Evaluation of risk factors for 14-day and 30-day mortality among treatment regimens against Pseudomonas aeruginosa resistant to carbapenem but susceptible to traditional antipseudomonal non-carbapenem β-lactam agents.

Pseudomonas aeruginosa associated with hospital-acquired infection is often resistant to various antibiotics and is associated with high mortality worldwide. The appropriate treatment of Pseudomonas aeruginosa resistant to carbapenems but susceptible to traditional antipseudomonal non-carbapenem β-lactam agents (Car-R/NonCar-S P. aeruginosa) remains unclear.

Innovative Use of sp. Biomass for the Sustainable Adsorption of Aflatoxin B and Ochratoxin A in Aqueous Solutions.

This research investigates the efficacy of sp. biomass as an effective adsorbent for the removal of AFB and OTA from aqueous solutions. Several factors, including contact time, adsorbent dosage, pH level, and initial mycotoxin concentration, were analyzed to evaluate their impact on adsorption efficacy.

Prevalence and Predictors of Fatigue among Thai Women after COVID-19 Infection.

Background: Several people suffered from fatigue after recovering from coronavirus disease 2019 (COVID-19). However, limited studies focused on fatigue in women who recovered from COVID-19 infection. This study aimed to investigate the prevalence of fatigue among Thai women after COVID-19 infection and to identify predictive factors, including depression, anxiety, fear, and insomnia.

Developing a High School Mental Health Action Checklist in Thailand: insights on perception and communication.

Background: This study aimed to develop a mental health action checklist for high school students that emphasized the importance of readiness, safety, and good hygiene at work to enhance their mental health and prepare them for the workforce.

Methods: In total, 949 students from public high schools in Bangkok, Thailand voluntarily participated in this study. The 15-item High School Mental Health Action Checklist was developed based on a literature review and a pilot study.

Synergistic Larvicidal and Pupicidal Toxicity and the Morphological Impact of the Dengue Vector () Induced by Geranial and -Cinnamaldehyde.

Monoterpenes are effective and eco-friendly alternatives to conventional chemical larvicides. We tested single and binary mixtures of monoterpenes-geranial and -cinnamaldehyde-for their larvicidal and pupicidal activities against L. and for non-target toxicity on guppies ( Peters), using 1% (/) temephos as a reference.

Discovery of novel coumarin triazolyl and phenoxyphenyl triazolyl derivatives targeting amyloid beta aggregation-mediated oxidative stress and neuroinflammation for enhanced neuroprotection.

This study involved designing, synthesizing, and evaluating the protective potential of compounds on microglial cells (BV-2 cells) and neurons (SH-SY5Y cells) against cell death induced by Aβ. It aimed to identify biologically specific activities associated with anti-Aβ aggregation and understand their role in oxidative stress initiation and modulation of proinflammatory cytokine expression. Actively designed compounds CE5, CA5, PE5, and PA5 showed protective effects on BV-2 and SH-SY5Y cells, with cell viability ranging from 60.

Ovicidal Toxicity and Morphological Changes in Housefly Eggs Induced by the Essential Oils of Star Anise and Lemongrass and Their Main Constituents.

This study attempted to evaluate the ovicidal activity of single-component formulations and combination formulations of lemongrass and star anise essential oils (EOs) and their main constituents against housefly eggs. The efficacies of the combinations were compared with those of single-component formulations and α-cypermethrin. Safety bioassays of all treatments and α-cypermethrin on non-target predators-guppy and molly-were conducted.

Basic regulatory science behind drug substance and drug product specifications of monoclonal antibodies and other protein therapeutics.

In this review, we focus on providing basics and examples for each component of the protein therapeutic specifications to interested pharmacists and biopharmaceutical scientists with a goal to strengthen understanding in regulatory science and compliance. Pharmaceutical specifications comprise a list of important quality attributes for testing, references to use for test procedures, and appropriate acceptance criteria for the tests, and they are set up to ensure that when a drug product is administered to a patient, its intended therapeutic benefits and safety can be rendered appropriately. Conformance of drug substance or drug product to the specifications is achieved by testing an article according to the listed tests and analytical methods and obtaining test results that meet the acceptance criteria.

