[The poor chemotherapeutic efficacy in lung adenocarcinoma overexpressing c-Src and nucleophosmin/B23(NPM1)].

Objective To observe the expressions of c-Src protein and nucleophosmin/B23 (NPM1) protein in lung adenocarcinoma tissues and explore their relationships with chemotherapeutic efficacy. Methods The study collected a total of 107 lung adenocarcinoma tissue specimens from the First People's Hospital of Huaihua City from 2012-10-10 to 2015-06-30. Immunohistochemistry was used to analyze the expressions of c-Src protein and NPM1 protein.

[Emodin alleviates pulmonary fibrosis through inactivation of TGF-β1/ADAMTS-1 signaling pathway in rats].

Objective To explore the role of transforming growth factor-β1 (TGF-β1)/a disintegrin-like and metalloproteinase with thrombospondin type 1 motif (ADAMTS-1) signaling pathway in emodin's anti-pulmonary fibrosis. Methods Sixty SD rats were randomly divided into 6 groups: normal control group, sham-operated group, model group, low-dose emodin intervention group (20 mg/kg), high-dose emodin intervention group (80 mg/kg) and prednisone group (5 mg/kg). Each group included 10 animals.

[Emodin inhibits the proliferation, transdifferentiation and collagen synthesis of pulmonary fibroblasts].

Objective To explore the effect of emodin on the proliferation, differentiation into myofibroblasts and collagen synthesis of pulmonary fibroblasts and the underlying mechanisms. Methods Human pulmonary fibroblasts MRC-5 were cultured in vitro, then the cells were inoculated with dimethyl sulfoxide (DMSO) added with 0, 10, 20, 40, 80 and 160 μmol/L emodin for 24, 48 and 72 hours. Inhibitory rate of cell proliferation was analyzed by MTT assay.