7 results match your criteria: "Hospital dos Plantadores de Cana[Affiliation]"

Increased circulating levels of High Mobility Group Box 1 (HMGB1) in acute-phase Chikungunya virus infection: Potential disease biomarker.

J Clin Virol

January 2022

Departamento de Biotecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil. Electronic address:

Article Synopsis
  • Chikungunya virus (CHIKV) causes severe joint pain and currently has no specific treatment or vaccine, prompting the need for reliable serological markers for better patient management.
  • The study investigated serum levels of the protein HMGB1 in CHIKV-infected patients, finding significantly higher levels compared to healthy controls, which remained elevated during the acute phase of the illness.
  • Results suggest that HMGB1 could serve as a useful biomarker for diagnosing and managing chikungunya fever, linking its levels to the severity of the infection.
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This patient was a 73-year-old man who initially came to our service with acute respiratory failure secondary to COVID-19. Soon after hospitalization, he was submitted to orotracheal intubation and placed in the prone position to improve hypoxia, due to severe acute respiratory syndrome (SARS). On the third day of hospitalization, he developed acute oliguric kidney injury and volume overload.

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Evidence of dengue virus replication in a non-traumatic spleen rupture case.

Arch Virol

November 2017

Laboratório Interdisciplinar de Pesquisa Médica, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

The present report describes a case of splenic rupture due to dengue, a rare complication of dengue that should be considered in any patient with suspected dengue disease who started with left upper quadrant abdominal pain and hypotension. The pathophysiology of this entity is not yet well elucidated, but one of the theories present in the literature is that it is due to a depletion of coagulation factors and platelets leading to intra-splenic hemorrhage and rupture. The RT-PCR technique detected serotype 1 and histopathological studies of the spleen revealed significant atrophy of lymphoid follicles and extensive hemorrhage areas.

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The increase in severe dengue (SD) cases has caused great impact on public health and has concerned authorities of countries where the disease is endemic and epidemics reach high proportions. The recognition of progression signs of this severe disease during the initial febrile phase can be difficult, since the symptoms are often indistinguishable from other febrile diseases. The aim of this study was to evaluate the clinical manifestations and laboratory findings in patients from two dengue outbreaks and their association with the disease.

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Hepatitis in dengue shock syndrome.

Braz J Infect Dis

December 2002

Campos Faculty of Medicine, Lílian Neves Clinic, Reference Center for Dengue, Hospital dos Plantadores de Cana, Campos dos Goytacazes, RJ, Brazil.

Dengue fever is the most frequent arbovirus disease in the world and the most important one in terms of morbidity and mortality. Atypical manifestations of dengue have become commonplace during the last few years, including hepatic damage, which manifests mainly by pain in the right hypochondrium and an increase in the levels of aminotransferases. We describe a case of acute hepatitis in a patient with Dengue Shock Syndrome Grade III.

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The frequency of IgA antibody activity to the structural protein subunit BfpA of the enteropathogenic Escherichia coli bundle-forming pilus was determined in 40 mother-infant pairs by immunoblot analysis using affinity purified recombinant BfpA to monitor for IgA in maternal colostrum and in feces of the neonates. Fecal samples were collected from exclusively breastfed term infants < 24-h after the first breastmilk feeding and colostral samples from their mothers. Infants were monitored prospectively with monthly visits to ascertain dietary practices and diarrheal illnesses.

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Unlabelled: The objective of this study was to examine the antibody responsiveness to the bundle-forming pilus subunit A of enteropathogenic Escherichia coli in human colostrum (n = 36) and serum (n = 90) of paediatric ambulatory patients, 3-24 months of age. Affinity purified recombinant bundle-forming pilus subunit A was used in immunoblot analysis to detect antigen-specific serum immunoglobulins G and A, and colostrum immunoglobulin A. Circulating immunoglobulin G antibody activity to the bundle-forming pilus subunit A was readily detected in all children.

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