31 results match your criteria: "Hospitalet de LL[Affiliation]"
Cabergoline as a Novel Strategy for Post-Pregnancy Breast Cancer Prevention in Mice and Human.
Res Sq
February 2024
Universidad de Salamanca-CSIC. IBSAL.
Post-pregnancy breast cancer often carries a poor prognosis, posing a major clinical challenge. The increasing trend of later-life pregnancies exacerbates this risk, highlighting the need for effective chemoprevention strategies. Current options, limited to selective estrogen receptor modulators, aromatase inhibitors, or surgical procedures, offer limited efficacy and considerable side effects.
View Article and Find Full Text PDFIntroduction: For more than a decade, after the ECTRIMS Congress, Spain has hosted the Post-ECTRIMS meeting, where neurologists with expertise in multiple sclerosis (MS) meet to review the new developments presented at the ECTRIMS.
Aim: This article, published in two parts, summarises the presentations of the post-ECTRIMS meeting, held online on 16 and 17 October 2020.
Development: This second part highlights the importance of gender and age in understanding the pathology of the disease and optimising its management.
Introduction: For more than a decade, following the ECTRIMS Congress, the Post-ECTRIMS Meeting has been held in Spain, where neurologists with expertise in multiple sclerosis (MS) from all over the country meet to review the most relevant latest developments presented at the ECTRIMS congress (on this occasion held together with ACTRIMS).
Aim: This article, published in two parts, summarises the presentations that took place at the Post-ECTRIMS Meeting, held online on 16 and 17 October 2020.
Development: This first part includes the latest results regarding the impact of the environment and lifestyle on risk of MS and its clinical course, and the role of epigenetics and genetic factors on these processes.
Physicochemical Properties of Lipoproteins Assessed by Nuclear Magnetic Resonance as a Predictor of Premature Cardiovascular Disease. PRESARV-SEA Study.
J Clin Med
March 2021
Unidad de Lípidos y Riesgo Vascular, Servicio de Medicina Interna, Hospital Universitario de Bellvitge-IDIBELL, 08907 Barcelona, Spain.
Article Synopsis
- Some lipoprotein disorders linked to premature cardiovascular disease (PCVD) are not identified by standard lipid tests.
- A case-control study involving 125 PCVD patients and 190 controls assessed the predictive value of serum small dense LDL cholesterol (sdLDL-C) and other lipoprotein characteristics using advanced techniques like nuclear magnetic resonance (NMR).
- PCVD patients exhibited lower total LDL particles but higher levels of sdLDL-C and specific triglycerides, revealing that these factors are strong predictors of PCVD, highlighting the need for more detailed lipoprotein analysis beyond conventional profiles.
A Phase I/II Clinical Trial to evaluate the efficacy of baricitinib to prevent respiratory insufficiency progression in onco-hematological patients affected with COVID19: A structured summary of a study protocol for a randomised controlled trial.
Trials
February 2021
Intensive Care Department, Hospital Universitari de Bellvitge, L'Hospitalet de LL., Barcelona, Spain.
Article Synopsis
- Baricitinib is being studied for its dual action against SARS-CoV-2 by reducing inflammation and inhibiting viral entry, aiming to improve respiratory outcomes in cancer patients with COVID-19.
- The study's primary focus is on the safety of baricitinib and its ability to reduce the need for mechanical oxygen support within 14 days, comparing outcomes to standard treatment.
- Conducted at a leading oncology center in Spain, the trial includes patients 18 and older with confirmed COVID-19 and certain health criteria, assessing mortality and immunological changes as secondary outcomes.
In-hospital outcomes of mechanical complications in acute myocardial infarction: Analysis from a nationwide Spanish database.
Cardiol J
September 2021
Hospital Universitario de Bellvitge, Universidad de Barcelona, IDIBELL, Hospitalet de Ll, Spain.
Background: Mechanical complications represent an important cause of mortality in myocardial infarction (MI) patients. This is a nationwide study performed to evaluate possible changes in epidemiology or prognosis of these complications with current available strategies.
Methods: Information was obtained from the minimum basis data set of the Spanish National Health System, including all hospitalizations for acute myocardial infarction (AMI) from 2010 to 2015.
