882 results match your criteria: "Huazhong University of Science and Technology Wuhan[Affiliation]"

Redefining the roles of alkali activators for porous carbon.

Chem Sci

December 2024

The State Key Laboratory of Refractories and Metallurgy, Institute of Advanced Materials and Nanotechnology, Wuhan University of Science and Technology Wuhan 430081 China.

Article Synopsis
  • Alkali activation is used to create porous carbon, but the roles of different alkalis in mixed systems need more exploration beyond just corrosiveness.
  • Research utilized advanced analysis techniques to track activation processes and understand the roles of strong and weak alkalis individually.
  • The optimal ratio of strong (KOH) to weak alkali (KCO) at 1:1 resulted in a product (CKK-122) with superior microporosity and specific capacitance, showing potential for high-performance supercapacitors.
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The Conference 2024 provides a platform to promote the development of an innovative scientific research ecosystem for microbiome and One Health. The four key components - Technology, Research (Biology), Academic journals, and Social media - form a synergistic ecosystem. Advanced technologies drive biological research, which generates novel insights that are disseminated through academic journals.

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  • After RFA treatment for liver cancer, there's a notable increase in the expression of /xCT and the number of dendritic cells (DCs) in the tumor microenvironment (TME).
  • /xCT is associated with poor prognosis in liver cancer and is primarily found in DCs within the TME.
  • Combining xCT targeting in DCs with RFA treatment boosts anti-tumor immune responses, reduces tumor growth, and suggests a potential strategy for better treatment outcomes in liver cancer.
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Introduction: This study protocol specifies the primary research line and theoretical framework of the 2023 Survey of the Psychology and Behavior of the Chinese Population. It aims to establish a consistent database of Chinese residents' psychological and behavioral surveys through multi-center and large-sample cross-sectional surveys to provide robust data support for developing research in related fields. It will track the public's physical and psychological health more comprehensively and systematically.

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High expression of cellular self-activated immunosuppressive molecules and extensive infiltration of suppressive immune cells in the tumor microenvironment are the main factors contributing to glioma's resistance to immunotherapy. Nonetheless, technology to modify the expression of glioma cellular self-molecules through gene editing requires further development. This project advances cell therapy strategies to reverse the immunosuppressive microenvironment of glioma (TIME).

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Photothermal therapy (PTT) has garnered significant attention in recent years, but the standalone application of PTT still faces limitations that hinder its ability to achieve optimal therapeutic outcomes. Nitric oxide (NO), being one of the most extensively studied gaseous molecules, presents itself as a promising complementary candidate for PTT. In response, various nanosystems have been developed to enable the simultaneous utilization of PTT and NO-mediated gas therapy (GT), with the integration of photothermal agents (PTAs) and thermally-sensitive NO donors being the prevailing approach.

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Coordination between 5,5',6,6'-tetrahydroxyindigo (4OH-ID) and boron tribromide unexpectedly affords a novel dynamic covalent polymer, namely P(ID-O-B), consisting of alternating indigo and indigo diradicaloid units. The catechol-boron dynamic bond plays a vital role in promoting the diradicaloid formation and stabilizing the formed diradicaloid segments. The diradicaloid segment in the polymer has a triplet ground state and a thermally populated doublet state, which has been confirmed by the EPR study.

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A mounting body of evidence suggests that the endoplasmic reticulum stress and the unfolded protein response are involved in the underlying mechanisms responsible for vascular diseases. Inositol-requiring protein 1α (IRE1α), the most ancient branch among the UPR-related signaling pathways, can possess both serine/threonine kinase and endoribonuclease (RNase) activity and can perform physiological and pathological functions. The IRE1α-signaling pathway plays a critical role in the pathology of various vascular diseases.

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A cross-linked magnetic chitosan bead (MCB) and tetraethylenepentamine grafted magnetic chitosan bead (TMCB) were synthesized using the water/oil (W/O) emulsion cross-linking method and characterized using scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM) and Fourier transform infrared spectroscopy (FTIR). The saturation magnetization and remanent magnetization of TMCB were 7.09 emu g and 0.

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Cotylenins (CNs) are bioactive fungal diterpene glycosides that exhibit stabilizing activity on 14-3-3 protein-protein interactions (PPIs), which has significant therapeutic potential. Although CNs were isolated as early as 1970, their biosynthetic pathway has remained unclear, and their limited supply has hindered further research. Here, we report the identification of the biosynthetic gene cluster and elucidation of the biosynthetic pathway of CNs.

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Extracellular vesicles (EVs) composed of various biologically active constituents, such as proteins, nucleic acids, lipids, and metabolites, have emerged as a noteworthy mode of intercellular communication. There are several categories of EVs, including exosomes, microvesicles, and apoptotic bodies, which largely differ in their mechanisms of formation and secretion. The amount of evidence indicated that changes in the EV quantity and composition play a role in multiple aspects of cancer development, such as the transfer of oncogenic signals, angiogenesis, metabolism remodeling, and immunosuppressive effects.

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Background: The prognostic value of 3-dimensional (3D)-left ventricular global longitudinal strain (LVGLS) in recipients of heart transplant (HT) reremains unknown. This study aimed to determine whether 3D-LVGLS was the more powerful predictor of poor outcomes in recipients of HT compared with 2-dimensional (2D)-LVGLS.

