and carbohydrate active enzymes contribute to the reduced fat deposition in pigs.

Pig gastrointestinal tracts harbor a heterogeneous and dynamic ecosystem populated with trillions of microbes, enhancing the ability of the host to harvest energy from dietary carbohydrates and contributing to host adipogenesis and fatness. However, the microbial community structure and related mechanisms responsible for the differences between the fatty phenotypes and the lean phenotypes of the pigs remained to be comprehensively elucidated. Herein, we first found significant differences in microbial composition and potential functional capacity among different gut locations in Jinhua pigs with distinct fatness phenotypes.

[Mechanism of Biejiajian Pills against non-alcoholic steatohepatitis based on lipidomics].

This study aims to explore the potential mechanism of Biejiajian Pills in the treatment of non-alcoholic steatohepatitis(NASH) based on lipidomics. A mouse model of NASH was induced by high-fat/high cholesterol diet, and the mice of the normal group were fed with a normal diet. The therapeutic efficacy of Biejiajian Pills against NASH was evaluated through biochemical indexes in both of serum and liver, as well as the hepatic histopathology.

High-throughput sequencing and fatty acid profile analyses of the Black Amur bream () reveal variation in dietary niche associated with geographic segregation.

Fish dietary niche is a core focus, and it reflects the diversity of resources, habitats, or environments occupied by a species. However, whether geographic segregation among different populations triggers dietary diversification and concomitant fish niche shift remains unknown. In the present study, we selected the Black Amur bream () is a migratory fish species that plays an important role in the material transfer and energy cycling of river ecosystems, inhabiting southern China drainage with multiple geographic populations.

Neuroinvasive virus facilitates viral replication by employing lipid droplets to reduce arachidonic acid-induced ferroptosis.

Lipids have been previously implicated in the lifecycle of neuroinvasive viruses. However, the role of lipids in programmed cell death and the relationship between programmed cell death and lipid droplets (LDs) in neuroinvasive virus infection remains unclear. Here, we found that the infection of neuroinvasive virus, such as rabies virus and encephalomyocarditis virus could enhance the LD formation in N2a cells, and decreasing LDs production by targeting diacylglycerol acyltransferase could suppress viral replication.

[Genome-wide identification and expression analysis of TCP gene family of Andrographis paniculata under abiotic stress].

Andrographis paniculata is an important medicinal plant in the Lingnan region of China, which has the functions of clearing heat, removing toxins, and resisting bacteria and inflammation. The TCP gene family is a class of transcription factors that regulate plant growth, development, and stress response. In order to analysis the role of the TCP gene family under abiotic stress in A.

Soil nutrient limitation and natural enemies promote the establishment of alien species in native communities.

The invasion of alien plant species threatens the composition and diversity of native communities. However, the invasiveness of alien plants and the resilience of native communities are dependent on the interactions between biotic and abiotic factors, such as natural enemies and nutrient availability. In our study, we simulated the invasion of nine invasive plant species into native plant communities using two levels of nutrient availability and suppression of natural enemies.

Modulation of physicochemical properties of lipid droplets using soy protein isolate and lactoferrin interfacial coatings.

In order to improve the physicochemical stability of soy protein isolate (SPI) emulsion, lactoferrin (LF) was used to modify the interface layer. The stable multilayer emulsion can be formed when the content of lactoferrin is 0.5% at pH 5.

Effect of preserved eggs on the health of SD rats, and anti-tumor action of HT-29 cells.

Preserved eggs are traditional alkali-pickled food in China and have been enjoyed by consumers and extensively studied by researchers for their nutritional tastes and their anti-tumor, anti-inflammatory, antioxidant, lipid-lowering, and blood pressure-lowering properties. To study the anti-tumor effects of preserved eggs, this project observed the health on rats, and anti-tumor effects and separated anti-tumor active components on HT-29 cells. SD rats fed for 80 days showed that preserved eggs had no significant effect on weight, food intake, blood pH, liver tissues, or organ indices.

Atomic insights into the mechanisms of Al or Cr affecting ferrihydrite nucleation.

Various exotic metal cations commonly coexist with ferrihydrite nanoparticles in natural environments. Lack of knowledge about the metal cations effects on ferrihydrite nucleation and growth greatly blights the deep understanding of ferrihydrite mineralogical properties and reactivities, and thus the fates of associated nutrients, heavy metals/metalloids, and organic pollutants. Here, the nucleation processes and mechanisms of ferrihydrite nanoparticles in the presence of Al or Cr were studied by combining visible spectroscopy, quick X-ray absorption fine structure spectroscopy and quantum chemical calculations.

Complete chloroplast genome sequence of and comparative genomics of related species in the family Ericaeae.

Hemsley et Wilson, 1907, a typical member of the family Ericaeae, possesses valuable medicinal and horticultural properties. In this research, the complete chloroplast (cp) genome of was sequenced and assembled, which proved to be a typical quadripartite structure with the length of 203,480 bp. In particular, the lengths of the large single copy region (LSC), small single copy region (SSC), and inverted repeat regions (IR) were 113,715 bp, 7,953 bp, and 40,918 bp, respectively.

Biotransformation of benzo[]pyrene by sp. JPA3 and the degradation mechanism through the initially oxidized benzo[]pyrene-4,5-dihydrodiol to downstream metabolites.

Owing to its adverse effects on the environment and human health, benzo[]pyrene (BaP) has attracted considerable attention and has been used as a model compound in ecotoxicology. In this study, sp. JPA3 as a BaP-degrading strain was isolated from the production water of an oil well.

