882 results match your criteria: "Huazhong University of Science and Technology Wuhan[Affiliation]"
Chem Sci
December 2024
The State Key Laboratory of Refractories and Metallurgy, Institute of Advanced Materials and Nanotechnology, Wuhan University of Science and Technology Wuhan 430081 China.
Imeta
December 2024
Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Shenzhen China.
The Conference 2024 provides a platform to promote the development of an innovative scientific research ecosystem for microbiome and One Health. The four key components - Technology, Research (Biology), Academic journals, and Social media - form a synergistic ecosystem. Advanced technologies drive biological research, which generates novel insights that are disseminated through academic journals.
View Article and Find Full Text PDFImeta
December 2024
Department of Oncology First Affiliated Hospital, Dalian Medical University Dalian China.
Introduction: This study protocol specifies the primary research line and theoretical framework of the 2023 Survey of the Psychology and Behavior of the Chinese Population. It aims to establish a consistent database of Chinese residents' psychological and behavioral surveys through multi-center and large-sample cross-sectional surveys to provide robust data support for developing research in related fields. It will track the public's physical and psychological health more comprehensively and systematically.
View Article and Find Full Text PDFPediatr Investig
December 2024
Department of Otorhinolaryngology Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China.
High expression of cellular self-activated immunosuppressive molecules and extensive infiltration of suppressive immune cells in the tumor microenvironment are the main factors contributing to glioma's resistance to immunotherapy. Nonetheless, technology to modify the expression of glioma cellular self-molecules through gene editing requires further development. This project advances cell therapy strategies to reverse the immunosuppressive microenvironment of glioma (TIME).
View Article and Find Full Text PDFPhotothermal therapy (PTT) has garnered significant attention in recent years, but the standalone application of PTT still faces limitations that hinder its ability to achieve optimal therapeutic outcomes. Nitric oxide (NO), being one of the most extensively studied gaseous molecules, presents itself as a promising complementary candidate for PTT. In response, various nanosystems have been developed to enable the simultaneous utilization of PTT and NO-mediated gas therapy (GT), with the integration of photothermal agents (PTAs) and thermally-sensitive NO donors being the prevailing approach.
View Article and Find Full Text PDFChem Sci
December 2024
Key Laboratory of Flexible Optoelectronic Materials and Technology, Ministry of Education, Jianghan University Wuhan 430056 P. R. China
Coordination between 5,5',6,6'-tetrahydroxyindigo (4OH-ID) and boron tribromide unexpectedly affords a novel dynamic covalent polymer, namely P(ID-O-B), consisting of alternating indigo and indigo diradicaloid units. The catechol-boron dynamic bond plays a vital role in promoting the diradicaloid formation and stabilizing the formed diradicaloid segments. The diradicaloid segment in the polymer has a triplet ground state and a thermally populated doublet state, which has been confirmed by the EPR study.
View Article and Find Full Text PDFA mounting body of evidence suggests that the endoplasmic reticulum stress and the unfolded protein response are involved in the underlying mechanisms responsible for vascular diseases. Inositol-requiring protein 1α (IRE1α), the most ancient branch among the UPR-related signaling pathways, can possess both serine/threonine kinase and endoribonuclease (RNase) activity and can perform physiological and pathological functions. The IRE1α-signaling pathway plays a critical role in the pathology of various vascular diseases.
View Article and Find Full Text PDFRSC Adv
December 2024
School of Environmental Science and Engineering, Huazhong University of Science and Technology Wuhan 430074 China.
A cross-linked magnetic chitosan bead (MCB) and tetraethylenepentamine grafted magnetic chitosan bead (TMCB) were synthesized using the water/oil (W/O) emulsion cross-linking method and characterized using scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM) and Fourier transform infrared spectroscopy (FTIR). The saturation magnetization and remanent magnetization of TMCB were 7.09 emu g and 0.
View Article and Find Full Text PDFChem Sci
January 2025
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030 Hubei Province People's Republic of China
Cotylenins (CNs) are bioactive fungal diterpene glycosides that exhibit stabilizing activity on 14-3-3 protein-protein interactions (PPIs), which has significant therapeutic potential. Although CNs were isolated as early as 1970, their biosynthetic pathway has remained unclear, and their limited supply has hindered further research. Here, we report the identification of the biosynthetic gene cluster and elucidation of the biosynthetic pathway of CNs.
View Article and Find Full Text PDFExtracellular vesicles (EVs) composed of various biologically active constituents, such as proteins, nucleic acids, lipids, and metabolites, have emerged as a noteworthy mode of intercellular communication. There are several categories of EVs, including exosomes, microvesicles, and apoptotic bodies, which largely differ in their mechanisms of formation and secretion. The amount of evidence indicated that changes in the EV quantity and composition play a role in multiple aspects of cancer development, such as the transfer of oncogenic signals, angiogenesis, metabolism remodeling, and immunosuppressive effects.
