6,319 results match your criteria: "Hotchkiss Brain Institute; Owerko Centre.[Affiliation]"
The safety and feasibility of transcranial direct current stimulation combined with conservative treatment for patients with cervicogenic headaches: A double-blinded randomized control study protocol.
Contemp Clin Trials Commun
December 2024
Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Alberta, Canada.
Article Synopsis
- Cervicogenic headaches (CGH) often occur after concussions and whiplash, leading to a decreased quality of life, and existing treatments like exercises and physiotherapy have had limited success.
- This trial will test the combination of transcranial direct current stimulation (tDCS) with exercise therapy (ET) in adults aged 18-65, assessing its feasibility and safety, with participants receiving either active or sham tDCS over six weeks.
- The study aims to show that tDCS is a safe and practical approach to treat CGH, potentially improving pain, strength, function, and overall quality of life for affected individuals.
Neurofilament heavy chain and chitinase 3-like 1 as markers for monitoring therapeutic response in multiple sclerosis.
Mult Scler Relat Disord
November 2024
University Hospital Ostrava, Institute of Laboratory Medicine, Department of Clinical Biochemistry, Ostrava, Czech Republic; University of Ostrava, Institute of Laboratory Medicine, Ostrava, Czech Republic.
Article Synopsis
- The study aimed to investigate the relationship between two biomarkers, serum neurofilament heavy chain (sNfH) and chitinase 3-like 1 (sCHI3L1), and their impact on treatment response and disease activity in multiple sclerosis (MS).
- Conducted at the MS Centre in the Czech Republic, the research analyzed 459 samples from 57 MS patients over approximately 22 months.
- Results indicated that higher sNfH levels were linked to disease relapses and shorter treatment duration, while sCHI3L1 levels did not correlate with relapse, suggesting that sNfH may be a useful biomarker for monitoring MS treatment and disease progression.
Ictal and interictal epileptic networks of 34 patients with hypothalamic hamartoma on scalp electroencephalography.
J Neurophysiol
November 2024
Department of Neuropediatrics and Muscle Disorders, Medical Center-University of Freiburg, Freiburg, Germany.
Article Synopsis
- The study examined the brain regions affected during seizures in 34 patients with epilepsy linked to hypothalamic hamartoma through long-term video-EEG monitoring.
- It found that seizure activity predominantly involved frontal and temporal areas, with advanced disease showing more frontal region involvement and distinct patterns based on seizure type.
- The findings suggest variations in cortical involvement based on disease stage and cognitive function, which may aid in understanding epilepsy progression and inform surgical treatment options.
Examining the upper frequency limit of dynamic cerebral autoregulation: Considerations across the cardiac cycle during eucapnia.
Exp Physiol
December 2024
Cerebrovascular Concussion Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada.
Article Synopsis
- There are different opinions on how high the frequency cut-off point of dynamic cerebral autoregulation (CA) is, with one method suggesting it's around 0.07 Hz and another saying it could be as high as 0.24 Hz.
- A study looked at how these limits are accurate by having 16 people perform squat-stand exercises at different frequencies while measuring blood flow in their brains.
- The results showed that while there were some differences between males and females, the overall upper frequency limit for CA was similar regardless of sex, the type of blood vessel, or the heartbeat phase.
Changes in work and adequacy of financial resources during COVID-19 among people with systemic sclerosis: A Scleroderma Patient-centered Intervention Network study.
J Scleroderma Relat Disord
October 2024
Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.
Article Synopsis
- The study examined changes in work status, financial adequacy, and preferences for remote versus in-office work among individuals with systemic sclerosis during the COVID-19 pandemic.
- Conducted with 298 participants, findings revealed that most people's work status and financial well-being remained stable from April 2020 to August 2022, with only a few changes in employment.
- Participants preferred flexible work arrangements, but most were required to work in a fixed, in-person setting, suggesting a need for more adaptable workplace policies to accommodate their conditions.
Family-Led Coaching of Patients During Weaning From Sedation and Mechanical Ventilation in the ICU.
Respir Care
October 2024
Department of Critical Care Medicine, Cumming School of Medicine, University of Calgary and Alberta Health Services, Calgary, Alberta, Canada; and Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Article Synopsis
- ICU patients often undergo a stressful process of weaning from sedation and ventilation, and a study pilot-tested a coaching tool led by family members to help ease this transition for both patients and their families.
- Conducted in Calgary, the study involved 25 family-patient dyads from two ICUs, with surveys assessing family demographics, anxiety, tool feedback, and attitudes towards family presence during weaning trials.
- Results showed that 60% of families found the coaching tool useful, 70% reported positive experiences with family involvement, and family anxiety significantly decreased after using the tool.
