5 results match your criteria: "Hospital Universitario Virgen del Rocío (HUVR-IBiS)[Affiliation]"
Clinical features and short-term outcomes of cancer patients with suspected and unsuspected pulmonary embolism: the EPIPHANY study.
Eur Respir J
January 2017
Dept of Pneumology, Hospital Universitario Virgen del Rocío (HUVR-IBiS). CIBERES, Sevilla, Spain.
Article Synopsis
- The study explored factors influencing 30-day mortality in cancer patients with pulmonary embolism, analyzing both suspected (SPE) and unsuspected (UPE) cases.
- The cohort consisted of 1,033 patients, with key predictors of mortality identified, such as VTE history, cancer type, disease progression, and vital signs.
- Mortality rates differed; truly asymptomatic UPE patients had a lower rate (3%) compared to UPE with symptoms (20%) and SPE (21%), indicating disease severity significantly impacts short-term mortality outcomes.
Dasatinib, a Src inhibitor, sensitizes liver metastatic colorectal carcinoma to oxaliplatin in tumors with high levels of phospho-Src.
Oncotarget
May 2016
Instituto de Biomedicina de Sevilla, IBIS/Hospital Universitario Virgen del Rocío/ Universidad de Sevilla/Consejo Superior de Investigaciones Científicas, Seville, Spain.
Despite the development of new antineoplastic agents for the treatment of colorectal cancer (CRC), oxaliplatin and fluoropyrimidines remain the most commonly employed drugs for the treatment of both early and advanced disease. Intrinsic or acquired resistance is, however, an important limitation to pharmacological therapy, and the development of chemosensitization strategies constitute a major goal with important clinical implications. In the present work, we determined that high levels of activated Src kinase, measured as phospho-Src at the Tyr419 residue in CRC cell lines, can promote colorectal carcinoma cell resistance to oxaliplatin, but not to 5-fluorouracil (5FU), and that inhibition of this protein restores sensitivity to oxaliplatin.
View Article and Find Full Text PDF[Pulmonary embolism in patients with cancer: foundations of the EPIPHANY study].
Med Clin (Barc)
January 2015
Departamento de Neumología, Hospital Universitario Virgen del Rocío (HUVR-IBiS), CIBERES, Sevilla, España.
Pulmonary thromboembolism (PE) is a common cause of morbidity and mortality in patients with cancer. Having cancer is an independent risk factor for death in the general series of patients with PE and is included as a variable in the prognostic scales of acute symptomatic PE. This fact limits the discriminatory power of these general scales for patients with cancer and has prompted the development of specific prognostic tools: POMPE-C and a scale derived from the RIETE registry.
View Article and Find Full Text PDFOutpatient management of pulmonary embolism in cancer: data on a prospective cohort of 138 consecutive patients.
J Natl Compr Canc Netw
March 2014
From the aMedical Oncology Department, Hospital Clinic, Barcelona, bMedical Oncology Department, Hospital Universitario Morales Meseguer, Murcia, and cDepartment of Pneumology, Hospital Universitario Virgen del Rocío, (HUVR-IBiS), CIBERES, Sevilla, Spain.
Article Synopsis
- The study evaluated the feasibility of treating cancer patients with pulmonary embolism (PE) on an outpatient basis while comparing different prognostic scales.
- Out of 138 patients, 45% were successfully managed as outpatients, with most cases being incidentally detected PE.
- There were lower mortality rates for outpatients compared to hospitalized patients at both 30 and 90 days, indicating that many cancer patients with PE can be safely treated at home, especially if the PE is detected incidentally.
Factors associated with elevated pulmonary arterial pressure levels on the echocardiographic assessment in patients with prior pulmonary embolism.
Thromb Res
May 2013
Department of Pneumonology, Hospital Universitario Virgen del Rocío, HUVR-IBIS, CIBERES, Sevilla, Spain.
Background: Factors associated with the detection of raised systolic pulmonary artery pressure (sPAP) levels in patients with a prior episode of pulmonary embolism (PE) are not well known.
Methods: We used the RIETE Registry database to identify factors associated with the finding of sPAP levels ≥50 mm Hg on trans-thoracic echocardiography, in 557 patients with a prior episode of acute, symptomatic PE.
Results: Sixty-two patients (11.