769 results match your criteria: "Huadong Hospital affiliated to Fudan University[Affiliation]"
Correction: Preparation and characterization of BSA‑loaded liraglutide and platelet fragment nanoparticle delivery system for the treatment of diabetic atherosclerosis.
J Nanobiotechnology
November 2024
Department of Cardiology, Huashan Hospital Affiliated to Fudan University, No.12 Urumqi Middle Road, Shanghai, 200040, China.
Phenyllactic acid modulates the gut microbiota, enhances intestinal health, and alleviates physical frailty in aging mice.
Eur J Pharmacol
December 2024
Department of Gerontology, Huadong Hospital Affiliated to Fudan University, Shanghai, China; Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai, China. Electronic address:
Phenyllactic acid (PLA) is a natural antibiotic-like compound derived from certain foods and probiotics. PLA levels have been associated with age-related sarcopenia and provide benefits to metabolic health when derived from probiotics. However, the specific regulatory effects of PLA in aging remain largely unexplored.
View Article and Find Full Text PDFC-Reactive Protein Level as a Novel Serum Biomarker in Sarcopenia.
Mediators Inflamm
November 2024
Department of Orthopedics Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China.
Background: The role of C-reactive protein (CRP), an inflammatory marker, in the development of sarcopenia remains uncertain.
Methods: This cross-sectional research involved the enrollment of 207 patients, classified into two groups: 74 patients with sarcopenia and 133 patients without sarcopenia. Clinical data of the participants, including hand grip strength, walking speed, appendicular lean mass (ALM), and calf circumference, were collected and recorded.
Preservation of the posterolateral cortex may not affect the biomechanical stability of lateral intra-articular varus osteotomy of the proximal tibia.
Clin Biomech (Bristol)
October 2023
Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai 200233, China. Electronic address:
Background: Lateral intra-articular varus osteotomy is an L-shaped osteotomy of the lateral tibial condyle to correct mild knee valgus and lateral plateau malunion of the proximal tibia. In order to minimize injury, it was modified to preserve the posterolateral cortex and the upper tibiofibular joint. The aim of this study was to evaluate the stability of modified lateral intra-articular varus osteotomy by comparing the biomechanical strength with lateral intra-articular varus osteotomy.
View Article and Find Full Text PDFFormononetin suppresses the malignant progression of papillary thyroid carcinoma depending on downregulation of CBX4.
Exp Ther Med
December 2024
Department of Vascular Medicine, Shanghai Traditional Chinese Medicine-Integrated Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200082, P.R. China.
Papillary thyroid carcinoma (PTC) is the most common malignant tumor of the endocrine system globally. Formononetin (FMNT), an isoflavonoid, exerts anti-tumorigenic effects and chromobox homolog 4 (CBX4) exerts tumor-promoting effect in specific types of tumors. Nevertheless, the predictive values and biological functions of FMNT and CBX4 in the pathological progress of PTC have not been fully understood till now.
View Article and Find Full Text PDFQuantitative analysis of imaging characteristics in lung adenocarcinoma in situ using artificial intelligence.
Thorac Cancer
December 2024
Department of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Background: With the rising incidence of pulmonary nodules (PNs), lung adenocarcinoma in situ (AIS) is a critical early stage of lung cancer, necessitating accurate diagnosis for early intervention. This study applies artificial intelligence (AI) for quantitative imaging analysis to differentiate AIS from atypical adenomatous hyperplasia (AAH) and minimally invasive adenocarcinoma (MIA), aiming to enhance clinical diagnosis and prevent misdiagnosis.
Methods: The study analyzed 1215 PNs with confirmed AAH, AIS, and MIA from six centers using the Shukun AI diagnostic module.
The role of moderate to vigorous physical activity level and number of treatments/medications in mediating the effect of body mass index on diabetic nephropathy: a Mendelian randomization study.
Ren Fail
December 2024
Department of Nephrology, Huadong Hospital affiliated to Fudan University, Shanghai, China.
Background: Body mass index (BMI) is associated with diabetic nephropathy (DN). However, the mediator factors in the BMI-DN effects remain unclear.
Methods: Univariate and multivariate Mendelian randomization (MR) analysis were performed to estimate the association between six lifestyles (moderate to vigorous physical activity levels, years of schooling, BMI, nap during day, number of treatments/medications taken and coffee intake) and DN.
