Prevalence and predictors of obstructive sleep apnea in patients with bipolar disorder: A systematic review and meta-analysis.

Background & Objective: Obstructive sleep apnea (OSA) has been increasingly recognized as a comorbidity in many psychiatric disorders, including bipolar disorder (BD). This study aimed to synthesize existing evidence to determine the frequency of OSA in patients diagnosed with BD and identify potential predictors of its occurrence.

Methods: PubMed, Scopus, CENTRAL (Cochrane Central Register of Controlled Trials), and Google Scholar databases were searched for English-language papers published up from 1 January 1960 to 31 October 2023 that reported incidences of OSA in patients with BP and provided sufficient data for quantitative analysis.

Effect of artificial fish nest placement on spawning site preference and reproductive efficiency in reservoir fish with adhesive and demersal eggs.

Artificial fish nests are common tools in fisheries management, providing spawning grounds to enhance the size and diversity of fish populations. This study aimed to explore the effects of deployment locations on the reproductive efficiency and preferences of fish with adhesive and demersal eggs using artificial nests. Floating artificial nests were deployed in three regions (upstream, midstream, and downstream) of a reservoir in Zhejiang, China, at locations with three topographical types: steep slope (reservoir shore, slopes > 60°), gentle slope (reservoir shore, slopes < 30°), and confluence (middle thread of channel).

Effects of Different Humeral Stem Length on Stem Alignment and Proximal Stress Shielding in Reverse Total Shoulder Arthroplasty.

Background: Few comparative studies on the correlation between stem length, stem alignment, and/or stress shielding have been conducted in reverse total shoulder arthroplasty (rTSA). This study aimed to investigate the effects of different humeral stem lengths on stem alignment and proximal stress shielding after rTSA.

Methods: A total of 320 patients who underwent primary rTSA from October 2010 to May 2020 with at least 2 years of follow-up (mean follow-up: 32.

Prediction of Survival Outcomes in Patients with Glioma Using Magnetic Resonance Imaging (MRI): A Systematic Review and Meta-Analysis.

Background: Glioma is the most common malignancy in the central nervous system. Even with optimal therapies, glioblastoma (the most aggressive form of glioma) is incurable, with only 26.5% of patients having a 2-year survival rate.

Photoredox-Mediated Immunotherapy Utilizing Rhenium(I) Photocatalysts with Electron Donor-Acceptor-Donor Configuration.

The hypoxic environment of solid tumors significantly diminishes the therapeutic efficacy of oxygen-dependent photodynamic therapy. Developing efficient photosensitizers that operate photoredox catalysis presents a promising strategy to overcome this challenge. Herein, we report the rational design of two rhenium(I) tricarbonyl complexes ( and ) with electron donor-acceptor-donor configuration.

Endothelin receptor antagonists (ERAs) can potentially be used as therapeutic drugs to reduce hypertension caused by small molecule tyrosine kinase inhibitors (TKIs).

The emergence of targeted anti-tumor drugs has significantly prolonged the lifespan and improved the prognosis of cancer patients. Among these drugs, vascular endothelial growth factor (VEGF) inhibitors, particularly novel small molecule tyrosine kinase inhibitors (TKIs), are extensively employed as VEGF inhibitors; however, they are also associated with a higher incidence of complications, with hypertension being the most prevalent cardiovascular toxic side effect. Currently, it is widely accepted that TKIs-induced hypertension involves multiple mechanisms including dysregulation of the endothelin (ET) axis, reduced bioavailability of nitric oxide (NO), imbalance in NO-ROS equilibrium system, vascular rarefaction, and activation of epithelial sodium calcium channels; nevertheless, excessive activation of ET system appears to be predominantly responsible for this condition.

Empowering young athletes: the influence of autonomy-supportive coaching on resilience, optimism, and development.

Introduction: The present study investigates how autonomy-supportive coaching style influences youth athlete development through psychological resilience and dispositional optimism. Despite growing interest in factors that contribute to athlete development, gaps remain in understanding how coaching approaches interact with psychological traits to foster youth athletes' growth. This study addresses these gaps by proposing a serial mediation model in which autonomy-supportive coaching indirectly enhances athlete development through resilience and optimism.

Probiotic LV149 enhances gut repair, modulates microbiota, and alters transcriptome in DSS-induced colitis mice.

