1 results match your criteria: "Huadong Hospital of Fudan University Shanghai 200338[Affiliation]"
Triptolide enhances the sensitivity of pancreatic cancer PANC-1 cells to gemcitabine by inhibiting TLR4/NF-κB signaling.
Am J Transl Res
June 2019
Department of Gastroenterology, Huadong Hospital of Fudan University Shanghai 200338, China.
Background: This study aimed to investigate roles of Toll-like receptor 4 (TLR4)/nuclear factor (NF)-κB signaling in triptolide (TPL)-induced sensitivity of pancreatic cancer cells to gemcitabine (GEM).
Methods: , pancreatic cancer PANC-1 cells were treated with lipopolysaccharide (LPS) to activate TLR4, TLR4-siRNA, GEM alone, or GEM plus TPL. , nude mice bearing PANC-1 cell xenografts were treated with GEM, TPL, or both.