Diagnostic performance of fully automatic coronary CT angiography-based quantitative flow ratio.
J Cardiovasc Comput Tomogr
October 2024
Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China; Department of Cardiology, Erasmus MC Medical University, Rotterdam, the Netherlands; Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai, China. Electronic address:
Article Synopsis
- A new method called CT-μFR, based on automatic CCTA reconstruction, was developed to identify significant coronary artery blockages using artificial intelligence, showing favorable accuracy when compared to traditional tests in the cath lab.
- This study analyzed data from the CAREER trial, where 657 vessels from 242 patients were evaluated for diagnostic accuracy and correlation with established physiological standards for determining significant stenosis.
- Results showed that CT-μFR effectively identified patients with serious blockages, achieving an accuracy rate of 83.0%, with a short average analysis time of around 1.6 minutes per patient, indicating its potential for clinical use.
Association between antithrombotic agents use and hepatocellular carcinoma risk: a two-sample mendelian randomization analysis.
J Cancer Res Clin Oncol
October 2024
Department of General Surgery (Hepatopancreatobiliary Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Article Synopsis
- Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer, and observational studies indicate that using antithrombotic agents may be linked to a decreased risk of developing HCC, though the exact causal relationship is unclear.
- To explore this connection, researchers conducted a two-sample Mendelian randomization analysis using genetic data from a genome-wide association study (GWAS) to examine the effects of antithrombotic agents on HCC risk.
- The analysis identified ten genetic variants related to antithrombotic use and found a strong negative causal association, suggesting that using these agents could lower the risk of HCC, with various methods confirming consistent results.
Oncogenic GALNT5 confers FOLFIRINOX resistance via activating the MYH9/ NOTCH/ DDR axis in pancreatic ductal adenocarcinoma.
Cell Death Dis
October 2024
Department of Biliary-Pancreatic Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, P.R. China.
Chemotherapy resistance has been a great challenge in pancreatic ductal adenocarcinoma(PDAC) treatments. Current first-line chemotherapy regimens for PDAC include gemcitabine-based regimens such as AG regimen (albumin paclitaxel and gemcitabine), fluorouracil-based regiments such as FOLFIRINOX regimen ((5-fluorouracil5-FU), oxaliplatin, Irinotecan) and platinum-based regimens for patients with BRCA mutations. large amounts of work have been done on exploring the mechanism underlying resistance of gemcitabine-based and platinum-based regimens, while little research has been achieved on the mechanism of FOLFIRINOX regimens resistance.
View Article and Find Full Text PDFAccuracy of coronary computed tomography angiography-derived quantitative flow ratio for onsite assessment of coronary lesions.
EuroIntervention
October 2024
Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Article Synopsis
- Coronary computed tomography angiography (CCTA) combined with Murray law-based quantitative flow ratio (CT-μFR) is a new non-invasive technique for quickly determining fractional flow reserve (FFR) in patients with coronary artery disease, though its effectiveness required validation.
- A trial involving 260 patients assessed the accuracy of onsite CT-μFR compared to invasive methods, focusing on its ability to detect significant coronary stenosis (narrowing of blood vessels).
- Results showed CT-μFR had a patient-level accuracy of 89.6%, surpassing the target accuracy of 72% and proving to be as effective as invasive methods in specific cases, confirming its potential as a reliable diagnostic tool.
Association between self-reported child maltreatment and risk of hospital-treated infectious diseases in middle-aged and older adults: A UK Biobank cohort study.
Prev Med
December 2024
Department of Biostatistics, Key Laboratory for Health Technology Assessment, National Commission of Health, Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health, Fudan University, Shanghai 200032, China. Electronic address:
Article Synopsis
- - This study examined how child maltreatment affects the risk of hospital-treated infectious diseases in adults aged 38-72, using data from over 145,000 participants in the UK Biobank from 2006 to 2010.
- - Results revealed that individuals who experienced any type of maltreatment faced a higher risk of infectious diseases, with the risk increasing based on the number of maltreatment types; those with multiple forms of maltreatment were particularly vulnerable.
- - The study concluded that early prevention of child maltreatment is crucial, as it appears to lead to an increased susceptibility to various infectious diseases later in life, influenced by factors like inflammation, mental health issues, and unhealthy lifestyles.
