Analysis of the risk of death and its associated risk factors in Chinese patients with young-onset type 2 diabetes.

Objectives: To examine the association between the age at onset of diabetes and the risk of all-cause mortality in a population of individuals diagnosed with type 2 diabetes mellitus (T2DM) and to identify risk factors associated with all-cause mortality in young-onset T2DM (YOD) patients in China.

Methods: This study utilized a cohort of 9759 patients who were diagnosed with T2DM and who were registered and enrolled in the National Basic Public Health Service Management Program in Qinghe District (now Qingjiangpu District) and Huai'an District, Huai'an City, Jiangsu Province, China. The patients were observed from November 2013 to July 2014, and all-cause mortality data were obtained by comprehensive matching with the Huai'an City Resident Mortality Database as of December 31, 2019.

A therapeutic regimen using neoantigen-specific TCR-T cells for HLA-A*2402-positive solid tumors.

The adoptive transfer of TCR-T cells specific to neoantigens preferentially exhibits potent cytotoxicity to tumor cells and has shown promising efficacy in various preclinical human cancers. In this study, we first identified a functional TCR, Tcr-1, which selectively recognized the SYT-SSX fusion neoantigen shared by most synovial sarcomas. Engineered T-cell expressing Tcr-1 (Tcr-T1) demonstrated HLA-A*2402-restricted, antigen-specific anti-tumoral efficacy against synovial sarcoma cells, both in vitro and in vivo.

Unveiling the shared genes between systemic sclerosis and lung cancer.

The risk of lung cancer is significantly increased in patients with systemic sclerosis (SSc), yet the specific genes underlying this association remain unexplored. Our study aims to identify genes shared by SSc and lung cancer. We identified differentially expressed genes (DEGs) from SSc and lung adenocarcinoma (LUAD) datasets (SSc: GSE95065, LUAD: GSE136043) in the GEO database.

Differential impact of TyG and TyG-BMI indices on short- and long-term mortality in critically ill ischemic stroke patients.

Background: Ischemic stroke is a major contributor to global morbidity and mortality, particularly in critically ill patients in intensive care units (ICUs). While advances in stroke management have improved outcomes, predicting mortality remains challenging due to the involvement of complex metabolic and cardiovascular factors. The triglyceride-glucose (TyG) index, a marker for insulin resistance, has gained attention for its potential to predict adverse outcomes in stroke patients.

Biomimetic intelligent nanoplatform with cascade amplification effect for tumor synergy therapy.

Tumor heterogeneity, immune-suppressive microenvironment and the precise killing of tumor cells by drugs are important factors affecting tumor treatment. In this study, we developed environment-responsive drug delivery system (FM@IQ/PST&ZIF-8/DOX) based on ZIF-8 for tumor photothermal/immunotherapy/chemotherapy synergistic therapy. The prepared FM@IQ/PST&ZIF-8/DOX nanoplatfrom not only has highly drug loading capacity for chemotherapeutic drug-doxorubicin, but also erythrocyte membrance modified on their surface can endow their immunity-escaping property and prolong their blood circulation time.

Integrating necroptosis into pan-cancer immunotherapy: a new era of personalized treatment.

Introduction: Necroptosis has emerged as a promising biomarker for predicting immunotherapy responses across various cancer types. Its role in modulating immune activation and therapeutic outcomes offers potential for precision oncology.

Methods: A comprehensive pan-cancer analysis was performed using bulk RNA sequencing data to develop a necroptosis-related gene signature, termed Necroptosis.

Predicting sarcopenia risk in stroke patients: a comprehensive nomogram incorporating demographic, anthropometric, and biochemical indicators.

Objective: Although there is a strong correlation between stroke and sarcopenia, there has been a lack of research into the potential risks associated with post-stroke sarcopenia. Predictors of sarcopenia are yet to be identified. We aimed at developing a nomogram able to predict sarcopenia in patients with stroke.

Multidimensional perspectives on nurse burnout in China: a cross-sectional study of subgroups and predictors.

Background: Burnout is a state of physical and mental exhaustion triggered by long-term work stress, which is manifested mainly as emotional exhaustion, depersonalization, and a decreased sense of accomplishment. Among them, emotional exhaustion is its core feature, which often leads to a significant decrease in an individual's enthusiasm for work. Owing to the high intensity of the work environment and the special requirements of emotional labor, the nursing community is more vulnerable to burnout.

Development and evaluation of pH-sensitive Euryale ferox starch-based films containing nano-SiO and Chinese rose (Rosa chinensis) extract for freshness monitoring of chicken breast meat.

In this study, smart films of EFS, EFS-SiO and EFS-SiO-CRE were successfully developed by using Euryale ferox starch (EFS), nano-SiO and Chinese rose extract (CRE). The Chinese rose flower had a high content of anthocyanins (1.73 mg/g) and CRE exhibited different colors in varying pH buffers (2-13).

Postoperative recurrence prediction model for atrial fibrillation: a meta-analysis.

Objective: To systematically evaluate a recurrence risk prediction model for patients with Atrial Fibrillation (AF) following ablation, and to provide a reference for the model establishment and optimization.

