Unlocking the role of miR-17: Driving G1-S cell cycle transition in oral tongue cancer through integrated bioinformatics and laboratory analyses.

Objective: This study aims to identify miRNA-mediated regulation of the cell cycle in oral tongue cancer.

Methods: Comprehensive computational analysis was performed on the GEO dataset "GSE168227". DIANA Tool-mir path v.

The effect of anti-scatter grids on radiation exposure during transcatheter patent ductus arteriosus closure in premature infants.

Background: Radiation exposure and the effect of anti-scatter grids are not well studied in premature infants during transcatheter patent ductus arteriosus closure.This study aimed to investigate whether the use of anti-scatter grids altered the level of radiation exposure to premature infants undergoing transcatheter patent ductus arteriosus closure.

Methods And Results: Demographic and radiation exposure data for premature infants who underwent transcatheter patent ductus arteriosus closure at the Stead Family Children's Hospital from 10/2019 to 10/2021 were retrospectively reviewed and analyzed.

Prostate cancer burden in South Asia: A systematic analysis of global burden of disease data (1990-2021).

Objectives: The objectives of this study were to analyze trends in prostate cancer incidence, incidence, mortality, and disability-adjusted life years (DALYs) from 1990 to 2021 via data from the Global Burden of Disease (GBD) study in South Asia. Additionally, the study projects future prostate cancer incidence rates up to 2031 to inform public health interventions in South Asia.

Methods: Data covering South Asian countries such as Bangladesh, Bhutan, India, Nepal, and Pakistan were obtained from the GBD 2021 portal.

Clear cell myoepithelioma of palate: A rare case report with brief review of literature.

Myoepitheliomas are very rare salivary gland neoplasms seen mainly in the major salivary glands (~40%) followed by minor salivary glands (~21%). Palatal myoepitheliomas are rare, with clear cell types being even rarer. Due to the rarity of this tumor, it lacks specific features that are diagnostic in cytology.

The Impact of Bhramari Pranayama and Om Chanting on Post-operative Wound Healing: A Focus on the Nitric Oxide Pathway.

Introduction  is a complex process influenced by various physiological and psychological factors. Stress, in particular, has been shown to impair wound healing by affecting the immune response and slowing the repair process. Yoga-based relaxation techniques, such as bhramari pranayama and Om chanting, have demonstrated the potential to reduce stress and improve overall well-being.

Pseudoachalasia Secondary to Metastatic Osteosarcoma.

Pseudoachalasia is a disorder in which symptoms, radiologic, endoscopic, and manometric results resemble idiopathic achalasia. Although these diagnoses may appear similar, their underlying causes and therapy differ significantly. Pseudoachalasia is frequently associated with malignancy, particularly primary adenocarcinoma of the esophagus or cardia.

Imaging in Zinner Syndrome, A Case Series: The Wolf in Sheep's Clothing.

Zinner syndrome is a rare congenital malformation of the Wolffian duct with seminal vesicle cyst, ipsilateral renal agenesis and ejaculatory duct obstruction, seen in less than 0.002 % of the male population. An increased awareness among clinicians, urologists, and radiologists is essential, as early diagnosis and management can impact fertility outcomes.

COPD Unveiled: Insights from Dwellers along a Busy Highway in Kattankulathur Block.

Background: Chronic obstructive pulmonary disease (COPD) is a serious lung condition that imposes a significant financial burden on individuals and society, straining the medical system. According to the World Health Organization, it was the third leading cause of death worldwide in 2020. In India, it ranks as the second leading cause of death, and in Tamil Nadu, it is the tenth.

Association of Abdominal Obesity and Diabetes among the Adult Tribal Population in Tamil Nadu.

Background: Previously overweight and obesity are considered to be an issue of high-income countries but now increasingly becoming more prevalent in low-income and middle-income countries. Obesity and overweight are growing health issues in India. It is important to determine the quantum of the risk contribution by individual risk factor siuch as abdominal obesity.

Clinical Profile, Etiology, and Outcomes of Patients With Eosinophilia: A Prospective Study From Western India.

This study investigated the clinical profile, etiology, and outcomes of eosinophilia in hospitalized patients. A total of 96 patients were included, with a mean eosinophil count of 3347.66 ± 1517.

Risk Factors and Predictors of Outcomes in Hypoxic-Ischemic Encephalopathy in Neonates.

