1,329 results match your criteria: "Hospital West[Affiliation]"

Association of body mass index with disability in activities of daily living in older adults: a systematic review of the literature based on longitudinal data.

BMC Public Health

January 2025

Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, 610041, China.

Background: The influence of Body Mass Index (BMI) on the functional capacity for daily activities in older adults is a significant concern. Our study is designed to delineate the longitudinal relationship between BMI and the ability of daily living activities among older adults.

Methods: Two researchers conducted a comprehensive literature search and independent screening of articles in PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), the Database for Chinese Technical Periodicals (VIP), and Wanfang, covering the period from January 2000 to May 2024.

View Article and Find Full Text PDF
Article Synopsis
  • The study defines anatomical landmarks using preoperative MRI for patients with pituitary adenomas, focusing on how these landmarks relate to tumor resection rates and potential recurrence.
  • A review of 626 patients treated via endoscopic endonasal approach was conducted, categorizing anatomical landmarks and utilizing statistical analysis to create a predictive model for surgical outcomes.
  • Results showed a high gross total resection rate of 91.05%, identifying key anatomical landmarks and factors significantly associated with tumor progression, supported by a strong predictive model's accuracy.
View Article and Find Full Text PDF

Aligning Large Language Models with Humans: A Comprehensive Survey of ChatGPT's Aptitude in Pharmacology.

Drugs

December 2024

Department of Pharmacy and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610212, China.

Article Synopsis
  • The study addresses the challenges in evaluating large language models (LLMs) in pharmacology due to the absence of a comprehensive test set.
  • It creates a specialized pharmacology test set with tasks like drug information retrieval and trend summarization, comparing the performance of GPT-3.5 and GPT-4.
  • The findings show that while these models excel in understanding and summarizing pharmacological information, they struggle with specific tasks like drug identification and interaction retrieval, suggesting that enhancing them with retrieval-augmented generation or specialized knowledge bases could improve their efficacy in pharmacology.
View Article and Find Full Text PDF

Factors Affecting the Readmission of Patients with Stroke.

World Neurosurg

December 2024

Neurosurgery Department, West China Hospital/West China School of Nursing, Sichuan University, Chengdu, China.

Background: Incidence of stroke is increasing annually in China, the readmission rate of patients with stroke remains high.

Method: In total, 441 patients were enrolled in this study. We described the incidence of stroke readmissions.

View Article and Find Full Text PDF

Low-input CUT&Tag for efficient epigenomic profiling of zebrafish stage I oocytes.

Front Cell Dev Biol

December 2024

Department of Pediatric Surgery and Laboratory of Pediatric Surgery, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China.

Histone modification signatures mark sites of transcriptional regulatory elements and regions of gene activation and repression. These sites vary among cell types and undergo dynamic changes during development and in diseases. Oocytes produce numerous maternal factors essential for early embryonic development, which are significantly influenced by epigenetic modifications.

View Article and Find Full Text PDF

Engineering Surface-Adaptive Metal-Organic Framework Armor to Promote Infected Wound Healing.

ACS Appl Mater Interfaces

December 2024

College of Polymer Science and Engineering and State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.

Metal-organic frameworks (MOFs) hold enormous promise for treating bacterial infections to circumvent the threat of antibiotic resistance. However, positioning MOFs on wound dressings is hindered and remains a significant challenge. Herein, a facile heterointerfacial engineering strategy was developed to tailor the "MOF armor" that adaptively weaponized the poly(ε-caprolactone) electrospun dressing with excellent bacteria-killing efficacy.

View Article and Find Full Text PDF

Efficacy of Higher-Voltage Long-Duration Pulsed Radiofrequency for Spinal Zoster-Associated Pain: A Randomized Controlled Trial.

Pain Physician

December 2024

Department of Pain Management, West China Hospital/West China Tianfu Hospital, Sichuan University, Chengdu, Sichuan Province, China.

Article Synopsis
  • The study evaluates the safety and effectiveness of a higher-voltage long-duration pulsed radiofrequency (HL-PRF) treatment for managing zoster-associated pain (ZAP) compared to standard treatment.
  • Patients in Group A received gradually increased voltage up to 100 V, while Group B maintained a steady 65 V throughout.
  • Results focused on pain levels, emotional well-being, and quality of life over 12 weeks, with an aim to address high recurrence rates associated with the existing methods.
View Article and Find Full Text PDF

Arteriovenous access creation for hemodialysis patients with superior vena cava occlusion.

J Vasc Access

December 2024

Department of Nephrology, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China.