Postural shifts and body perceived discomfort during 1-hour sitting when leaning and sitting on an air-filled seat cushion among healthy office workers.

This study compared the number of postural shifts and perceived discomfort while leaning and sitting on an air-filled seat cushion for 1 hour. Sixty office workers typed a standard text while leaning on a cushion placed behind the low back, sitting on a cushion placed under the buttocks, and sitting without a cushion (a control condition). The number of postural shifts was collected using a seat pressure mat device.

Combinations of Lemongrass and Star Anise Essential Oils and Their Main Constituent: Synergistic Housefly Repellency and Safety against Non-Target Organisms.

The present study evaluated the housefly repellency of single-component formulations and combinations of lemongrass and star anise essential oils (EOs) and their main constituents. The efficacies of the combinations were compared against those of single-component formulations and DEET. Safety bioassays of all formulations and DEET on non-target species-guppy, molly, dwarf honeybee, and stingless bee-were conducted.

Adulticidal synergy of two plant essential oils and their major constituents against the housefly and bioassay on non-target species.

Single and mixture formulations of lemongrass ( (DC.) Stapf.) and star anise ( (J.

Use of Pesticides and Health Risks to Chinese Water Chestnut Farmers in Suphanburi Province, Thailand.

Background: We aimed to study the relationship between the use of pesticides and the health risks faced by Chinese water chestnut farmers in this country.

Methods: This cross-sectional survey was conducted among 425 farmers in Sriprachan district, Suphanburi Province, Thailand in 2021. Samples were recruited using the cluster sampling method, and data collection took place through questionnaires.

Potential Lipolytic Effect of Panduratin A Loaded Microspicule Serum as a Transdermal Delivery Approach for Subcutaneous Fat Reduction.

Boesenbergia rotunda (L.) Mansf contained a potent anti-obesity agent. The objectives of this study were to investigate the anti-adipogenesis and lipolysis effects of panduratin A from B.

New visible-light-driven BiMoO/CsSbBr heterostructure for selective photocatalytic oxidation of toluene to benzaldehyde.

Herein, new BiMoO/CsSbBr heterostructure (BiMo/CSB) was investigated for the first time as a visible-light-driven photocatalyst for C(sp)-H bond activation using molecular oxygen as a green oxidant and toluene as a model substrate. The optimized BiMo/CSB photocatalyst exhibited enhanced toluene oxidation activity (2,346 μmol gh), which was almost two- and five-fold that of pristine CSB (1,165 μmol gh) and BiMo (482 μmol gh), respectively. The improved photocatalytic performance was essentially attributed to the formation of staggered band energy lineup in the BiMo/CSB hybrid, which promoted S-scheme charge transfer across the BiMo/CSB heterointerface as supported by ultraviolet photoelectron spectroscopy (UPS), density functional theoretical (DFT), time-resolve photoluminescence (TRPL), and photoelectrochemical studies.

Levodopa-induced dyskinesia in early-onset Parkinson's disease (EOPD) associates with glucocerebrosidase mutation: A next-generation sequencing study in EOPD patients in Thailand.

Background: With the benefit of using next-generation sequencing (NGS), our aim was to examine the prevalence of known monogenic causes in early-onset Parkinson's disease (EOPD) patients in Thailand. The association between clinical features, such as levodopa-induced dyskinesia (LID), and genotypes were also explored.

Method: NGS studies were carried out for EOPD patients in the Tertiary-referral center for Parkinson's disease and movement disorders.

Association of electronic learning devices and online learning properties with work-related musculoskeletal disorders (WMSDs): A cross-sectional study among Thai undergraduate students.

Computers and mobile devices are becoming the primary instruments used by students worldwide in all facets of their working and learning activities. This study aimed to investigate the relationship between the use of electronic devices, the characteristics of learning properties, and the potential predictors of work-related musculoskeletal disorders (WMSDs) among Thai undergraduate students. In this cross-sectional study, data were collected using Microsoft Forms with an online self-administered scale.