Background Hypoxic-ischemic encephalopathy (HIE) in neonates results from oxygen deprivation at birth, often leading to long-term neurological issues like cerebral palsy. Early detection is key to improving outcomes, but HIE remains a significant cause of neonatal complications. Here we aim to study the risk factors and predictors of outcome in moderate to severe HIE in inborn Term babies in the neonatal intensive care unit (NICU) Methods This prospective observational study was conducted in the NICU at a tertiary care center between August 2022 and July 2024.

Cervicovaginal and gastrointestinal microbiomes in gynecological cancers and their roles in therapeutic intervention.

Cancer remains a significant global health concern, and understanding factors that regulate cancer development is important. The microbiome, with its potential role in cancer development, progression, and treatment, has garnered increasing attention in recent years. The cervicovaginal and gastrointestinal microbiomes in females constitute complex biological ecosystems.

Arthroscopic algorithm for acute traumatic triangular fibrocartilage complex (TFCC) tears.

The triangular fibrocartilage complex (TFCC) is crucial for stability and acts as a shock absorber and load transmitter at the distal radioulnar joint (DRUJ). It is often injured in wrist trauma, particularly in young athletes. Clinical assessment involves patient history, physical examination, and imaging modalities like MRI, with wrist arthroscopy as the gold standard for diagnosing TFCC tears.

Use of Saline Infusion Sonography to Evaluate Intrauterine and Tubal Factors in Subfertile Patients.

Objectives:  This study aims to observe and report on the use of saline infusion sonography (SIS) to find out intrauterine and tubal factors in infertile/subfertile women, focusing on its diagnostic use, clinical advantages, and practical implications.

Methods: A prospective observational study was conducted involving 86 women presenting with subfertility and/or recurrent pregnancy loss in a tertiary care hospital. These participants were selected based on inclusion and exclusion criteria relevant to the study objectives.

Drop and Swell: Unanticipated Corneal Edema From Netarsudil Therapy.

Neovascular glaucoma (NVG) poses significant treatment challenges, often necessitating complex medication regimens to manage intraocular pressure (IOP). This report details a 65-year-old male with NVG secondary to central retinal artery occlusion (CRAO), who developed corneal epithelial bullae as a rare side effect of topical netarsudil therapy. Despite this complication, a continued treatment led to the gradual resolution of corneal lesions while maintaining controlled IOP.

Unexpected Victory: High-Risk Papillary Thyroid Cancer with Distant Metastases Shows Extraordinary Response to First RAI Treatment.

Papillary Thyroid Cancer (PTC) is the most prevalent type of differentiated thyroid cancer. Its incidence is growing worldwide although it has low death rates. Treatment includes surgery followed by radioactive iodine therapy.

Placental expression and methylation of angiogenic factors in assisted reproductive technology pregnancies from India.

Aim: This study aims to examine the gene expression and DNA methylation patterns of angiogenic factors in the placentae of Indian women who underwent assisted reproductive technology (ART) procedures and their association with maternal one-carbon metabolites and birth outcome.

Methods: Placental gene expression and DNA methylation of angiogenic factors (, , , ) in Indian women who underwent ART procedures ( = 64) and women who conceived naturally (Non-ART) ( = 93) was investigated using RT-qPCR and Epitect Methyl-II PCR assay kits. Maternal plasma one-carbon metabolites were assessed by CMIA technology.

Anxiety and Depression Among Patients With Irritable Bowel Syndrome in Hail, Saudi Arabia: Towards a Better Understanding of the Psychological Role.

Introduction: Patients with irritable bowel syndrome (IBS) often experience psychiatric disorders such as anxiety and depression. This study examined the association between IBS and anxiety and depression and explored how these variables interact with various IBS indices in the general population of Hail, Saudi Arabia.

Methods: This cross-sectional descriptive study utilized standardized assessments for diagnosing IBS, anxiety, and depression.

Stenotrophomonas maltophilia in Hemodialysis: An Opportunistic Pathogen or a Malevolent Foe.

Catheter-related bloodstream infections (CRBSIs) add to the morbidity and mortality of hemodialysis patients. is an extremely resistant, gram-negative, non-lactose-fermenting nosocomial bacterium that contributes significantly to mortality and morbidity. This bacterium is predominantly associated with community-acquired pneumonia, bacteremia, eye afflictions, biliary sepsis, urinary tract infection, skin and soft tissue infection, and very rarely chronic enteritis with colonic ulcers.