Background: The feasibility of creating arteriovenous (AV) access in hemodialysis patients with superior vena cava occlusion (SVCO) is debated due to impaired blood return to the right atrium. However, collateral venous networks may offer an alternative solution, allowing for the creation of peripheral AV access. This study evaluates the outcomes of AV access construction in hemodialysis patients with SVCO.

View Article and Find Full Text PDF

Objectives: Vaccine hesitancy persists as a significant global health concern, especially during public health crises. This study aimed to explore factors influencing vaccination acceptance during a major public health crisis and establish a model of influencing factors.

Design: A cross-sectional study.

View Article and Find Full Text PDF

Establishment of sex-specific reference intervals for PIVKA-II in Southwest China: A real-world data analysis.

Ann Clin Biochem

December 2024

West China Second University Hospital/ West China Women's and Children's Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Chengdu, China.

Objective: We aim to establish the sex-related reference intervals (RIs) of PIVKA-II in southwest China by indirect method with the real-world data.

Methods: Between 29 July 2016 and 5 February 2024, PIVKA-II test data were collected from 120,780 healthy adult participants (aged 18 to 97 years) in the Laboratory Information System (LIS) of West China Hospital to establish reference intervals. Additionally, a validation group comprised of 2068 healthy adults was evaluated using the same detection algorithm and platform.

View Article and Find Full Text PDF

3D Biofabrication of Microporous Hydrogels for Tissue Engineering.

Adv Healthc Mater

December 2024

Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, P. R. China.

Microporous hydrogels have been utilized in an unprecedented manner in the last few decades, combining materials science, biology, and medicine. Their microporous structure makes them suitable for wide applications, especially as cell carriers in tissue engineering and regenerative medicine. Microporous hydrogel scaffolds provide spatial and platform support for cell growth and proliferation, which can promote cell growth, migration, and differentiation, influencing tissue repair and regeneration.

View Article and Find Full Text PDF

Peripheral nerve imaging is a powerful tool in evaluating peripheral neuropathy. This review aims to provide an overview of the anatomy, clinical significance and pathologies of small peripheral nerves, typically less than 2 mm in diameter. High frequency ultrasound probes offer the best assessment of these nerves whilst permitting real-time clinical correlation, while the role of MRI is inherently limited by spatial resolution constraints and the lack of patient contact.

View Article and Find Full Text PDF

EMR-LIP: A lightweight framework for standardizing the preprocessing of longitudinal irregular data in electronic medical records.

Comput Methods Programs Biomed

February 2025

Center for Computational Systems Medicine, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, Texas, 77030, USA. Electronic address:

Article Synopsis
  • The study introduces the EMR-LIP framework, designed to standardize and optimize the preprocessing of complex Electronic Medical Records (EMRs) data for better clinical predictive modeling.
  • EMR-LIP allows for a more detailed categorization of variables and tailor-made preprocessing techniques, demonstrating its effectiveness through analysis of two public EMR databases, MIMIC-IV and eICU-CRD.
  • The results indicated that models using EMR-LIP preprocessing improved overall performance, achieving high accuracy rates in predicting in-hospital deaths and ensuring fairness across different ethnic groups.
View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the link between atherosclerosis (plaque buildup in arteries) and types of myocardial ischemia (insufficient blood flow to the heart) in patients without significant coronary artery blockage (INOCA).
  • It employs advanced invasive tests to assess coronary microvascular function and quantifies plaque burden using the Gensini score, which takes into account the severity of artery blockage.
  • Findings reveal that higher Gensini scores correlate with poorer microvascular function, and different INOCA endotypes (like microvascular angina and vasospastic angina) show variations in plaque scores, indicating the complexity of heart conditions in patients without obvious artery blockage.
View Article and Find Full Text PDF

This study aimed to evaluate the clinical utility of intravenous indocyanine green (ICG) in the context of robot-assisted cystectomy (RAC) through a systematic review and meta-analysis. The primary focus was to compare postoperative complications and perioperative outcomes between the ICG cohort and the non-ICG cohort. The primary outcome indicators were the incidence of ureteroenteric strictures and the number of strictures anastomoses.

View Article and Find Full Text PDF

Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing's syndrome.

Nat Metab

December 2024

Metabolomics and Cell Biology Platforms, UMS AMMICa, Gustave Roussy Institut, Villejuif, France.