Methods And Results: All consecutive adult patients who received HT and underwent at least 1 comprehensive 2D and 3D transthoracic echocardiographic examination for clinical surveillance were retrospectively enrolled.

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Background: Accumulating evidence indicates that coronary microvascular dysfunction (CMD) caused by hypercholesterolemia can lead to myocardial ischemia, with or without obstructive atherosclerotic coronary artery disease. However, the molecular pathways associated with compromised coronary microvascular function before the development of myocardial ischemic injury remain poorly defined. In this study, we investigated the effects of hypercholesterolemia on the function and integrity of the coronary microcirculation in mice and the underlying mechanisms.

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Strain-induced charge delocalization achieves ultralow exciton binding energy toward efficient photocatalysis.

Chem Sci

November 2024

State Key Laboratory of Materials Processing and Die & Mould Technology, and School of Materials Science and Engineering, Huazhong University of Science and Technology Wuhan 430074 China

The exciton effect is commonly observed in photocatalysts, where substantial exciton binding energy ( ) significantly hampers the efficient generation of photo-excited electron-hole pairs, thereby severely constraining photocatalysis. Herein, we propose a strategy to reduce through strain-induced charge delocalization. Taking TaO as a prototype, tensile strain was introduced by engineering a crystalline/amorphous interface, weakening the interaction between Ta 5d and O 2p orbitals, thus endowing a delocalized charge transport and significantly lowering .

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Article Synopsis
  • Ferroptosis is a type of cell death triggered by iron-related damage to lipids, leading to membrane breakdown and is linked to various diseases like cancer and neurodegenerative disorders.
  • Despite progress in understanding ferroptosis mechanisms, including genetic and epigenetic factors, the precise regulatory pathways and how to develop effective therapies targeting this process are still unclear.
  • The review highlights the need for further research to clarify the role of ferroptosis in diseases and suggests potential strategies for clinical monitoring and treatment development.
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The endogenous neurosteroids dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate (PS) are allosteric modulators of γ-aminobutyric acid type A (GABA) and -methyl-d-aspartate (NMDA) type glutamate receptors. Analogues of these endogenous steroid sulfates can be either positive or negative allosteric modulators (PAMs or NAMs, respectively) of these receptors, but there is limited information about the steroid-protein binding interactions that mediate these effects and photoaffinity labeling reagents (PALs) of sulfated steroids have not been reported previously. The synthesis of a panel of ten sulfated steroid analogues containing a diazirine group, five of which also contain an alkyne group for click chemistry reactions, for use in photoaffinity labeling studies to identify binding sites for steroid sulfates that are either positive or negative allosteric modulators is reported.

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Advanced metastasis of hepatocellular carcinoma (HCC) significantly contributes to high death rates among patients. The efficiency of targeted therapies and chemotherapeutic agents shows individual variability. Therefore, there is no effective treatment for advanced HCC.

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Article Synopsis
  • Diabetic nephropathy (DN) is a common and costly complication of diabetes, with unclear mechanisms and limited treatments, and this study investigates the role of interleukin-33 (IL-33) in DN.
  • Research shows increased IL-33 and its receptor ST2 in both mice models and DN patients, and both reducing and increasing IL-33 levels worsens kidney damage, indicating its harmful effects in DN.
  • The study suggests that partial inhibition of IL-33 may protect kidneys by reducing cellular senescence and related damage, highlighting a new potential pathway for treating DN.
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Vaccine-based therapeutics for cancers face several challenges including lack of immunogenicity and tumor escape pathways for single antigen targets. It has been reported that radiotherapy has an in situ vaccine effect that provides tumor antigens following irradiation, helping to activate antigen-presenting cells (APCs). Herein, a new vaccine approach is developed by combining genetically engineered irradiated tumor cell debris (RTD) and hyaluronic acid (HA), termed HA@RTD.

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Waste tobacco stalk is blended with graphite carbon to form a composite carbon source, which is a promising external heating system for heat-not-burn tobaccos. In the current work, the effects of tobacco stalk amounts and the catalyst KCO on the co-combustion characteristics (, the ignition temperature, burnout temperature, ) of graphite carbon were investigated. As a result, the ignition temperatures of the blend were determined by the tobacco straw, while the burnout temperature of the samples was reduced by approximately 60 °C due to the addition of a tobacco stalk.

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T cell is an indispensable component of the immune system and its multifaceted functions are shaped by the distinct T cell types and their various states. Although multiple computational models exist for predicting the abundance of diverse T cell types, tools for assessing their states to characterize their degree of resting, activation, and suppression are lacking. To address this gap, a robust and nuanced scoring tool called T cell state identifier (TCellSI) leveraging Mann-Whitney statistics is established.

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Background: No study explored the association of noise exposure in the workplace and genetic susceptibility with incidence of atrial fibrillation (AF). We aimed to assess the separate and joint relationship of noise exposure in the workplace and genetic susceptibility with the risk of AF.

Methods And Results: We included 167 577 participants without AF at baseline in UK Biobank.

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Article Synopsis
  • * The rise of machine algorithms, especially in deep learning and machine learning, offers new ways to analyze clinical data and improve prognostic assessments in liver cancer patients through identifying patterns.
  • * Key challenges remain in this field, such as integrating diverse clinical data, addressing ethical concerns, and ensuring the transparency of how these algorithms make decisions, which this paper aims to address through a systematic review.
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