34 results match your criteria: "Hospital Universitario de Ciudad Real.[Affiliation]"

Article Synopsis
  • The PROGRESER study is a 3-year, multicenter observational study in Spain aiming to identify risk factors for the progression of stage 3 chronic kidney disease (CKD), specifically comparing patients with and without diabetes mellitus.
  • A total of 462 patients (average age 66.5) were monitored biannually for clinical data, with biological samples collected for analysis.
  • Results showed that approximately two-thirds of patients experienced renal damage progression, with similar rates in diabetic (67.3%) and non-diabetic (65.3%) patients, suggesting that diabetes did not significantly increase the risk of CKD progression compared to other factors like hypertension.
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Objective: To assess the survival outcomes of patients diagnosed with muscle-invasive bladder cancer (MIBC) who are not candidates for curative treatment and to identify the factors influencing these outcomes.

Methods: We conducted an analysis of patients diagnosed with MIBC who were either unable or unwilling to undergo curative therapy. We evaluated overall survival (OS) and cancer-specific survival (CSS) and examined their associations with various clinical variables.

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Prevalence of Fabry disease in patients with left ventricular hypertrophy and renal involvement (PrEFaCe).

Med Clin (Barc)

November 2024

Servicio de Cardiología, Hospital Universitario Ramón y Cajal, Madrid, España; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, España.

Introduction And Aims: Fabry disease (FD) causes glycosphingolipid accumulation in the vascular endothelium, with predominantly cardiac and renal involvement. Its prevalence in patients with concomitant involvement of these two organs is unknown. The objective of the study was to determine the prevalence of FD in patients with left ventricular hypertrophy and any degree of chronic kidney disease.

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Rare mediastinal small round cell melanoma with synovial sarcoma-like immunophenotype: A potential diagnostic pitfall.

Pathol Res Pract

October 2024

Pathology Department, Hospital Clínico Universitario de Valencia, Valencia 46010, Spain; Pathology Department, University of Valencia, Valencia 46010, Spain; Cancer CIBER (CIBERONC), Madrid, Spain.

Melanoma can pose a significant diagnostic challenge due to the high variability in histological morphology and expression of non-melanocytic immunomarkers. We present a case of a 47-year-old male with an aggressive mediastinal neoplasm and disseminated disease posing several diagnostic challenges. Multiple biopsies were submitted from different anatomic locations and during multiple time points showing an undifferentiated round cell tumor (URCT) with synovial sarcoma-like immunophenotype.

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Article Synopsis
  • * Analysis showed that while LDL-cholesterol reductions over time were similar for both sexes, a higher percentage of males had existing cardiovascular disease both at enrollment and during follow-up compared to females.
  • * Notably, males experienced their first ASCVD event at a median age of 50.6 years, significantly earlier than females, who had their first event at a median age of 61.6 years, highlighting important sex-related differences in
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Purpose: To evaluate the impact of sustained hypogonadism after androgen deprivation therapy (ADT) associated with radiotherapy in prostate cancer (PCa) patients with biochemical relapse-free survival (bRFS).

Methods: A retrospective cohort analysis of 213 consecutive PCa patients referred for radiotherapy plus ADT was carried out. Follow-up times including time to testosterone recovery (TTR) and bRFS were calculated from the end of ADT.

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Introduction: Patients with incomplete response to initial therapy of thyroid cancer can be managed with ongoing observation or potentially additional therapies. Our aim was to assess the effect of a second radioactive iodine treatment (RAIT) and its relationship with causes and clinical variables.

Material And Methods: Patients undergoing a second RAIT for biochemical or structural incomplete response to initial therapy of DTC were retrospectively included (n=120).

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Glucometrics knowledge and its relationship to glycemic control in people living with type 1 diabetes: The GluKometrics study.

Diabetes Metab

January 2024

Endocrinology and Nutrition Department, Clínica Universidad de Navarra, Universidad de Navarra, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.

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Article Synopsis
  • This study evaluated how effective proton pump inhibitors (PPIs) are for treating children with eosinophilic esophagitis (EoE) in both the short- and long-term, using a step-down therapy approach.
  • Results showed that after initial treatment, over half of the children achieved significant histological and clinical remission, with normal endoscopic appearances linked to better outcomes, while those with fibrostenotic phenotypes averaged poorer responses.
  • Long-term follow-up indicated that most children could maintain remission with reduced medication, and those starting with complete histological remission had a higher chance of sustained success; adverse effects were minimal.
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Unlabelled: There is uncertainty regarding Wilson's disease (WD) management.

Objectives: To assess, in a multicenter Spanish retrospective cohort study, whether the approach to WD is homogeneous among centers.

Methods: Data on WD patients followed at 32 Spanish hospitals were collected.

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Recommendations regarding transversal topics applicable to bladder cancer patients independent of tumor grade and stage were established by members of the Spanish Oncology Genitourinary Multidisciplinary Working Group (SOGUG). Liquid biopsy in urine and blood samples is useful in the surveillance of non-muscle-invasive and muscle-invasive bladder cancer, respectively. Multiparametric MRI is an accurate, faster and non-invasive staging method overcoming the understaging risk of other procedures.

