Comparing costs and timing of ankle sprain care in two first-tier care systems.

Objective: To compare the costs of care and the opportunity of care for the management of grade I-II ankle sprain in two Family Medicine Units, one with rehabilitation service (FMU 13) and one without rehabilitation service (FMU 41).

Method: Observational analytical study, records with diagnosis of grade I-II ankle sprain attended at the FMU were included January-November 2021. Consultations were recorded in the emergency department, family medicine, rehabilitation, cabinet studies and time to grant the appointment in the rehabilitation service (opportunity of care), the Mann-Whitney U test was used to compare costs of care and timeliness of care.

[Breast cancer: suspicious findings on mastography associated with the histopathological result].

Background: Breast cancer occupies first place in mortality by neoplasms in women in Mexico; mammography screening (MS) interpreted by BI-RADS (Breast Imaging-Reporting and Data System), allows suspicion of malignancy, which will be confirmed when having the histopathological result (HPR).

Objective: o evaluate whether suspicious findings for breast cancer in MS are associated with malignant HPR in women aged ≥ 40 years.

Material And Methods: Observational, analytical, cross-sectional, prolective study.

Schizophrenia and antipsychotic medications present distinct and shared gut microbial composition: A meta-analysis.

There are some conflicting results regarding alterations of gut microbial composition in schizophrenia (SZ), even a few meta-analysis studies have addressed this field. Ignoring of antipsychotic medication effects may cause the large heterogeneity and impact on study results. This study is a meta-analysis to systematically evaluate composition of gut microbiota in patients with SZ, to elucidate the impact of antipsychotic use and reveal distinct and shared gut bacteria in SZ and antipsychotic medications.

Adult People with Hemophilia A Have Low Annualized Bleeding Rate, However the Arthropathy Remains a Burden: A Retrospective Cohort Study.

Congenital Hemophilia A is a complex disease to treat, especially in places without access to hemophilia treatment centers (HTCs). The primary aim of this study was to analyze the outcomes of a cohort of adult people with congenital hemophilia A in an HTC localized in the Bajio region of Mexico. Observational retrospective study of a cohort of 82 adult people with congenital hemophilia A treated in a tertiary-level hospital in the Bajio region of Mexico, between June 2022 and June 2023.

Association of oropharyngeal colostrum administration with decreased inflammatory indices in premature newborns weighing less than 1500 g.

Background: The administration of colostrum through its absorption at the oropharyngeal level stimulates the mucosa-associated lymphoid tissue, providing a local immunological protection barrier. The study aimed to investigate the association of oropharyngeal colostrum administration with the reduction of inflammatory indices.

Materials And Methods: This was an observational, ambispective, analytical study of newborns < 32 weeks of gestation at risk of sepsis.

Piracetam reduces oxidative stress and mitochondrial function impairment in an in vitro model of vascular dementia.

Vascular dementia (VaD) is the most common cause of dementia in older adults. Due to the lack of effective treatment options, there is an urgent need to find an effective pharmaceutical compound to combat VaD. Piracetam has been reported to improve impaired cognitive function in a variety of conditions in both human and animal models.

Shikonin reduces M2 macrophage population in ovarian cancer by repressing exosome production and the exosomal galectin 3-mediated β-catenin activation.

Background: Shikonin (SK), a naphthoquinone with anti-tumor effects, has been found to decrease production of tumor-associated exosomes (exo). This study aims to verify the treatment effect of SK on ovarian cancer (OC) cells, especially on the production of exo and their subsequent effect on macrophage polarization.

Methods: OC cells SKOV3 and A2780 were treated with SK.

Case report: A familial B-acute lymphoblastic leukemia associated with a new germline pathogenic variant in . The first report in Mexico.

B-cell acute lymphoblastic leukemia (B-ALL) is one of the most common childhood cancers worldwide. Although most cases are sporadic, some familial forms, inherited as autosomal dominant traits with incomplete penetrance, have been described over the last few years. Germline pathogenic variants in transcription factors such as , and have been identified as causal in familial forms.

Validation of the stratify scale for the prediction of falls among hospitalized adults in a tertiary hospital in Colombia: a retrospective cohort study.

The STRATIFY scale has been implemented as a preventive strategy for predicting the risk of accidental falls among hospitalized adults. However, there is still uncertainty about its accuracy. This study aimed to perform an external validation of the STRATIFY fall prediction scale in hospitalized adults in one tertiary care hospital in Bogotá, Colombia.

[Inflammatory indexes during remission induction of pediatric acute leukemia].

Background: Inflammatory indexes can reflect the severity of serious diseases such as acute leukemia (AL), which is why they can predict mortality.

Objective: To evaluate the prognostic value of mortality of inflammatory indexes during the remission induction stage in patients with pediatric AL.

Material And Methods: Observational, longitudinal, analytical and retrolective study.

[Comparison of unfavorable perinatal outcomes in primiparous adolescents and adults].

Background: Adolescent pregnancy may be associated with medical complications related to the biological immaturity of the mother, and adult primiparous mothers may present perinatal outcomes associated with pre-existing age-related chronic changes.

