17,622 results match your criteria: "HuBei University[Affiliation]"

Trans-dimensional nanocoral gold foam interfaces affords ultrasensitive detection of influenza virus.

Anal Chim Acta

February 2025

School of Laboratory Medicine, Hubei University of Chinese Medicine, 16 Huangjia Lake West Road, Wuhan, 430065, PR China; Hubei Shizhen Laboratory, Wuhan, Hubei, 430065, PR China. Electronic address:

Development of sensitive and cost-effective strategies for detecting influenza viruses is crucial to combat the spread of infectious diseases. In this study, a novel trans-dimensional nanocoral gold foam (NCGF) was fabricated on screen-printed carbon electrodes using hydrogen template electrodeposition method. This unique structure, with interconnected large and small pores, significantly increased the specific surface area and stability of the sensor.

View Article and Find Full Text PDF

Uptake and Transpiration of Solid and Hollow SiO Nanoparticles by Terrestrial Plant (Apium Graveolens var. secalinum).

Chemosphere

January 2025

Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China; Division of Environment and Sustainability, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China; HKUST Shenzhen-Hong Kong Collaborative Innovation Research Institute, Futian, Shenzhen, Guangdong Province, China. Electronic address:

Recent studies have raised concerns about the potential toxicity of amorphous silica (SiO) nanoparticles (NPs). This investigation explores the uptake, transport, and transpiration of silica NPs in Apium graveolens var. secalinum.

View Article and Find Full Text PDF

Multifunctional porphyrinic metal-organic framework-based nanoplatform regulating reactive oxygen species achieves efficient imaging-guided cascaded nanocatalytic therapy.

J Colloid Interface Sci

January 2025

Department of Chemistry, Kay Lab of Bioorganic Phosphorus Chemistry and Chemical Biology of Ministry of Education, Beijing Key Laboratory for Analytical Methods and Instrumentation, Tsinghua University, 100084 Beijing, China. Electronic address:

The integration of reactive oxygen species (ROS) related photodynamic therapy (PDT) with the strategy of reshaping the tumor microenvironment (TME) has emerged as a potential approach for nanodiagnostic and therapeutic interventions. However, the therapeutic efficacy based on ROS treatments may be hindered by intracellular antioxidants such as glutathione (GSH) and tumor hypoxia. To address these challenges, a nanoplatform based on GSH-responsive multifunctional porphyrinic metal-organic framework (PCN-224@Au@MnO@HA, PAMH) was proposed.

View Article and Find Full Text PDF

Osteogenic differentiation is crucial in normal bone formation and pathological calcification, such as calcific aortic valve disease (CAVD). Understanding the proteomic and transcriptomic landscapes underlying this differentiation can unveil potential therapeutic targets for CAVD. In this study, we employed RNA sequencing transcriptomics and proteomics on a timsTOF Pro platform to explore the multiomics profiles of valve interstitial cells (VICs) and osteoblasts during osteogenic differentiation.

View Article and Find Full Text PDF

18beta-glycyrrhetinic acid alleviates deoxynivalenol-induced hepatotoxicity by inhibiting GPX4-dependent ferroptosis.

Toxicon

January 2025

School of Basic Medical Sciences, Xianning Medical College, Hubei University of Science and Technology, Xianning, 437100, China; Hubei Key Laboratory of Diabetes and Angiopathy, Medicine Research Institute, Xianning Medical College, Hubei University of Science and Technology, Xianning 437100, China. Electronic address:

Deoxynivalenol (DON), a mycotoxin that severely contaminates agri-food products can cause hepatotoxicity. Ferroptosis is an iron-dependent form of cell death, and the liver is an important organ for iron accumulation. 18beta-glycyrrhetinic acid (GA) has anti-ferroptosis and hepatoprotective effects.

View Article and Find Full Text PDF

Promoted expression of a lipase for its application in EPA/DHA enrichment and mechanistic insights into its substrate specificity.

