Evaluation of barium tungstate nanocrystals for the sorption of radioactive cobalt and europium from aqueous solutions.

Herein, barium tungstate BaWO nanocrystals were chemically prepared and then estimated as inorganic sorbent material to eliminate the radioactive cobalt and europium from the waste stream. The characterization of BaWO nanocrystals is completed over several analytical techniques. TEM and SEM images show the formation of sphere-shaped BaWO structures in the nanoscale range.

A comprehensive study for the potential removal of Eu radionuclides using a promising modified strontium-based MOF.

A facile modification of a strontium-based MOF using oxalic acid was carried out to prepare MTSr-OX MOF, which was used as a potential substance for eliminating Eu radioisotopes. Various analytical techniques were used to characterize MTSr-OX-MOF. The prepared MOF had a rod-like structure with a BET surface area of 101.

Recent progress in high-performance environmental impacts of the removal of radionuclides from wastewater based on metal-organic frameworks: a review.

The nuclear industry is rapidly developing and the effective management of nuclear waste and monitoring the nuclear fuel cycle are crucial. The presence of various radionuclides such as uranium (U), europium (Eu), technetium (Tc), iodine (I), thorium (Th), cesium (Cs), and strontium (Sr) in the environment is a major concern, and the development of materials with high adsorption capacity and selectivity is essential for their effective removal. Metal-organic frameworks (MOFs) have recently emerged as promising materials for removing radioactive elements from water resources due to their unique properties such as tunable pore size, high surface area, and chemical structure.

Cyanopyridinone- and Cyanopyridine-Based Cancer Cell Pim-1 Inhibitors: Design, Synthesis, Radiolabeling, Biodistribution, and Molecular Modeling Simulation.

In this study, two new series of 3-cyanopyridinones () and 3-cyanopyridines () were synthesized and evaluated for their cytotoxicity and Pim-1 kinase inhibitory activity adopting 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay and Pim-1 kinase inhibition assay, respectively. Most of the tested compounds revealed promising cytotoxicity against HepG-2, HCT-116, MCF-7, and PC-3 cell lines. Among them, compounds and showed more potent cytotoxicity against the HePG2 cell line with IC = 8.

Sorption and transport characteristics of europium on sandy soils.

Radioactive europium can be released as a fission product during nuclear incidents and pose a threat to the human and surrounding environment because of its biological activity and long decay half-lives. For safe design issues and human health protection demands in construction of the planned nuclear power plants (NPPs) at Al-Dabaa site, it is necessary to study the sorption and transport of different radionuclides as europium within the selected area for predicting their fate at any crisis. Many soil samples were collected from different locations at the area selected along the northwestern coast of Egypt.

Radio-iodination and biological evaluation of pentoxifylline as a novel probe for diagnosis of intermittent claudication.

The diagnosis of intermittent claudication (IC) is challenging. Imaging with radiopharmaceuticals provides a new method for detecting acute IC. Pentoxifylline improves blood flow to ischemic tissues via increasing erythrocyte elasticity and inhibiting platelet aggregation.

A novel strontium-based MOF: synthesis, characterization, and promising application in removal of Eu from active waste.

Removal of hazardous radioactive materials such as Eu from active waste using the batch approach has attracted attention nowadays. In this work, a novel melamine-terephthalic strontium metal-organic framework (MTSr-MOF) was prepared a hydrothermal method. The MTSr-MOF was characterized by various analytical techniques such as FT-IR, H/C-NMR, mass spectroscopy, XPS, XRD, TGA, BET, FE-SEM/EDX, TEM, and UV.

Radiolabeling, biological distribution, docking and ADME studies of Tc-Ros as a promising natural tumor tracer.

Rosmarinic acid (Ros) is one of phenolic metabolites with powerful potency as an anticancer agent, with different mechanisms to diminish the cancer cells. This current study represents radiolabeling of Ros with Tc using SnCl in pH4 for 15 min at 60 °C, The yield up to 92.2%.

New repurposed rolapitant in nanovesicular systems for lung cancer treatment: Development, in-vitro assessment and in-vivo biodistribution study.

