486 results match your criteria: "Hospital de Oncologia[Affiliation]"

Severe coronavirus disease 2019 (COVID-19) is characterized by lung injury, cytokine storm, and increased neutrophil-to-lymphocyte ratio (NLR). Current therapies focus on reducing viral replication and inflammatory responses, but no specific treatment exists to prevent the development of severe COVID-19 in infected individuals. Angiotensin-converting enzyme-2 (ACE2) is the receptor for SARS-CoV-2, the virus causing COVID-19, but it is also critical for maintaining the correct functionality of lung epithelium and endothelium.

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Background: The aim of the study was to Estimate and compare the radiobiological ratio α/β with the heuristic method for a cohort of Mexican patients with prostate cancer (PCa) who were treated with external radiotherapy (RT) techniques at three Hospital Institutions in Mexico City. With the Kaplan-Meier technique and the Cox proportional hazards model, the biochemical relapse-free survival (bRFS) is determined and characterized for cohorts of Mexican patients with PCa who received treatment with external RT. Using these clinical outcomes, the radiobiological parameter α/β is determined using the heuristic methodology of Pedicini et.

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Prognostic factors in cancer patients infected with SARS-CoV-2: a Latin American country results.

Ther Adv Chronic Dis

September 2021

Department of Infectious Disease, Instituto Nacional de Cancerología, Av. San Fernando N. 22, ZC 14080 Mexico City, Mexico. Hospital Epidemiology, Instituto Nacional de Cancerología, Mexico City, Mexico.

Purpose: The aim of this study was to evaluate the demographic characteristics, clinical and pathological factors, and the outcome of cancer and COVID-19 patients in Mexico.

Patients And Methods: A prospective, multicentric study was performed through a digital platform to have a national registry of patients with cancer and positive SARS-CoV-2 test results through reverse transcription quantitative polymerase chain reaction (RT-qPCR). We performed the analysis through a multivariate logistic regression model and Cox proportional hazard model.

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Transoral laser microsurgery in laryngeal cancer.

Cir Cir

October 2021

Departamento de Tumores de Cabeza y Cuello, Hospital de Oncología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.

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Isolation of human and murine hematopoietic stem cells for DNA damage and DNA repair assays.

STAR Protoc

December 2021

Department of Radiation Oncology and Center for DNA Damage and Repair, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

Hematopoietic stem and progenitor cells (HSPCs) reside in the bone marrow and supply blood cells. Efficient methods for isolation of HSPCs are required. Here, we present protocols for the isolation of human and murine HSPCs using manual and FACS-assisted techniques.

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Objective: To identify and evaluate the indexed studies that allow us to understand the implications of imaging studies in MRI and PET/CT related to COVID-19 research.

Methods: Scoping review. Articles in PubMed, Scopus, and Web of Science (WoS) were scanned from 2019 to 2021 with COVID-19, MRI, and PET-CT as keywords.

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Article Synopsis
  • Saliva testing for SARS-CoV-2 is a promising alternative to traditional nasopharyngeal swabs, allowing for self-collection and reducing the risk of exposure to the virus.
  • Current saliva tests are hindered by high costs due to the need for specialized tubes, prompting the development of a method using TRIzol to stabilize RNA and inactivate the virus.
  • The new TRIzol saliva testing method has been shown to be just as effective as traditional swabs, offers greater accessibility, is less expensive, and is particularly beneficial for low-income countries in managing COVID-19 cases.
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COVID-19 Vaccine Guidance for Patients with Cancer in Mexico: Report From the Working Group of the Mexican Society of Oncology.

Arch Med Res

February 2022

Departamento de Piel y Partes Blandas. Instituto Nacional de Cancerología de México Ciudad de México, México.; Sociedad Mexicana de Oncología, Ciudad de México, México.

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[Comment on article: "Neutrophil-to-lymphocyte ratio as a serum biomarker associated with community acquired pneumonia"].

Rev Med Inst Mex Seguro Soc

August 2021

Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Oncología, Departamento de Medicina Interna. Ciudad de México, México.

Identify in a timely manner, through the neutrophil / lymphocyte index, the severity of patients with pneumonia, including that produced by COVID-19, to improve the surveillance-treatment process towards therapeutic success.

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Retrospective analysis of the clinical presentation and imaging of eight primary benign mediastinal schwannomas.