Epidemiological Investigation, Risk Factors, Spatial-Temporal Cluster, and Epidemic Trend Analysis of Pseudorabies Virus Seroprevalence in China (2017 to 2021).

Pseudorabies virus (PRV) is a double-stranded linear DNA virus capable of infecting various animals, including humans. We collected blood samples from 14 provinces in China between December 2017 and May 2021 to estimate PRV seroprevalence. The PRV gE antibody was detected using the enzyme-linked immunosorbent assay (ELISA).

abuse exhibits a pro-inflammatory effect by activating the NF-κB pathway.

( C. A. Meyer) is a well-known traditional medicine that has been used for thousands of years to treat diseases.

Enantio- and diastereodivergent synthesis of fused indolizines enabled by synergistic Cu/Ir catalysis.

Highly diastereo-/enantioselective assembly of 2,3-fused indolizine derivatives could be easily available through a cascade allylation/Friedel-Crafts type reaction enabled by a synergistic Cu/Ir catalysis. This designed protocol provides an unprecedented and facile route to enantioenriched indolizines bearing three stereogenic centers in moderate to high yields with excellent stereoselective control, which also featured broad substrate generality. Remarkably, four stereoisomers of the 2,3-fused indolizine products could be efficiently constructed in a predictable manner through the pairwise combination of copper and iridium catalysts.

Productivity and global warming potential of direct seeding and transplanting in double-season rice of central China.

Labor and water scarcity requires crop establishment of double-season rice to be shifted from traditional transplanting to direct seeding. Owing to the limited thermal time, only ultrashort-duration cultivars of about 95 d can be used for direct-seeded, double-season rice (DDR) in central China. However, whether the shift in crop establishment of double-season rice can reduce greenhouse gas emissions without yield penalty remains unclear.

Sustained release of tumor cell lysate and CpG from an injectable, cytotoxic hydrogel for melanoma immunotherapy.

Many basic research studies have shown the potential of autologous cancer vaccines in the treatment of melanoma. However, some clinical trials showed that simplex whole tumor cell vaccines can only elicit weak CD8 T cell-mediated antitumor responses which were not enough for effective tumor elimination. So efficient cancer vaccine delivery strategies with improved immunogenicity are needed.

Million-atom molecular dynamics simulations reveal the interfacial interactions and assembly of plant PSII-LHCII supercomplex.

Protein-protein interface interactions dictate efficient excitation energy transfer from light-harvesting antennas to the photosystem II (PSII) core. In this work, we construct a 1.2 million atom-scale model of plant CS-type PSII-LHCII supercomplex and perform microsecond-scale molecular dynamics (MD) simulations to explore the interactions and assembly mechanisms of the sizeable PSII-LHCII supercomplex.

One-pot cascade construction of nonsubstituted quinoline-bridged covalent organic frameworks.

Irreversible locking of imine linkages into stable linkages represents a promising strategy to improve the robustness and functionality of covalent organic frameworks (COFs). We report, for the first time, a multi-component one-pot reaction (OPR) for imine annulation to construct highly stable nonsubstituted quinoline-bridged COFs (NQ-COFs), and that equilibrium regulation of reversible/irreversible cascade reactions by addition of MgSO desiccant is crucial to achieve high conversion efficiency and crystallinity. The higher long-range order and surface area of NQ-COFs synthesized by this OPR than those of the reported two-step post-synthetic modification (PSM) facilitate charge carrier transfer and photogeneration ability of superoxide radicals (O˙), which makes these NQ-COFs more efficient photocatalysts for O˙ mediated synthesis of 2-benzimidazole derivatives.

Descriptions of a new species of genus and life history of (Alexander, 1935) (Diptera, Tipulidae).

Background: is a small genus of Tipulidae with only fourteen described species in the world and seven known species in China.

New Information: Here, one new species is added to the fauna of Sichuan. The life history of (Alexander, 1935) is presented and the morphologies of all stages are described.

[Biosynthetic pathways of triterpenes in medicinal plants and key enzyme genes: a review].

Triterpenes, with high diversity and a wide range of sources, can be found in many medicinal plants. They have been found free or as glycosides/esters by combining with sugars. Most of them act as signaling molecules and function in stress response.

Jasmonate activates a CsMPK6-CsMYC2 module that regulates the expression of β-citraurin biosynthetic genes and fruit coloration in orange (Citrus sinensis).

Carotenoids are natural pigments that influence the color of citrus fruit. The red-colored carotenoid β-citraurin is responsible for the peel color in "Newhall" orange (Citrus sinensis). Although jasmonates are known to regulate the biosynthesis and accumulation of carotenoids, their effects on β-citraurin biosynthesis in citrus fruit remain unclear.

High-efficiency genome editing of an extreme thermophile using endogenous type I and type III CRISPR-Cas systems.

is an attractive species in the bioindustry due to its valuable natural products, abundant thermophilic enzymes, and promising fermentation capacities. However, efficient and versatile genome editing tools are not available for this species. In this study, we developed an efficient genome editing tool for HB27 based on its endogenous type I-B, I-C, and III-A/B CRISPR-Cas systems.

Chemical constitutes and anti-obesity potential of seedlings of purple-leafed rice in high-fat diet induced obese mice.

The seedlings of purple leafed rice (SPLR) are characterized by high contents of anthocyanins and various polyphenols, whose total anthocyanin content can reach 15.16 mg g, indicating that SPLR may have many bioactivities. Therefore, in order to evaluate the anti-obesity potential value of SPLR, the nutrient components were first identified, and the anti-obesity effect of SPLR was evaluated with a high-fat diet (HFD) induced obese mouse model for 12 weeks.