6,411 results match your criteria: "Hospital Universitario Virgen del[Affiliation]"
Conditional Pten inactivation in pituitary results in sex-specific prolactinoma formation.
Biochim Biophys Acta Mol Basis Dis
January 2025
Unidad de Gestión de Endocrinología y Nutrición, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain. Electronic address:
Pituitary tumors, including prolactinomas, present significant clinical challenges that require a deeper understanding of their molecular roots for improved diagnostics and therapies. Here, we investigate the role of the phosphatase and tensin homolog (PTEN)/phosphoinositide 3-kinase (PI3K) pathway in pituitary tumorigenesis using a mouse model. Conditional knockout of Pten in all pituitary cell lineages resulted in prolactinoma formation exclusively in female mice, demonstrating the critical role of PTEN in pituitary homeostasis.
View Article and Find Full Text PDFArchivos de Bronconeumología: 60 Years and Going on.
Arch Bronconeumol
September 2024
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; Hospital Universitario y Politécnico la Fe, Valencia, Spain.
Exploring Tenebrio molitor as a source of low-molecular-weight antimicrobial peptides using a n in silico approach: correlation of molecular features and molecular docking.
J Sci Food Agric
February 2025
Department of Medical Biochemistry, Molecular Biology, and Immunology, School of Medicine, University of Seville, Seville, Spain.
Background: Yellow mealworm (Tenebrio molitor) larvae are increasingly recognized as a potential source of bioactive peptides due to their high protein content. Antimicrobial peptides from sustainable sources are a research topic of interest. This study aims to characterize the peptidome of T.
View Article and Find Full Text PDFCharacterization of Vitronectin Effect in 3D Ewing Sarcoma Models: A Digital Microscopic Analysis of Two Cell Lines.
Cancers (Basel)
September 2024
Incliva Biomedical Health Research Institute, 46010 Valencia, Spain.
Ewing sarcoma (ES) is an aggressive bone and soft-tissue pediatric cancer. High vitronectin (VN) expression has been associated with poor prognosis in other cancers, and we aimed to determine the utility of this extracellular matrix glycoprotein as a biomarker of aggressiveness in ES. Silk fibroin plus gelatin-tyramine hydrogels (HGs) were fabricated with and without cross-linked VN and cultivated with A673 and PDX73 ES cell lines for two and three weeks.
View Article and Find Full Text PDFArticle Synopsis
- Loss of heterozygosity for defective alleles of the SDH enzyme can lead to paragangliomas, a type of tumor originating in neuroendocrine cells in humans.
- Researchers created mouse models with conditional loss of the SDHC subunit in early development, hypothesizing it would induce paraganglioma in chromaffin cells.
- Instead of tumors, mice showed developmental defects like gait anomalies and fur discoloration, indicating neural crest cell dysfunction without tumor formation, suggesting differences between human and mouse responses to SDH loss.
Rational application of the ESPGHAN 2022 recommendations for the follow-up of the paediatric coeliac patient: consensus document of scientific societies (SEGHNP, AEPAP, SEPEAP, SEEC, AEG, SEPD, SEMFYC, SEMG and SEMERGEN).
An Pediatr (Engl Ed)
October 2024
Sección de Gastroenterología y Hepatología Pediátrica, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Coeliac disease is a common condition for which the only current treatment is a gluten-free diet. Adherence to this diet is not always easy and is associated with a reduction in quality of life for the patient and their family. Non-adherence is associated with complications of varying severity.
View Article and Find Full Text PDFCurrent Management of Head and Neck Paragangliomas: A Multicenter Series With Long-Term Follow-Up.
Otolaryngol Head Neck Surg
January 2025
Endocrinology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.
Article Synopsis
- - The study analyzed 202 patients with head and neck paragangliomas (HN-PGL) across 16 Spanish hospitals, noting that 67.8% of participants were women, with a mean age of 53.1 years and 264 tumors examined, primarily located in the carotid body.
- - Among patients, 20.8% had multiple tumors and 4% had metastatic disease; genetic testing revealed a pathogenic variant in SDHx in half of those tested, which was linked to younger patients and more complex tumor profiles.
- - The results showed that while surgery was the most common treatment, radiotherapy and observation (monitoring without active treatment) were also effective, and long-term survival rates remained high
Article Synopsis
- Liquid biopsy (LB) with FoundationOne Liquid CDx (F1L CDx) offers a non-invasive way to detect genetic changes in advanced non-small cell lung cancer (NSCLC) patients when tissue biopsies aren't possible, and this study assesses its cost-effectiveness in Spain.