Neighborhood ethnoracial diversity and positive psychotic symptoms among youth at high-risk and healthy comparisons.
Psychiatry Res
December 2024
Department of Psychology, The City College of New York, City University of New York, New York, NY, USA; The Graduate Center, City University of New York, New York, NY, USA.
Article Synopsis
- This study looked at how living in diverse neighborhoods affects young people at risk for schizophrenia compared to those who are not.
- Researchers found that living in neighborhoods with lots of different racial and ethnic groups can lead to fewer symptoms of mental health issues for some young people.
- They also discovered that experiences like being bullied and discrimination can play a role in how these feelings are affected by neighborhood diversity.
Development of Tetrahydroquinoline-Based Inhibitors for Chronic Pain.
ACS Chem Neurosci
October 2024
Department of Chemistry, University of Calgary, Calgary T2N 1N4, Alberta, Canada.
Chronic pain affects a substantial portion of the population, posing a significant health challenge. Current treatments often come with limitations and side effects, necessitating novel therapeutic approaches. Our study focuses on disrupting the Cav3.
View Article and Find Full Text PDFSystemic determinants of brain health in ageing.
Nat Rev Neurol
November 2024
Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Article Synopsis
- Preservation of brain health is a global priority, with traditional therapies targeting intrinsic brain issues but new evidence highlights the role of peripheral organs in brain dysfunction.
- Dysfunction in organs like the gut, liver, kidney, and lung is increasingly recognized as a significant factor affecting age-related brain problems, including dementia.
- The review suggests a framework for understanding how these organ dysfunctions can influence brain health and offers recommendations for public health strategies and clinical care to address these connections.
Carbon dioxide for neurogenic orthostatic hypotension in adults: a novel therapy.
Eur Heart J
October 2024
Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Health utilities of patients with epilepsy in a Canadian population.
Epilepsia
December 2024
Department of Community Health Sciences and O'Brien Institute of Public Health, University of Calgary, Calgary, Alberta, Canada.
Article Synopsis
- The study aims to explore health state utilities in patients with epilepsy, which are important for assessing quality-adjusted life years and informing clinical decisions.
- Researchers analyzed data from the Calgary Comprehensive Epilepsy Program, using the EQ-5D-5L scale to measure patient-reported health utilities and identify influencing factors.
- Findings reveal that lower health utilities are associated with factors like being female, older, unmarried, experiencing depression, and having medication side effects, leading to a resource for estimating health utilities based on these characteristics.*
Article Synopsis
- Changes in the brain from Alzheimer's and other age-related diseases can cause problems with thinking and behavior, even before serious symptoms appear.
- The study looked at how a person's cognitive reserve (a mix of education and experiences) relates to mild behavioral issues.
- Results showed that people with a higher cognitive reserve had better brain test scores and fewer behavior problems, which suggests that keeping mentally active might help both thinking and behavior as we get older.
Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries.
medRxiv
August 2024
Brain & Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
Article Synopsis
- Subcortical brain structures play a crucial role in various disorders, and a study analyzed the genetic basis of brain volumes in nearly 75,000 individuals of European ancestry, revealing 254 loci linked to these volumes.
- The research identified significant gene expression in neural cells, relating to brain aging and signaling, and found that polygenic scores could predict brain volumes across different ancestries.
- The study highlights genetic connections between brain volumes and conditions like Parkinson's disease and ADHD, suggesting specific gene expression patterns could be involved in neuropsychiatric disorders.
Magnetic resonance spectroscopy reveals evidence of brain oxidative stress in Tourette syndrome.
Parkinsonism Relat Disord
November 2024
Department of Clinical Neurosciences, University of Calgary and Hotchkiss Brain Institute, Calgary, AB, Canada.
Differences in the human gut microbiota with varying depressive symptom severity scores.
Biosci Microbiota Food Health
June 2024
Institute for Advanced Academic Research, Chiba University, 1-33 Yayoicho, Inage, Chiba, Chiba 263-8522, Japan.
Article Synopsis
- Depression rates have increased during the COVID-19 pandemic, prompting interest in the gut microbiome's role in mental health through the gut-brain axis.
- A study in Japan analyzed the gut microbiome of participants with varying depression screening scores, finding no major differences in overall composition but noting potential changes in specific bacterial families like Bifidobacteriaceae and Streptococcaceae.
- While the research contributes to understanding the gut-mind connection and the possibility of microbiome-based depression treatments, limitations include insufficient medical history of participants and a need for larger studies.
A brave new framework for glioma drug development.
Lancet Oncol
October 2024
The Preston Robert Tisch Brain Tumor Center at Duke, Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA. Electronic address:
Article Synopsis
- Patients with brain tumors want to help doctors understand their illness better by participating in tests that involve taking samples of their tumor tissue.
