The impact of achievement goals on college students' English performance-A moderated mediation model.

The study investigated the relationship between learning engagement and achievement goals, and English performance among college students. With the increasing popularity of online teaching methods, exploring how different teaching modes (online and classroom teaching) might influence students' learning outcomes is important. The researcher sought to understand how adopting different achievement goals such as mastery and performance-avoidance approaches could impact English performance and learning engagement.

Dynamic Structure-Aware Modulation Network for Underwater Image Super-Resolution.

Image super-resolution (SR) is a formidable challenge due to the intricacies of the underwater environment such as light absorption, scattering, and color distortion. Plenty of deep learning methods have provided a substantial performance boost for SR. Nevertheless, these methods are not only computationally expensive but also often lack flexibility in adapting to severely degraded image statistics.

Synthesis and anti-tumor activity of menthylamine derivatives: Focusing on the potent inhibitory effect of compound W8 on glioma growth.

In this work, we successfully synthesized eight distinct compounds, comprising four chiral menthylamines and related derivatives. We evaluated their cytotoxic potential against a panel of human cancer cell lines, including human colon cancer HCT-116 cells, human esophageal squamous KYSE-150 cells, human breast cancer MCF-7 cells, and human glioma U87 cells. The U87 cells were chosen for a more in-depth investigation of their anti-tumor efficacy.

Modulating Aggregation and Deaggregation Based on Assembling Strategy to Switch on NIR-II Light-Excited Fluorescence for Self-Reporting Viability of Eliminating Cancer Cell.

The fabrication of self-reporting photosensitizers (PSs), enabling real-time evaluation of the extent of elimination of cancer cells, holds significant scientific importance in the photodynamic therapy (PDT) process. To address the intrinsic challenge of the short-wavelength light source, this work proposed an innovative approach of rational design second near-infrared (NIR-II, 1000-1700 nm) light-excited fluorescent PS systems (named , , and , respectively) through modulating aggregation and deaggregation based on assembling strategy. Therein, the suitable interplanar distance of adjacent linked with C-H···π interactions was an idea for relieving compact π···π packing for fluorescent imaging as well as elevating the spin-orbit coupling for reactive oxygen species (ROS) generation.

Cobalt-Catalyzed Highly α-Stereoselective Glycosylation of Glycals.

Following the satisfactory catalytic performance of cobalt in the -glycosylation of glycals, further study of cobalt's application values was performed under mild conditions, leading to a range of highly α-stereoselective 2,3-unsaturated , , and glycosides. The synthetic potential of the developed protocol was underscored by the late-stage functionalization of pharmaceutically relevant molecules including the canagliflozin derivative (a potential candidate for treating type 2 diabetes and alleviating pathological aging). Furthermore, control experiments were conducted to elucidate a reasonable mechanism and rule out the pathway involving the configuration conversion between and anomers.

Directional false discovery rate control in large-scale multiple comparisons.

The advance of high-throughput biomedical technology makes it possible to access massive measurements of gene expression levels. An important statistical issue is identifying both under-expressed and over-expressed genes for a disease. Most existing multiple-testing procedures focus on selecting only the non-null or significant genes without further identifying their expression type.

Integrative Analysis of Acupuncture Targets and Immune Genes in Diabetes, Diabetic Peripheral Neuropathy, and Adjunct Therapy of Cancer.

Introduction: Acupuncture may help treat diabetes mellitus (DM), diabetic peripheral neuropathy (DPN), and adjunct therapy for cancer, but the biological mechanisms and immune-related genes involved are unclear; this study aims to clarify these aspects.

Methods: Comprehensive gene expression analysis revealed differentially expressed genes (DEGs) among DM, DPN, and control samples. Key genes from WGCNA were intersected with DEGs and acupuncture targets.

Evaluating the performance of carbon dioxide and methane observations from carbon-monitoring satellite products over China.

As the primary greenhouse gases contributing to climate change, carbon dioxide (CO₂) and methane (CH) play a critical role in the Earth's radiative balance and temperature regulation. Continuous and accurate satellite monitoring of CO₂ and CH₄ is essential for developing effective policies and strategies to mitigate their impacts. This study utilizes ground-based Fourier-transform infrared measurements from the Total Carbon Column Observing Network (TCCON) to evaluate the performance of current mainstream carbon-monitoring satellites over China, the world's largest carbon emitter.

Water-Soluble Lipophilic Near-Infrared Region II Fluorophores for High-Brightness Lipid Layer and Lipid Droplets Imaging Applications.

Fluorescence imaging in the second near-infrared region (NIR-II, 1000-1700 nm) has garnered considerable attention for displaying the biological information of deep tissues. However, the lack of biocompatible contrast agents with bright NIR-II emission has hampered the precise clinical application of deep tissue imaging. Here, a lipophilic enhancement strategy employing donor-acceptor-donor (D-A-D) molecules, introducing long alkoxy chains and quaternary ammonium salts for the development of highly bright water-soluble NIR-II fluorophores (BBTD-2C-N), is described.

CDMPred: a tool for predicting cancer driver missense mutations with high-quality passenger mutations.