12th Post-ECTRIMS Meeting: review of the novelties from the 2019 ECTRIMS Congress (II).
Rev Neurol
June 2020
Hospital de Cruces, Baracaldo, España.
Article Synopsis
- The Post-ECTRIMS Meeting highlighted new research in multiple sclerosis, focusing on disease-modifying treatments, especially during pregnancy.
- Recent phase 3 trials assessed the safety and efficacy of ponesimod and ofatumumab for relapsing-remitting multiple sclerosis, while also reviewing existing and experimental treatments for progressive forms.
- There has been no significant progress in symptomatic treatments, but patients diagnosed recently show milder forms of the disease, possibly due to earlier diagnosis and more available treatments.
[12th Post-ECTRIMS Meeting: review of the novelties from the 2019 ECTRIMS Congress (I)].
Rev Neurol
May 2020
Hospital de Cruces, Baracaldo, España.
Introduction: Like every year, after the ECTRIMS Congress, renowned Spanish neurologists who are experts in multiple sclerosis presented the main novelties in research in this field at the Post-ECTRIMS Meeting.
Aim: To summarise the content presented at the 12th edition of the Post-ECTRIMS Meeting, which took place in September 2019 in Sevilla and is presented in two parts.
Development: This first part addresses the latest studies on vitamin D deficiency and the discrepancies that currently exist regarding its treatment.
[Historical perspective of the studies with the greatest impact on the treatment of gliomas].
Rev Neurol
March 2020
Hospital Universitari de Bellvitge-ICO L'Hospitalet (IDIBELL) , Hospitalet de Ll., España.
Article Synopsis
- Advances in neuro-oncology have been limited for a long time, with significant progress seen mainly since 2005 when cytostatics were confirmed as potential treatments for brain tumours, changing treatment standards.
- This shift led to the development of new systemic therapies and an increased understanding of gliomagenesis, as well as improvements in clinical trial designs and outcomes.
- While these advancements are promising, they also raise new questions about past studies and their interpretations, focusing this review mainly on trials that have altered the clinical approach to glioma treatment.
[Depressive symptoms and burden in family caregivers in Alzheimer's disease: a model of structural equations].
Rev Neurol
July 2019
Hospital Universitari de Bellvitge, Hospitalet de Ll., Espana.
Introduction: The care of patients with Alzheimer's disease increases the burden and depression of the main caregiver, although the relationship between the two is not clearly defined.
Aims: To explore the factors associated with depressive symptomatology and burden in the main caregiver and to apply a model of structural equations to identify the relationship between them.
Subjects And Methods: The sample consisted of 127 family caregivers of people with Alzheimer's disease, with a follow-up of 24 months.
Review of the novelties presented at the 2018 ECTRIMS Congress: 11th Post-ECTRIMS Meeting (II).
Rev Neurol
June 2019
Hospital de Cruces, Baracaldo, Espana.
The Post-ECTRIMS Meeting was held for the eleventh consecutive year in October 2018 in Madrid, with the aim of analysing the advances made in multiple sclerosis that were highlighted at the latest ECTRIMS annual congress. Based on the issues discussed at this meeting, attended by the nation's foremost opinion leaders on multiple sclerosis, two review articles are presented. This second part includes the growing body of evidence confirming the safety of exposure to disease-modifying treatments in women planning a pregnancy, and the beneficial effect of breastfeeding, provided that the disease is not very active.
View Article and Find Full Text PDF[Review of the novelties presented at the 2018 ECTRIMS Congress: 11th Post-ECTRIMS Meeting (I)].
Rev Neurol
May 2019
Hospital de Cruces, Baracaldo, Espana.
The Post-ECTRIMS Meeting is an emblematic event in Spain which seeks to review and disseminate the main advances in multiple sclerosis presented at the ECTRIMS annual congress. In October 2018, the eleventh Post-ECTRIMS meeting was held in Madrid and was attended by the country's leading experts in multiple sclerosis. As a result of this meeting, we present two articles which outline the most interesting novelties discussed there.
View Article and Find Full Text PDF[Radiation-induced cognitive toxicity in adults].
Rev Neurol
February 2019
Hospital Universitari de Bellvitge, Hospitalet de Ll., Espana.