Lung cancer is characterized by poor prognosis, and is considered a serious disease that causes a significant mortality. The available conventional chemotherapeutic agents suffer from several limitations; hence, new drug molecules are constantly being sought. In the current study, lipid nanovesicles (LNVs) were selected as a colloidal vehicle for encapsulation of the FDA-approved drug; rolapitant (RP), which is used particularly for the treatment of nausea and vomiting, but is repurposed for the treatment of lung cancer in the current work.

Allantoin may modulate aging impairments, symptoms and cancers.

Allantoin increases in different stress conditions and environment such as physical activity, amniotic fluids and oxidative stress. So, we inspired to explore the role of allantoin as a metabolic by-product in health improvement and protection using irradiation as simulator for oxidative stress. Allantoin was injected i.

Novel adsorbent based on carbon-modified zirconia/spinel ferrite nanostructures: Evaluation for the removal of cobalt and europium radionuclides from aqueous solutions.

Herein, a novel adsorbent based on carbon-modified zirconia/spinel ferrite (C@ ZrO/MnMgZnFeO) nanostructures were chemically prepared to remove Co and Eu radionuclides from liquid media using batch experiments. The XRD pattern confirms the successful preparation of the C@ZrO/MnMgZnFeO composite. Also, SEM and TEM images confirmed that the composite owns a heterogeneous morphology in the nanoscale range.

Sponge-like Ca-alginate/Lix-84 beads for selective separation of Mo(VI) from some rare earth elements.

In this investigation, a novel alginate complex was developed for the selective separation of molybdenum (Mo(VI)) ions from some rare earth elements (REEs). In this regard, alginate as a natural polysaccharide was impregnated and modified with 2-hydroxy-5-nonylacetophenone oxime (Lix-84) and characterized using FT-IR, TGA/DTA and SEM-EDX. The relation between medium acidity, adsorption kinetics, sorbent dose, isotherm models, temperature and Mo(VI) recovery was investigated.

Formulation of chitosan coated nanoliposomes for the oral delivery of colistin sulfate: characterization, Tc-radiolabeling and biodistribution studies.

Colistin sulfate is a very important antibiotic for the treatment of multidrug-resistant Gram-negative infections. Unfortunately, it has low oral bioavailability and several side effects following parenteral administration. The present study aims to develop chitosan-coated colistin nanoliposomes to improve the stability in the gastrointestinal tract and to enhance the oral delivery of colistin.

Taguchi L optimization approach for simultaneous removal of Cs and Sr ions by a novel scavenger.

This study targeted to investigate the efficacy of a novel nano 2-naphtyl amine6:6-azulene sodium methanesulfonate di sulphonic acid-impregnated zeolite scavenger for simultaneous elimination of Cs and Sr ions from binary aqueous systems. Fractal analysis is introduced to assign a fractal dimension and other fractal characteristics necessary for the surface characterization in terms of fractal dimension (D) and pre-exponential coefficient (C), which, in theory, are independent tool and sole for each surface. It is found that the D value of nano 2-naphtyl amine6:6-azulene sodium methanesulfonate di sulphonic acid-impregnated zeolite of type Y (NAASMS-ZY) is higher than that of nano 2-naphtyl amine6:6-azulene sodium methanesulfonate di sulphonic acid-impregnated zeolite of type X (NAASMS-ZX) and nano 2-naphtyl amine6:6-azulene sodium methanesulfonate di sulphonic acid-impregnated zeolite of type A (NAASMS-ZA) which accordingly, suggests the irregularity of NAASMS-ZY surface and thus demonstrates a large surface area.

Nano-sized Prussian blue immobilized costless agro-industrial waste for the removal of cesium-137 ions.

For human health and safety, it is of great importance to develop innovative materials with a vast capacity for powerful removal of radioactive ions from aqueous solutions. Prussian blue functionalized sugarcane bagasse (PB-SCB) was successfully prepared for the efficient elimination of radioactive cesium (Cs) using a nontoxic, environmentally friendly, and costless method. The prepared renewable material was characterized using different techniques to emphasize morphology, functional groups, crystal structure, and the adsorption process.

Optimizing the removal of strontium and cesium ions from binary solutions on magnetic nano-zeolite using response surface methodology (RSM) and artificial neural network (ANN).

