Enhancing lipid digestion and absorption rate: The role of whey protein isolate short fibrils in emulsions.

Lipid serve as a crucial energy source during prolonged endurance exercise, and whey protein isolate (WPI) is commonly applied in food emulsions to modulate lipid digestibility. Herein, we prepared WPI short fibrils, <400 nm in length, to stabilize emulsion and increase lipid digestion and absorption rates. Specifically, a 2 % (w/v) WPI solution was adjusted to pH 2 and heated at 90 °C for 6 h to produce long fibrils, followed by 168 h of shear force treatment to obtain short fibrils.

Prevalence and Related Factors of Hypokalemia in Patients with Acute Ischemic Stroke.

Aim: This study aimed to investigate the prevalence and associated factors of hypokalemia in patients with acute ischemic stroke.

Methods: A cohort of 996 patients was assessed using a general data questionnaire, laboratory indicators, the NIH Stroke Scale (NIHSS), the Barthel Index (BI), the Frail scale, Nutritional Risk Screening (NRS-2002), and the Kubota drinking water test.

Results: Among the 996 patients, 205 (20.

Circ_0089761 accelerates colorectal cancer metastasis and immune escape via miR-27b-3p/PD-L1 axis.

Circular RNAs have been implicated as critical regulators in the initiation and progression of colorectal cancer (CRC). This study was intended to elucidate the functional significance of the circ_0089761/miR-27b-3p/programmed cell death ligand 1 (PD-L1) axis in CRC. Our findings indicated that circ_0089761 expression was significantly elevated in CRC tissues and cell lines.

Programmable Circular Multispecific Aptamer-Drug Engager to Broadly Boost Antitumor Immunity.

Safely and effectively harnessing innate immunity to boost cancer immunotherapy is promising yet challenging. Hence, we have developed a series of programmable aptamer-based multispecific engagers by encoding various artificial aptamer-drug codons with DNA-templated polymerization, aiming to broadly boost innate and adaptive immunity for antitumor therapy. All circular single-stranded multivalent aptamer-drug conjugates (os-mvApDCs) had a dendritic structure, precise size, and excellent stability, enabling prolonged blood circulation, targeted tumor accumulation, and rapid multireceptor-mediated endocytosis.

P53 status combined with MRI findings for prognosis prediction of single hepatocellular carcinoma.

Object: To develop and validate a nomogram for predicting recurrence in individuals suffering single hepatocellular carcinoma (HCC) after curative hepatectomy.

Material And Methods: A retrospective analysis was conducted on 189 patients with single HCC undergoing curative resection in our center were randomized into training and validation cohorts. P53 status was determined using immunohistochemistry.

Association between cardiometabolic index and female infertility: A population-based study.

Background: One of the risk indicators of infertility is obesity. The cardiometabolic index (CMI) comprises obesity and blood lipids and is regarded as a novel indicator for evaluating obesity. Nevertheless, it is unclear whether it has any connection to infertility.

Anti-rheumatic arthritis efficacy of Pueraria montana extract against type-II collagen-induced rheumatoid arthritis rat model an in vitro and in vivo assessment.

Ethnopharmacological Relevance: Pueraria montana (PM) is a Chinese medicinal herb used to treat alcoholism, inflammation, swelling, and anti-apoptosis. However, the mechanisms and active compounds of PM remain poorly understood.

Aim Of The Study: Chronic inflammatory diseases such as rheumatoid arthritis (RA) can affect multiple joints.

Ferroptosis and the tumor microenvironment.

Ferroptosis is a type of regulated cell death characterized by its non-apoptotic, iron-dependent and oxidative nature. Since its discovery in 2012, extensive research has demonstrated its pivotal roles in tumorigenesis, metastasis and cancer therapy. The tumor microenvironment (TME) is a complex ecosystem comprising cancer cells, non-cancer cells, extracellular matrix, metabolites and cytokines.

Application of Healthcare Failure Mode and Effect Analysis in the Management of Patients With Intrathecal Morphine Pump Implantation.

Background: Intrathecal morphine pump helps alleviate pain in the advanced stages of cancer, and thus, ensuring safe intrathecal morphine pump infusion is important. In this study, we investigated the effect of healthcare failure mode and effects analysis (HFMEA) in the management of patients with intrathecal morphine pump implantation.

