Combination of Intravenous Ondansetron and Intravenous Glycopyrrolate Versus Intravenous Ondansetron and Intramuscular Glycopyrrolate for Reduction of Post-spinal Hypotension in Cesaraen Section: A Randomized Double-Blinded Study.

Background: In parturients, post-spinal hypotension is common due to loss of sympathetic tone. Compression of the inferior vena cava by the gravid uterus further aggravates it. Various pharmacologic and non-pharmacologic techniques are used to reduce the severity of hypotension.

Stem cell factor-mediated upregulation of SIRT1 protects melanin-deprived keratinocytes against UV-induced DNA damage in individuals with vitiligo.

Despite the loss of melanocytes, individuals with vitiligo have a significantly lower risk of developing skin malignancies compared to ethnicity-matched controls. The study investigated the molecular mechanisms that protect skin cells (keratinocytes) from UV-B-induced DNA damage in individuals with vitiligo. The study found that upregulation of stem cell factor (SCF) signaling significantly reduced γ-H2AX positivity and cyclobutane pyrimidine dimer formation and improved mitochondrial health (elongated mitochondria, reduced reactive oxygen species [ROS] and lipid peroxidation) in keratinocytes upon UV-B exposure.

A Rare Case of Darier Disease Flaring Up During Pregnancy.

Darier disease (DD), which was also known as keratosis follicularis or Darier-White disease, is an autosomal dominant hereditary illness. The illness typically first manifests in adolescence and progresses as a woman reaches reproductive age. Research on the potential effects of DD on the skin and fetus, especially when it affects the groin and vulva, is insufficient.

Primary Renal Synovial Sarcoma: A Rare Case Presentation.

Synovial sarcoma is a rare mesenchymal tumor, and its occurrence as a primary renal tumor is exceedingly rare. We are presenting a case of renal synovial sarcoma with lung involvement in a 47-year-old female patient who initially presented with typical renal symptoms, including blood in urine and left flank pain. Imaging revealed a large renal mass with extension into the renal vein and metastatic nodules in the lungs.

Castleman's Disease Presenting as an Unusual Pelvic Retroperitoneal Mass.

Castleman's disease (CD) is characterised by benign lymphoepithelial proliferation and is a peculiar form of angiofollicular lymph node hyperplasia rather than a neoplasm or a hamartoma. CD is broadly classified as unicentric CD (UCD) and multicentric CD. In the unicentric variant, patients have localised disease affecting only a single lymph node or a group of adjacent nodes in a single region, which clinically presents as an enlarging mass without any other significant symptoms.

A Comparative Study on the Efficacy of Intravenous Palonosetron Versus a Combination of Ondansetron and Dexamethasone as Prophylaxis for Prevention of Postoperative Nausea and Vomiting After Laparoscopic Surgeries.

Background: The most troublesome complaint after general anaesthesia and surgery, especially laparoscopic surgeries, is postoperative nausea and vomiting (PONV). We routinely use pharmacologic prophylaxis to prevent PONV. In patients undergoing laparoscopic procedures, we assessed the effectiveness of palonosetron compared to ondansetron combined with dexamethasone in preventing the incidence of PONV.

Exertional Heatstroke Encephalopathy With Chronic Neurological Deficit.

Heat exhaustion progresses to heat stroke and then on to heatstroke encephalopathy, a serious illness. Extreme hyperthermia (over 40.5 °C), central nervous system failure, multiorgan dysfunction, and hypovolemic shock are the hallmarks of the clinical presentation of heatstroke.

Qualitative exploration of awareness about risk factors and transformative behaviours among Pakistani patients with coronary artery disease.

Objectives: To explore patients' awareness of risk factors for coronary artery disease (CAD) and experiences of the behavioural modifications, they made during their recovery through in-depth semistructured interviews.

Design: Qualitative exploration was undertaken as part of a larger project to answer the study questions.

Setting: Participants were recruited from a public-sector tertiary care hospital in Lahore Pakistan.

Examining the hidden dangers: Understanding how microplastics affect pregnancy.

Microplastics, a fast-growing environmental concern, play a crucial role in developing the major pollution crisis that affects nearly the entire surface of the planet. Microplastics are tiny particles, measuring less than 5 mm which are ubiquitous, in occurrence, and found in a wide array of products including plastic packaging, synthetic textiles, seafood, fruits, vegetables, salt, sugar, bottled water, and even personal care products. The presence of microplastics in our environment and the potential adverse health effects they may cause have made them a significant perturbation in recent years.