Article Synopsis
  • Cushing's syndrome is linked to high levels of glucocorticoids and is associated with increased plasma levels of ACBP/DBI, which stimulates food intake and fat production.
  • Researchers explored multiple methods to inhibit ACBP/DBI in mice, including genetic modifications and antibody injections, to address Cushing's symptoms.
  • The findings suggest that targeting ACBP/DBI could be an effective strategy for treating Cushing's syndrome and its related complications like obesity and diabetes.
View Article and Find Full Text PDF

Different types of combined endoscopic and transcranial approaches for complex giant pituitary adenomas: how I do it.

Acta Neurochir (Wien)

November 2024

Department of Neurosurgery, West China Hospital/West China School of Medicine, Sichuan University, No. 37, Guoxue Alley, Chengdu, Sichuan, China, 610041.

Article Synopsis
  • Surgery for giant pituitary adenomas (GPAs) is difficult, especially when standard methods (EEA or MTCA) aren't enough.
  • Researchers combined two surgical approaches for tough GPAs: expanded endoscopic endonasal approach with microscopic pterional approach (EEEA-MPA) and EEEA with endoscopic transventricular approach (ETVA).
  • The combined methods are effective, with EEEA-MPA for tumors extending upwards and sideways, and EEEA-ETVA for tumors invading lateral ventricles.
View Article and Find Full Text PDF
Article Synopsis
  • Hemoperfusion using the HA330/HA380 cartridge has become popular in ICUs over the last decade for treating critical illnesses by removing inflammatory substances from the blood.
  • While numerous studies indicate its potential benefits in reducing inflammation and organ failure, there is still no comprehensive assessment of its safety and effectiveness in critical care.
  • This paper aims to review the HA330/HA380 hemoperfusion technique, summarize recent clinical findings across various conditions, and highlight drug clearance capabilities to address safety issues.
View Article and Find Full Text PDF

A psychometric assessment for evaluating spiritual care competency for geriatric nurses.

Geriatr Nurs

November 2024

West China Hospital /West China School of Nursing, Sichuan University, Chengdu, Sichuan, PR China. Electronic address:

This study evaluates the validity and reliability of the Chinese Version of Spiritual Care Competency (C-SCC) for geriatric nurses. Using convenience and snowball sampling, 1,094 geriatric nurses were randomly divided into two groups of 547 each for exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). EFA confirmed a four-dimensional structure, explaining 74.

View Article and Find Full Text PDF
Article Synopsis
  • Gastric cancer (GC) is a difficult-to-treat malignancy characterized by diverse tumor behavior, particularly in HER2-positive, PD-L1 negative patients who often resist standard treatments like chemotherapy with trastuzumab.
  • A case study demonstrated that a patient with this type of GC experienced resistance to trastuzumab after a brief remission; however, introducing a PD-1 inhibitor led to a significant and lasting treatment response.
  • The findings suggest that adding PD-1 inhibitors could be a viable strategy for managing treatment resistance in HER2-positive, PD-L1-negative metastatic GC patients following initial chemotherapy and trastuzumab.
View Article and Find Full Text PDF

Objective: Patients with diffuse cutaneous systemic sclerosis (dcSSc) frequently show spontaneous improvement of skin fibrosis. Our aim was to examine whether an improvement in skin fibrosis predicts lower likelihood of visceral organ progression and better survival.

Methods: Patients from the European Scleroderma Trials and Research (EUSTAR) cohort with dcSSc, baseline modified Rodnan skin score (mRSS) ≥7, and valid mRSS at 12±3 months follow up were included.

View Article and Find Full Text PDF

The Association Between Solid Fuel Use and Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia in Sichuan, China: Cross-Sectional Study.

JMIR Public Health Surveill

October 2024

Department of Urology, Institute of Urology, National Clinical Research Center for Geriatrics and Center of Biomedical Big Data, West China Hospital of Sichuan University, Chengdu, China.

Article Synopsis
  • - The study investigates the link between using solid fuel for household energy and experiencing lower urinary tract symptoms (LUTS) indicative of benign prostatic hyperplasia (BPH) among older Chinese men, highlighting that over half of men aged 70 and older may be affected by BPH.
  • - Utilizing data from the West China Natural Population Cohort Study, researchers found a significant positive correlation between solid fuel use and LUTS/BPH, with participants using solid fuel nearly twice as likely to report symptoms compared to those using clean fuel.
  • - Further analysis revealed that non-smoking and non-drinking individuals had a higher odds ratio for LUTS/BPH when using solid fuels, suggesting lifestyle factors may influence the severity of symptoms associated with
View Article and Find Full Text PDF