Angiotensin II: A novel biomarker in vascular diseases.

The renin-angiotensin system (RAS), composed mainly of renin, angiotensin, and aldosterone, is a key endocrine pathway involved in cardiovascular activity regulation. Under physiological conditions, the RAS plays a vital role in water and salt metabolism, blood pressure regulation, and electrolyte balance. Angiotensin II (Ang II) is the most important active component of the RAS, and its receptors are concentrated in vascular, pulmonary, cardiac, and renal tissues in vivo.

Enhancement of Oryzanol application by constructing modified β-CD inclusion complex and polycaprolactone-chitosan electrospun fiber membranes: Perspectives on wound dressings and grape preservation.

Oryzanol has a variety of physiological activities and is widely used in food and medicine. However, its utilization form and bioavailability are limited by poor solubility and photothermal stability. In this paper, an inclusion complex (IC) was prepared by modifying β-cyclodextrin as a molecular carrier to encapsulate Oryzanol.

Adjuvant radiation improves survival outcomes in adrenocortical carcinoma: A population-based study.

The aim of this study was to evaluate the clinical benefits and outcomes of adjuvant radiation therapy on adrenocortical carcinoma (ACC) patients. All patients with ACC that were reported between 2010 and 2015 were identified from the Surveillance, Epidemiology, and End Results database. A forward-stepwise Cox proportional hazards regression was used to identify independent risk factors.

Study on the evolution of the spatial patterns and driving factors of national agricultural cultural heritage in China.

The study analyzed the spatial distribution characteristics, evolution rules, and driving factors of 138 China's national agricultural cultural heritage sites from 2013 to 2021 at the overall and regional levels, using kernel density analysis, Centres for standard deviation ellipse analyses, spatial autocorrelation analysis, and geographical detector analysis.The results showed that: ①From an overall perspective, the spatial pattern of China's national agricultural cultural heritage changed greatly from 2013 to 2021, with a highly uneven spatial distribution, gradually showing a distribution pattern of "widely distributed, locally concentrated". The spatial distribution of China's national agricultural cultural heritage is increasingly evident, and the spatial distribution type has evolved from discrete to clustered.

Association of Biomarkers Such as CA, TP, TES and ALP With Osteoarthritis Risk: A Mendelian Randomized Study.

Objective: Osteoarthritis is a common joint disease caused by a variety of risk factors, and it has been found that many biochemical markers are abnormal in peripheral blood and urine of patients with OA. The aim of this study was to elucidate the causal relationship between biomarkers associated with these processes and OA using Mendelian randomization (MR) analysis.

Method: The inverse variance weighted (IVW) approach to MR was primarily used to explore causal associations between exposures and outcomes using publicly available genetic variants from large genome-wide association studies (GWAS).

A surgical orthotopic xenograft approach with immune response for colorectal cancer research.

The high morbidity and mortality of colorectal cancer (CRC) is a major challenge in clinical practice. Although a series of alternative research models of CRC have been developed, appropriate orthotopic animal models that reproduce the specific clinical response as well as pathophysiological immune features of CRC are still lacking. In the current study, we constructed a CRC orthotopic xenograft model by implanting the tumor tubes at the colorectum of mice and monitored the model development using bioluminescence imaging.

Dynamic Accommodation Responses in Subjects Wearing Myopia Control Spectacles Modifying Peripheral Refraction.

Purpose: Peripheral optics have been suggested to play a role in myopia progression, with accommodation responses also considered a potential contributor. This study aimed to investigate whether modifications in peripheral optics through different spectacle lenses affect accommodation responses.

Methods: Dynamic accommodation responses were assessed using a double-pass instrument while switching the target from distance (3 m for 3 seconds) to near (0.

A Multi-Scale Computational Model of the Hepatic Circulation Applied to Predict the Portal Pressure After Transjugular Intrahepatic Portosystemic Shunt (TIPS).

Transjugular intrahepatic portosystemic shunt (TIPS) is a widely used surgery for portal hypertension. In clinical practice, the diameter of the stent forming a shunt is usually selected empirically, which will influence the postoperative portal pressure. Clinical studies found that inappropriate portal pressure after TIPS is responsible for poor prognosis; however, there is no scheme to predict postoperative portal pressure.

Role of NLRP3 Inflammasome in Chronic Pain and Alzheimer's Disease-A Review.

