14 results match your criteria: "Hospital of the University of Pennsylvania Philadelphia PA USA.[Affiliation]"
Background: Kidney disease is common in heart failure with preserved ejection fraction (HFpEF). However, the biologic correlates and prognostic significance of kidney injury (KI), in HFpEF, beyond the estimated glomerular filtration rate (eGFR), are unclear.
Methods And Results: Using baseline plasma samples from the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) trial, we measured the following KI biomarkers: cystatin-C, fatty acid-binding protein-3, Beta-2 microglobulin, neutrophil gelatinase-associated lipocalin, and kidney-injury molecule-1.
Background: The role of cellular senescence in human heart failure (HF) remains unclear. The senescence-associated secretory phenotype (SASP) is composed of proteins released by senescent cells. We assessed the prognostic significance and biologic pathways associated with the SASP in human HF using a plasma proteomics approach.
View Article and Find Full Text PDFMendelian Randomization and Bayesian Colocalization Analysis Implicate Glycoprotein VI as a Potential Drug Target for Cardioembolic Stroke in South Asian Populations.
J Am Heart Assoc
August 2024
Department of Epidemiology and Biostatistics School of Public Health, Imperial College London London United Kingdom.
Article Synopsis
- This study investigates the relationship between plasma proteins and stroke risk specifically in South Asian individuals, utilizing genetic data from the UK Biobank and stroke data from the GIGASTROKE consortium.
- Using advanced statistical methods, researchers identified a potential causal link between the glycoprotein GP6 levels and the likelihood of cardioembolic stroke, showing an odds ratio indicating a significant increase in risk.
- Findings suggest that GP6 may not have the same effect on stroke risk in European populations, highlighting the importance of genetic ancestry in biomedical research.
Body Mass Index and Hypertension as Mediators of the Association Between Age at Menarche and Subclinical Atherosclerosis: A Sex-Specific Mendelian Randomization Analysis.
J Am Heart Assoc
July 2024
Department of Epidemiology and Biostatistics, School of Public Health Imperial College London London United Kingdom.
Article Synopsis
- - Early age at menarche (AAM) may lead to higher carotid artery intima-media thickness (cIMT), which is a sign of early vascular disease, and understanding this relationship could improve prevention and treatment strategies for cardiovascular issues.
- - The study explored how AAM affects various cardiometabolic risk factors like body mass index (BMI) and blood pressure, using genetic analyses to determine these connections.
- - Results indicated that AAM was negatively linked to cIMT and positively linked to cholesterol levels, with BMI and systolic blood pressure identified as partial mediators in this association.
Background: Although several studies have addressed plasma proteomics in heart failure with preserved ejection fraction, limited data are available on the prognostic value of urinary proteomics. The objective of our study was to identify urinary proteins/peptides associated with death and heart failure admission in patients with heart failure with preserved ejection fraction.
Methods And Results: The study population included participants enrolled in TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist Trial).
Background: Despite significant cardiac involvement in sarcoidosis, real-world data on death due to cardiovascular disease among patients with sarcoidosis is not well established.
Methods And Results: We queried the Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research database for data on patients with sarcoidosis aged ≥25 years from 1999 to 2020. Diseases of the circulatory system except ischemic heart disease were listed as the underlying cause of death, and sarcoidosis was stated as a contributing cause of death.
Background: Identifying novel molecular drivers of disease progression in heart failure (HF) is a high-priority goal that may provide new therapeutic targets to improve patient outcomes. The authors investigated the relationship between plasma proteins and adverse outcomes in HF and their putative causal role using Mendelian randomization.
Methods And Results: The authors measured 4776 plasma proteins among 1964 participants with HF with a reduced left ventricular ejection fraction enrolled in PHFS (Penn Heart Failure Study).
Cost-Effectiveness of Icosapent Ethyl in REDUCE-IT USA: Results From Patients Randomized in the United States.
J Am Heart Assoc
January 2024
Center of Biostatistics, Informatics and Data Science MedStar Health Research Institute Washington DC USA.
Article Synopsis
- The REDUCE-IT USA trial found that icosapent ethyl (IPE) significantly reduced cardiovascular events by 31% and 36% over approximately 4.9 years.
- An analysis of the cost-effectiveness of IPE compared to standard care (SC) showed that IPE was less expensive and provided better health outcomes, particularly at a daily cost of $4.59.
- Overall, IPE is recommended for U.S. patients similar to those in the trial, as it remains cost-effective even at a higher daily cost of $11.48.
Article Synopsis
- Cardiotoxicity is a significant issue for cancer patients, but current imaging methods for monitoring it are expensive and not very effective, highlighting the need for better, more affordable surveillance strategies.
- Research suggests that circulating cardiovascular biomarkers, like troponins and natriuretic peptides, could be a promising solution for monitoring cardiotoxicity in patients undergoing cancer treatment, though evidence supporting their use is limited.
- The review emphasizes the need for improved study designs and analytical approaches, such as centralized biobanking and machine learning, to enhance the reliability and predictive power of these biomarkers in assessing heart risk in cancer patients.
Background In REDUCE-IT (Reduction of Cardiovascular Events With Icosapent Ethyl-Intervention Trial), icosapent ethyl (IPE) versus placebo) reduced cardiovascular death, myocardial infarction, stroke, coronary revascularization, or unstable angina requiring hospitalization, but was associated with increased atrial fibrillation/atrial flutter (AF) hospitalization (3.1% IPE versus 2.1% placebo; =0.
View Article and Find Full Text PDFShedding light in otolaryngology: A brief history on the surgical tools of visualization and access.
World J Otorhinolaryngol Head Neck Surg
September 2022
Visualization and access. Historically, these have been the two major factors that have limited advancement in the field of Otolaryngology. No other surgical specialty deals with anatomical challenges quite like those presented by the structures of the head and neck.
View Article and Find Full Text PDFSevere complications may not always present with "classic" signs and symptoms. In the setting of recent mastoiditis, complications including cerebral venous sinus thrombosis, skull base osteomyelitis, and retropharyngeal abscess should be considered, particularly with persistent or worsening symptoms. A broad differential can lead to prompt diagnosis and treatment, thereby reducing the likelihood of morbidity and mortality.
View Article and Find Full Text PDF