970 results match your criteria: "Hospital del Mar Research Institute[Affiliation]"

Background: European cancer programmes and policies lack a unified health-related quality of life (HRQoL) assessment tool. The European oncology quality of life toolkit (EUonQoL-Kit) is a novel set of HRQoL questionnaires, co-designed with cancer patients and survivors, translated and culturally adapted into 31 European languages, and with both static and dynamic electronic administration modes. The main aim of this study is the psychometric assessment of the static version.

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We explored predictors of shift work adaptation and how it relates to disease risk biomarker levels. These analyses included 38 male, rotating shift workers, sampled twice at the end of a 3-week night shift and a 3-week day shift rotation. Participants collected all 24-h urine voids, wore activity sensors, and responded to questionnaires during each shift.

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: Radiculopathy leads to pain, consequently reducing patient's quality of life (QoL). Research indicates that certain nucleotides, such as cytidine and uridine, along with vitamins B1 and B12, may help alleviate pain and enhance QoL. This study assessed the impact of adding a supplement containing cytidine and uridine nucleotides and vitamins B1 and B12, alongside standard treatment, on radiculopathy-associated pain.

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Accelerated cell-type-specific regulatory evolution of the human brain.

Proc Natl Acad Sci U S A

December 2024

Neuroscience Research Institute, University of California, Santa Barbara, CA 93106.

The molecular basis of human brain evolution is a key piece in understanding the evolution of human-specific cognitive and behavioral traits. Comparative studies have suggested that human brain evolution was accompanied by accelerated changes of gene expression (referred to as "regulatory evolution"), especially those leading to an increase of gene products involved in energy production and metabolism. However, the signals of accelerated regulatory evolution were not always consistent across studies.

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Background: Advanced chronic kidney disease disrupts the delicate equilibrium between protein anabolism and catabolism, leading to alterations in muscle quantity, quality, and function. Musculoskeletal ultrasound emerges as a promising assessment tool due to its widespread availability and high reliability.

Aim: To evaluate the efficacy of rectus femoris (RF) echogenicity, measured using greyscale software, in identifying diminished muscle quality and strength in candidates for kidney transplant.

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Plasma phosphorylated-tau217 (p-tau217) has been shown to be one of the most accurate diagnostic markers for Alzheimer's disease. No studies have compared the clinical performance of p-tau217 as assessed by the fully automated Lumipulse and single molecule array (SIMOA) AlZpath p-tau217. The study included 392 participants, 162 with Alzheimer's disease, 70 with other neurodegenerative diseases with CSF biomarkers and 160 healthy controls.

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Background: The use of ecological momentary assessment (EMA) designs has been on the rise in mental health epidemiology. However, there is a lack of knowledge of the determinants of participation in and compliance with EMA studies, reliability of measures, and underreporting of methodological details and data quality indicators.

Objective: This study aims to evaluate the quality of EMA data in a large sample of university students by estimating participation rate and mean compliance, identifying predictors of individual-level participation and compliance, evaluating between- and within-person reliability of measures of negative and positive affect, and identifying potential careless responding.

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Circulating miRNAs Associated With 3-Month Outcome in Patients With Acute Ischemic Stroke.

Neurology

January 2025

From the Neurovascular Research Group (I.F.-P., M.V.-P., L.R.-Á., E.G.S., A.O., E.C.-G., A.R.-C., A.S.-P., A.M.-G., J.J.-B., J.J.-C.), Hospital del Mar Research Institute; Neurology Department (I.F.-P., E.G.S., A.O., E.C.-G., A.R.-C., A.S.-P., A.M.-G., J.J.-C.), Hospital Del Mar; Faculty of Medicine and Life Sciences (E.G.S., A.O., E.C.-G., A.R.-C., J.J.-C.), Universitat Pompeu Fabra, Barcelona, Spain; Department of Psychiatry (C.S.-T.), Washington University School of Medicine, St. Louis, MO; Department of Neurology (F.F.P.), Arnau de Vilanova Hospital, Lleida; Clinical Neurosciences Group (F.F.P., G.A.), Biomedical Research Institute of Lleida, University of Lleida; Neurobiology Laboratory (S.T., G.C., C.V.-B.), Neurology Department, Son Espases University Hospital, Health Research Institute of Balearic Islands; Department of Biology (G.C., C.V.-B.), Universitat de les Illes Balears, Palma de Mallorca; Department of Neurology (T.S.), and Research Unit (G.S.-H.), Albacete University Hospital Complex; and Center for Cooperative Research in Biosciences (U.L.), Basque Research and Technology Alliance, Bizkaia Technology Park, Derio, Spain.

