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miR-129-5p targets HOXC10 to control BMSC adipogenesis and osteogenesis in a model of steroid-induced osteonecrosis of the femoral head.
Am J Transl Res
December 2024
Department of Orthopedics, Huai'an Hospital of Huai'an City Huai'an 223200, Jiangsu, China.
Background: Steroid-induced osteonecrosis of the femoral head (SONFH) is a pathological condition primarily driven by an impaired balance in the differentiation of bone marrow mesenchymal stem cells (BMSCs) into adipogenic and osteogenic lineages. This study aimed to explore the role of miR-129-5p as a regulator of SONFH progression and associated mechanisms.
Methods: BMSCs were harvested from a rat SONFH model.