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Article Synopsis
  • Alzheimer's dementia (AD) affects 3-32% of the population and currently has no effective treatments to slow cognitive decline, prompting investigation into exogenous melatonin as a potential therapy.
  • A recent network meta-analysis compared the cognitive benefits of melatonin supplementation with FDA-approved medications, using changes in cognitive function (measured by the MMSE) and quality of life as key outcomes.
  • Results show that medium-term low-dose melatonin leads to significant improvements in cognitive function and quality of life, with acceptability similar to that of placebo.
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