Development and verification of a nomogram for recurrence risk of Benign Paroxysmal Positional Vertigo in middle-aged and older populations.

Background: Benign Paroxysmal Positional Vertigo (BPPV) is the most common cause of peripheral vertigo, with frequent recurrence, particularly pronounced among middle-aged and elderly populations, significantly affecting patients' quality of life. This study aimed to identify predictive factors for recurrence in middle-aged and older patients with BPPV and to develop a nomogram prediction model based on these predictors.

Methods: This retrospective study included 582 participants aged ≥45 years who were selected from the electronic medical records system of the First Hospital of Changsha between March 2021 and March 2024.

Down-regulation of SHP2 promotes neutrophil autophagy and inhibits neutrophil extracellular trap formation to alleviate asthma through the ERK5 pathway.

Introduction: Neutrophil autophagy and neutrophil extracellular trap (NET) formation are closely related to asthma pathogenesis. Src homology domain 2-containing protein tyrosine phosphatase 2 (SHP2) is an important regulatory factor in airway remodeling in asthma. This study aimed to explore the molecular mechanisms of SHP2 in neutrophils.

Sclerostin as a new target of diabetes-induced osteoporosis.

Sclerostin, a protein synthesized by bone cells, is a product of the gene. Sclerostin is a potent soluble inhibitor of the WNT signaling pathway, and is known to inhibit bone formation by inhibiting osteocyte differentiation and function. Currently, sclerostin has been the subject of numerous animal experiments and clinical investigations.

Repurposing pinaverium bromide against Staphylococcus and its biofilms with new mechanisms.

Antibiotic resistance by methicillin-resistant Staphylococcus aureus (MRSA) is an urgent threat to human health. The biofilm and persister cells formation ability of MRSA and Staphylococcus epidermidis often companied with extremely high antimicrobial resistance. Pinaverium bromide (PVB) is an antispasmodic compound mainly used for irritable bowel syndrome.

Identification of EXO1 as a potential biomarker associated with prognosis and tumor immune microenvironment for specific human cancers.

Exonuclease 1 (EXO1) is an evolutionarily conserved exonuclease, which have function on maintaining genomic stability. Elevated expression of EXO1 has been reported in certain cancers. However, a comprehensive pan-cancer analysis of EXO1 is still lacking and its role in human cancer development remains poorly understood.

Efficient analysis of drug interactions in liver injury: a retrospective study leveraging natural language processing and machine learning.

Background: Liver injury from drug-drug interactions (DDIs), notably with anti-tuberculosis drugs such as isoniazid, poses a significant safety concern. Electronic medical records contain comprehensive clinical information and have gained increasing attention as a potential resource for DDI detection. However, a substantial portion of adverse drug reaction (ADR) information is hidden in unstructured narrative text, which has yet to be efficiently harnessed, thereby introducing bias into the research.

Radiation-induced aberrant structural covariance networks in patients with nasopharyngeal carcinoma: a source-based morphometry study.

Background: Radiation-induced brain injury (RBI) is a common complication in patients with nasopharyngeal carcinoma (NPC) who have undergone radiotherapy (RT), which is characterized by significant cognitive and psychological impairments. Although radiation-induced regional structural abnormalities have been well-reported, the effects of RT on the whole brain structural covariance networks are mostly unknown. Here, we performed a source-based morphometry (SBM) study to solve this issue.

Corrigendum: A bibliometric analysis of interstitial cells of Cajal research.

[This corrects the article DOI: 10.3389/fmed.2024.

First-line treatments for KRAS-mutant non-small cell lung cancer: current state and future perspectives.

mutations are common in non-small cell lung cancer (NSCLC) and are associated with patient prognosis; however, targeting has faced various difficulties. Currently, immunotherapy, chemotherapy, and chemoimmunotherapy play pivotal roles in the first-line treatment of -mutated NSCLC. Here, we summarize the current evidence on first-line therapies and compare the treatment outcomes and biomarkers for different regimens.

A Novel Triptolide Nano-Liposome with Mitochondrial Targeting for Treatment of Hepatocellular Carcinoma.

Background: Modern pharmacological studies have demonstrated that although triptolide (TP) is effective against hepatocellular carcinoma, it has poor water solubility and more toxic side effects. In this study, we used triptolide (TP), a bioactive constituent in Hook F, as a model drug to develop a novel nano-liposome drug delivery system for the treatment of liver tumours.

Methods: We constructed a functionally-modified triptolide liposome (FA+TPP-TP-Lips) using the film-dispersion method and investigated its physicochemical properties, mitochondrial targeting of hepatic tumour cells, in vitro and in vivo anti-hepatic tumour activity and its mechanism.

Influence of myosteatosis on survival of patients with pancreatic cancer: A systematic review and meta-analysis.

The present meta-analysis aims to evaluate the impact of myosteatosis on overall survival (OS) and progression-free survival (PFS) in patients with pancreatic cancer (PC). A comprehensive literature search was conducted in the Medline, Web of Science, and Embase databases. The hazard ratio (HR) and corresponding 95% confidence interval (CI) for the association between myosteatosis and survival outcomes were pooled using a random-effects model.