Int J Biol Macromol

January 2025

State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Key Laboratory of Industrial Biotechnology, School of Life Sciences, Hubei University, Wuhan 430062, PR China. Electronic address:

Expanding toolkits of EPA/DHA enrichment from natural sources is essential for better satisfying increasing demands for them. Lipase K80, from Proteus vulgaris K80, showed an application potential in EPA/DHA enrichment, whereas no desired heterologous expression in generally regarded as safe (GRAS) hosts restricted its relevant applications. In this study, expression of lipase K80 in a well-reputed GRAS host, Pichia pastoris, was achieved and further enhanced via combining disruption of its C-terminal KKL motif with co-expression of N-Acetyltransferase Mpr1, with a cumulative increment of nearly 200 % in the secretion level and the volumetric activity.

View Article and Find Full Text PDF

Background: Although the association of short-term ozone and heatwave exposure with cerebrovascular disease has been well documented, it remains largely unknown whether their co-exposure could synergistically trigger ischemic stroke (IS) mortality.

Methods: We performed an individual-level, time-stratified case-crossover analysis utilizing province-wide IS deaths (n =59079) in warm seasons (May-September) during 2016-2019, across Jiangsu, eastern China. Heatwave was defined according to a combination of multiple temperature thresholds (90-97.

View Article and Find Full Text PDF

Background: Internet-delivered transdiagnostic psychological interventions are promising approaches for the treatment of anxiety and depression. This study aimed to review and synthesize evidence related to the effectiveness of Internet-based transdiagnostic interventions for reducing anxiety and depression, and to compare the effects of universal versus tailored interventions.

Methods: A Systematic review search was conducted on the PubMed, EMBASE, Cochrane Library, Web of Science, PsychINFO, Medline, and CINAHL databases as of 28 March 2024.

View Article and Find Full Text PDF

In this work, the electrochemical biosensor based on the subtle combination of terminal deoxynucleotidyl transferase (TdT), CRISPR/Cas14a, and magnetic nanoparticles (MNPs) was developed for the detection of nasopharyngeal carcinoma (NPC)-derived exosomes. Due to the synergistic effect of the following factors: the powerful elongation capacity of TdT for single-stranded DNA (ssDNA) with 3-hydroxy terminus, the outstanding trans-cleavage ability of CRISPR/Cas14a specifcally activated by the crRNA binding to target DNA, and the excellent separation ability of MNPs, the developed electrochemical biosensor exhibited high sensitivity for the detection of NPC-derived exosome, with a linear range from 6.0 × 10 ∼ 1.

View Article and Find Full Text PDF

Due to the diverse chemical and physical properties of functional groups, mild and controllable ligation methods are often required to construct complex drugs and functional materials. To make diverse sets of products with tunable physicochemical properties, it is also useful to employ complimentary ligation methods that adopt the same starting materials. Here, we disclose the efficient and modular synthesis of amides or thioamides through the chemical ligation of acyl silanes with amines, simply by turning a light on or off.

View Article and Find Full Text PDF

Background: Non-small cell lung cancer (NSCLC) is a fatal disease, and radioresistance is an important factor leading to treatment failure and disease progression. The objective of this research was to detect radioresistance-related genes (RRRGs) with prognostic value in NSCLC.

Methods: The weighted gene coexpression network analysis (WGCNA) and differentially expressed genes (DEGs) analysis were performed to identify RRRGs using expression profiles from TCGA and GEO databases.

View Article and Find Full Text PDF

Large visual language models like Contrastive Language-Image Pre-training (CLIP), despite their excellent performance, are highly vulnerable to the influence of adversarial examples. This work investigates the accuracy and robustness of visual language models (VLMs) from a novel multi-modal perspective. We propose a multi-modal fine-tuning method called Multi-modal Depth Adversarial Prompt Tuning (MDAPT), which guides the generation of visual prompts through text prompts to improve the accuracy and performance of visual language models.