Most computational methods for predicting driver mutations have been trained using positive samples, while negative samples are typically derived from statistical methods or putative samples. The representativeness of these negative samples in capturing the diversity of passenger mutations remains to be determined. To tackle these issues, we curated a balanced dataset comprising driver mutations sourced from the COSMIC database and high-quality passenger mutations obtained from the Cancer Passenger Mutation database.

NIR-photoactivatable DNA nanomachines for spatiotemporally controllable monitoring of microRNA-21 in living cells based on signal amplification strategy.

Precise and spatiotemporally controllable analysis of microRNA-21 in living cells is crucial for accurate diagnosis and effective treatment of related diseases. Herein, a near-infrared (NIR)-photoactivatable DNA nanomachine (PUCNPs-NH/PEG-ZL-DNA) was constructed for the precise analysis and diagnosis of microRNA-21 in tumor cells. Peanut-shaped upconversion nanoparticles (PUCNPs) were employed as the carriers and activators for the intelligent DNA probe, specifically enabling the cleavage of the photocleavable linker (PC-linker) from the hairpin DNA probe (Hp-Dzy) upon exposure to 808 nm irradiation.

Study on the Compressive Strength and Reaction Mechanism of Alkali-Activated Geopolymer Materials Using Coal Gangue and Ground Granulated Blast Furnace Slag.

By reutilizing industrial byproducts, inorganic cementitious alkali-activated materials (AAMs) contribute to reduced energy consumption and carbon dioxide (CO) emissions. In this study, coal gangue (CG) blended with ground granulated blast furnace slag (GGBFS) was used to prepare AAMs. The research focused on analyzing the effects of the GGBFS content and alkali activator (i.

Integrative transcriptome-proteome approach reveals key hypoxia-related features involved in the neuroprotective effects of Yang Xue oral liquid on Alzheimer's and Parkinson's disease.

This study investigates the role of hypoxia-related genes in the neuroprotective efficacy of Yang Xue oral liquid (YXKFY) in Alzheimer's disease (AD) and Parkinson's disease (PD). Using differential expression and weighted gene co-expression network analysis (WGCNA), we identified 106 and 9 hypoxia-associated genes in AD and PD, respectively, that are implicated in the transcriptomic and proteomic profiles. An artificial intelligence-driven hypoxia signature (AIDHS), comprising 17 and 3 genes for AD and PD, was developed and validated across nine independent cohorts ( = 1713), integrating 10 machine learning algorithms and 113 algorithmic combinations.

A new record and a novel morph description of (Squamata, Colubridae) from China.

Background: The Asian Cat Snake genus Fitzinger, 1826 includes 37 species, with high species diversity. Five species of have been recorded in China including (Boie, 1827), (Stejneger, 1902), (Duméril, Bibron & Duméril, 1854), (Wen, 1998) and (Nutaphand, 1971). Previously, the validity of the species (Wall, 1909) was controversial.

20( S )-Protopanaxatriol Improves Atherosclerosis by Inhibiting Low-Density Lipoprotein Receptor Degradation in ApoE KO Mice.

Atherosclerosis (AS) is a chronic progressive disease caused by various factors and causes various cerebrovascular and cardiovascular diseases (CVDs). Reducing the plasma levels of low-density lipoprotein cholesterol is the primary goal in preventing and treating AS. Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a crucial role in regulating low-density lipoprotein cholesterol metabolism.

Formulation design and characterization of silymarin liposomes for enhanced antitumor activity.

Liposomes, a nanoscale carrier, plays an important role in the delivery of drug, affects the in vivo efficacy of drugs. In this paper, silymarin(SM)-loaded liposomes was optimized using the response surface method (RSM), with entrapment efficiency (EE%) as an index. The formulation was optimized as follow: lecithin (7.

Remarkably Enhanced Phosphate Sequestration from Waters by Biochar with High-Density Quaternary Ammonium Groups.

A new biochar (N-BC) was fabricated by incorporating high-density positively charged quaternary ammonium groups into the pristine biochar without any adsorption for phosphate. N-BC can highly efficiently remove phosphate with an optimal pH of 5.0, a maximum experimental adsorption capacity of 30 mg of P/g, and an adsorption equilibrium time of 180 min.

Enhanced interfacial effect via acid theory with boosted photocatalytic performance of nitenpyram removal.

Surface reaction is a prominent aspect that affects the efficiency of photocatalysis. In this work, acid theory was employed to facilitate the reaction dynamics and enhance the interfacial effect between photocatalysts and target molecules. The photocatalytic removal efficiency of NTP was 66 % for bare CdS in 50 min with apparent rate constants of 0.

Carbon removal, sequestration and release by mariculture in an important aquaculture area, China.

To combat with climate change, most countries have set carbon neutrality target. However, our understanding on carbon removal, release and sequestration by mariculture remains unclear. Here, carbon removal, release and sequestration by maricultured seaweeds, shellfish and fish in Shandong Province during 2003-2022 were assessed using a comprehensive method that considers the processes of biological metabolism, seawater chemistry and carbon footprint.