The coexistence of Alzheimer's disease (AD) and chronic pain (CP) in the elderly population has been extensively documented, and a growing body of evidence supports the potential interconnections between these two conditions. This comprehensive review explores the mechanisms by which CP may contribute to the development and progression of AD, with a particular focus on neuroinflammatory pathways and the role of microglia, as well as the activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome. The review proposes that prolonged pain processing in critical brain regions can dysregulate the activity of the NLRP3 inflammasome within microglia, leading to the overproduction of pro-inflammatory cytokines and excessive oxidative stress in these regions.

Function of N-acetyltransferase in the biotransformation of aniline in green alga Chlamydomonas reinhardtii.

Phytoplankton plays a crucial role in the fate of pollutants in aquatic ecosystems by biotransformation and bioaccumulation. Aniline was listed in priority pollutants due to its toxicity and widespread distribution in the aquatic environment. This study focused on investigating the capacity and mechanism of eukaryotic alga Chlamydomonas reinhardtii in transforming aniline.

Synthesis and antifungal activity of arecoline derivatives containing amino acid fragments.

A series of new arecoline derivatives containing amino acid fragments were synthesized, and their fungicidal activities were investigated. All synthesized compounds were characterized by H NMR, CNMR, and HRMS. Preliminary bioactivity assays demonstrated that Compounds 3k, 3n, 3p, 3q, 3r, and 3s exhibited significant antifungal activity against Botryosphaeria cactivora, Botryosphaeria dothidea, and Fusarium pseudograminearum at a concentration of 100 μg/mL.

Improvement in XIa Selectivity of Snake Venom Peptide Analogue BF9-N17K Using P2' Amino Acid Replacements.

Coagulation factor XIa is a new serine-protease family drug target for next-generation anticoagulants. With the snake venom Kunitz-type peptide BF9 as the scaffold, we obtained a highly active XIa inhibitor BF9-N17K in our previous work, but it also inhibited the hemostatic target plasmin. Here, in order to enhance the selectivity of BF9-N17K toward XIa, four mutants, BF9-N17K-L19A, BF9-N17K-L19S, BF9-N17K-L19D, and BF9-N17K-L19K, were further designed using the P2' amino acid classification scanning strategy.

Exploration of the mechanism of tetramethoxyflavone in treating osteoarthritis based on network pharmacology and molecular docking.

Objectives: This study aimed to explore the potential mechanisms of TMF (5,7,3',4'-tetramethoxyflavone) in treating osteoarthritis (OA) using network pharmacology and molecular docking.

Materials And Methods: Databases including SwissTargetPrediction, BATMAN-TCM, PharmMapper, TargetNet, SuperPred, and SEA were utilized to screen the targets of TMF. "OA" was used as the disease keyword to predict OA-related genes through GeneCards, Therapeutic Target Database, PharmGKB, Online Mendelian Inheritance in Man, and Comparative Toxicogenomics Database.

An ammonia-responsive aerogel-type colorimetric sensor for non-destructive monitoring of shrimp freshness.

The colorimetric sensor for volatile amines (VA) detection can realize non-destructive monitoring of shrimp quality. However, its sensing performance still needs to be improved. In this study, we proposed an aerogel-type colorimetric sensor to improve VA sensing performance and realize early detection of shrimp spoilage.

Dietary content and eating behavior in ulcerative colitis: a narrative review and future perspective.

Ulcerative colitis (UC) has experienced a steady increase in global incidence and prevalence recently. Current research into UC pathogenesis focuses on the complex interplay of genetic and environmental factors with the immune system and gut microbiome, leading to disruption of the intestinal barrier. Normally, the microbiome, intestinal epithelium, and immune system interact to maintain intestinal homeostasis.

Droplets impact on sparse microgrooved non-wetting surfaces.

Droplets impinging on sparse microgrooved polydimethylsiloxane (PDMS) surfaces with different solid fractions was experimentally investigated. First, wettability and stability of droplets on these surfaces was analyzed. The advancing and receding contact angles were found to have a large difference between in the longitudinal direction and in the transverse one, which could be attributed to the anisotropy of the micropatterned surfaces.

[The effect of concentrated growth factor on the biological performance of human dental pulp stem cells under oxidative stress status].

To investigate the effect of concentrated growth factor (CGF) on the biological performance of human dental pulp stem cells (hDPSCs) under oxidative stress status induced by hydrogen peroxide (HO). The hDPSCs were isolated by using tissue block separation method from healthy permanent teeth extracted for orthodontic reason. hDPSCs surface markers CD34, CD45, CD90 and CD105 were detected by flow cytometry.

