Advances in natural small molecules on pretranslational regulation of gluconeogenesis.

Different tissues and organs coordinate to keep glucose levels at homeostasis. However, excessive gluconeogenesis in patients with type 2 diabetes mellitus increases blood glucose and causes dysregulation of homeostasis, which easily induces various diseases. Therefore, inhibiting excessive gluconeogenesis is a potential direction to regulate the disorder of blood glucose homeostasis and treat diabetes.

Dynamic Reconstructed RuO /NiFeOOH with Coherent Interface for Efficient Seawater Oxidation.

Developing efficient oxygen evolution reaction (OER) electrocatalysts for seawater electrolysis is still a big challenge. Herein, a facile one-pot approach is reported to synthesize RuO -incorporated NiFe-metal organic framework (RuO /NiFe-MOF) with unique nanobrick-nanosheet heterostructure as precatalyst. Driven by electric field, the RuO /NiFe-MOF dynamically reconstructs into RuO nanoparticles-anchored NiFe oxy/hydroxide nanosheets (RuO /NiFeOOH) with coherent interface, during which the dissolution and redeposition of RuO are witnessed.

Optimizing the preparative capacity of two-dimensional liquid chromatography based on analytes retention behaviors.

In this work, a solute retention optimization method (SRO) was proposed to exploit the purification potential of two-dimensional liquid chromatography (2D-LC). According to our findings, the complementarity of 2D-LC correlates with some specific impurities. In the two methods used in 2D-LC, the retention order of these impurities and target compound is completely opposite.

Cultural ecology cognition and heritage value of huizhou traditional villages.

Heritage value is a prerequisite for protecting and utilising traditional villages. In response to the unclear definition of heritage value, this study develops a conceptual model and an indicator system of traditional village heritage value based on cultural ecology. Additionally, the study analyses heritage value using a three-dimensional matrix model and cluster analysis.

Comparative Transcriptome and Co-Expression Network Analyses Reveal the Molecular Mechanism of Calcium-Deficiency-Triggered Tipburn in Chinese Cabbage ( L. ssp. ).

Chinese cabbage tipburn is characterized by the formation of necrotic lesions on the margin of leaves, including on the insides of the leafy head. This physiological disorder is associated with a localized calcium deficiency during leaf development. However, little information is available regarding the molecular mechanisms governing Ca-deficiency-triggered tipburn.

Dynamical changes of land use/land cover and their impacts on ecological quality during China's reform periods: A case study of Quanzhou city, China.

The rapid growth of China's economy has greatly accelerated the process of urbanization during China's reform periods. Urbanization has significantly caused land use and land cover (LULC) changes and thus has impacts on the local climate and ecosystem. This study chooses Quanzhou, a fast-developing city of southeast China, as an example to detect and quantify the LULC and ecological changes from 1989 to 2018 by using the remotely sensed technique.

Flute-type porous carbon derived from soybean shells for high-performance all-solid-state symmetric supercapacitors.

Flute-type porous carbon was successfully prepared from soybean shells through convenient methods. The influence of mass ratio on the structure and electrochemical performance of porous carbon obtained from soybean shells was investigated in detail. The obtained porous carbon exhibited a micro-tube morphology structure with a specific surface area of 2802 m g, pore volume of 1.

Multi-step phase transition crystal with dielectric constant bistability and temperature-dependent conductivity.

Here, we report the crystal structures, phase transitions, and thermal, dielectric, and conducting properties of an ion-pair compound [C-bmim][Ni(mnt)] (1). 1 undergoes a three-step phase transition with four phases before melting. A two-step dielectric constant bistability is also realized by the structural phase transition in 1 occurring among phases I, II, and III, which is due to the in-plane oscillations of the alkyl chain and crystal-to-mesophase transition, respectively.

Me-Better Drug Design Based on Nevirapine and Mechanism of Molecular Interactions with Y188C Mutant HIV-1 Reverse Transcriptase.

In this paper, the Y188C mutant HIV-1 reverse transcriptase (Y188CM-RT) target protein was constructed by homology modeling, and new ligands based on nevirapine (NVP) skeleton were designed by means of fragment growth. The binding activity of new ligands to Y188CM-RT was evaluated by structural analysis, ADMET prediction, molecular docking, energy calculation and molecular dynamics. Results show that 10 new ligands had good absorbability, and their binding energies to Y188CM-RT were significantly higher than those of wild-type HIV-1 reverse transcriptase(wt).

