, with five in each group. The mice in the db/db+GP and db/m+GP groups were gavaged with 150 mg·kg~(-1) GP for eight successive weeks.

Ultrasound vs. histologic findings in 40 patients with special types of ectopic pregnancy.

Purpose: The purpose of the study was to analyze the ultrasound findings and imaging features of patients with special types of ectopic pregnancy.

Methods: The ultrasound findings of 40 patients with special types of ectopic pregnancy in our hospital were retrospectively analyzed.

Results: Among 40 patients, there were 17 cases of corneal pregnancy, 12 cases of cervical pregnancy, 8 cases of uterine scar pregnancy, and 3 cases of incomplete abortion confirmed by operation and pathology.

Sevoflurane-induced neuronal apoptosis in neonatal mice is prevented with intranasal administration of insulin.

Concerns about the potential neurotoxicity of general anesthesia to the developing brain have been increasing in recent years. Animal studies have shown that neonatal exposure to general anesthesia causes both acute neurotoxicity and behavioral abnormalities later in life. In the present study, we observed over-activation of neuronal apoptosis in the brain of neonatal mice after a single exposure to anesthesia with sevoflurane for 6 hours at the age of 7 days.

A checklist of spiders in tea plantations of China.

Background: Spiders are the most dominant predatory natural enemies of insect pests in the tea plantation ecosystem. There has been a large amount of literature published about the investigation of spider species in Chinese tea plantations from 1982 to 2020. Here, the spider species in Chinese tea plantations has been summarised and the dominant spider species in each regional tea plantation recorded.

One new species of the genus from Hubei Province, with description of the male of (Araneae, Sparassidae).

Background: In the past year, Prof. Jian Chen conducted several spider collections in Hubei Province. Almost 1000 spiders were collected.

Correlation between microstructure and properties of graphene oxide/waterborne polyurethane composites investigated by positron annihilation spectroscopy.

A quantitative description of microstructure is highly desirable for the precise construction of high performance graphene based polymer composites. In this paper, the effects of doping graphene oxide (GO) on the microstructure, thermal and mechanical properties of the obtained graphene oxide/waterborne polyurethane (GO/WPU) composites were systematically investigated. In order to give a deep insight into the microstructure of GO/WPU composites, especially for the relative free volume fraction ( ) and interfacial interaction intensity (), positron annihilation lifetime spectroscopy (PALS) was employed for its quantitative characterization.

Two-dimensional aluminum phosphide semiconductor with tunable direct band gap for nanoelectric applications.

More and more attractive applications of two-dimensional (2D) materials in nanoelectronic devices are being achieved successfully, which promotes the rapid and extensive development of new 2D materials. In this work, the structural and electronic properties of the V structure aluminum phosphide (V-AlP) monolayer are examined by density functional calculations, and its electronic properties under strain and an electric field are also explored in detail. The computation results indicate that it has good stability.

[Pharmacological mechanism of traditional sedative effect of alkaloids in Nelumbinis Plumula based on network pharmacology].

Nelumbinis Plumula has the traditional sedative effect,but its mechanism is unclear. In this study,the relationship between traditional sedative effect and hypnotic effect of Nelumbinis Plumula was taken as the starting point to study the hypnotic mechanism of the major medicinal components in Nelumbinis Plumula by the network pharmacology method. Targets of active Nelumbinis Plumula alkaloids were screened by Swiss Target Prediction server,TCMSP and BATMAN-TCM.

Transition-metal-free amination phosphoryl azide for the synthesis of phosphoramidates.

A facile and efficient approach to phosphoramidates was developed amination of phosphoryl azides. A variety of phosphoramidates were obtained in one step with good to excellent yields under a mild reaction system. The process uses easily available amines as a N source and offers a new opportunity for P-N bond formation.

[Virtual screening of antithrombotic alkaloids from Houttuynia cordata].

Antithrombus is one of the effective methods to prevent and treat cardiovascular diseases. Based on the theory of traditional Chinese medicine,the author's previous research and relevant literature,it was found that the alkaloids in Houttuynia cordata has potential antithrombotic effect. However,the pharmacological substance basis and antithrombotic mechanism of H.

Effects of stacking method and strain on the electronic properties of the few-layer group-IVA monochalcogenide heterojunctions.

Group-IV monochalcogenides (GeSe, SnSe, GeS, SnS) are a class of promising monolayer materials for nanoelectronic applications. However, the GeSe monolayer is the only direct semiconductor in the group-IV monochalcogenides, which limits their application in nanoelectronic fields. Stacking is usually a good strategy to design two-dimensional (2D) materials with novel properties.

Inhibitory effect of miR-145 on RPE cell proliferation.

Objective: This study aims to explore the impact of micro RNA miR-145 on retinal pigment epithelial cell proliferation and apoptosis.

Methods: A stable culture and passage system of hPNE cells was first established, and its migration ability was determined. Then, miR-145 lentiviral vectors were constructed to transfect hPRE cells.