- In a model evaluating 1,000 patients, F1L CDx identified 386 alterations, enabling targeted treatments and yielding significant health benefits compared to traditional non-molecular diagnosis, evidenced by an additional 383.95 life years (LYs) and 305.94 quality-adjusted life years (QALYs) despite a higher overall cost of €2,898,308.
- The analysis concludes that F1L CDx
Patch test results to the Spanish baseline patch test series according to age groups: A multicentric prospective study from 2019 to 2023.
Contact Dermatitis
February 2025
Servicio de Dermatología, Hospital del Mar Research Institute, Barcelona, Spain.
Article Synopsis
- Patch test outcomes can be affected by age, but there are mixed findings on how age impacts these results.
- The study involved over 13,000 patients and revealed that middle-aged adults (31-65 years) had the highest rates of positive skin sensitisation results, particularly for certain substances like nickel and potassium dichromate.
- Overall, while age does influence some patch test results, most allergens showed consistent reactivity across ages, underscoring the importance of standard testing regardless of age.
Avatrombopag in immune thrombocytopenia: A real-world study of the Spanish ITP Group (GEPTI).
Am J Hematol
December 2024
Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla, IBiS/CSIC, Universidad de Sevilla, Sevilla, Spain.
Article Synopsis
- Avatrombopag is a newly approved treatment for immune thrombocytopenia (ITP), with limited real-world effectiveness and safety data available.
- A study by the Spanish ITP Group involving 268 patients showed that 90.1% of those with low platelet counts improved significantly after starting the drug, with many achieving stable platelet levels.
- The treatment allowed most patients to reduce or stop corticosteroid use, and only a small percentage experienced thrombocytosis or thromboembolic events, indicating its potential as an effective management option for ITP.
Mechanical circulatory support in cardiogenic shock patients.
Med Intensiva (Engl Ed)
December 2024
Department of Intensive Care Medicine, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain.
Article Synopsis
- Cardiogenic shock (CS) is a serious medical condition that requires quick intervention to address its cause and provide support for blood circulation.* -
- Mechanical circulatory support (MCS) is often used for patients with severe CS to replace ineffective heart function and prevent multiple organ failure, with different devices available for short or intermediate durations.* -
- Effective management of patients with MCS involves careful monitoring for complications and following structured protocols for device use and discontinuation.*
Impact of left ventricular unloading on postheart transplantation outcomes in patients bridged with VA-ECMO.
Rev Esp Cardiol (Engl Ed)
October 2024
Servicio de Cardiología, Complejo Hospitalario Universitario de A Coruña (CHUAC), Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; Facultad de Ciencias de la Salud, Universidad de A Coruña, A Coruña, Spain.
Article Synopsis
- * A total of 245 patients were analyzed, with 54.3% using mechanical LV unloading techniques, primarily the intra-aortic balloon pump, showing an improved 1-year survival rate of 74.4% compared to 59.8% in those without LV unloading.
- * The findings suggest that preoperative LV unloading is linked to better survival rates after a year post-transplant, with no notable differences in other postoperative complications between groups.
Sustained jaundice after endoscopic retrograde cholangiopancreatography.
Gastroenterol Hepatol
October 2024
Departamento de Aparato Digestivo, Hospital Universitario Virgen del Rocío, Sevilla, España.
[Translated article] Real-World Clinical, Psychosocial and Financial Burden of Atopic Dermatitis: Results from the Spanish Cohort of the MEASURE-AD Trial.
Actas Dermosifiliogr
January 2025
Servicio de Dermatología, Hospital Universitario de Basurto, Bilbao, Spain.
Article Synopsis
- * The MEASURE-AD trial was conducted to gather comprehensive data on the burden of AD, using both patient and physician feedback, focusing on adults with moderate-to-severe cases.
- * Results from the Spanish cohort revealed that patients with higher disease severity (EASI scores 21.1-72) experienced greater symptom burden, mental health issues, reduced quality of life, increased healthcare usage, and higher out-of-pocket costs compared to those with lower severity scores.
Article Synopsis
- JCO CheckMate 274 is a phase III trial comparing adjuvant nivolumab to placebo for high-risk muscle-invasive urothelial carcinoma (MIUC) post-surgery, showing improved disease-free survival (DFS) metrics with nivolumab treatment.
- The study documented results at a median follow-up of 36.1 months, with larger survival benefits noted for patients with positive PD-L1 expression.
- No new safety issues were discovered, reinforcing the role of nivolumab as standard treatment for high-risk MIUC following radical resection.