Purpose: Gut microbiota dysbiosis significantly impacts ulcerative colitis (UC) progression and exacerbation. Probiotics show promise in UC management. This study evaluated the effects of different doses of LV149, an aquatic-derived probiotic, on gut injury repair in male C57BL/6 mice with dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) and investigated the underlying mechanisms.

Candidate Biomarker of Response to Immunotherapy In Small Cell Lung Cancer.

Small-cell lung cancer accounts for about 15% of lung cancers with an extremely poor prognosis. The incorporation of immunotherapy to platinum-based chemotherapy offers sustained overall survival benefits and become the standard for the first-line setting of extensive-stage small-cell lung cancer. However, only a limited number of patients derive prolonged benefits.

Facile fabrication of biocompatible carbon dots from egg white by one-step neutralization heat reaction: a capillary array-based fluorimetric strategy for high-throughput detection of total iron ions in fish blood.

Water-soluble and biocompatible protein carbon dots (P-CDs) were simply prepared from egg white by a rapid one-step neutralization heat reaction. Unexpectedly, the thus-fabricated P-CDs could present excitation-dependent tunable fluorescence that could be quenched specifically by Fe and Fe ions with obvious color changes. A high-throughput fluorimetric platform was thereby developed by coating the P-CDs onto a capillary array for detection of total iron ions in fish blood samples, with a linear concentration range of 0.

mTOR Ser1261 is an AMPK-dependent phosphosite in mouse and human skeletal muscle not required for mTORC2 activity.

The kinases AMPK, and mTOR as part of either mTORC1 or mTORC2, are major orchestrators of cellular growth and metabolism. Phosphorylation of mTOR Ser1261 is reportedly stimulated by both insulin and AMPK activation and a regulator of both mTORC1 and mTORC2 activity. Intrigued by the possibilities that Ser1261 might be a convergence point between insulin and AMPK signaling in skeletal muscle, we investigated the regulation and function of this site using a combination of human exercise, transgenic mouse, and cell culture models.

Fecal occult blood affects intestinal microbial community structure in colorectal cancer.

Background: Gut microbes have been used to predict CRC risk. Fecal occult blood test (FOBT) has been recommended for population screening of CRC.

Objective: To analyze the effects of fecal occult blood test (FOBT) on gut microbes.

Mediating role of health literacy in the relationship between social isolation and psychological distress among pre-frail older adults.

Background: Frailty has become a significant public health issue. The recent increase in the number of frail older adults has led to increased attention being paid to psychological care services in communities. The social isolation of pre-frail older adults can impact their psychological distress.

The combined evaluation of preoperative serum CEA and postoperative tissue CEA as a prognostic factor in stages 0-IV colorectal cancer: a retrospective cohort study.

Background: The roles of preoperative serum carcinoembryonic antigen (sCEA) and postoperative tissue carcinoembryonic antigen (tCEA) have been extensively studied in isolation in colorectal cancer (CRC). However, the combined role of sCEA and tCEA remains inadequately described.

Methods: A total of 1,757 retrospective cases of stage 0-IV CRC from January 2006 to January 2016 in our institution were included.

Characteristics and Associated Factors of Insomnia Among the General Population in the Post-Pandemic Era of COVID-19 in Zhejiang, China: A Cross-Sectional Study.

Objective: This study aimed to analyze the changes in insomnia characteristics among the general population and explore associated factors during the COVID-19 pandemic and post-pandemic periods.

Methods: A cross-sectional study was conducted using an anonymous online survey. Questionnaires were administered at two-time points (T1: March 1-31, 2022; T2: March 1-31, 2023), which included an Insomnia Severity Index (ISI) and questions related to sleep risk factors, including the COVID-19 pandemic, familial influences, work and study conditions, social activities, physical health, use of electronic devices before sleep, sleep environment, food intake and exercise before sleep, etc.

Photocatalytic Organic Semiconductor-Bacteria Imprinted Polymers for Highly Selective Determination of at the Single-Cell Level.

