2,626 results match your criteria: "Hubei University of Arts & Science[Affiliation]"

Article Synopsis
  • Despite progress in HIV treatment through antiretroviral therapy (ART), limitations like lifelong medication and viral resistance drive the need for new approaches.
  • Ibalizumab is currently the only approved CD4-specific antibody, and research into anti-CD4 nanobodies, particularly one called Nb457 from an alpaca, shows promise for better efficacy against HIV-1.
  • Nb457, especially in its engineered trimeric form, not only surpasses Ibalizumab in effectiveness but also demonstrates significant therapeutic benefits in mouse models, indicating potential for future clinical applications.
View Article and Find Full Text PDF

Background: Precise glioma segmentation from multi-parametric magnetic resonance (MR) images is essential for brain glioma diagnosis. However, due to the indistinct boundaries between tumor sub-regions and the heterogeneous appearances of gliomas in volumetric MR scans, designing a reliable and automated glioma segmentation method is still challenging. Although existing 3D Transformer-based or convolution-based segmentation networks have obtained promising results via multi-modal feature fusion strategies or contextual learning methods, they widely lack the capability of hierarchical interactions between different modalities and cannot effectively learn comprehensive feature representations related to all glioma sub-regions.

View Article and Find Full Text PDF

Introduction: Venous thromboembolism (VTE), including deep venous thrombosis and pulmonary embolism, is a common and potentially fatal post-surgery complication. Research has shown that 50% of VTE causes are intraoperative, with the risk of occurrence highest during and immediately post-surgery. Therefore, strategies for early assessment and prevention should be established.

View Article and Find Full Text PDF

Objective: Complications or serious adverse events (SAEs) are common in the treatment of patients with large vessel occlusion stroke. There has been limited study of the impact of SAEs for patients after endovascular thrombectomy (EVT). The goal of this study was to characterize the rates and clinical impact of SAEs following EVT.

View Article and Find Full Text PDF

Background/aims:  Incidence of colorectal cancer is rapidly increasing worldwide. Extracellular superoxide dismutase (EcSOD; SOD3) is an antioxidant enzyme. However, SOD3 roles in colorectal cancer progression remain uncertain.

View Article and Find Full Text PDF

Automatic diagnosis for adenomyosis in ultrasound images by deep neural networks.

Eur J Obstet Gynecol Reprod Biol

October 2024

Department of Ultrasound in Medicine, Renmin Hospital of Wuhan University, China. Electronic address:

Objective: To present a new noninvasive technique for automatic diagnosis of adenomyosis, using a novel end-to-end unified network framework based on transformer networks.

Study Design: This is a prospective descriptive study conducted at a university hospital.1654 patients were recruited to the study according to adenomyosis diagnosed by transvaginal ultrasound (TVS).

View Article and Find Full Text PDF

ncRNA Coding Potential Prediction Using BiLSTM and Transformer Encoder-Based Model.

J Chem Inf Model

August 2024

School of Computer Science and Engineering, Central South University, Changsha 410018, China.

Article Synopsis
  • Noncoding RNAs (ncRNAs) play critical roles in biological processes, and recent findings suggest that some can be translated into functional peptides, prompting the need for better methods to predict their coding potential.
  • A new model called nBAT, which uses BiLSTM and Transformer encoders, introduces a unique way to encode intrinsic features of ncRNAs, leading to improved predictions of their coding abilities.
  • nBAT outperforms existing methods on various datasets and shows promise for identifying coding potential in new ncRNAs, positioning it as a valuable tool for high-throughput analysis in this field.
View Article and Find Full Text PDF

Immune response to Aeromonas hydrophila and molecular characterization of polymeric immunoglobulin receptor in juvenile Megalobrama amblycephala.