Background And Objectives: Post-ischemic stroke (IS) outcomes vary widely among individuals, independently of clinical factors. This variability could be related to epigenetic mechanisms that regulate biological processes involved in recovery after ischemia. While several microRNAs (miRNAs) and their target genes are implicated in the pathophysiology of IS, their role in functional outcomes remains unclear.

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Making blood from iPSCs: Reaching for the most sought-after prize.

Cell Stem Cell

December 2024

Program in Cancer Research. Hospital del Mar Research Institute, Barcelona, Spain; Josep Carreras Leukemia Research Institute, Barcelona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.

After many years of little progress, there is now hope for improved in vitro production of hematopoietic stem cells (HSCs). Ng et al. have developed defined conditions that allow the generation of HSCs from induced pluripotent stem cells (iPSCs) with unprecedented blood-repopulating capacity.

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Article Synopsis
  • E-52862, a selective sigma-1 receptor antagonist, was tested for its effectiveness and safety in treating chronic pain conditions (CPSP and PDN) through phase 2 randomized studies involving adult patients.
  • In CPSP patients, E-52862 showed a greater reduction in pain intensity compared to placebo after 4 weeks, while no significant difference was found in PDN patients likely due to a high response rate to placebo.
  • Although the treatment had a higher incidence of adverse events in CPSP patients compared to placebo, overall, E-52862 was deemed tolerable and effective in providing meaningful pain relief for chronic postsurgical pain.
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A highly-configurable session designer for VR nursing training.

Heliyon

November 2024

Social Determinants and Health Education Research Group (SDHEd), Hospital del Mar Research Institute, Barcelona, Spain.

Virtual Reality (VR) has proven to be a valuable tool for medical and nursing education. VR simulators are available at any time and from anywhere, and can be used with or without faculty supervision, which results in a significant optimization of time, space, and resources. In this paper we present a highly-configurable session designer for VR-based nursing education following the Standards for QUality Improvement Reporting Excellence: SQUIRE 2.

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Sex-specific maladaptive responses to acute stress upon in utero THC exposure are mediated by dopamine.

Pharmacol Res

December 2024

Dept. Biomedical Sciences, Div. Neuroscience and Clinical Pharmacology, University of Cagliari, Italy. Electronic address:

Article Synopsis
  • * Research demonstrates that male rats exposed to THC during pregnancy exhibit altered dopamine activity and increased vulnerability to stress, affecting their sensorimotor functions.
  • * The study found that the HPA axis's regulation of dopamine neurons differs by sex, influencing stress responses and sensorimotor gating, with potential for therapeutic interventions to correct these disruptions.
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Article Synopsis
  • Researchers explored the link between mindfulness and neuroticism, a personality trait tied to mental health issues, suggesting mindfulness could help manage neuroticism's negative effects.* -
  • A scoping review of 49 studies found that mindfulness generally has a negative correlation with neuroticism, indicating it may reduce both mental health challenges and physical symptoms related to this trait.* -
  • Despite some limitations in the studies, the findings are encouraging, pointing to the need for further research to clarify the mindfulness-neuroticism relationship.*
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The transition to parenthood: Linking hormones, brain, and behavior.

Psychoneuroendocrinology

November 2024

Unitat de Recerca en Neurociència Cognitiva, Departament de Psiquiatria i Medicina Legal, Universitat Autònoma de Barcelona, Barcelona, Spain; Neuroimaging of Mental Disorders Group. Hospital del Mar Research Institute, Barcelona, Spain. Electronic address:

This Special Issue brings together pioneering research that explores the neurobiological and hormonal underpinnings of parenting, with an important emphasis on translational perspectives that bridge laboratory findings with real-world applications. By integrating evidence from both human and animal studies, this collection sheds light on the biological flexibility that supports adaptive caregiving behaviors, offering insights into the hormonal shifts, neural adaptations, and stress responses that characterize the perinatal and postpartum periods.

