Exploring the molecular mechanisms of comorbidity of myocardial infarction and anxiety disorders by combining multiple data sets with in vivo experimental validation.

Background: The incidence of comorbidity between myocardial infarction (MI) and anxiety disorders is increasing. However, the biological association between them has not been fully understood.

Objective: This study aims to investigate the molecular mechanisms of comorbidity between MI and anxiety disorders and to predict their key genes and potential therapeutic drugs.

Gold nanoclusters/manganese dioxide nanosheets hybrid nanozyme with fluorescence and oxidase-like activity for dual-mode detection of acetylcholinesterase and inhibitors screening.

The abnormal expression of acetylcholinesterase (AChE) is linked to the development of various diseases. Accurate determination of AChE activity as well as screening AChE inhibitors (AChEIs) holds paramount importance for early diagnosis and treatment of AChE-related diseases. Herein, a fluorescent and colorimetric dual-channel probe based on gold nanoclusters (AuNCs) and manganese dioxide nanosheets (MnO NSs) was developed.

Injectable MXene/Ag-HA composite hydrogel for enhanced alveolar bone healing and mechanistic study.

Introduction: Alveolar bone defects pose significant challenges in dentistry. Due to the complexity of alveolar bone anatomy and insufficient repair mechanisms, large bone defects are difficult for the body to heal naturally. Clinical treatment typically involves the use of bone substitute materials.

Associations of C-reactive protein to lymphocyte ratio and metabolic-dysfunction-associated steatotic liver disease: evidence from NHANES 2017-2018.

Background: This study aimed to investigate the association between Metabolic-dysfunction-associated steatotic liver disease(MASLD)and C-reactive protein/lymphocyte ratio (CLR).

Methods: MASLD was defined as a Controlled Attenuation Parameter (CAP ≥ 274dB/m) and CLR = C-reactive protein/lymphocyte. A multifactor linear regression model was used to test the relationship between MASLD and CLR.

[Biomechanical study of load-bearing stability of Pilon fracture fixed with external fixator].

Objective: To explore weight-bearing stability of Pilon fracture fixed by external fixator.

Methods: Six ankle bone models (right side) and 4 pairs (8 ankle cadaver specimens) were selected. Pilon fracture model was prepared by using the preset osteotomy line based on Ruedi Allgower Pilon fracture type.

[Correlation analysis between myopia growth and physical development parameters of school-age children in Shihezi area, Xinjiang Uyghur Autonomous Region].

To study the correlation between myopia growth and physical development of primary school student in Shihezi area of Xinjiang Uyghur Autonomous Region by measuring the ocular biometry and physical parameters of the eye, and to provide an objective basis for the development of myopia prevention and control. A cross-sectional study design was used. The Grade 1-6 students from 33 schools in Shihezi area were randomly selected in October 2023.

DAMNet: Dynamic mobile architectures for Alzheimer's disease.

Alzheimer's disease (AD) presents a significant challenge in healthcare, highlighting the necessity for early and precise diagnostic tools. Our model, DAMNet, processes multi-dimensional AD data effectively, utilizing only 7.4 million parameters to achieve diagnostic accuracies of 98.

Application characteristics and clinical effectiveness of clinical finding staging in guiding non-surgical treatment of knee osteoarthritis involving 92 medical institutions.

Background: Accumulating evidence suggests that the radiographic phenotypes of patients with knee osteoarthritis (KOA) often do not correlate with their clinical findings, which are the primary reason for seeking medical care. Therefore, at OARSI 2024, we proposed a clinical finding staging system-Chinese medicine staging (CMS)-to guide the treatment of KOA. However, the clinical effectiveness and application characteristics of CMS in guiding non-surgical treatment of KOA remain unclear.

Effectiveness of ultrasound-guided ilioinguinal and iliohypogastric nerve block in pediatric inguinal hernia surgery: a systematic review and meta-analysis of randomized controlled trials.

Aim: To evaluate the efficacy of ultrasound-guided ilioinguinal and iliohypogastric nerve block (IIHB) in children undergoing surgery for inguinal hernias.

Material And Methods: PubMed, Embase, Cochrane Library, and Web of Science databases were searched to January 4, 2024. For continuous data, the effect sizes were presented as weighted mean differences (WMDs), and for categorical data, they were reported as relative ratios (RR), each accompanied by 95% confidence intervals (CIs).

Targeted therapy‑associated cardiotoxicity in patients with stage‑IV lung cancer with or without cardiac comorbidities.

Targeted drugs have revolutionized the treatment of advanced non‑small cell lung cancer (NSCLC). However, the understanding of how cardiac comorbidity and toxicity affect the clinical outcomes of patients following targeted therapy remains limited. In a 14‑year cohort, cardiac comorbidities and toxicities among patients with stage‑IV NSCLC treated with targeted therapy were identified.

Correction method for ionization chamber dosimetry in flattening filter free radiotherapy based on Monte Carlo simulation.

Background: The clinical use of flattening filter free (FFF) radiotherapy has significantly increased in recent years due to its effective enhancement of dose rates and reduction of scatter dose. A proposal has been made to adjust the incident electron angle of the accelerator to expand the application of FFF beams in areas such as large planning target volumes (PTVs). However, the inherent softening characteristics and non-uniformity of lateral dose distribution in FFF beams inevitably lead to increased dosimetry errors, especially for ionization chambers widely used in clinical practice, which may result in serious accidents during FFF radiotherapy.