This work utilized a combination of photocatalytic organic semiconductors and bacteria to create a photocatalytic organic semiconductor-bacterial biomixture system based on a bacteria imprinted polymers (OBBIPs-PEC) sensor, for the detection of with high sensitivity in "turn-on" mode at the single-cell level. This outstanding sensor arises from an integration of two different types of semiconductor materials to form heterojunctions. As well this sensor involves combining a semiconductor material with cationic side chains and an electron transport chain within a natural cellular environment, in which the cationic side chain of poly(fluorene--phenylene) organic semiconductor at 2-(4-mesyl-2-nitrobenzoyl)-1,3-cyclohexanedione (PFP-OC@MNC) demonstrated the ability to penetrate the cell membrane of and interact with specific binding sites through electrostatic interactions.

Unleashing the potential of Er-Tm coupling for the regulation of power-dependent multi-color upconversion luminescence.

1550 nm-responsive upconversion luminescence (UCL) has attracted increasing attention due to its potential applicability in a new generation of bio-probes and photonic devices. However, regulating multi-color UCL with pump power remains a challenge. In this work, through constructing the coupling between Er and Tm ions and suppressing the energy transfer upconversion process of Er ions, the response of UCL color in Gd(MoO):Er/Tm to pump power is enhanced significantly.

Hypoxia and lipid metabolism related genes drive proliferation migration and immune infiltration mechanisms in colorectal cancer subtyping.

Hypoxia and lipid metabolism play crucial roles in the progression of colorectal cancer (CRC). However, the specific functions of hypoxia- and lipid metabolism-related genes (HLPG) in CRC and their relationships with patient prognosis remain unclear. Differential expression analysis using the TCGA-COAD and GEO databases identified 117 HLPGs through the intersection of the two gene sets.

Parental burnout and parent-child relationship: the role of harsh parenting in couples.

Parental burnout is a prominent topic in current family research, with proven detrimental effects on the well-being of both parents and children. However, the specific mechanism by which parenting burnout impacts the parent-child relationship within families remains unclear. Furthermore, there is limited research exploring whether parenting burnout has a direct impact on the parent-child relationship.

Lysine succinylome analysis of MRSA reveals critical roles in energy metabolism and virulence.

Methicillin-resistant Staphylococcus aureus's (MRSA) resistance poses a global health challenge. This study investigates lysine succinylation in MRSA using proteomics and bioinformatics approaches to uncover metabolic and virulence mechanisms, with the goal of identifying novel therapeutic targets. Mass spectrometry and bioinformatics analyses mapped the MRSA succinylome, identifying 8048 succinylation sites on 1210 proteins.

Research Progress on Extracellular Matrix-Based Composite Materials in Antibacterial Field.

Due to their exceptional cell compatibility, biodegradability, and capacity to trigger tissue regeneration, extracellular matrix (ECM) materials have drawn considerable attention in tissue healing and regenerative medicine. Interestingly, these materials undergo continuous degradation and release antimicrobial peptides (AMPs) while simultaneously promoting tissue regeneration, thereby exerting a potent antibacterial effect. On this basis, a variety of basic properties of ECM materials, such as porous adsorption, hydrophilic adsorption, group crosslinking, and electrostatic crosslinking, can be used to facilitate the integration of ECM materials and antibacterial agents through physical and chemical approaches in order to enhance the antibacterial efficacy.

Multi-omics dataset of individual variations in growth performance of large yellow croaker.

Large yellow croaker (Larimichthys crocea) is a highly economically important marine fish species in China. However, substantial individual variations in growth performance have emerged as a limiting factor for the sustainable development of the large yellow croaker industry. Gut microbiota plays a crucial role in fish growth and development by regulating metabolic processes.

The relationship of spatial visualization ability and number representation: evidence from multiple tasks.

It is well established in the literature that the relation of spatial ability and the number representation, but the intrinsic relation of spatial visualization ability and number representation are not well understood. In the Current study, Chinese Preschool children (N = 200; 107 girls; Mage = 5.47years, SD = 0.

Research Status and Direction of Chronic Obstructive Pulmonary Disease Complicated with Coronary Heart Disease: A Bibliometric Analysis from 2005 to 2024.

Objective: There is increasing evidence that chronic obstructive pulmonary disease (COPD) is associated with coronary heart disease (CHD). In this study, we provide valuable insights in the field by examining the evolution of the relationship between COPD and CHD over the past 20 years.

Methods: A comprehensive computer search was conducted in the Web of Science (WOS) core dataset, covering literature on COPD combined with CHD from January 1, 2005, to August 20, 2024.