14 results match your criteria: "Hospital das Clínicas da Universidade Federal de Pernambuco - HC-UFPE[Affiliation]"

Systemic autoimmune myopathies (SAMs) are rare diseases that lead to muscle inflammation and may be associated with a variety of systemic manifestations. Although there is great heterogeneity in the spectrum of extra-muscular involvement in SAMs, interstitial lung disease (ILD) is the most frequent lung manifestation. SAM-related ILD (SAM-ILD) presents significant variations according to geographic location and temporal trends and is associated with increased morbidity and mortality.

View Article and Find Full Text PDF

CYP broth: a tool for Yersinia pestis isolation in ancient culture collections and field samples.

Appl Microbiol Biotechnol

April 2023

Department of Microbiology, Aggeu Magalhães Institute - FIOCRUZ PE, Av. Prof. Moraes Rego, S/N Cidade Universitária, Recife, PE, Brazil.

We developed a simple new selective LB-based medium, named CYP broth, suitable for recovering long-term stored Y. pestis subcultures and for isolation of Y. pestis strains from field-caught samples for the Plague surveillance.

View Article and Find Full Text PDF

Objective: To investigate vascular and perivascular abnormalities in the carotid arteries using ultrasound, as well as to evaluate their association with mortality and clinical variables in hospitalized patients with coronavirus disease 2019 (COVID-19).

Materials And Methods: This was a prospective study in which 53 hospitalized patients with severe COVID-19 were evaluated and underwent carotid ultrasound. We documented the carotid ultrasound findings in these patients.

View Article and Find Full Text PDF

Dengue fever has been associated with several neurological complications, cerebellar involvement being among the rarest of them. Here, we describe the case of a 70-year-old female who presented a cerebellar syndrome during the first day of an arboviral infection, posteriorly confirmed as dengue fever. Among the seven other cases in which the relationship between dengue virus and ataxia was reported, only in one cerebellar presentation occurred as early.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates factors influencing neuropsychiatric (NP) manifestations in patients with newly diagnosed Systemic Lupus Erythematosus (SLE), aiming to identify both disease-related and demographic factors.
  • A total of 1,193 patients without NP involvement at the start were analyzed using clinical and lab data, applying a multivariable regression model to find independent risk factors.
  • Key findings highlight that certain conditions like myalgias, pneumonitis, and hemolytic anemia increase the risk of NP involvement, while longer disease duration at the start is linked to a lower risk.
View Article and Find Full Text PDF

Genetic variants in are related to lower galectin-3 serum levels and clinical outcomes in systemic sclerosis patients: A case-control study.

Autoimmunity

June 2021

Laboratório de Imunomodulação e Novas Abordagens Terapêuticas (LINAT), Núcleo de Pesquisa em Inovação Terapêutica - Suely Galdino (NUPIT-SG), Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil.

Article Synopsis
  • Systemic sclerosis (SSc) is a rare disease that involves blood vessel damage, autoimmune responses, and fibrosis in skin and organs, with Galectin-3 (Gal-3) implicated in its mechanisms.
  • A study with 88 SSc patients and 151 controls explored the link between certain gene variants (SNPs) and Gal-3 levels, using advanced genetic and statistical methods.
  • Results indicated a higher frequency of the rs4652 A/C genotype in SSc patients and a correlation with lower Gal-3 levels; however, no significant associations with clinical symptoms were found.
View Article and Find Full Text PDF

Introduction: to evaluate urinary biochemical alterations related to urolithogenesis processes after sleeve gastrectomy (SG).

Materials And Methods: : prospective study with 32 individuals without previous diagnosis of urolithiasis who underwent SG. A 24-h urine test was collected seven days prior to surgery and at 6-month follow-up.

View Article and Find Full Text PDF

Aim: A decrease in proteinuria has been considered protective from renal damage in lupus nephritis (LN), but a cut-off point has yet to be established. The aim of this study was to identify the predictors of renal damage in patients with LN and to determine the best cut-off point for a decrease in proteinuria.

Methods: We included patients with LN defined clinically or histologically.

View Article and Find Full Text PDF

Introduction: Although it is the most common agent among the fungal causes of endocarditis, Candida albicans endocarditis is rare.

Objective: To evaluate the efficacy of amphotericin B in the treatment of C. albicans endocarditis beyond a systematic review.

View Article and Find Full Text PDF
Article Synopsis
  • * A study was conducted by rheumatologists and methodologists, leading to the formulation of guidelines addressing common clinical issues faced by SLE patients in the region, based on best available evidence.
  • * The guidelines cover nine organ/system sections, focusing on pharmacological treatments, their benefits and risks, and emphasize regional implementation, considering ethnic and socioeconomic factors.
View Article and Find Full Text PDF

The Role of PPAR Gamma in Systemic Sclerosis.

PPAR Res

June 2015

Laboratório de Imunomodulação e Novas Abordagens Terapêuticas da Universidade Federal de Pernambuco (LINAT-UFPE), 50670-901 Recife, PE, Brazil.

Fibrosis is recognized as an important feature of many chronic diseases, such as systemic sclerosis (SSc), an autoimmune disease of unknown etiology, characterized by immune dysregulation and vascular injury, followed by progressive fibrosis affecting the skin and multiple internal organs. SSc has a poor prognosis because no therapy has been shown to reverse or arrest the progression of fibrosis, representing a major unmet medical need. Recently, antifibrotic effects of PPARγ ligands have been studied in vitro and in vivo and some theories have emerged leading to new insights.

View Article and Find Full Text PDF

PPARγ Agonists in Adaptive Immunity: What Do Immune Disorders and Their Models Have to Tell Us?

PPAR Res

August 2013

Serviço de Reumatologia do Hospital das Clínicas da Universidade Federal de Pernambuco (HC-UFPE), Recife 50670-901, PE, Brazil ; Laboratório de Imunomodulação e Novas Abordagens Terapêuticas (LINAT), Núcleo de Pesquisa em Inovação Terapêutica (NUPIT SG), Universidade Federal de Pernambuco (UFPE), Recife 50670-901, PE, Brazil.

Adaptive immunity has evolved as a very powerful and highly specialized tool of host defense. Its classical protagonists are lymphocytes of the T- and B-cell lineage. Cytokines and chemokines play a key role as effector mechanisms of the adaptive immunity.

View Article and Find Full Text PDF

Background And Objectives: Spinal anesthesia is an integral part of the daily routine of countless anesthesiologists. It is considered to be a safe procedure, although some complications related to this technique, among them the most feared is cardiopulmonary arrest (cardiac arrest, CA), do exist. The real incidence of CA related to spinal anesthesia, as well as its etiology, is not known and has motivated this review article.

View Article and Find Full Text PDF