View Article and Find Full Text PDF

Autonomous driving has demonstrated impressive driving capabilities, with behavior decision-making playing a crucial role as a bridge between perception and control. Imitation Learning (IL) and Reinforcement Learning (RL) have introduced innovative approaches to behavior decision-making in autonomous driving, but challenges remain. On one hand, RL's policy networks often lack sufficient reasoning ability to make optimal decisions in highly complex and stochastic environments.

View Article and Find Full Text PDF
Article Synopsis
  • This paper addresses the challenge of accurately segmenting images of Ming-style furniture, aiming to enhance preservation and analysis of this cultural heritage.
  • It introduces two innovations: the Material Attribute Prompter (MAP) for automatic prompt generation based on material properties, and the Structure Refinement Module (SRM) to improve segmentation accuracy through feature combination.
  • The proposed method, validated with the MF2K dataset consisting of 2073 annotated images, shows significant improvement in segmentation performance compared to existing models, highlighting the effectiveness and efficiency of the MAP and SRM.
View Article and Find Full Text PDF

Preparation of Molecularly Imprinted Electrochemical Sensors and Analysis of the Doping of Epinephrine in Equine Blood.

Sensors (Basel)

December 2024

Shandong Provincial Key Laboratory of Monocrystalline Silicon Semiconductor Materials and Technology, Shandong Provincial Engineering Research Center of Organic Functional Materials and Green Low-Carbon Technology, Shandong Universities Engineering Research Center of Integrated Circuits Functional Materials and Expanded Applications, College of Chemistry and Chemical Engineering, Dezhou University, Dezhou 253023, China.

In this paper, a novel molecularly imprinted polymer membrane modified glassy carbon electrode for electrochemical sensors (MIP-OH-MWCNTs-GCE) for epinephrine (EP) was successfully prepared by a gel-sol method using an optimized functional monomer oligosilsesquioxane-AlO sol-ITO composite sol (ITO-POSS-AlO). Hydroxylated multi-walled carbon nanotubes (OH-MWCNTs) were introduced during the modification of the electrodes, and the electrochemical behavior of EP on the molecularly imprinted electrochemical sensors was probed by the differential pulse velocity (DPV) method. The experimental conditions were optimized.

View Article and Find Full Text PDF

Effects of on Metabolites and Flavors in Synthetic Microbiota During Baijiu Fermentation.

Foods

December 2024

Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Key Laboratory of Industrial Microbiology, School of Life and Health Sciences, Hubei University of Technology, Wuhan 430068, China.

The distinctive flavor and aroma of Chinese baijiu are closely linked to the microorganisms involved in the fermentation process. , a dominant species in the fermentation of Chinese baijiu, has become a prominent research focus. In this study, we selected well-characterized pure cultures of microorganisms to construct diverse chassis microflora.

View Article and Find Full Text PDF

The influence of different pore sizes on the compressive strength and elastic modulus of recycled concrete is an important issue in the academic circle. Aiming at this problem, a quantitative characterization model of the compressive strength and elastic modulus of recycled concrete based on pore grading was established in this paper. The compressive strength, elastic modulus, porosity and distribution of pore size of recycled concrete were measured by a concrete test and nuclear magnetic resonance technology, and the influences of different pore sizes on the compressive strength and elastic modulus of recycled concrete were analyzed, and the rationality of the quantitative characterization model was verified.

View Article and Find Full Text PDF

A Convenient and Highly Efficient Strategy for Esterification of Poly (γ-Glutamic Acid) with Alkyl Halides at Room Temperature.

Polymers (Basel)

December 2024

State Key Laboratory of Biocatalysis and Enzyme Engineering, Environmental Microbial Technology Center of Hubei Province, College of Life Sciences, Hubei University, Wuhan 430062, China.

The presented work discusses the highly efficient esterification of poly (γ-glutamic acid) (γ-PGA) with alkyl halides at room temperature. The esterification reaction was completed within 3 h, and the prepared γ-PGA esters were obtained with excellent yields (98.6%) when 1,1,3,3-tetramethylguanidine (TMG) was used as a promoter.