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Background: The pre-surgical evaluation for drug-resistant epilepsy achieves seizure freedom in only 50-60% of patients. Efforts to identify quantitative intracranial EEG (qEEG) biomarkers of epileptogenicity are needed. This review summarizes and evaluates the design of qEEG studies, discusses barriers to biomarker adoption, and proposes refinements of qEEG study protocols.

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β-blockers that easily cross the blood-brain barrier (BBB) seem to diminish the risk of Alzheimer's disease (AD), hypothetically facilitating waste clearance. However, their effect on AD pathophysiological markers is unknown. We compared cerebrospinal fluid (CSF) AD biomarker levels among non-demented individuals taking low, intermediate, or high BBB permeable β-blockers in two samples (ADNI:  = 216; EPAD:  = 79).

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Background And Hypothesis: Duration of untreated psychosis (DUP) has been linked to worse mental health outcomes in psychotic disorders. We meta-analytically studied the relationship between "long" vs. "short" DUP and mental health outcomes.

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Childhood exposure to non-persistent endocrine disruptors, glucocorticosteroids, and attentional function: A cross-sectional study based on the parametric g-formula.

Environ Res

January 2025

ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; Spanish Consortium for Research and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

Background: Evidence suggests that endocrine disrupting chemicals (EDCs) may perturb the hypothalamic-pituitary-adrenocortical (HPA) axis, which has a major role in brain development. We aimed to evaluate the effects of childhood exposure to organophosphate pesticides, phenols, and phthalate metabolites, on urinary glucocorticosteroids and inattention in childhood.

Methods: We used data from the Human Early-Life Exposome (HELIX) cohort (2013-2016) and the parametric g-formula to estimate associations between EDCs, glucocorticosteroids, and hit reaction time standard error (HRT-SE), a measure of inattention, and tested for possible effect modification by sex.

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Background: Bariatric surgery (BS) is the most effective intervention for severe obesity, leading to sustained weight loss, reduced obesity-related comorbidities, and cardiovascular mortality.

Aim: To assess changes in high-density lipoprotein (HDL) functions [cholesterol efflux capacity (CEC) and anti-inflammatory capacity] at different follow-up times in patients with severe obesity undergoing BS.

Methods: A prospective observational study within a cohort of consecutively enrolled patients with severe obesity scheduled to undergo BS.

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Microbiota and social behavior alterations in a mouse model of down syndrome: Modulation by a synbiotic treatment.

Prog Neuropsychopharmacol Biol Psychiatry

November 2024

Integrative Pharmacology and Systems Neuroscience, Neuroscience Research Program, Hospital del Mar Research Institute, Barcelona, Spain. Electronic address:

Sex differences in the composition and functionality of gut microbiota are an emerging field of interest in neurodevelopmental disorders, as they may help in understanding the phenotypic disparities between males and females. This study aimed to characterize sex-related specific alterations in gut microbiota composition in a mouse model of Down syndrome (Ts65Dn mice, TS mice) through the sequencing of the PCR-amplified 16S ribosomal DNA fraction. Moreover, it intended to examine whether the modulation of gut microbiota by the administration of a synbiotic (SYN) treatment would be beneficial for the behavioral alterations observed in male and female TS mice.

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HDL-free cholesterol influx into macrophages and transfer to LDL correlate with HDL-free cholesterol content.

J Lipid Res

November 2024

Department of Medicine, Houston Methodist, Houston, TX, USA; Department of Medicine, Weill Cornell Medicine, New York, NY, USA. Electronic address:

High-density lipoprotein (HDL)-free cholesterol (FC) transfers to other lipoproteins and cells, the former by a spontaneous mechanism and the latter by both spontaneous and receptor-mediated mechanisms. Macrophages are an important cell type in all stages of atherosclerotic cardiovascular disease (ASCVD), and the magnitude of FC efflux from macrophages to HDL, a metric of HDL function, inversely associated with several metrics of ASCVD. Very high plasma HDL concentrations are associated with increased all-cause and ASCVD mortality, suggesting that the reverse process, FC influx from HDL into macrophages, is atherogenic.

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