View Article and Find Full Text PDFJ Am Heart Assoc
December 2024
Department of Ultrasound Medicine Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Background: The prognostic value of 3-dimensional (3D)-left ventricular global longitudinal strain (LVGLS) in recipients of heart transplant (HT) reremains unknown. This study aimed to determine whether 3D-LVGLS was the more powerful predictor of poor outcomes in recipients of HT compared with 2-dimensional (2D)-LVGLS.
Methods And Results: All consecutive adult patients who received HT and underwent at least 1 comprehensive 2D and 3D transthoracic echocardiographic examination for clinical surveillance were retrospectively enrolled.
J Am Heart Assoc
December 2024
Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy University of Houston TX.
Background: Accumulating evidence indicates that coronary microvascular dysfunction (CMD) caused by hypercholesterolemia can lead to myocardial ischemia, with or without obstructive atherosclerotic coronary artery disease. However, the molecular pathways associated with compromised coronary microvascular function before the development of myocardial ischemic injury remain poorly defined. In this study, we investigated the effects of hypercholesterolemia on the function and integrity of the coronary microcirculation in mice and the underlying mechanisms.
View Article and Find Full Text PDFChem Sci
November 2024
State Key Laboratory of Materials Processing and Die & Mould Technology, and School of Materials Science and Engineering, Huazhong University of Science and Technology Wuhan 430074 China
The exciton effect is commonly observed in photocatalysts, where substantial exciton binding energy ( ) significantly hampers the efficient generation of photo-excited electron-hole pairs, thereby severely constraining photocatalysis. Herein, we propose a strategy to reduce through strain-induced charge delocalization. Taking TaO as a prototype, tensile strain was introduced by engineering a crystalline/amorphous interface, weakening the interaction between Ta 5d and O 2p orbitals, thus endowing a delocalized charge transport and significantly lowering .
View Article and Find Full Text PDFRSC Adv
November 2024
Department of Developmental Biology, Washington University in St. Louis 660 S. Euclid Ave. St. Louis MO 63110 USA
The endogenous neurosteroids dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate (PS) are allosteric modulators of γ-aminobutyric acid type A (GABA) and -methyl-d-aspartate (NMDA) type glutamate receptors. Analogues of these endogenous steroid sulfates can be either positive or negative allosteric modulators (PAMs or NAMs, respectively) of these receptors, but there is limited information about the steroid-protein binding interactions that mediate these effects and photoaffinity labeling reagents (PALs) of sulfated steroids have not been reported previously. The synthesis of a panel of ten sulfated steroid analogues containing a diazirine group, five of which also contain an alkyne group for click chemistry reactions, for use in photoaffinity labeling studies to identify binding sites for steroid sulfates that are either positive or negative allosteric modulators is reported.
View Article and Find Full Text PDFAdvanced metastasis of hepatocellular carcinoma (HCC) significantly contributes to high death rates among patients. The efficiency of targeted therapies and chemotherapeutic agents shows individual variability. Therefore, there is no effective treatment for advanced HCC.
View Article and Find Full Text PDFMedComm (2020)
November 2024
Vaccine-based therapeutics for cancers face several challenges including lack of immunogenicity and tumor escape pathways for single antigen targets. It has been reported that radiotherapy has an in situ vaccine effect that provides tumor antigens following irradiation, helping to activate antigen-presenting cells (APCs). Herein, a new vaccine approach is developed by combining genetically engineered irradiated tumor cell debris (RTD) and hyaluronic acid (HA), termed HA@RTD.
View Article and Find Full Text PDFRSC Adv
October 2024
State Key Laboratory of Coal Combustion, School of Energy and Power Engineering, Huazhong University of Science and Technology Wuhan 430074 China.
Waste tobacco stalk is blended with graphite carbon to form a composite carbon source, which is a promising external heating system for heat-not-burn tobaccos. In the current work, the effects of tobacco stalk amounts and the catalyst KCO on the co-combustion characteristics (, the ignition temperature, burnout temperature, ) of graphite carbon were investigated. As a result, the ignition temperatures of the blend were determined by the tobacco straw, while the burnout temperature of the samples was reduced by approximately 60 °C due to the addition of a tobacco stalk.
View Article and Find Full Text PDFImeta
October 2024
Department of Thoracic Surgery West China Biomedical Big Data Center, West China Hospital, Sichuan University Chengdu China.
T cell is an indispensable component of the immune system and its multifaceted functions are shaped by the distinct T cell types and their various states. Although multiple computational models exist for predicting the abundance of diverse T cell types, tools for assessing their states to characterize their degree of resting, activation, and suppression are lacking. To address this gap, a robust and nuanced scoring tool called T cell state identifier (TCellSI) leveraging Mann-Whitney statistics is established.
View Article and Find Full Text PDFJ Am Heart Assoc
November 2024
Department of Occupational & Environmental Health, School of Public Health Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China.
Background: No study explored the association of noise exposure in the workplace and genetic susceptibility with incidence of atrial fibrillation (AF). We aimed to assess the separate and joint relationship of noise exposure in the workplace and genetic susceptibility with the risk of AF.
Methods And Results: We included 167 577 participants without AF at baseline in UK Biobank.
Am J Cancer Res
September 2024
Department of Interventional Vascular Surgery, First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital) Changsha 410000, Hunan, China.