The feasibility of using magnetic nano-zeolite (MNZ) to remove cesium and strontium from their binary corrosive solutions was investigated by considering the multi-variant/multi-objective nature of the process. RSM (Response Surface Methodology) and ANN (Artificial Neural Network) were used to model and optimize the removal system and assess sensitive parameters that can affect the process reliability. MNZ is characterized by its high surface area and cation exchange capacity and possesses good regeneration behavior for both elements using citric acid.

Hydroxyapatite/NiFeO superparamagnetic composite: Facile synthesis and adsorption of rare elements.

A magnetic hydroxyapatite composite (CaHAP/NF) derived from calcium hydroxyapatite [Ca(PO)(OH)] and nickel ferrite [NiFeO] was successfully synthesized by a coprecipitation method. The synthesized composite was characterized using Fourier transform infrared spectroscopy (FT-IR), X-Ray diffractometer (XRD), thermogravimetric differential thermal analysis (TG-DTA), scanning electron microscopy (SEM) and vibrating sample magnetometer (VSM). Results clarify that the composite is a crystalline in nature, thermally stable up to 800 °C and possesses a high porous structure.

Improved Targeting and Tumor Retention of a Newly Synthesized Antineoplaston A10 Derivative by Intratumoral Administration: Molecular Docking, Technetium 99m Radiolabeling, and In Vivo Biodistribution Studies.

Background: Recently, the direct intratumoral (i.t.) injection of anticancer agents has been investigated.

Design and development of microemulsion systems of a new antineoplaston A10 analog for enhanced intravenous antitumor activity: In vitro characterization, molecular docking, I-radiolabeling and in vivo biodistribution studies.

A10, (3-phenylacetylamino-2,6-piperidinedione), is a natural peptide with broad antineoplastic activity. Recently, in vitro antitumor effect of a new A10 analog [3-(4-methoxybenzoylamino)-2,6-piperidinedione] (MPD) has been verified. However, poor aqueous solubility represents an obstacle towards intravenous formulation of MPD and impedes successful in vivo antitumor activity.

Penetration enhancer-containing spanlastics (PECSs) for transdermal delivery of haloperidol: in vitro characterization, ex vivo permeation and in vivo biodistribution studies.

Haloperidol (Hal) is one of the widely used antipsychotic drugs. When orally administered, it suffers from low bioavailability due to hepatic first pass metabolism. This study aimed at developing Hal-loaded penetration enhancer-containing spanlastics (PECSs) to increase transdermal permeation of Hal with sustained release.

Pharmacophore, 3D-QSAR Models and Dynamic Simulation of 1,4-Benzothiazines for Colorectal Cancer Treatment.

Aim And Objective: Interleukin-6 has become an attractive protein target. This is found in the progression of colon cancer. It performs various functions in the colon cancer cells such as inflammation, activates various cell types signaling and also promotes proliferation in colon cancer cells.

A novel serum-stable liver targeted cytotoxic system using valerate-conjugated chitosan nanoparticles surface decorated with glycyrrhizin.

The aim of this study was to target a naturally chemotherapeutic agent: ferulic acid to the liver using a biocompatible and an in vivo stable carrier. Accordingly, chitosan as a biopolymer was modified using a hydrophobic moiety and valeric acid in order to increase its in vivo stability. The structure of the newly synthesized product was confirmed using FT-IR and NMR techniques together with the ninhydrin assay.

Intranasal brain-targeted clonazepam polymeric micelles for immediate control of status epilepticus: in vitro optimization, ex vivo determination of cytotoxicity, in vivo biodistribution and pharmacodynamics studies.

Clonazepam (CZ) is an anti-epileptic drug used mainly in status epilepticus (SE). The drug belongs to Class II according to BCS classification with very limited solubility and high permeability and it suffers from extensive first-pass metabolism. The aim of the present study was to develop CZ-loaded polymeric micelles (PM) for direct brain delivery allowing immediate control of SE.

(125)I labeling of clomiphene and biodistribution studies for possible use as a model in breast cancer imaging.

Clomiphene has growth-inhibitory effects of breast cancer cells, clomiphene was successfully labeled with (125)I via direct electrophilic substitution reaction with labeling yield 97%. It was obtained at optimum substrate amount of 0.5mg, Chloramine-T was used as an oxidizing agent at optimum amount of 25µg.