Objective: To compare unfavorable perinatal outcomes in adolescent and adult primiparous women.

Material And Methods: Observational, cross-sectional, retrospective and analytical study.

[Acceptance of family planning methods in birth, cesarean and curettage].

Background: More than 120 million women worldwide want to avoid pregnancy, but most are not using contraception. This could be because they may not have received clear instructions on how to use the method properly, may not have obtained the most appropriate method for their needs, or may not have been aware of the side effects.

Objective: To compare the acceptance of family planning methods (FPM) in women attended for childbirth, caesarean section, and curettage.

[Association of the Pediatric Appendicitis Score with hospital stay and postoperative complications].

Background: Acute appendicitis (AA) is the most common surgical emergency in children. Assessment scales improve the timely detection of cases.

Objective: To evaluate the association of the Pediatric Appendicitis Scale (PAS) with hospital stay (HS) and postoperative complications of appendectomy.

[Inflammatory indexes and their association with the severity of preeclampsia].

Background: Recent studies have confirmed the relationship between some inflammatory indexes and preeclampsia (PE); however, they have not been analyzed in PE with and without severity criteria.

Objective: To know the association between inflammatory indexes and the severity of PE.

Material And Methods: Analytical cross-sectional prolective study.

[Prognostic utility of inflammatory indexes in critically ill newborns].

Background: Critically ill newborns (NB) are susceptible to serious complications due to their immature immune system.

Objective: To know the prognostic utility of inflammatory indexes in critically ill NBs.

Material And Methods: Observational, analytical, longitudinal, prospective study.

[Inflamatory indexes predictors of complicated acute apendicitis in children].

Background: Appendicitis is the main cause of acute surgical abdomen in pediatrics. Delay in the diagnosis implies serious consequences.

Objective: To know the utility of inflammation markers for predicting complicated acute appendicitis (CAA) in children.

[Home therapeutic adherence of pelvic floor muscle exercises in urinary incontinence].

Background: Urinary incontinence (UI) is a medical and social problem that has a great impact on the quality of life of women. Pelvic floor muscle strengthening exercises have been shown to be a form of conservative treatment. However, there is still high failure in this treatment.

[Determining factors of domestic violence in women from Guanajuato].

Background: Women across the globe are at risk of physical or sexual abuse by an intimate partner or other offender. Violence against women can lead to physical injuries, impaired mental health, and specific chronic diseases. In some cases, such types of violence can even result in disability or death for some victims.

[Prenatal diagnosis of placenta acretta by ultrasound and its histopathological association].

Background: Anomalous adhesions of the placenta, known as placenta accreta and its variants, are the cause of obstetric hemorrhages that put the pregnant woman at risk. Accretism is strongly associated with a history of uterine surgery (cesarean section, myomectomy, curettage), as well as ultrasonographic signs, such as the presence and size of placental lacunae, loss of the placenta/bladder interface, location on the anterior face of the placenta, and presence of Doppler flow; these markers can be assessed by prenatal ultrasound.

Objective: To analyze the association of prenatal diagnosis of placenta accreta by ultrasound with the histopathological result using the Tovbin index.

[Maternal and perinatal morbidities associated to advanced age in pregnant women].

Background: Women in advanced maternal age (older than 35 years of age) are at higher risk of obstetric complications and adverse perinatal outcomes than younger women.

Objective: To know the maternal and perinatal morbidities associated to advanced age in pregnant women.

Material And Methods: Analytical cross-sectional study.

[Comment on article "Risk factors at admission associated with intubation in patients with COVID-19"].

Risk factors associated with intubation in patients with COVID-19, should not be confused with criteria for intubation in patients with respiratory problems. In the treatment of patients with COVID-19, it is important to consider the time from the onset of symptoms and the delay of patients to seek hospital care. This could be another factor influencing patient's evolution.

[Saturation index and fraction of inspired oxygen as a predictor in COVID-19].

Background: Coronavirus disease leads to silent hypoxia, ARDS, and organ failure. The saturation and fraction of inspired oxygen have been related to the degree of lung damage, can be considered as a monitoring tool for lung function during hospitalization and a predictor of mortality in patients with pneumonia by COVID-19.

Objective: To evaluate the usefulness of the oxygen saturation index and fraction of inspired oxygen as a predictor of mortality in patients with COVID-19 pneumonia.

Autosomal dominant distal renal tubular acidosis in two pediatric patients with mutations in the SLC4A1 gene. Can the maximum urinary pCO test be normal?

Primary distal renal tubular acidosis (dRTA) is a rare tubulopathy characterised by the presence of hyperchloremic metabolic acidosis. It is caused by the existence of a defect in the function of the H -ATPase located on the luminal side of the α-intercalated cells or the Cl HCO3 (AE1) anion exchanger located on the basolateral side. Patients do not acidify the urine after acid overload (NH4Cl) or after stimulating H secretion by obtaining a high intratubular concentration of an anion such as chlorine (pH is measured) or HCO3- (urinary pCO is measured).