Effect of bioactive compounds of on proteins of Wnt/β catenin pathway in pulmonary hypertension by in silico approach.

Modulation of the Wnt/β-catenin signaling pathway may aid in discovering new medications for the effective management of pulmonary artery hypertension (PAH). Given the therapeutic potential of Mucuna pruriens in several diseases, the present study aimed to analyze interactions of different bioactive compounds of Mucuna pruriens plant seeds with Wnt/β-catenin pathway targeting its various components like Wnt 3a, Frizzled 1, LRP 5/6, β-catenin, Disheveled, cyclin D1 by in silico analysis. The proposed work is based on computational analysis including ADME/T properties, by a Swiss ADME server.

Atypical Manifestation of Enterobius vermicularis Infestation in Adults: A Report of a Rare Case.

, commonly known as pinworm, is a parasitic nematode primarily affecting children, with adult infestations being rare. The infection is typically transmitted via the fecal-oral route and is characterized by intense perianal itching, particularly at night. We present a case of a 39-year-old male with an unusual case of infestation.

Reclassifying cT4b buccal mucosa/gingivobuccal complex cancers: do we need to change?

T4b carcinomas are termed as very locally advanced carcinomas of the oral cavity and are deemed borderline resectable or unresectable. The role of surgery for these patients is not well defined. We therefore aimed to relook at the role of surgery for cT4b carcinoma of the oral cavity.

Analysis of Single Nucleotide Polymorphisms of Liver X Receptor Alpha (LXR-α) Gene in Diabetic Kidney Disease.

Introduction Genetic factors significantly contribute to the progression of diabetic kidney disease (DKD), which is one of the world's most common causes of chronic kidney disease (CKD). Inflammation, glucose homeostasis, and lipid metabolism are all significantly influenced by the liver X receptor alpha (LXR-α) gene. Single nucleotide polymorphisms in the liver X receptor alpha gene may result in the altered function of the gene, making the individual susceptible to DKD.

Assessment of Depression, Anxiety, Stress, Quality of Life, and Fatigue in Patients After a Cerebrovascular Accident.

Background A cerebrovascular accident, or stroke, is a neurological disorder. Those who suffer from a stroke not only face physical disabilities but also a range of psychological issues resulting from concerns about their current situation. The purpose of this study was to assess depression, anxiety, stress, and fatigue after a stroke, along with its effects on quality of life (QoL), degree of disability, and prevalence of various risk factors of stroke.

The Strategic Management of Infected Pancreatic Pseudocyst in the Postpartum Period After Cesarean Delivery in a Pregnancy Complicated by Preeclampsia/Hemolysis, Elevated Liver Enzymes, and Low Platelets (HELLP) Syndrome and Shock.

Pancreatitis is a rare but serious condition in obstetric patients, associated with significant morbidity and mortality. It can range from mild acute pancreatitis to severe complications such as necrosis, abscesses, pseudocysts, and multi-organ failure. While hypertriglyceridemia is a common cause, pancreatitis has also been linked to preeclampsia and shock.

Sociodemographic and Psychological Factors Influencing Human Milk Donation: A Cross-Sectional Study of 420 Lactating Mothers in Vijayapura.

Background Breastfeeding is crucial for infant health, but not all mothers can breastfeed due to various constraints. Making human milk banks (HMBs) is essential for providing donor milk to preterm and sick infants. Methods  This is a cross-sectional study at Shri BM Patil Medical College Hospital and Research Centre in Vijayapura involving 420 lactating mothers.

Assessment of the Prevalence and Types of Mental Compulsions in Patients With Obsessive-Compulsive Disorder in North Karnataka: A Cross-Sectional Study.

Background: Obsessive-compulsive disorder (OCD) is a significant mental condition characterized by the presence of obsessions and compulsions. Mental compulsions are defined as compulsions with no overt behavioral or motoric symptoms, such as repeating certain words or phrases in the mind. The exact prevalence of mental compulsions could be underestimated due to measurement issues using the Y-BOCS (Yale-Brown Obsessive Compulsive Scale) and its clinical characteristics.

Comparison of Depression, Stress, Anxiety, Cognitive Status, and Quality of Life Before and After Renal Transplantation.

Introduction: Chronic kidney disease is a prevalent and life-altering condition that significantly impacts quality of life. Kidney transplantation (KT) is an effective treatment for CKD, but it may also trigger psychological distress, including depression, anxiety, and cognitive impairment. This study aims to compare the levels of depression, anxiety, stress, cognitive status, and quality of life in KT recipients before and after surgery.