Effects of Maillard Reaction on Volatile Compounds and Antioxidant Capacity of Cat Food Attractant.

In this study, self-made cat food attractant was prepared by Maillard reaction using hydrolysate of grass carp waste as raw material and glucose and cysteine hydrochloride as substrate. Its volatile compounds, antioxidant capacity, and pet palatability were investigated. The volatile compounds of attractants were analyzed using gas chromatography-mass spectrometry (GC-MS) which showed that alcohols and aldehydes were the most volatile in self-made attractants, accounting for 34.

Integrated one-dimensional CuO-nanowire arrays/Cu-foam nanoarchitecture for ultrahigh sensitive and non-enzymatic electrochemical determination of histamine levels in different-bacteria fermented mandarin fish.

Integrated one-dimensional CuO-nanowire arrays/Cu-foam (CuO-NWAs/Cu-foam) nanostructure, which was fabricated by oxidation and calcination, has been newly utilized as non-enzymatic electrocatalytic electrode for exploring histamine level. Under optimal condition of pH at 13 and potential at 0.55 V (vs Ag/Ag/Cl), the sensitivity of CuO-NWAs/Cu-foam electrode towards non-enzymatic electrochemical histamine determination presented as high as 12.

Identification and quantitation of the novel insecticide sulfoxaflor and its metabolites in floral nectar from Salvia splendens Ker Gawl. (Lamiaceae).

Sulfoxaflor is a new systemic insecticide developed as a replacement for older neonicotinoids which are known to be toxic to pollinators. However, its metabolism in nectar and effect on nectar biosynthesis have not been investigated. After soil and foliar application, sulfoxaflor and its main metabolites in soil, leaf and Salvia splendens nectar, were measured by liquid chromatography coupled with triple quadrupole mass spectrometer (LC-MS/MS).

Synthesis, biological activity and toxicity to zebrafish of benzamides substituted with pyrazole-linked 1,2,4-oxadiazole.

To find pesticidal lead compounds with high activity, a series of novel benzamides substituted with pyrazole-linked 1,2,4-oxadiazole was designed and synthesized by using the splicing principle of active substructures. The chemical structures of the target compounds were confirmed by H NMR, C NMR and HRMS. The preliminary bioassay showed that most compounds displayed good larvicidal activities against mosquito larvae at 10 mg L.

Cultural Connotation and Image Dissemination of Ancient Villages under the Environment of Ecological Civilization: A Case Study of Huizhou Ancient Villages.

Ecological civilization refers to the sum of the material production and consumption mode, social organization and management system, values and ethics, and resource development and environmental influence mode between man and nature created in the practice of transforming nature, adapting to nature, conserving nature, and savoring nature. The construction of ecological civilization is an important part of the realization of the new rural construction goal of "production development, well-off life, civilized village customs, clean village appearance, and democratic management." With the comprehensive promotion of the construction of a new socialist countryside in China, the ancient villages, as the source foundation of Chinese national culture and the real record of historical information, have become an urgent and severe topic for the current village renovation and protection.

Analysis of the meteorological factors affecting the short-term increase in O concentrations in nine global cities during COVID-19.

Surface ozone (O) is a major air pollutant around the world. This study investigated O concentrations in nine cities during the Coronavirus disease 2019 (COVID-19) lockdown phases. A statistical model, named Generalized Additive Model (GAM), was also developed to assess different meteorological factors, estimate daily O release during COVID-19 lockdown and determine the relationship between the two.

Ethylene (co) oligomerization using iminopyridyl Ni(II) and Pd(II) complexes bearing benzocycloalkyl moieties to access hyperbranched ethylene oligomers and ethylene-MA co-oligomers.

Hyperbranched ethylene oligomers and polar functionalized co-oligomers synthesized ethylene chain walking (co) oligomerization is a very attractive strategy. In this study, a series of dibenzhydryl iminopyridyl ligands with benzocycloalkyl and naphthyl moieties and the corresponding Ni(II) and Pd(II) complexes were synthesized and characterized. The Ni(II) complexes were highly effective in ethylene oligomerization and ethylene oligomers with hyperbranched microstructures were generated from this system.

Design and characterization of gambogic acid-loaded mixed micelles system for enhanced oral bioavailability.

