Landscape of Multilocus Inherited Neoplasia Allele Syndrome in Mexican Population.

Purpose: Hereditary cancer syndromes (HCS) explain 5%-10% of all cancer cases. Patients with more than one germline pathogenic variant (GPV) result in a clinical syndrome known as multilocus inherited neoplasia allele syndrome (MINAS). In recent years, an increasing number of MINAS cases have been reported.

Describing quality of life trajectories in young Hispanic women with breast cancer: 5-year results from a large prospective cohort.

Introduction: Cancer treatments have a detrimental impact on the quality of life (QoL) of young women with breast cancer (YWBC). Research exploring QoL trajectories has been mostly centered on postmenopausal women. Here we report longitudinal changes across all QoL domains and associated factors in YWBC.

Translation, cross-cultural adaptation and validation of the General Movement checklist.

Background: The Prechtl's General Movement Assessment (GMA) is a widely accepted tool for predicting neurodevelopmental outcomes in infants. However, access to formal training in GMA is limited in low- and middle-income countries, such as Mexico. This study aimed to validate the Spanish version of the General Movement checklist (GMC), a tool designed to facilitate the evaluation of general movements, particularly for clinicians with limited experience.

Open versus endoscopic surgery with helmet molding therapy in non-syndromic patients with craniosynostosis: an updated systematic review and meta-analysis of clinical outcomes and treatment-related costs.

Objective: There is an ongoing debate regarding the optimal treatment for craniosynostosis as diverse factors influence the election between endoscopic and open surgery. Previous evidence favors endoscopic procedures. However, evidence remains unfulfilled by a limited number of patients and clustered in very few centers worldwide making it difficult to define it as a replicable technique in different populations.

Correction: Alvarado-Miranda et al. Capecitabine Plus Aromatase Inhibitor as First Line Therapy for Hormone Receptor Positive, HER2 Negative Metastatic Breast Cancer. 2023, , 6097-6110.

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Transposition of Megadolichoectatic Basilar Artery in Trigeminal Neuralgia: 3-Dimensional Operative Video.

Trigeminal neuralgia is usually associated with vascular compression of the nerve entry zone. However, a dolichoectatic basilar artery represents the cause in only up to 3% of cases. This is characterized by dilation, elongation, or tortuosity of the vertebrobasilar arteries.

[Impact of COVID-19 on gallbladder disease: presentation of postponed surgeries].

Introduction: Since the COVID-19 outbreak escalated to pandemic levels, numerous hospitals deferred elective interventions. Studies reporting the incidence, presentation, severity, and outcomes in the surgical management of biliary diseases differ before, during and after the pandemic.

Objective: Evaluate the presentation of biliary pathology by diagnosis and Parkland Grading Scale in patients whose surgeries were postponed due to the pandemic, and who were later surgically intervened.

Anatomical analysis of vertebral arteries in vertebrobasilar dolichoectasia: A multi-center study.

Background: Vertebrobasilar dolichoectasia (VBD) is a rare disease with significant morbidity. Its propensity for posterior circulation and relationship with aneurysms is poorly understood. Here, we aimed to describe the anatomical characteristics of the vertebral arteries (VA) in patients with VBD.

[Diffuse gastric carcinoma in the youth: Case report].

Background: Gastric cancer is the 5th most common neoplasm in Mexico with an incidence of 13.6 per 100,000 inhabitants. In those under 35 years of age, it represents the 13th cause of cancer with an incidence of 0.

Screening Adherence for Second Primary Malignancies in Breast Cancer Survivors: Behaviors, Facilitators, and Barriers to Enhance Quality Care.

Due to genetic, hormonal, and environmental factors, alongside increased life expectancy, breast cancer (BC) survivors have an increased risk of developing a second primary malignancy. Therefore, regular screening for other types of cancer is of utmost importance for their comprehensive care. This cross-sectional study evaluated BC survivors' compliance with cervical, lung, and colorectal cancer screening, and identified facilitators and barriers influencing adherence.

Bariclip Removal and Conversion to Gastric Sleeve: A Case Report.

Obesity has been recognized as the main pandemic of this century. Multiple treatments have been developed: the use of medications, exercise, diet, and surgery. Bariatric surgery is one of the treatments that has shown the greatest effectiveness.

Combined microscopic transoral and endoscopic endonasal approach for a clival chordoma: A case report and literature review.

Background: Chordomas are primary bone tumors derived from the embryonic notochord. They represent 1-4% of all malignant bone tumors. They have a predominantly extra-axial location, arising in the clival region in 35% of reported cases.

Sexual function and satisfaction in young women with breast cancer: a 5-year prospective study.

Background: Young women with breast cancer (YWBC) face unique challenges that can affect their sexual health. This study aimed to identify factors associated with sexual activity, function, and satisfaction in YWBC up to 5 years postdiagnosis.

Methods: We conducted a prospective cohort study of 474 women 40 years of age or younger diagnosed with nonmetastatic breast cancer in Mexico.

Validation of the Zarit Burden Interview in Informal Caregivers of Patients with Severe Visual Impairment and Blindness.

Introduction: The needs of family caregivers providing care to relatives with visual impairment are often dismissed, leading to caregiver burden. The Zarit Burden Interview (ZBI) can measure the caregiver burden of caring for a family member with vision impairment. The purpose of this study is to validate the ZBI in Mexican family caregivers of patients with visual impairment.

Uptake of Risk-Reducing Surgeries in an International Real-World Cohort of Hispanic Women.

Purpose: Women with pathogenic variants (PVs) in breast cancer (BC) and ovarian cancer (OC) associated genes are candidates for cancer risk-reducing strategies. Limited information is available regarding risk-reducing surgeries (RRS) among Hispanics. The aim of this study was to describe the uptake of RRS in an international real-world experience of Hispanic women referred for genetic cancer risk assessment (GCRA) and to identify factors affecting uptake.

Evaluation of a Proteomics-Guided Protein Signature for Breast Cancer Detection in Breast Tissue.

The distinction between noncancerous and cancerous breast tissues is challenging in clinical settings, and discovering new proteomics-based biomarkers remains underexplored. Through a pilot proteomic study (discovery cohort), we aimed to identify a protein signature indicative of breast cancer for subsequent validation using six published proteomics/transcriptomics data sets (validation cohorts). Sequential window acquisition of all theoretical (SWATH)-based mass spectrometry revealed 370 differentially abundant proteins between noncancerous tissue and breast cancer.

Systemic vs. in-irrigation tranexamic acid in percutaneous nephrolithotomy A systematic review, Bayesian network meta-analysis, and meta-regression.

Introduction: Percutaneous nephrolithotomy (PCNL) is the gold-standard treatment for large renal stones. One potentially significant complication of PCNL is blood loss, which can result in transfusion requirement and poorer stone-free outcomes. Tranexamic acid (TXA) has emerged as a promising intervention, administered systemically (TXA-S) or as part of irrigation fluid (TXA-I) in endourology.

Health care transition models in spina bifida care: evidence-based lessons in support of neurosurgical practice.

Objective: The purpose of this study was to conduct a literature review on transition programs from pediatric to adult care and the role of neurosurgery as individuals with spina bifida (SB) transition, and to provide a framework for neurosurgical providers to assist in the transition to adult-centered care.

Methods: A comprehensive literature review was conducted according to the PRISMA statement, with a search in Medline and Embase to identify US clinical programs reporting on their experiences establishing a transition program for adolescents and young adults with SB. Data were collected for authors, year, transition clinic location, model of care for transition clinic, ages served, and specialty clinical team.