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The Flash Guide (FG) for insulin dosing (A. Chico, C. González) was the first document intended for FreeStyle Libre® (FSL) user patients to help with decision-making depending on glucose level and trend.

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Background: Thyroid metastases are extremely rare, with an incidence of 1-3% according to different data. Colon cancer is the second most common tumor that metastasizes to this organ.

Case Report: We report a case of a long-standing colon cancer with an atypical metastatic pattern and the appearance of a thyroid metastases.

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Evaluation of the usefulness of and satisfaction with the flash glucose monitoring system (FreeStyle Libre®) guide for use in patients with type 1 diabetes.

Endocrinol Diabetes Nutr (Engl Ed)

August 2021

Servicio de Endocrinología y Nutrición, Hospital de la Santa Creu i Sant Pau, Barcelona, España; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, España; Universitat Autònoma de Barcelona, Bellaterra, Barcelona, España. Electronic address:

The Flash Guide (FG) for insulin dosing (A. Chico, C. González) was the first document intended for FreeStyle Libre® (FSL) user patients to help with decision-making depending on glucose level and trend.

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Objective: As scarce literature on the topic is available, we aimed to compare diagnostic utility of semi-quantitative versus visual analysis in labelled white blood cell scintigraphy (WBCS) for osteoarticular infection. One-day and two-day protocols were assessed, particularly in orthopaedic devices.

Material And Methods: Prospective study of 79 consecutive patients with suspected osteoarticular infection.

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La infección por el virus SARS-CoV-2 provoca, además de cuadros respiratorios graves, episodios trombóticos en múltiples localizaciones debido a una mala regulación de la respuesta inmune. Presentamos el caso de un paciente con colecistitis incipiente que desarrolló trombosis portal aguda sin ningún otro antecedente salvo haber pasado de forma asintomática una infección por COVID-19. Dado que esta complicación es extremadamente infrecuente en pacientes sin factores predisponentes ni infecciones graves, consideramos que la infección por COVID-19 pudo ser un factor desencadenante de la trombosis portal y debemos de tenerlo en cuenta de cara al manejo y tratamiento de futuros casos similares.

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Effectiveness and Safety of Inhaled Antibiotics in Patients With Chronic Obstructive Pulmonary Disease. A Multicentre Observational Study.

Arch Bronconeumol

January 2022

Pneumology Service, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Barcelona Hospital Campus, CIBER de Enfermedades Respiratorios (CIBERES), Passeig de la Vall d'Hebron 119, 08035, Barcelona, Spain.

Background: We aimed to describe the effectiveness and safety of inhaled antibiotics in chronic obstructive pulmonary disease (COPD) patients, as well as the patient profile in which they are usually prescribed and the patient groups that can most benefit from this treatment.

Methods: Multicentre retrospective observational cohort study in COPD patients who had received ≥1 dose of inhaled antibiotics in the last 5 years. Clinical data from the two years prior to and subsequent to the start of the treatment were compared.

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Background: In allergology, the intradermal approach is generally used to establish an aetiological diagnosis, with limited experience in specific allergen immunotherapy.

Objective: To evaluate the efficacy and safety of immunotherapy with an allergen extract of glutaraldehyde-polymerized Phleum pratense, administered intradermally, in patients with rhinoconjunctivitis sensitized to grass pollen.

Methods: Multicentre, randomized, double-blind, placebo-controlled clinical trial in patients from 12 to 65 years of age with rhinitis or rhinoconjunctivitis, with or without asthma, due to grass pollen allergy.

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Article Synopsis
  • Researchers investigated the role of the stem cell marker CD133 in medullary thyroid cancer (MTC) to identify high-risk patients and improve treatment outcomes.
  • The study analyzed 74 MTC cases, finding that increased CD133 expression was linked to worse clinical outcomes and faster disease progression, especially in RET-mutated tumors.
  • Additionally, a specific microRNA (hsa-miR-30a-5p) was identified as a regulator of CD133 expression, suggesting potential avenues for targeted therapies in aggressive MTC cases.*
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Objectives: The aim of this study is to assess the value of the F-choline PET/computed tomography (CT) in predicting significant prostate cancer (sPCa) in patients with persistently increased prostate-specific antigen (PSA) levels and previous negative biopsies. To study the possible predictive added value of F-choline PET/CT to clinical variables and biomarkers derived from PSA in detecting sPCa.

Methods: We evaluated patients who underwent F-choline PET/CT because of ongoing suspicion of prostate cancer (PCa) due to elevated PSA levels (4-20 ng/mL) and at least one previous negative or no conclusive prostate biopsy for PCa.

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The data presented in this article is part of the whole slide imaging (WSI) datasets generated in European project AIDPATH This data is also related to the research paper entitle "Glomerulosclerosis Identification in Whole Slide Images using Semantic Segmentation", published in Computer Methods and Programs in Biomedicine Journal [1]. In that article, different methods based on deep learning for glomeruli segmentation and their classification into normal and sclerotic glomerulous are presented and discussed. The raw data used is described and provided here.

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