- To improve treatments, everyone including patients, researchers, and regulatory agencies need to work together and use consistent methods when taking these samples.
- Even though new tests using blood samples show some promise, they can't replace the need for the usual tissue tests just yet, and it's important to clearly explain the risks and benefits of these procedures to patients.
Sex-specific post-inflammatory dysbiosis mediates chronic visceral pain in colitis.
Gut Microbes
October 2024
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Background: Despite achieving endoscopic remission, over 20% of inflammatory bowel disease (IBD) patients experience chronic abdominal pain. Visceral pain and the microbiome exhibit sex-dependent interactions, while visceral pain in IBD shows a sex bias. Our aim was to evaluate whether post-inflammatory microbial perturbations contribute to visceral hypersensitivity in a sex-dependent manner.
View Article and Find Full Text PDFImpact of psilocybin on cognitive function: A systematic review.
Psychiatry Clin Neurosci
December 2024
Interventional Psychiatry Program, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.
Psilocybin is a classic psychedelic with demonstrated preliminary clinical efficacy in a range of psychiatric disorders. Evaluating the impact of psilocybin on cognitive function is essential to unravel its potential benefits and risks. In this systematic review, we assessed psilocybin's effect on cognitive function through a comprehensive search of electronic databases from inception to January 2024, identifying 20 articles involving 2,959 participants.
View Article and Find Full Text PDFThe role of ganglionic plexi neurons in atrial fibrillation following spinal cord injury.
J Physiol
September 2024
Hotchkiss Brain Institute, Libin Cardiovascular Institute, University of Calgary, Calgary, AB, Canada.
Rising out-of-hospital mortality in Canada during 2020‒2022: A striking impact observed among young adults.
Can J Public Health
September 2024
Department of Industrial Engineering, Dalhousie University, Halifax, NS, Canada.
Objective: Out-of-hospital mortality rates surged during the early COVID-19 pandemic. While expecting a return to pre-pandemic levels, the evolving patterns of out-of-hospital mortality in Canada remain uncertain. We investigated whether these rates returned to pre-pandemic levels.
View Article and Find Full Text PDFMild Behavioral Impairment and Quality of Life in Community Dwelling Older Adults.
Int J Geriatr Psychiatry
October 2024
Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.
Article Synopsis
- Mild behavioral impairment (MBI) is identified as a warning sign for dementia in older adults, affecting their quality of life (QoL) through various neuropsychiatric symptoms.
- The study involved over 1,100 individuals aged 50 and older, analyzing how severity of MBI symptoms correlates with QoL using specific measurement tools.
- Results showed that higher MBI symptom scores significantly correlated with poorer QoL, regardless of sex, highlighting the need to address MBI in healthcare for older adults.
Antiseizure Medications and Cardiovascular Events in Older People With Epilepsy.
JAMA Neurol
September 2024
Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada.
Importance: How epilepsy may promote cardiovascular disease remains poorly understood.
Objective: To estimate the odds of new-onset cardiovascular events (CVEs) over 6 years in older people with vs without epilepsy, exploring how enzyme-inducing antiseizure medications (EIASMs) and traditional cardiovascular risk factors mediate these odds.
Design, Setting, And Participants: This was a prospective cohort study using the comprehensive cohort of the Canadian Longitudinal Study on Aging (CLSA), with 6 years of follow-up (2015-2021, analysis performed in December 2023).
Examination of methods to separate overlapping metabolites at 7T.
Magn Reson Med
February 2025
Department of Radiology, University of Calgary, Calgary, Alberta, Canada.
Purpose: Neurochemicals of interest quantified by MRS are often composites of overlapping signals. At higher field strengths (i.e.
View Article and Find Full Text PDFProperties of the prefrontal tracts and cingulum bundle in children with prenatal alcohol exposure.
J Affect Disord
January 2025
Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Alberta Children's Hospital Research Institute, Calgary, Alberta, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada. Electronic address:
Background: Prenatal alcohol exposure (PAE) significantly impacts brain structure and function, including cognition and behavior. The cingulum bundle and frontal lobe mediate social-, emotional- and cognitive-related functioning that are affected by PAE. However, the neurobehavioural development of the cingulum and intra-frontal tracts has not been examined in people with PAE.
View Article and Find Full Text PDFProposed Physiological Mechanisms Underlying the Association between Adverse Childhood Experiences and Mental Health Conditions: A Narrative Review.
Children (Basel)
September 2024
Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada.
Adverse childhood experiences (ACEs; e.g., physical abuse) can impact lifelong mental health both directly and intergenerationally, with effects transmitted from the parent to the child.
View Article and Find Full Text PDF