Methods: We included 112 cancer patients with severe pain who met the inclusion criteria for intrathecal morphine pump implantation treatment in the pain department of our hospital from November 2021 to October 2022.

Analysis of the efficacy of two kinds of loss restoration of posterior teeth using 3D printing temporary crown during the second phase of implant surgery.

Background: This study aimed to analyze the effect of 3D printing temporary crowns on the single and continuous loss restoration of posterior teeth during secondary implant surgery.

Methods: This study adopted a single-center, randomized, single-blind, parallel-controlled trial design. Thirty patients who were admitted to the Department of Stomatology, Affiliated Hospital of Jiangnan University between January 2020 and February 2023 and who had >2 consecutive missing posterior teeth were implanted with the same implant system.

Perception and coping with self-perceived burden among colorectal cancer patients and their caregivers: A qualitative study.

Purpose: Self-perceived burden can take a toll on the physical and psychological well-being of cancer couples and prevent them from achieving favorable outcomes. There is limited qualitative research synthesizing the cognition and coping with self-perceived burden among Chinese colorectal cancer patients and their caregivers. Therefore, this study examined perceptions of self-perceived burden and coping strategies from the perspectives of colorectal cancer patients, their spousal caregivers and nursing staff.

Negative Pressure Smart Patch to Sense and Heal the Wound.

Negative pressure wound therapy (NPWT) offers significant advantages in terms of rate and time for healing through generating sub-vacuum to draw out inflammatory exudate and promote wound closure. However, continuous drainage probably leads to healing delay due to the lack of information about the real status of the wound bed and the potential risk of infection. To address this concern, printed Negative Pressure Smart Patch (NPSP) is reported by integrating smart real-time sensing acidity (infection) and glucose, and anti-infection into NPWT systems.

Transcriptomic profiling with vascular tension analyses reveals molecular targets and phenotypes in preeclamptic placental vasculature.

Introduction: The placental vascular system plays an important role in the development of pregnancy hypertension in preeclampsia. The gene profiles of whole placental tissue (containing blood vessels and many other structural components) and pure vascular tissue should be very different. All previous reports using RNA-seq analysis in the placenta have tested its whole tissue or the villous part, and thus the gene profiles in the pure placental blood vessels are unknown.

Insights into the pathogenesis of gestational and hepatic diseases: the impact of ferroptosis.

Ferroptosis, a distinct form of non-apoptotic cell death characterized by iron dependency and lipid peroxidation, is increasingly linked to various pathological conditions in pregnancy and liver diseases. It plays a critical role throughout pregnancy, influencing processes such as embryogenesis, implantation, and the maintenance of gestation. A growing body of evidence indicates that disruptions in these processes can precipitate pregnancy-related disorders, including pre-eclampsia (PE), gestational diabetes mellitus (GDM), and intrahepatic cholestasis of pregnancy (ICP).

Longitudinal FDG-PET Radiomics for Early Prediction of Treatment Response to Chemoradiation in Locally Advanced Cervical Cancer: A Pilot Study.

: This study aimed to assess the capacity of longitudinal FDG-PET radiomics for early distinguishing between locally advanced cervical cancer (LACC) patients who responded to treatment and those who did not. : FDG-PET scans were obtained before and midway through concurrent chemoradiation for a study cohort of patients with LACC. Radiomics features related to image textures were extracted from the primary tumor volumes and stratified for relevance to treatment response status with the aid of random forest recursive feature elimination.

TLN1: an oncogene associated with tumorigenesis and progression.

Talin-1 (TLN1), encoded by the TLN1 gene, is a focal adhesion-related protein capable of binding various proteins in the cytoskeleton. It is also expressed at high levels in many cancers wherein it influences cellular adhesion and the activation of integrins. TLN1 is also capable of promoting tumor cell invasivity, proliferation, and metastatic progression, in addition to being a relevant biomarker and therapeutic target in certain cancers.

Heterogeneity of pain-fatigue-sleep disturbance symptom clusters in lung cancer patients after chemotherapy: a latent profile analysis.

Purpose: Pain-fatigue-sleep disturbance symptom cluster (PFS) was common in patients with lung cancer and seriously affected the life quality of patients. However, the heterogeneity and subgroups of PFS were unclear in lung cancer patients after chemotherapy. This study was conducted to identify distinct subgroups of PFS in patients with lung cancer after chemotherapy, and explore the differences and risk factors of PFS subgroups.