Identification of serum small non-coding RNA as biomarkers for endometrial receptivity.

Background: Current endometrial receptivity analysis is invasive, preventing embryo transfer during the biopsy cycle. This study aims to screen serum sncRNAs as non-invasive biomarkers for ERA tests.

Methods: The study included 12 infertile patients undergoing IVF-ET and ERA, whose serum samples were collected for high-energy sequencing technology to detect sncRNA expression profiles.

Valorization of rapeseed straw through the enhancement of cellulose accessibility, lignin removal and xylan elimination using an n-alkyltrimethylammonium bromide-based deep eutectic solvent.

n-Alkyltrimethylammonium bromide (CTAB)-based deep eutectic solvent (DESs) has potential in the efficient delignification and utilization of carbohydrates in biomass. In this research, DESs containing Brønsted acid and Lewis acid were prepared with CTAB (alkyl-chain length 12-18), organic acids and metal chlorides, and the optimal treatment conditions were acquired by pretreatment optimization. Through the pretreatment with TTAB/LCA/Fe (1:4:0.

Beyond Facilitating Unisensory Processing: Crossmodal Associative Memory Training Further Modulates Sensory Integration.

Audiovisual associative memory and audiovisual integration involve common behavioral processing components and significantly overlap in their neural mechanisms. This suggests that training on audiovisual associative memory may have the potential to improve audiovisual integration. The current study tested this hypothesis by applying a 2 (group: audiovisual training group, unimodal control group) * 2 (time: pretest, posttest) design.

Predictive value of the systemic inflammatory response index and APACHE II score for acute respiratory distress syndrome caused by wasp stings.

Objective: This study aimed to assess the predictive value of the systemic inflammatory response index (SIRI) and APACHE II score for acute respiratory distress syndrome (ARDS) resulting from wasp stings.

Methods: A retrospective study was conducted, including patients who suffered wasp stings and developed ARDS between January 2018 and November 2024 in the Shiyan area of Hubei province. Based on the 28-day prognosis, patients were categorized into two groups: survivors (n = 21) and non-survivors (n = 25).

Scalable one-step fabrication of integrated electrode arrays for highly sensitive and portable carbendazim detection.

Highly sensitive and portable pesticide residues detection are indispensable for safeguarding food safety and environmental health. Herein, we introduce a one-step vacuum filtration strategy for the scalable production of cobalt-based conjugated coordination polymers (CoCCPs) electrode arrays, utilizing carboxylated single-walled carbon nanotubes (c-SWNTs) as bonding bridges (CoCCPs@c-SWNTs). Due to their abundant active sites and high conductivity, the CoCCPs@c-SWNTs arrays exhibit superior electrochemical performance (e.

Arterial stiffness mediates insulin resistance-related risk of atherosclerotic cardiovascular disease: a real-life, prospective cohort study.

Background: The precise pathways connecting insulin resistance (IR) to atherosclerotic cardiovascular disease (ASCVD) remain undefined. The present study aimed to examine the mediating role of arterial stiffness in the association between IR and ASCVD, providing epidemiology insights into the potential mechanisms driving IR to incident ASCVD.

Methods: A total of 59,777 participants from the Kailuan Study Arterial Stiffness Subcohort who were free of ASCVD at baseline were enrolled in the present study.

Global burden and trends of the infection-associated diseases from 1990 to 2021: an observational trend study.

Background: This study was aimed to explore the global burden and trends of Clostridioides difficile infections (CDI) associated diseases.

Methods: Data for this study were obtained from the Global Burden of Disease Study 2021. The burden of CDI was assessed using the age-standardized rates of disability-adjusted life years (ASR-DALYs) and deaths (ASDRs).

Water-Deficient Interface Induced via Hydrated Eutectic Electrolyte with Restrictive Water to Achieve High-Performance Aqueous Zinc Metal Batteries.

The development of aqueous zinc metal batteries (AZMBs) is hampered by dendrites and side reactions induced by reactive HO. In this study, a hydrated eutectic electrolyte with restrictive water consisting of zinc trifluoromethanesulfonate (Zn(OTf)), 1,3-propanediol (PDO), and water is developed to improve the stability of the anode/electrolyte interface in AZMBs via the formation of a water-deficient interface. Additionally, PDO participates in the Zn solvation structure and inhibits the movement of water molecules.