Article Synopsis
- Cognitive toxicity from cranial radiation significantly affects the quality of life for brain tumor survivors and is a key limitation of radiation therapy.
- Recent studies utilizing neuropsychological assessments and advanced imaging techniques have pinpointed critical brain areas related to this injury, aiding in better clinical diagnosis.
- While there isn't a proven effective treatment yet, strategies like sparing the hippocampus and using memantine show promise in mitigating cognitive damage and improving patient outcomes.
[The role of diffusion tensor imaging in the pre-surgical study of temporal lobe epilepsy].
Rev Neurol
December 2016
Hospital Universitario de la Princesa, 28006 Madrid, Espana.
Article Synopsis
- Diffusion tensor imaging (DTI) is a non-invasive method used to evaluate white matter integrity in the brain, particularly useful for understanding temporal lobe epilepsy (TLE).
- The study analyzed 11 TLE patients who were seizure-free after surgery, using DTI to compare white matter connectivity between the surgical and non-surgical hemispheres.
- Results showed significant reductions in various brain areas on the side of the epileptogenic focus, suggesting that DTI can help localize the epileptic region during pre-surgical assessments, but further research with more patients is required to validate these findings.
Once-daily LCP-Tacro MeltDose tacrolimus for the prophylaxis of organ rejection in kidney and liver transplantations.
Expert Rev Clin Immunol
December 2014
Hospital Universitari de Bellvitge, University of Barcelona, Feixa Llarga, s/n, 08907 Hospitalet de Ll., Catalunya, Barcelona, Spain.
Tacrolimus is a cornerstone of the immunosuppression regimen for prevention of allograft rejection in kidney and liver transplantations, with efficacy proven in many clinical trials. The currently available and extensively used tacrolimus formulations are flawed by large inter- and intra-individual variability, low bioavailability, wide peak-to-trough fluctuations and a narrow therapeutic index. Drug delivery technology can significantly impact the pharmacologic action of a drug, influencing its pharmacokinetic and subsequent therapeutic profile.
View Article and Find Full Text PDFHuman papillomavirus prevalence and type distribution in penile carcinoma.
J Clin Pathol
October 2009
Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Program, Institut Català d' Oncologia, IDIBELL, L' Hospitalet de Ll, Barcelona, Spain.
Article Synopsis
- Penile carcinoma is a rare and severe type of cancer with various causes, where Human papillomavirus (HPV) plays a significant role in many cases, particularly linked to certain histological types.
- A systematic review analyzed 31 studies from 1986 to June 2008, finding a global HPV prevalence of 46.9% in penile carcinomas, predominantly linked to HPV-16 and HPV-18.
- The findings suggest that a notable proportion of penile cancers are associated with HPV, highlighting the potential effectiveness of existing HPV vaccines in preventing these tumors.
Immunoglobulin E levels and risk of lymphoma in a case-control study in Spain.
Cancer Epidemiol Biomarkers Prev
July 2007
Epidemiology and Cancer Registry Unit, Institut Català d' Oncologia, Gran Via km 2.7, 08907 L' Hospitalet de Ll., Barcelona, Spain.
Article Synopsis
- Epidemiologic studies show an inverse relationship between atopy (allergic conditions) and lymphoma, but findings are mixed.
- A study involving 467 lymphoma patients and 544 controls measured various immunoglobulin levels, revealing that higher total serum IgE was linked to a significantly lower risk of lymphoma.
- Results indicate that lower levels of immunoglobulins in lymphoma patients may be connected to the disease process rather than protective effects from atopy, highlighting the need for further long-term research to clarify these associations.
Dying in hospital of terminal heart failure or severe dementia: the circumstances associated with death and the opinions of caregivers.
Palliat Med
January 2007
Geriatric Unit, Internal Medicine Service, Hospital Universitari de Bellvitge, L'Hospitalet de LL, Barcelona, Spain.
Article Synopsis
- Improving end-of-life care for elderly patients with chronic diseases in hospitals is vital, and this study evaluated the circumstances of death among patients with dementia and heart failure along with caregivers' perspectives.
- Out of 102 patients studied, caregivers reported varying levels of satisfaction with the accuracy of clinical information, symptom control, and overall quality of end-of-life care, with a notable percentage still experiencing pain and dyspnea.