Methods: Literature retrieval was conducted in databases including PubMed, Cochrane Library, EMbase, and Web of Science to collect studies on recurrence risk prediction models for AF patients following ablation. Study quality was assessed using Prediction Model Risk of Bias Assessment Tool, and a meta-analysis was performed using MedCalc statistical software.

Total burden of cerebral small vessel disease predict subjective cognitive decline in patients with Parkinson's disease.

Introduction: This study investigates the correlation between the total burden of Cerebral Small Vessel Disease (CSVD) and Subjective Cognitive Decline (SCD) in patients with Parkinson's disease (PD).

Methods: A cross-sectional design was employed, involving 422 patients with PD. Demographic and clinical data were collected.

CRH-YOLO for precise and efficient detection of gastrointestinal polyps.

Gastrointestinal polyps are early indicators of many significant diseases within the digestive system, and timely detection of these polyps is crucial for preventing them. Although clinical gastrointestinal endoscopy and interventions help reduce the risk of malignancy, most current methods fail to adequately address the uncertainties and scale issues associated with the presence of polyps, posing a threat to patients' health. Therefore, this paper proposes a novel single-stage method for polyp detection.

miR-122/NEGR1 axis contributes colorectal cancer liver metastasis by PI3K/AKT pathway and macrophage modulation.

Colorectal cancer (CRC) is a prevalent malignant tumor in the gastrointestinal tract, with around 50% of patients experiencing distant metastases, predominantly to the liver. Colorectal cancer liver metastasis (CRLM) is a leading cause of CRC-related death, and effective treatments remain limited. This study aims to identify new targets for predicting and treating CRLM.

Deciphering mechanism of Buyang Huanwu Decoction in regulating macrophage polarization to alleviate atherosclerosis via virtual screening and experimental verification.

Ethnopharmacological Relevance: Buyang Huanwu Decoction (BYHWD), a traditional prescription known for its Supplementing Qi and Promoting Blood Circulation, has demonstrated noteworthy therapeutic roles in regulating macrophage polarization to atherosclerosis (AS). However, its underlying mechanisms remain unknown.

Aim Of The Study: The purpose of this paper was to decipher mechanism of BYHWD in regulating macrophage polarization to alleviate AS.

The clinical significance of intraoperative lavage fluid culture during pancreaticoduodenectomy on organ/space surgical site infection.

Organ/space surgical site infection (SSI) are common after pancreaticoduodenectomy (PD). There is limited research on the clinical impact of intraoperative lavage fluid contamination in patients undergoing PD. One hundred five patients who underwent PD between August 2022 and July 2023 were retrospectively enrolled.

Comprehensive multi-omics analysis identifies chromatin regulator-related signatures and TFF1 as a therapeutic target in lung adenocarcinoma through a 429-combination machine learning approach.

Introduction: Lung cancer is a leading cause of cancer-related deaths, with its incidence continuing to rise. Chromatin remodeling, a crucial process in gene expression regulation, plays a significant role in the development and progression of malignant tumors. However, the role of chromatin regulators (CRs) in lung adenocarcinoma (LUAD) remains underexplored.

NOP10 predicts poor prognosis and promotes pancreatic cancer progression.

Background: Telomere shortening and RNA pseudo-uridylation are common features of tumors. NOP10 is a member of the H/ACA snoRNP family, essential for maintaining telomerase activity and RNA pseudouridylation. NOP10 has been indicated to be substantially expressed in tumors such as breast and lung cancers and is associated with poor prognosis.

Carboxymethyl chitosan/alendronate sodium/Sr modified TiO nanotube arrays enhancing osteogenic activity and antibacterial property.

Titanium and its alloys are widely used as orthopedic implants owing to their good mechanical properties and excellent corrosion resistance. However, the insufficient osteogenic activity and antibacterial properties hinder their clinical applications. To address these issues, TiO nanotube arrays (TNT) were first fabricated on the TA2 alloy surface via an anodizing technique, and strontium ions (Sr) were then loaded by hydrothermal reaction (TNT + Sr) and annealing treatment (TNT + A).

Development and validation of a machine learning-based diagnostic model for Parkinson's disease in community-dwelling populations: Evidence from the China health and retirement longitudinal study (CHARLS).

Background: Parkinson's disease (PD) is a major neurodegenerative disorder in Middle-aged and elderly people.There is a pressing need for effective predictive models, particularly in chinese population.

Objective: This study aims to develop and validate a machine learning-based diagnostic model to identify individuals with PD in community-dwelling populations using data from the China Health and Retirement Longitudinal Study (CHARLS).

Miller fisher syndrome with positive anti-GQ1b/GT1a antibodies associated with COVID-19 infection: A case report.

Background: Miller fisher syndrome (MFS) is a variant of Guillain-Barré syndrome, an acute immune-mediated peripheral neuropathy that is often secondary to viral infections. Anti-ganglioside antibodies play crucial roles in the development of MFS. The positive rate of ganglioside antibodies is exceptionally high in MFS patients, particularly for anti-GQ1b antibodies.

Corrigendum: Radiosensitizing effects of pyrogallol-loaded mesoporous or-ganosilica nanoparticles on gastric cancer by amplified ferroptosis.

[This corrects the article DOI: 10.3389/fbioe.2023.