4 results match your criteria: "Hospital-Escola Fernando Pessoa[Affiliation]"
Radiotherapy Metastatic Prostate Cancer Cell Lines Treated with Gold Nanorods Modulate miRNA Signatures.
Int J Mol Sci
February 2024
(i3S), Instituto de Investigação e Inovação em Saúde, 4200-135 Porto, Portugal.
MicroRNA (miRNA) modulation has been identified as a promising strategy for improving the response of human prostate cancer (PCa) to radiotherapy (RT). Studies have shown that mimics or inhibitors of miRNAs could modulate the sensitivity of PCa cells to RT. In addition, pegylated gold nanoparticles have been studied as a therapeutic approach to treat PCa cells and/or vehicles for carrying miRNAs to the inside of cells.
View Article and Find Full Text PDFHarvesting the Power of Green Synthesis: Gold Nanoparticles Tailored for Prostate Cancer Therapy.
Int J Mol Sci
February 2024
FP-I3ID, FP-BHS, Instituto de Investigação, Inovação e Desenvolvimento, Biomedical Health Sciences, Universidade Fernando Pessoa (UFP), 4249-004 Porto, Portugal.
Article Synopsis
- Biosynthetic gold nanoparticles (bAuNPs) offer a safer and more sustainable alternative to traditional production methods by reducing hazardous chemicals, with potential applications in cancer treatment.
- This study focuses on optimizing conditions for bAuNP production, such as growth phase, temperature, pH, and incubation time, and uses DCIP as a redox indicator.
- Results show that bAuNPs produced under specific conditions (9 h/OD600 = 1, pH 9.0, 24 h at 58 °C) are smaller and less aggregated, displaying little toxicity to healthy cells but significantly reducing viability and migration in cancer cells.
Application of Gold Nanoparticles as Radiosensitizer for Metastatic Prostate Cancer Cell Lines.
Int J Mol Sci
February 2023
FP-I3ID, FP-BHS, Universidade Fernando Pessoa (UFP), 4249-004 Porto, Portugal.
More than 50% of all prostate cancer (PCa) patients are treated by radiotherapy (RT). Radioresistance and cancer recurrence are two consequences of the therapy and are related to dose heterogeneity and non-selectivity between normal and tumoral cells. Gold nanoparticles (AuNPs) could be used as potential radiosensitizers to overcome these therapeutic limitations of RT.
View Article and Find Full Text PDFEarly results of a distance learning paediatric surgery programme in Mozambique.
Afr J Paediatr Surg
July 2022
Department of Pediatric Surgery, Centro Materno-Infantil do Norte Albino Aroso, Centro Hospitalar Universitário do Porto, Largo do Professor Abel Salazar, Porto; Health4Moz ONGD, Rua Francisco Sá Carneiro n°142 - 5°Esq, Leça da Palmeira; EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Rua das Taipas n° 135; Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR); Instituto de Investigação, Inovação e Desenvolvimento, Fundação Fernando Pessoa (FP-I3ID), Porto; Pediatric Surgery, Hospital-Escola Fernando Pessoa, Universidade Fernando Pessoa, Porto, Portugal.
Introduction: A pre-graduate training programme in paediatric surgery was applied to students in four medical schools of Mozambique. In this paper, we evaluate the early results of the programme.
Materials And Methods: A pre-graduate training programme was developed and applied in two stages, theoretical education available at an online platform and a face-to-face session.