BMC Res Notes

July 2021

Department of Pathology, UMAE Hospital de Oncologia, Centro Medico Nacional Siglo XXI, IMSS, Av. Cuauhtemoc No. 330, Col. Doctores, Delegacion Cuauhtemoc, CP 06725, Mexico City, Mexico.

Objective: Mediastinal schwannomas are sometimes confused with other neoplasms during initial radiological studies, especially when there is a history of cancer in another area. In these cases, a more accurate analysis using computed tomography (CT) or even magnetic resonance (MRI) is required. Our study aimed to perform a retrospective analysis of the clinical and imaging features for a series of patients with mediastinal schwannomas that were confirmed by histology and immunohistochemistry.

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Background: Progressive fibrodysplasia ossificans is a rare genetic disease with heterozygous mutations (autosomal dominant inheritance) in the ACVR1 gene, which causes progressive heterotopic ossification in muscles, tendons, and ligaments, usually secondary to trauma. The ossification foci generate pain, joint ankyloses, and restricted movement. Congenital shortening and medial deviation first metatarsal of the foot is a distinctive feature.

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BIK and GRP78 protein expression as possible markers of response to preoperative chemotherapy and survival in breast cancer.

Taiwan J Obstet Gynecol

March 2021

Medical Research Unit in Reproductive Medicine, Unidad Médica de Alta Especialidad Hospital de Gineco Obstetricia No. 4 "Luis Castelazo Ayala", Instituto Mexicano Del Seguro Social, Río Magdalena 289, Colonia Tizapan San Ángel, Alcaldía Álvaro Obregón, CP 01090, Mexico City, Mexico. Electronic address:

Objective: BIK and GRP78 have shown differential expression profiles in breast cancer (BC) tissue, in addition to its important participation in the pathophysiology of cancer. The purpose of this study was to evaluate the association of BIK and GRP78 protein expression with clinical and pathologic response to preoperative chemotherapy, recurrence, disease-free survival (DFS) and overall survival (OS), in patients with BC.

Material And Methods: Fifty-three patients who received preoperative chemotherapy where included in an observational, analytical and retrospective study to assess the BIK and GRP78 protein expression by immunohistochemistry in microarrays of BC tissue obtained before treatment.

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During immune responses, B cells home to lymph nodes (LNs), where they encounter antigens. Homing starts with capture and L-selectin-dependent rolling on the activated endothelium of high endothelial venules (HEV). After recognition of chemokines presented on HEV, activation of B cell integrins occurs mediating firm arrest.

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Advanced head and neck treatment. Neoadjuvantly, concomitantly or surgery?

Cir Cir

September 2021

Departamento de Tumores de Cabeza y Cuello, Hospital de Oncología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.

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Increased expression of hypoxia-induced factor 1α mRNA and its related genes in myeloid blood cells from critically ill COVID-19 patients.

Ann Med

December 2021

Unidad de Investigación Médica en Enfermedades Endocrinas, UMAE Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico city, Mexico.

Background: COVID-19 counts 46 million people infected and killed more than 1.2 million. Hypoxaemia is one of the main clinical manifestations, especially in severe cases.

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A Shift Towards an Immature Myeloid Profile in Peripheral Blood of Critically Ill COVID-19 Patients.

Arch Med Res

April 2021

Unidad de Investigación Médica en Enfermedades Endocrinas, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México. Electronic address:

Background: SARS-CoV-2, the etiological agent causing COVID-19, has infected more than 27 million people with over 894000 deaths worldwide since its emergence in December 2019. Factors for severe diseases, such as diabetes, hypertension, and obesity have been identified however, the precise pathogenesis is poorly understood. To understand its pathophysiology and to develop effective therapeutic strategies, it is essential to define the prevailing immune cellular subsets.

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Immunotherapy has improved the clinical response in melanoma patients, although a relevant percentage of patients still cannot be salvaged. The search for the immune populations that provide the best tumor control and that can be coaxed by immunotherapy strategies is a hot topic in cancer research nowadays. Tumor-infiltrating TCF-1 progenitor exhausted CD8 T cells seem to grant the best melanoma prognosis and also efficiently respond to anti-PD-1 immunotherapy, giving rise to a TIM-3 terminally exhausted population with heightened effector activity.

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MicroRNA-7 Regulates Migration and Chemoresistance in Non-Hodgkin Lymphoma Cells Through Regulation of KLF4 and YY1.

Front Oncol

October 2020

Molecular Signal Pathway in Cancer Laboratory, Unidad de Investigación Medica en Enfermedades Oncologicas (UIMEO), Oncology Hospital, Siglo XXI National Medical Center, Instituto Méxicano del Seguro Social (IMSS), Mexico City, Mexico.