Biodegradable silk fibroin membranes for potential localized treatment of melanoma: optimized preparation andstudy.

As a lethal skin cancer, melanoma is highly aggressive and metastatic with high recurrence rates and the common therapy is surgical resection followed by chemotherapy. To minimize the side effects of chemotherapeutic drugs and prevent tumor recurrence, localized therapy is a more suitable treatment method. Here, a fully biodegradable silk fibroin (SF) membrane loaded with the therapeutic drug doxorubicin (Dox) is fabricated for potential localized chemotherapy of melanoma.

Effects of CYP2C19 and CYP2C9 polymorphisms on the efficacy and plasma concentration of lacosamide in pediatric patients with epilepsy in China.

Unlabelled: To evaluate the effects of cytochrome P450 family 2 subfamily C member 9 (CYP2C9) and cytochrome P450 family 2 subfamily C member 19 (CYP2C19) polymorphisms on the plasma concentrations, efficacy, and safety of lacosamide (LCM) among pediatric patients with epilepsy. This prospective study was conducted at two institutions. It included 215 pediatric patients with epilepsy who were under LCM.

The effectiveness of Tai Chi for patients with mild cognitive impairment: a systematic review and meta-analysis.

Objective: To explore the effectiveness of Tai Chi on cognitive function in patients with mild cognitive impairment (MCI).

Methods: According to the PRISMA guidelines, randomized controlled trial (RCT) literature on the efficacy of Tai Chi on MCI patients was searched in China National Knowledge Network (CNKI), China Biomedical Literature Database (CBM), Wanfang Data, China Scientific Journal Database (VIP), PubMed, Embase, Duxiu Database, Web of Science and Cochrane Library from their inception to April 2024. The risk of bias in each study was appraised using the Cochrane risk-of-bias tool using Revman 5.

Identifying biomarkers of endoplasmic reticulum stress and analyzing immune cell infiltration in chronic obstructive pulmonary disease using machine learning.

Background: Endoplasmic reticulum stress (ERS) is a crucial factor in the progression of chronic obstructive pulmonary disease (COPD). However, the key genes associated with COPD and immune cell infiltration remain to be elucidated. Therefore, this study aimed to identify biomarkers pertinent to the diagnosis of ERS in COPD and delve deeper into the association between pivotal genes and their possible interactions with immune cells.

A case report of a newborn who underwent ultra-high enterostomy and intestinal fluid return after necrosis of intestinal volvulus.

Background: Neonatal intestinal malrotation complicated by midgut volvulus is a serious and common life-threatening complication. When the midgut volvulus is prolonged or severe, it can lead to secondary necrosis of the entire midgut, with high mortality rates. Therefore, improving understanding the clinical characteristics of this condition is necessary to facilitate early diagnosis and treatment.

Depression of Any Severity Was Associated With Stress Urinary Incontinence in Females: A Retrospective Study Based on NHANES 2005-2018.

Objective: To assess the relationship between depression and stress urinary incontinence (SUI) in females.

Methods: A cross-section study was conducted using from National Health and Nutrition Examination Survey (NHANES) 2005-2018. Data on the association of depression by the Patient Health Questionnaire (PHQ-9) and SUI by questionnaire answering women.

Impact of physical indicators on ocular development in preschool children.

Objective: Understanding the impact of early childhood physical growth on visual development is crucial, as this period marks a critical phase for foundational physical and ocular maturation. The aim of the current study was to investigate the associations between the anthropometric indicators of height, weight, and body mass index (BMI), as well as visual acuity, refraction, and ocular biometrics, in Chinese preschool children.

Methods: This cross-sectional study consisted of 1,477 Chinese 3- to 6-year-old preschool children from nine kindergartens in Tongzhou District, Beijing.

Corrigendum: Effects of quinoa on cardiovascular disease and diabetes: a review.

[This corrects the article DOI: 10.3389/fnut.2024.

A new treatment for ingrown toenail with CO laser: a retrospective study.

Background: There are various surgical treatments on ingrown toenails. However, the treatment without matricectomy, damaging the nail and not operating on the nail bed could be better.

Objective: To present a new treatment for ingrown toenail that completely preserve the nail and nail matrix.

Modulation of metabolic pathways and EndMT inhibition by a traditional Chinese herbal formula in the treatment of high-risk infections.

Background: Herbal products have long been utilized as remedies for various disease conditions, including infections. This study investigates the therapeutic mechanism of a traditional Chinese herbal combination in treating high-risk HPV infections.

Methods: The herbal formula was prepared using common herbs: dry Millettia speciosa, Guanzhong (a spermatophyte), Sarsaparilla, White Fruit, and Cockscomb Flower.

Novel non-HDLc/HDLc ratio for predicting MASLD: a cross-sectional study in a Chinese health screening population.

Background: Previous studies have shown a positive correlation between the non-high-density lipoprotein cholesterol/high-density lipoprotein cholesterol(non-HDLc/HDLc ratio) and metabolism-associated steatohepatitis (MASLD), suggesting it is a superior predictor of MASLD.The aim of this study is to assess the predictive value of the non-HDLc/HDLc ratio for MASLD.

Methods: In this study, we retrospectively analyzed data from 4,498 adult patients at the Health Management Centre of Guangdong Provincial Hospital of Integrative Medicine, regardless of gender, and the diagnostic criteria for MASLD were derived from guidelines.