View Article and Find Full Text PDF

Effects of Polyol Types on Underwater Curing Properties of Polyurethane.

Polymers (Basel)

December 2024

CNBM Zhongyan Technology Co., Ltd., Beijing 100024, China.

This study aims to develop castable polyurethane suitable for applications on wet substrates or underwater construction. Polyurethanes were synthesized using various polyols with similar hydroxyl values, including poly(tetrahydrofuran) polyol, polyester polyol, castor oil-modified polyol, soybean oil-modified polyol, and cashew nut shell oil-modified polyol. The corresponding polyurethane curing products were evaluated for their underwater curing characteristics by volume expansion ratios and adhesion strength on dry and wet substrates, combined with analyses of reaction exothermic behavior, wetting properties on dry and wet substrates, interfacial tension, and microstructure characterization from the perspectives of reaction activity and water solubility.

View Article and Find Full Text PDF

Ultra-Fast Removal of CBB from Wastewater by Imidazolium Ionic Liquids-Modified Nano-Silica.

Molecules

December 2024

State Key Laboratory of Advanced Electromagnetic Engineering and Technology, School of Electrical and Electronic Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.

The efficient removal of dyes is of significant importance for environmental purification and human health. In this study, a novel material (Si-MPTS-IL) has been synthesized by the immobilization of imidazole ionic liquids (ILs) onto nano-silica using the radiation grafting technique. The adsorption performance of Si-MPTS-IL for Coomassie Brilliant Blue (CBB) removal is studied by a series of static adsorption experiments.

View Article and Find Full Text PDF

Background And Aims: Type 2 diabetes mellitus (T2DM) is usually complicated by cardiovascular diseases, hyperglycemia, and obesity, which worsen the outcome for the patient. Since recent evidence underlines the epigenetic role of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in the management of these comorbidities, this study compared the effects of these agents, namely liraglutide, semaglutide, dulaglutide, and exenatide, on miRNA regulation in the management of T2DM.

Results: GLP-1RAs modify the expression of miRNAs involved in endothelial function, sugar metabolism, and adipogenesis, including but not limited to miR-27b, miR-130a, and miR-210.

View Article and Find Full Text PDF

Background: Ischemia/reperfusion (I/R) is an inevitable pathophysiological process during heart transplantation, and ferroptosis is an important pathogenic mechanism. Unlike other modes of cell death, ferroptosis depends on the accumulation of iron within the cell and the oxidative degradation of polyunsaturated fatty acids. Dysregulation of this pathway has been linked to the progression of multiple pathological conditions, making it an attractive target for therapeutic intervention.

View Article and Find Full Text PDF

Monitoring of single-nucleus chromatin landscape of ischemic stroke in mouse cerebral cortex across time.

Sci Data

January 2025

Hubei Clinical Research Center of Central Nervous System Repair and Functional Reconstruction, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, China.

Ischemic stroke constitutes a multifaceted neurological affliction that spans various cellular types. Lack of dynamic chromatin accessibility data after stroke is one of the obstacles to understanding this process. To gain insights into the variations in transcriptional regulation among various cell types subsequent to a stroke, we employed single-nucleus ATAC-seq to curate a chromatin accessibility compendium from the cerebral cortex of mice subjected to middle cerebral artery occlusion/reperfusion (MCAO/R).

View Article and Find Full Text PDF

Aims: The aim of this study was to evaluate the impact of the introduction of a phosphoribosylpyrophosphate synthetase (PRS) mutation into a plant growth-promoting strain of Methylorubrum on the enhancement of phyllosphere colonization, with the ultimate goal of improving plant growth and quality.

Methods And Results: A strain of Methylorubrum populi (named HS04) was isolated from the groundnut leave and found to process the plant-promoting traits, including the ability to produce indole acetic acid, siderophore, 1-aminocyclopropane-1- carboxylate deaminase, and to fix nitrogen. The application via foliar spray significantly increased the fresh weight of cucumber seedlings cultivated in a standard growth chamber, with 43.

View Article and Find Full Text PDF