Beta 2-adrenergic polymorphisms and total serum IgE levels in children with asthma from Argentina.

Background: Beta 2-Adrenergic receptor polymorphisms occurring at amino acid positions 16 (arginine/glycine) and 27 (glutamine/glutamic acid) are known to be functionally relevant. Associations with several asthma-related phenotypes, such as total serum IgE, have been investigated with different results.

Objective: To determine the contribution of polymorphisms and haplotypes of beta 2-adrenergic receptor with serum IgE levels in children from Argentina with mild, moderate, and severe asthma.

Influence of beta2-adrenoceptor polymorphisms on the response to chronic use of albuterol in asthmatic children.

Background: Several studies have suggested that after regular use of short acting beta2-agonists the bronchodilator effect of the drug may decline and this condition would be related to polymorphisms of the beta2-adrenergic receptor (beta2-AR).

Objective: To assess the frequency of beta2-AR polymorphisms in asthmatic children from Argentina, and to evaluate their influence on bronchodilator desensitization to albuterol over a 4-week treatment.

Methods: beta2-AR genotypes were determined in 117 children with asthma and 101 of them were under 4 weeks treatment with albuterol.

[Treatment of vancomycin-resistant Enterococcus with linezolid in paediatric hospitals].

Objective: To describe the use of linezolid in vancomycin-resistant Enterococcus infections in a paediatric hospital.

Method: Retrospective, observational study of hospitalised patients at the "Juan P. Garrahan" paediatric hospital receiving linezolid for the treatment of vancomycin-resistant Enterococcus, during the period between January 2002 and July 2004.

Prevalence of type 2 diabetes mellitus and impaired glucose tolerance in obese Argentinean children and adolescents.

The aim of this study was to evaluate the prevalence of type 2 diabetes mellitus (DM2) and impaired glucose tolerance (IGT) in obese children and adolescents and to examine insulin resistance and insulin secretion. We studied 427 asymptomatic obese patients. DM2 and IGT were diagnosed by an oral glucose tolerance test.

Sirolimus in pediatric renal transplantation.

Side effects of calcineurin inhibitors (CNIs) include nephrotoxicity and hypertension. Moreover, children have a higher risk of infections and posttransplantation lymphoproliferative disorders. We retrospectively evaluated the efficacy and safety of Sirolimus (SRL) in 18 patients, who were 10.