Fish Shellfish Immunol

October 2024

Department of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Wuhan, Hubei, 430070, China. Electronic address:

Article Synopsis
  • The study focuses on the polymeric immunoglobulin receptor (pIgR) in Megalobrama amblycephala, highlighting its role in mucosal immunity and response to Aeromonas hydrophila infection.
  • Significant pathological changes were observed in various organs post-infection, alongside an increase in immune-related enzyme activities and inflammatory cytokine gene expressions over time.
  • The complete pIgR cDNA sequence was determined, revealing important structural features and phylogenetic relationships with similar genes in cyprinidae fish.
View Article and Find Full Text PDF

Corynespora cassiicola is a highly diverse fungal pathogen that commonly occurs in tropical, subtropical, and greenhouse environments worldwide. In this study, the isolates were identified as C. cassiicola, and the optimum growth and sporulation were studied.

View Article and Find Full Text PDF

Grasshopper platform-assisted design optimization of fujian rural earthen buildings considering low-carbon emissions reduction.

Sci Rep

August 2024

Hubei Province Changjiang Industry Investment Group Co., Ltd., Wuhan, 430070, People's Republic of China.

This work aims to explore optimization methods for the design of earthen buildings in rural Fujian to achieve low-carbon emissions and improve the structural stability of earthen buildings. First, parametric modeling and optimization algorithms are employed through the Grasshopper platform. An intelligent earthen building design is created by combining the optimization of factors such as the structure of earthen buildings, building materials, and orientation.

View Article and Find Full Text PDF

Laparoscopic versus open surgery for rectal neuroendocrine tumors: a multicenter real-world study.

BMC Cancer

August 2024

Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, no. 1277 Jiefang Avenue, Wuhan, 430022, Hubei Province, China.

Background: Owing to the lack of evidence-based medical studies with large sample sizes, the surgical approach for the radical resection of rectal neuroendocrine tumors remains controversial.

Methods: We retrospectively collected the medical records of patients with rectal neuroendocrine tumors who underwent radical resection at 17 large tertiary care hospitals in China between January 1, 2010, and April 30, 2022. All patients were divided into laparoscopic and open surgery groups.

View Article and Find Full Text PDF

Genome-scale metabolic models (GEMs) are powerful tools for predicting cellular metabolic and physiological states. However, there are still missing reactions in GEMs due to incomplete knowledge. Recent gaps filling methods suggest directly predicting missing responses without relying on phenotypic data.

View Article and Find Full Text PDF

Background: In recent years, the incidence of abdominal obesity among the middle-aged and older adult population in China has significantly increased. However, the gender disparities in the spatial distribution of abdominal obesity incidence and its relationship with meteorological factors among this demographic in China remain unclear. This gap in knowledge highlights the need for further research to understand these dynamics and inform targeted public health strategies.

View Article and Find Full Text PDF

Evaluation of the inhibitory effects of sitamaquine on Babesia infections.

Parasitol Int

December 2024

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan. Electronic address:

The treatment strategies for either human or animal babesiosis have been established and used for many years. With the rising indications of drug resistance and adverse side effects, finding effective and alternative therapies is urgently needed. Sitamaquine (SQ) is an 8-aminoquinoline that was first synthesized as a part of the collaborative anti-malarial program that led to primaquine.

View Article and Find Full Text PDF

Principles and challenges of generative artificial intelligence detection.

Br J Anaesth

October 2024

Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Department of Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China. Electronic address:

View Article and Find Full Text PDF

Objective: To investigate the value of fat-suppression (FS) T2 relaxation time (T2RT) derived from FS T2 mapping and water fraction (WF) derived from T2 IDEAL to predict the treatment response to intravenous glucocorticoids (IVGC) in patients with thyroid-associated ophthalmopathy (TAO) based on texture analysis.

Materials And Methods: In this study, 89 patients clinically diagnosed with active and moderate-to-severe TAO were enroled (responsive group, 48 patients; unresponsive group, 41 patients). The baseline clinical characteristics and texture features were compared between the two groups.

