Monoclonal antibodies toward different Tn-amino acid backbones display distinct recognition patterns on human cancer cells. Implications for effective immuno-targeting of cancer.

The Tn antigen (GalNAcα-O-Ser/Thr) is a well-established tumor-associated marker which represents a good target for the design of anti-tumor vaccines. Several studies have established that the binding of some anti-Tn antibodies could be affected by the density of Tn determinant or/and by the amino acid residues neighboring O-glycosylation sites. In the present study, using synthetic Tn-based vaccines, we have generated a panel of anti-Tn monoclonal antibodies.

[Incidence of accidental dura mater punctures in a university hospital: a prospective observational study].

Objective: Accidental dura mater puncture is a potential complication during epidural block, and may be associated with multiple factors. Our objective was to determine the prevalence and risk factors of accidental dural puncture in a university hospital, evaluating the differences in the number of complications during different working hours.

Material And Methods: A prospective observational study was conducted on all women who requested regional anaesthesia in the Epidural Analgesia Unit between 1 January 2009 and 1 January 2011, and who fulfilled the inclusion criteria.

[Case report: coordination of the care provided to patients with breast cancer].

In Spain, cancer is the leading cause of death in absolute terms. Statistically, the most frequent type of cancer in women in developed countries is breast cancer, which is becoming the leading cause of death from cancer among women. The breast cancer is statistically the most frequent in women and it is getting the first reason of death by cancer between the feminine population, in most of developed countries.

[Epidemiological profile of premature labor].

Preterm birth is the most important cause of neonatal mortality and birth-related short- and long-term neurological morbidity. This health problem has a meaningful social and economic cost for families and governments. Its frequency varies from 5 to 12% in world-developed regions and can be as high as 40% in poorest regions.

[Gestational malaria: HELLP syndrome mistaken diagnosis].

Malaria is one of the most important parasitic infections in Mexico and Latin America. Here we report a case of a 21 year-old female with 38.4 weeks of pregnancy and previous hospitalization due to malaria.

[Pregnancy induced hypertension risk factors in diabetes mellitus pregnant women].

Background: Relation between gestational diabetes mellitus and pregnancy-induced hypertension increases significantly the maternal and perinatal morbidity and mortality risk.

Objective: The purpose of this study was to investigate the risk factors for pregnancy-induced hypertension in women with gestational diabetes mellitus.

Material And Methods: In this case-control study, were compared a total of 90 women with gestational diabetes mellitus according to absence (controls, n = 60) or presence (cases, n = 30) of pregnancy-induced hypertension in terms of demographic data, previous reproductive history, maternal and neonatal characteristics.

[Advances in hormonal contraception].

This review provides an update regarding newer options in hormonal contraception that include the progestin-releasing intrauterine system, the contraceptive patch and ring, the single rod progestin-releasing implant, extended and emergency oral contraception and recent advances in hormonal male contraception. These methods represent a major advancement in this field, allowing for the development of more acceptable, safety and effective birth control regimens.

[Analgesic-antispasmodic effect and safety of lysine clonixinate and L-hyoscinbutylbromide in the treatment of dysmenorrhea].

The purpose of this longitudinal open but not comparative study was to confirm the safety and efficacy of Lysine clonixinate (125 mg) and hyoscinbutylbromide (10 mg) capsules, during a period of observation of there menstrual cycles on 30 women with uterine dysfunction due to primary or secondary dysmenorrhea. The time of evolution for primary dysmenorrhea was of 4.46 years, and for secondary was of 1.

[Breast tuberculosis, A case report and a review of the literature].

Breast tuberculosis is considered a rare entity throughout the world. A case of tuberculous mastitis in a 39 year woman who presented with a breast mass with initial diagnosis of carcinoma is described. A review of literature was also done.

[Proposed normal values for alpha fetoprotein in maternal serum for the detection of neural tube closure defects and Down syndrome. Preliminary study].

To establish a normal range of alpha fetoprotein in maternal serum (AFP sm) in the population at the "20 de Noviembre" Hospital in Mexico City, there were studied 46 patients with a normal pregnancy confirmed with ultrasonography between 16 to 18 week of gestation. The 97 determinations of AFPsm were made by radioimmunoanalysis. The multiples of the median (MoM) were 2.