4 results match your criteria: "Hubei Center for ADR Monitoring[Affiliation]"

Chrysanthemum morifolium attenuates metabolic and alcohol-associated liver disease via gut microbiota and PPARα/γ activation.

Phytomedicine

July 2024

Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China; Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan 430065, China. Electronic address:

Article Synopsis
  • Metabolic and alcohol-associated liver disease (MetALD) has no effective treatment, but the water extract of Chrysanthemum morifolium Ramat. (WECM) shows promise due to its anti-inflammatory and hepatoprotective properties.
  • The study tested WECM on MetALD rats, assessing its impact on liver health and underlying mechanisms over a six-week period through various biochemical and microbiota analyses.
  • Results indicated that WECM significantly improved liver conditions, helped restore gut microbiota balance, activated beneficial signaling pathways, and enhanced lipid metabolism, suggesting its potential as a therapeutic agent for MetALD.
View Article and Find Full Text PDF

The present study aimed to explore the therapeutic effect and mechanism of non-polysaccharide fraction of Bletillae Rhizoma in the treatment of gastric ulcer by network pharmacology and animal experiments. UPLC-Q-TOF-MS/MS was employed to chara-cterize the chemical components of non-polysaccharide fraction of Bletillae Rhizoma, and the common targets of Bletillae Rhizoma and gastric ulcer were screened out by network pharmacology. The "drug-component-target-disease" network was constructed.

View Article and Find Full Text PDF

Chrysanthemi Flos (Juhua), an edible herbal medicine that possesses efficacies of dispersing wind, clearing heat and detoxifying. Studies have demonstrated that the health benefits of Chrysanthemi Flos are largely attributable to its anti-inflammatory effects. However, the correlation between the compounds monitored by the current quality control methods and the anti-inflammatory effects of Chrysanthemi Flos is unclear.

View Article and Find Full Text PDF

The chemical components in rats after oral administration of the water extract of Chrysanthemum morifolium cv. Fubaiju(CMF) were analyzed by UPLC-Q-TOF-MS/MS technique. Forty-four compounds were identified from the water extract of CMF and 11 components were identified from the rat serum.

View Article and Find Full Text PDF