View Article and Find Full Text PDF
Article Synopsis
  • * Researchers analyzed data from 1408 patients and identified key prognostic factors such as tumor grade, size, and nutritional index, forming the basis for the GATIS score.
  • * The GATIS score demonstrated better predictive accuracy for patient outcomes compared to traditional methods like TNM staging and WHO grading, indicating it could significantly enhance prognosis evaluation for R-NENs.
View Article and Find Full Text PDF

In recent years, great progress has been made on the study of nanozymes with enzyme-like properties. Here, bimetallic Fe and Ni nanoclusters were anchored on the nanosheets of nitrogen-rich layered graphitic carbon nitride by one-step pyrolysis at high temperature (Fe/Ni-CN). The loading content of Fe and Ni on Fe/Ni-CN is as high as 8.

View Article and Find Full Text PDF

Engineering d-p Orbital Hybridization with P, S Co-Coordination Asymmetric Configuration of Single Atoms Toward High-Rate and Long-Cycling Lithium-Sulfur Battery.

Adv Mater

September 2024

State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, International School of Materials Science and Engineering, Wuhan University of Technology, Wuhan, Hubei, 430070, P. R. China.

Single-atom catalysts (SACs) have been increasingly explored in lithium-sulfur (Li-S) batteries to address the issues of severe polysulfide shuttle effects and sluggish redox kinetics. However, the structure-activity relationship between single-atom coordination structures and the performance of Li-S batteries remain unclear. In this study, a P, S co-coordination asymmetric configuration of single atoms is designed to enhance the catalytic activity of Co central atoms and promote d-p orbital hybridization between Co and S atoms, thereby limiting polysulfides and accelerating the bidirectional redox process of sulfur.

View Article and Find Full Text PDF

Objective: To develop a nomogram for predicting occurrence of secondary pulmonary infection in patients with critically traumatic brain injury (TBI) during their stay in the intensive care unit, to further optimise personalised treatment for patients and support the development of effective, evidence-based prevention and intervention strategies.

Data Source: This study used patient data from the publicly available MIMIC-IV (Medical Information Mart for Intensive Care IV) database.

Design: A population-based retrospective cohort study.

View Article and Find Full Text PDF

Spectral Decomposition and Transformation for Cross-domain Few-shot Learning.

Neural Netw

November 2024

School of Computer Science and Technology, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, 430070, Hubei, China.

Cross-domain few-shot Learning (CDFSL) is proposed to first pre-train deep models on a source domain dataset where sufficient data is available, and then generalize models to target domains to learn from only limited data. However, the gap between the source and target domains greatly hampers the generalization and target-domain few-shot finetuning. To address this problem, we analyze the domain gap from the aspect of frequency-domain analysis.

View Article and Find Full Text PDF

Introduction: With the discovery of extracorporeal membrane oxygenation (ECMO), it is considered as a valuable tool for supporting the treatment of severe acute respiratory distress syndrome (ARDS). It has gained increasing attention, particularly during the COVID-19 epidemic. However, to date, no relevant bibliometric research on the association between ECMO and ARDS (ECMO-ARDS) has been reported.

View Article and Find Full Text PDF

Objective: To explore the structure and characteristics of China's national policies regarding antimicrobial resistance (AMR) governance.

Method: This research constitutes a quantitative content analysis of AMR policies issued by the central government from 2004 to 2023. A systematic search identified 112 policy documents, which were analysed using a three-dimensional framework.

View Article and Find Full Text PDF

Efficacy of azasetron on postoperative chronic pain after pulmonary surgery: a randomized triple-blind controlled trial.

BMC Anesthesiol

July 2024

Institute of Neuroscience and Brain Disease, Department of Anesthesiology, Xiangyang Central Hospital, Hubei University of Arts and Science, No.136. Jinzhou Street, Xiangcheng District, Xiangyang, 441000, China.

Background: Inhibition of 5-HT3 (5-Hydroxyl Tryptamine) receptors is known to enhance morphine analgesia in animal models. We tested the efficacy of azasetron, a 5-HT3 receptor antagonist, on postoperative chronic pain after pulmonary surgery in a randomized triple-blind controlled study.

Methods: A total of 250 patients who were scheduled to receive pulmonary surgery were randomized to patient-controlled analgesia (PCA) using 200 µg sufentanil with normal saline or 200 µg sufentanil with 20 mg azasetron.

View Article and Find Full Text PDF