Nanotopography promotes cardiogenesis of pluripotent stem cell-derived embryoid bodies through focal adhesion kinase signaling.
Biochem Biophys Res Commun
November 2024
Department of Cardiology, Cardiovascular Center, College of Medicine, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, South Korea. Electronic address:
Controlling the microenvironment surrounding the pluripotent stem cells (PSCs) is a pivotal strategy for regulating cellular differentiation. Surface nanotopography is one of the key factors influencing the lineage-specific differentiation of PSCs. However, much of the underlying mechanism remains unknown.
View Article and Find Full Text PDFEIF4A3-Induced Circular RNA CircDdb1 Promotes Muscle Atrophy through Encoding a Novel Protein CircDdb1-867aa.
Adv Sci (Weinh)
December 2024
Cardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Sciences, Shanghai University, Nantong, 226011, China.
Article Synopsis
- Researchers have identified a specific circular RNA, circDdb1, that plays a significant role in causing skeletal muscle atrophy, which is often linked to aging and various diseases.
- CircDdb1 levels are significantly increased during muscle atrophy, and adding it artificially leads to more atrophy, whereas its inhibition can prevent muscle loss caused by different factors.
- The study also finds that circDdb1 regulates protein translation via its interaction with eukaryotic elongation factor 2 (eEF2) and suggests that targeting circDdb1 could serve as a new therapeutic approach to combat muscle atrophy.
Letter to the editor-long-term outcomes of infliximab treatment in neuro-Behçet syndrome: a single-center retrospective study.
Clin Rheumatol
December 2024
Geriatrics Department, Shidong Hospital, #999 Shiguang Road, Shanghai, 200438, China.
Recaticimab Monotherapy for Nonfamilial Hypercholesterolemia and Mixed Hyperlipemia: The Phase 3 REMAIN-1 Randomized Trial.
J Am Coll Cardiol
November 2024
Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address:
Article Synopsis
- Monoclonal antibodies like recaticimab target PCSK9 to effectively lower LDL cholesterol levels, offering an alternative to more frequent treatments due to its long-acting nature.
- The study evaluated recaticimab's effectiveness and safety in patients with nonfamilial hypercholesterolemia and low-to-moderate atherosclerotic cardiovascular disease risk, comparing various dosing strategies.
- Results showed significant LDL-C reductions (up to 52.8%) compared to placebo, with safety profiles similar to that of placebo, suggesting recaticimab may provide a flexible treatment option for patients.
Prevalence and assessment of sleep-disordered breathing in head and neck cancer patients: a systematic review.
Sleep Breath
December 2024
Department of Nursing, Shanghai Ninth People's Hospital, School of Medicine, Shanghai jiaotong University, 639 S Zhizaoju Rd, Shanghai, 200011, China.
Article Synopsis
- Sleep-disordered breathing (SDB) is a prevalent but often overlooked condition in patients with head and neck cancers (HNC), and untreated SDB can have serious health consequences.
- The study aimed to assess how common SDB is among HNC patients and to evaluate the effectiveness of different assessment methods.
- Results showed that SDB prevalence ranges from 57-90% before cancer treatment and varies widely after treatment, highlighting the need for consistent diagnostic criteria in future studies.
No causal relationship serum lipids on age-related hearing loss based on Mendelian randomized evidence.
Hear Res
November 2024
Department of Otorhinolaryngology Head & Neck Surgery, Huadong Hospital affiliated Fudan University, Shanghai 200040, China. Electronic address:
Objectives: Presbycusis, or age-related hearing loss (ARHL) has been a common disability disease among the elderly population. It is particularly essential to identify the underlying role of related risk factors for ARHL diagnosis and treatment. Observational studies have shown that cardiovascular disease may be a factor in ARHL.
View Article and Find Full Text PDFmiR-149-3p targeting regulates the sensitivity to cisplatin to inhibit the progression of lung cancer.
Biomol Biomed
December 2024
Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
Article Synopsis
- Lung cancer cells often develop resistance to cisplatin (DDP), making it important to find ways to improve sensitivity to this chemotherapy drug.
- Research involving cell lines and bioinformatics identified miR-149-3p as a key regulator that can enhance the effectiveness of DDP by targeting TMPRSS4, a protein associated with cancer progression.