Short term effect of tetrahydrocurcumin on adipose angiogenesis in very high-fat diet-induced obesity mouse model.

Tetrahydrocurcumin (THC) has been shown to possess anti-angiogenic activities. This study aims to investigate the effects of THC on adipose angiogenesis and expression of angiogenic factors that occurs in 60% high-fat diet-induced obese mice. Male ICR mice were randomly divided into 3 groups: mice fed with a low-fat diet (LFD group); mice fed with very high fat diet (VHFD group), and mice fed with VHFD supplemented with THC (300 mg/kg/day orally) (VHFD+THC treated group) for 6 weeks.

Validation of depression, anxiety, and stress scales (DASS-21) among Thai nursing students in an online learning environment during the COVID-19 outbreak: A multi-center study.

The Depression, Anxiety and Stress Scale (DASS-21), an introductory scale used to identify common mental disorders (CMDs) among adults, was validated across cultures in Asian populations; nevertheless, its capacity for screening these disorders may be limited for some specified groups, including nursing students. This study attempted to investigate the psychometric scale's unique features of DASS-21 for Thai nursing students in an online learning environment during the COVID-19 outbreak. A cross-sectional study using the multistage sampling technique recruited 3,705 nursing students from 18 universities located in south and northeast Thailand.

Addressing Consumer Misconceptions on Antibiotic Use and Resistance in the Context of Sore Throat: Learnings from Social Media Listening.

A misunderstanding of the mechanism of action and bacterial targets of antibiotics by consumers may drive inappropriate antibiotic use and antimicrobial resistance (AMR). Tackling AMR requires an in-depth understanding of consumer beliefs and misconceptions. We explored consumer conversations on a number of social media platforms on antibiotic use and AMR in the context of sore throat and how coronavirus disease 2019 (COVID-19) affected online conversations between 1 January 2018 and 25 November 2021 across eight countries.

Antibacterial efficacy of (makrut lime) essential oil against clinical multidrug-resistant methicillin-resistant and methicillin-susceptible isolates.

The increasing incidence of methicillin-resistant is a major public health concern. Recently, the performance of essential oil (CHEO) has been shown to contain broad-spectrum antibacterial activity. Therefore, this study aims to determine the antibacterial activity of CHEO alone and in combination with gentamicin against panels of clinical isolates of methicillin-susceptible (MSSA,  = 45) and methicillin-resistant (MRSA,  = 40).

Prototype development of bilateral arm mirror-like-robotic rehabilitation device for acute stroke patients.

During the early six months after the onset of a stroke, patients usually remain disabled with limbs weakness and need intensive rehabilitation. An increased number of stroke patients is countered with a reduced number of physical therapists. The development of medical robots to substitute therapists' work should be helpful.

One-Pot Synthesis and Evaluation of Antioxidative Stress and Anticancer Properties of an Active Chromone Derivative.

Chromones are the structural building blocks of several natural flavonoids. The synthesis of chromones, which contain a hydroxy group on the ring, presents some challenges. We used the one-pot method to synthesize ten chromone derivatives and two related compounds using modified Baker-Venkataraman reactions.

Telepharmacy during home isolation: drug-related problems and pharmaceutical care in COVID-19 patients receiving antiviral therapy in Thailand.

Background: Home isolation has been proposed for coronavirus disease 2019 (COVID-19) patients with mild symptoms to avoid hospital overcrowding. This study aimed to describe the drug-related problems (DRPs) and the pharmaceutical care of home-isolating COVID-19 patients in Thailand.

Methods: Our cross-sectional study was undertaken from July 1 to September 30, 2021, at the King Chulalongkorn Memorial Hospital, Thailand.

Exploring Potential Antimalarial Candidate from Medicinal Plants of Kheaw Hom Remedy.

The Kheaw Hom remedy is a traditional Thai medicine widely used to treat fevers. Some plant ingredients in this remedy have been investigated for their antimicrobial, antiviral, anti-inflammatory, and antioxidant activities. However, there have been no reports on the antimalarial activities of the medicinal plants in this remedy.