An Epidemiological and Clinical Study of Monkeypox in Changsha, China: A Retrospective Analysis of HIV-Infected and Non-HIV-Infected Patients from June to December 2023.

Background: The World Health Organization (WHO) declared Human Monkeypox (mpox) as a public health emergency of international concern (PHEIC) in July 2022. Due to border quarantine and isolation measures implemented from January 2020 to December 2022, Beijing did not report its first locally transmitted case of mpox until May 31, 2023, which represented a delayed occurrence compared to other countries. The aim of this observational analysis is to describe demographical data, symptoms presentation and clinical course till outcome of patients diagnosed with monkeypox (mpox) from June to December 2023 at a tertiary level hospital in Changsha, china.

Risks of malignancies related to disease-modifying antirheumatic drugs in rheumatoid arthritis: a pharmacovigilance analysis using the FAERS database.

Objectives: Over the years when disease-modifying antirheumatic drugs (DMARDs) have been used in rheumatoid arthritis patients, reports of malignancies have emerged. This study aims to investigate the association between malignancies and DMARDs by using data extracted from the Food and Drug Administration Adverse Event Reporting System (FAERS).

Methods: FAERS data (January 2019 to December 2023) were reviewed.

[The influence of vowel and sound intensity on the results of voice acoustic formant detection was analyzed].

This study aims to explore the influence of vowels and sound intensity on formant, so as to provide reference for the selection of sound samples and vocal methods in acoustic detection. Thirty-eight healthy subjects, 19 male and 19 female, aged 19-24 years old were recruited. The formants of different vowels（/a/, //, /i/ and /u/） and different sound intensities（lowest sound, comfort sound, highest true sound and highest falsetto sound） were analyzed, and pairings were compared between groups with significant differences.

Sevoflurane regulates DICER1 expression by targeting miR-192-5p to protect cerebral ischemia-reperfusion injury in rats.

Sevoflurane is considered an effective neuroprotector in cerebral ischemia/reperfusion injury (CIRI). Sevoflurane preconditioning in CIRI, however, remains unknown precisely by its molecular mechanism. The middle cerebral artery occlusion reperfusion (MCAO/R) rat model was established, and neurological function was evaluated by Zea-Longa score.

A novel treatment option for Kummell's disease using percutaneous kyphoplasty with a mesh-hold bone filling container.

Percutaneous kyphoplasty (PKP) is an effective, minimally invasive treatment for Kummell's disease, but challenges like cement leakage, fracture, and displacement remain. This study explores the use of PKP with a mesh-hold bone filling container for this disease.A retrospective analysis was conducted on nine Kummell's disease cases treated with this technique at a spinal surgery department from June 2016 to May 2022.

Protection against cigarette smoke-induced chronic obstructive pulmonary disease via activation of the SIRT1/FoxO1 axis by targeting microRNA-132.

Objective: To investigate the biological role of miR-132 in a murine model of chronic obstructive pulmonary disease (COPD) via activation of the SIRT1/FoxO1 axis.

Methods: COPD was induced in C57BL/6J male mice by exposing them to cigarette smoke (CS) for 8 weeks. A miR-132 knockout mouse model was used to assess the role of miR-132 in CS-induced COPD.

Platelet-rich plasma promotes wound repair in diabetic foot ulcer mice via the VEGFA/VEGFR2/ERK pathway.

Diabetic foot ulcers (DFUs) are a severe microvascular complication. Platelet-rich plasma (PRP) pitches in DFU treatment. This study explored the mechanism of PRP facilitating wound repair in DFU mice via vascular endothelial growth factor A (VEGFA)/VEGF receptor 2 (VEGFR2)/extracellular signal-regulated kinase (ERK) pathway.

The effect of cardiac rehabilitation prescription on medication complications and ET-1, WMSI in elderly patients with coronary heart disease.

Objective: To explore the effects of cardiac rehabilitation prescriptions on medication complications, Endothelin 1 (ET-1), and Wall Motion Score Index (WMSI) in elderly patients with coronary heart disease.

Methods: 98 elderly patients with coronary heart disease admitted to the Department of Cardiology of a hospital from January 2020 to June 2022 are selected. According to the red and blue ball method, 98 research subjects are divided into a control group and an observation group.

Oxidative stress and inflammatory factors mediate the association between dietary antioxidant intake and depressive symptoms in middle and old-aged individuals: A cross-sectional study from NHANES.

Background: The relationship between dietary antioxidant intake and depression remains controversial. This study aimed to explore the intermediary role of oxidative stress and inflammatory markers in linking dietary antioxidant intake to depression among middle-aged and older adults.

Methods: This is a cross-sectional study from the 2003-2014 National Health and Nutrition Examination Survey (NHANES), depressive symptoms were identified using a score of 10 or above on the Patient Health Questionnaire-9 (PHQ-9).