The aim of this study was to develop a gambogic acid-loaded mixed micelles (GA-M) system, using Kolliphor HS15 and lecithin, for enhancement of oral bioavailability. GA-M was prepared using the thin film hydration method, and particle size and zeta potential indexes were used to determine the optimized formulation was optimized with taking particle size, zeta potential as indexes. The optimal GA-M system had a mean particle size in the nanometer range (87.

Deeply Virtual Compton Scattering Cross Section at High Bjorken x_{B}.

We report high-precision measurements of the deeply virtual Compton scattering (DVCS) cross section at high values of the Bjorken variable x_{B}. DVCS is sensitive to the generalized parton distributions of the nucleon, which provide a three-dimensional description of its internal constituents. Using the exact analytic expression of the DVCS cross section for all possible polarization states of the initial and final electron and nucleon, and final state photon, we present the first experimental extraction of all four helicity-conserving Compton form factors (CFFs) of the nucleon as a function of x_{B}, while systematically including helicity flip amplitudes.

Investigating the Effect of Tyrosine Kinase Inhibitors on the Interaction between Human Serum Albumin by Atomic Force Microscopy.

It is important for elucidating the regulation mechanism of life activities, as well as for the prevention, diagnosis, and drug design of diseases, to study protein-protein interactions (PPIs). Here, we investigated the interactions of human serum albumin (HSA) in the presence of tyrosine kinase inhibitors (TKIs: imatinib, nilotinib, dasatinib, bosutinib, and ponatinib) using atomic force microscopy (AFM). The distribution of rupture events including the specific interaction force and the non-specific interaction force between HSA pairs was analyzed.

Abnormal Antennal Olfactory Sensilla Phenotypes Involved in Olfactory Deficit in (Diptera: Tephritidae).

The guava fruit fly, , is one of the most destructive pests in the genus and detects environmental odorants mainly through antennal olfactory sensilla phenotypes with nanopores. However, it is unclear whether there are naturally occurring abnormal antennal olfactory sensilla phenotypes that affect olfaction. Here, we found that there were abnormal bulges besides nanopores on the surface of trichoid and basiconic olfactory sensilla in the antennal flagellum of long-term laboratory rearing colony (LTC), and that nanopore number in these olfactory sensilla was also remarkably reduced.

Study on distribution characteristic of tourism attractions in international cultural tourism demonstration region in South Anhui in China.

Taking data of tourism attractions in international cultural tourism demonstration region in South Anhui in China, this study summarized the distribution characteristics of tourism attractions in region by applying GIS spatial analysis method such as nearest neighbor distance index and kernel density estimation method, and explored how natural conditions, urban infrastructure, social and economic development affect the distribution in order to better understand the distribution of regional tourism resources and serve the direction of tourism development. The study found that the tourist attractions in the demonstration area have a significant agglomeration on the whole, with Huangshan City as the main center and other districts and counties as the sub centers, presenting the trend of hierarchical development. In different kinds of tourism attractions, the distribution of natural tourism attractions and rural pastoral tourism attractions highly related to the topography.

Collaborative Construction of a Silver Nanocluster Fluorescent Probe Using the Pyridinium-Based Ionic Liquid [Cpy][DCA].

A silver nanocluster fluorescent probe was synthesized by using the pyridinium-based ionic liquid [Cpy][DCA] as the protective agent, AgNO as the precursor, and NaBH as the reducing agent. The presence of pyridine group enhanced the fluorescence intensity of Ag nanoclusters and facilitated the coordination interaction between Ag nanoclusters and AsO . Therefore, the collaborative construction of a silver nanocluster probe using the pyridinium-based ionic liquid [Cpy][DCA] offered outstanding selectivity and sensitivity to detect AsO in water.

[Research progress on camptothecin and its derivative nano-prodrugs based on tumor microenvironment response].

Nano-prodrug, one of the most widely used nano-formulation at present, has excellent efficacies in tumor treatment with high potential and clinical value. Camptothecin and its derivatives have broad prospects in the preparation of prodrugs for the treatment of tumors. Given the special microenvironment of tumors, including partial acidity, high concentration of reactive oxygen species, high concentration of glutathione and enzyme concentration, a large number of tumor microenvironment-responsive camptothecin and its derivative prodrugs were prepared.