- Findings indicate a need for enhancements in palliative care, specifically in communication of clinical details and managing symptoms effectively, highlighting that although many aspects like DNR orders and palliative care initiation were followed, there's room for improvement.
[Wallenberg's syndrome as the presenting symptom of a cavernous angioma].
Rev Neurol
May 2005
Servicio de Neurología, Hospital de Bellvitge, L'Hospitalet de Ll., Barcelona, Spain.
Article Synopsis
- Cavernous angiomas make up 5-13% of vascular malformations, primarily located in the posterior fossa, often linked with abnormal venous drainage and potentially leading to hemorrhage.
- A case study discusses a 54-year-old man with symptoms resembling Wallenberg's syndrome, initially misdiagnosed as an ischemic stroke due to normal CT scans, but later identified as a venous angioma through MRI.
- The study highlights that cavernous angiomas can show no signs of bleeding on scans despite significant symptoms, emphasizing the importance of MRI in differentiating between vascular malformations and ischemic strokes.
[Brain metastases as the first manifestation of an ovarian adenocarcinoma].
Rev Neurol
September 2004
Servicio de Neurología, Hospital Universitari de Bellvitge, Universitat de Barcelona, L'Hospitalet de Ll., Barcelona, Spain.
Prevalence of BRCA1 and BRCA2 germline mutations in young breast cancer patients: a population-based study.
Int J Cancer
September 2003
International Agency for Research on Cancer, Lyon, France.
Our aim was to estimate the prevalence of mutations in the BRCA1 and BRCA2 genes among unselected incident cases of breast cancer in young women. We identified 158 incident breast cancer cases diagnosed before age 46 years in predefined geographic areas in Girona and Tarragona, Spain, during 1995-1997. Of these, 136 (86%) provided information on family history of cancer and were screened for BRCA1 and BRCA2 mutations.
View Article and Find Full Text PDF[Sphincter function disorders. physiopathology and neurophysiological study].
Rev Neurol
March 2004
Servicio de Neurología, Ciutat Sanitària i Universitària de Bellvitge, L 'Hospitalet de Ll., Barcelona, España.
Article Synopsis
- Miction and defecation disturbances are common, especially in neurological patients, highlighting the need to understand their underlying physiology.
- The neurological control of these functions involves complex interactions between brain regions and peripheral structures, relying on intact anatomical and sensory systems for proper functioning.
- The integration of neurological and specialized assessments, alongside new treatment techniques that stimulate sacral roots, is essential for better management of incontinence issues.
Cervical and anal HPV infections in HIV positive women and men.
Virus Res
November 2002
Department of Epidemiology and Cancer Registry, Catalan Institute of Oncology, Gran Via km 2.7, 08907 Hospitalet de Ll, Barcelona, Spain.
Article Synopsis
- The review highlights the increased likelihood of HIV-positive individuals developing oncogenic HPV infections and lesions like cervical intraepithelial neoplasia (CIN) and anal intraepithelial neoplasia (AIN).
- Despite advancements in treatment, the risk for cervical and anal cancer remains high for those with HIV, emphasizing the need for ongoing monitoring.
- Regular screening for CIN in HIV-positive women and potential screening for AIN in all long-term AIDS survivors is recommended to prevent complications and improve outcomes.
Dying from heart failure in hospital: palliative decision making analysis.
Heart
August 2002
Geriatric Unit, Internal Medicine Service, CSU de Bellvitge. L'Hospitalet de LL, Barcelona, Spain.
Effect of different prophylaxis methods on sealant adhesion.
J Clin Pediatr Dent
May 2001
Dental School, University of Barcelona, Pabellón de Gobierno, 2a planta, Feixa Llarga s/n, 08907 Hospitalet de Ll., Barcelona, Spain.
Article Synopsis
- The study aimed to assess how different prophylaxis methods and etching times affect the retention of a light-cured sealant on extracted third molars.
- Eighty third molars were divided into eight groups based on two prophylaxis types (pumice powder, fluoridated paste, sodium bicarbonate spray, and control) and varying etching times (30 seconds and 15 seconds).
- Results showed no significant difference in retention between the two etching times, but sodium bicarbonate and fluoridated paste demonstrated significantly better sealant retention compared to other prophylaxis methods.