Article Synopsis
  • The study highlights the significance of microRNA-7 (miR-7) in the regulation of proteins linked to cancer development, specifically in non-Hodgkin lymphoma (NHL).
  • Researchers found that miR-7 negatively regulates the expression of YY1 and KLF4, two proteins known to play a role in NHL.
  • Analysis of cell lines and tumor samples showed that lower levels of miR-7 are associated with higher YY1 and KLF4 levels, impacting cell migration, chemoresistance, and patient survival, suggesting that targeting these proteins could be a potential therapy for NHL.
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Inhibition of TGFβ1 and TGFβ3 promotes hematopoiesis in Fanconi anemia.

Exp Hematol

January 2021

Department of Radiation Oncology and Center for DNA Damage and Repair, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA. Electronic address:

Fanconi anemia (FA) is a chromosome instability syndrome with congenital abnormalities, cancer predisposition and bone marrow failure (BMF). Although hematopoietic stem and progenitor cell (HSPC) transplantation is the recommended therapy, new therapies are needed for FA patients without suitable donors. BMF in FA is caused, at least in part, by a hyperactive growth-suppressive transforming growth factor β (TGFβ) pathway, regulated by the TGFβ1, TGFβ2, and TGFβ3 ligands.

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Physicians' Attitudes, Knowledge, and Perceived Barriers toward Fertility Preservation in Young Breast Cancer Patients in a Developing Country.

Rev Invest Clin

November 2021

Unidad de Epidemiología e Investigación Biomédica en Cáncer, INCan-UNAM, Mexico City; Department of Medical Oncology, Unidad Médica de Alta Especialidad, Hospital de Oncología, Centro Médico Nacional Siglo XXI, Mexico City, Mexico.

Background: In Mexico, up to 15% of breast cancer (BC) patients are 40 years or younger. Therefore, fertility preservation and pregnancy after cancer treatment are major concerns in this population. However, no data are available regarding Mexican physicians' knowledge and attitudes toward these issues.

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MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia.

Cell Stem Cell

January 2021

Department of Radiation Oncology and Center for DNA Damage and Repair, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

Article Synopsis
  • Bone marrow failure (BMF) in patients with Fanconi anemia (FA) is linked to faulty hematopoietic stem and progenitor cells (HSPCs), which are crucial for producing blood cells.
  • Researchers conducted single-cell transcriptome profiling of HSPCs from FA patients and found high expressions of genes related to p53, TGF-β, and notably, MYC.
  • Inhibiting MYC expression reduced the ability of FA HSPCs to proliferate and suggested that MYC may lead to increased DNA damage and diminished stem cell function, contributing to BMF symptoms in FA patients.
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Preneoplasia of the Breast and Molecular Landscape.

Arch Med Res

November 2020

Departamento de Patologia, Hospital de Especialidades Dr. Bernardo Sepúlveda, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico.

The current model of human breast cancer progression proposes a linear multi-step process which initiates as flat epithelial atypia (FEA), progresses to atypical ductal hyperplasia (ADH), evolves into ductal carcinoma in situ (DCIS) and culminates in the potentially lethal stage of invasive ductal carcinoma. FEA commonly coexists with well-developed examples of ADH, low-grade DCIS, lobular neoplasia and tubular carcinoma. These findings and those of recent genetic studies suggest that FEA is a neoplastic lesion that may represent a precursor to or the earliest morphologic manifestation of ductal carcinoma in situ.

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Deciphering the Molecular Pathology of Cancer.

Arch Med Res

November 2020

Department of Pathology, Harvard Medical School, Boston, USA; Department of Pathology, Massachusetts General Hospital, Massachusetts, USA.

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Molecular Oncology of Gynecologic Tumors.

Arch Med Res

November 2020

Departamento de Patología, Hospital de Oncología, Centro Médico Nacional, Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, Mexico. Electronic address:

Oncologists and pathologists alike have recognized that the broad histologic categories, especially for ovarian and endometrial carcinomas, do not reliably segregate groups with similar clinical courses or responses to therapeutic interventions. During the last decade a paradigm shift was invoked when the results from The Cancer Genome Atlas (TCGA) project were published. Comprehensive genomic profiling data from TCGA has shown that there are four molecular subgroups of endometrioid carcinomas instead of the two subtypes proposed by Bokhman in the 1970s.

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