- Overexpressing miR-149-3p in lung cancer cells not only promoted cell death and reduced tumor growth but also increased their sensitivity to chemotherapy by downregulating TMPRSS4, revealing a potential therapeutic approach for lung cancer treatment.
Inhibition of EREG/ErbB/ERK by Astragaloside IV reversed taxol-resistance of non-small cell lung cancer through attenuation of stemness via TGFβ and Hedgehog signal pathway.
Cell Oncol (Dordr)
December 2024
School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Article Synopsis
- Taxol is the primary chemotherapy for advanced non-small cell lung cancer (NSCLC), but many patients develop resistance, making it crucial to find ways to counteract this resistance.
- The study evaluated the potential of ASIV to reverse taxol resistance using various assays and discovered that it works by suppressing genes linked to the cancer cell's stemness.
- ASIV's mechanism involves promoting the degradation of epiregulin (EREG), which suppresses the signaling that leads to resistance, suggesting that targeting pathways like EREG/ErbB/ERK could be a way to improve treatment outcomes for resistant NSCLC.
Clinical characteristics of Behçet's syndrome in Shanghai database: Baseline data of a cross-sectional cohort study.
Int J Rheum Dis
October 2024
Department of Rheumatology and Immunology, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
Article Synopsis
- This study analyzed 1216 cases of Behçet's syndrome patients to better understand its diverse clinical features, particularly focusing on differences related to gender and age.
- It found that male patients had higher rates of conditions like pseudofolliculitis and uveitis, while female patients more commonly experienced genital ulcers and erythema nodosum.
- The study suggests that recognizing these differences can help in understanding Behçet's syndrome better and may support future multi-center research efforts.
Discordant definitions of small airway dysfunction between spirometry and parametric response mapping: the HRCT-based study.
Insights Imaging
October 2024
Department of Radiology, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
Article Synopsis
- The study aimed to explore lung structure differences in small airway dysfunction (SAD) using both spirometry and parametric response mapping (PRM) evaluated through high-resolution computed tomography (HRCT).
- It involved 388 participants who underwent pulmonary function tests and chest CT scans, leading to the identification of predictive factors for SAD based on clinical and imaging data.
- Results indicated that spirometry-defined SAD was more related to airway morphology, while PRM was more sensitive to early dysfunction, and predictive models combining clinical data and HRCT assessments showed high accuracy.
Prognostic Value of Quantitative Flow Ratio Combined with SYNTAX Scores I/II in Multivessel Coronary Artery Disease: A Small-Sample, Single-Center Study.
Rev Cardiovasc Med
September 2024
Department of Cardiology, Huadong Hospital Affiliated to Fudan University, 200040 Shanghai, China.
Article Synopsis
- A study investigated how the non-invasive Quantitative Flow Ratio (QFR) impacts risk stratification in patients with multivessel coronary disease by comparing it to traditional SYNTAX scores.
- The research involved 160 patients over a year, indicating that using Functional SYNTAX Scores (FSS and FSSII) resulted in a significant reduction of high-risk patients for major cardiovascular events.
- Findings suggest that FSSII is more effective than other scoring methods in predicting risks, leading to better identification of patients who are actually at lower cardiovascular risk.
Metabolic regulation of cytoskeleton functions by HDAC6-catalyzed α-tubulin lactylation.
Nat Commun
September 2024
School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Posttranslational modifications (PTMs) of tubulin, termed the "tubulin code", play important roles in regulating microtubule functions within subcellular compartments for specialized cellular activities. While numerous tubulin PTMs have been identified, a comprehensive understanding of the complete repertoire is still underway. In this study, we report that α-tubulin lactylation is catalyzed by HDAC6 by using lactate to increase microtubule dynamics in neurons.
View Article and Find Full Text PDFCHAMP: A Centrifugal Microfluidics-Based CRISPR/Cas12b-Combined Real-Time LAMP One-Pot Method for Infection Diagnosis.
ACS Omega
September 2024
Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, P. R. China.
The outbreak poses health risks to community residents. However, it still has limitations for current clinical diagnostic methods (qPCR nucleic acid assay or IgM immunoassay), including specialized handling, expensive equipment, prolonged turnaround time, and false positives and negatives, highlighting the need to improve clinical diagnostic methods. Herein, we present a novel centrifugal microfluidics-based method for rapidly diagnosing infections (CHAMP system).
View Article and Find Full Text PDF