[Translated article] Management of Psoriasis Through Patient Support Programs: Professional Support for Long-Term Success.
Actas Dermosifiliogr
January 2025
Almirall S.A., Barcelona, Spain. Electronic address:
Gender Differences in Outcomes of Ambulatory and Hospitalized Patients With Obesity Hypoventilation Syndrome.
Chest
January 2025
Instituto Universitario de Investigación Biosanitaria de Extremadura, Badajoz, Spain; CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain; Respiratory Department, Virgen del Puerto Hospital, Plasencia, Cáceres, Spain.
Article Synopsis
- Obesity hypoventilation syndrome (OHS) has high health risks, and this study looks into whether gender affects outcomes for patients with OHS, focusing on both outpatient and hospitalized cases.
- The research analyzed two groups: stable ambulatory patients and hospitalized patients with respiratory failure, assessing gender differences through various statistical methods.
- Findings indicate that while women were generally older and more obese, gender alone did not significantly influence emergency room visits or mortality rates after adjustments for factors like age and obesity.
Article Synopsis
- There is a pressing need for new treatments for serious infections caused by Gram-negative bacteria, which the REVISIT study examined by evaluating aztreonam-avibactam against standard treatments in complicated infections.
- The study involved a multinational, open-label design with adults who had complicated intra-abdominal infections or hospital-acquired pneumonia, comparing aztreonam-avibactam with meropenem or colistin over 5-14 days.
- Results showed that out of 422 enrolled patients, 64% had identified Gram-negative pathogens, and the study aimed to determine clinical cure rates and safety without formal hypothesis testing.
AML typical mutations (CEBPA, FLT3, NPM1) identify a high-risk chronic myelomonocytic leukemia independent of CPSS molecular.
Blood Adv
January 2025
Grupo Español de Síndromes Mielodisplásicos, Madrid, Spain.
Article Synopsis
- Mutations commonly associated with acute myeloid leukemia (AML) were studied in 127 patients with chronic myelomonocytic leukemia (CMML), revealing varying prevalence rates like CEBPA (7), FLT3 (8), IDH1 (12), IDH2 (26), and NPM1 (11).
- CMML patients with CEBPA, FLT3, and/or NPM1 mutations showed more severe symptoms and higher risk characteristics, indicating they were more frequently linked to the myeloproliferative subtype (MP-CMML).
- The study suggests that these mutations should be included in CMML prognostic models and advocates for treating these patients with AML-type therapies due to their poor
Prevalence of chronic postsurgical hypoparathyroidism not adequately controlled: an analysis of a nationwide cohort of 337 patients.
Front Endocrinol (Lausanne)
October 2024
Department of Endocrinology, Hospital Universitario de Toledo, Toledo, Spain.
Article Synopsis
- The study aimed to identify patients with chronic hypoparathyroidism who either had adequate (AC) or not adequately controlled (NAC) disease, as poor control is linked to complications and increased mortality.
- Researchers analyzed data from 337 patients across 16 Spanish hospitals to assess disease control through biochemical criteria and clinical wellness, finding that many patients were not adequately controlled.
- Findings revealed that 45.9% to 63.1% of patients met the NAC criteria, with those who had dyslipidemia being at a greater risk, and NAC patients exhibited higher rates of associated comorbidities like chronic kidney disease and eye disorders compared to AC patients.
High-Throughput Hybridization Assay as First-Line Diagnostic Test for Sarcomas: Clinical Assessment in a Tertiary Referral Center.
Arch Pathol Lab Med
October 2024
From the Department of Pathology, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, CSIC-Universidad de Sevilla, Seville, Spain (Salguero-Aranda, Perez, Vargas-Padilla, Beltrán-Povea, Delgado-Bellido, Marcilla, Civantos, de Álava, Díaz-Martín).
Article Synopsis
- Sarcomas are rare tumors that are hard to diagnose due to their varied appearances; traditional diagnostic methods have limitations in accurately identifying them.
- The study aimed to enhance the diagnostic capabilities of the NanoString nCounter technology by incorporating 188 probes to detect specific gene fusions associated with various types of sarcomas, which were validated through retrospective and prospective sample testing.
- The results showed that this optimized NanoString approach achieved over 88% sensitivity and 100% specificity, proving to be more effective than standard methods, especially for identifying crucial gene fusions in solitary fibrous tumors and low-grade fibromyxoid sarcomas.
Editorial: Microglia in neurodegenerative diseases.
Front Cell Neurosci
September 2024
Institute of Biomedicine of Seville (IBiS), Hospital Universitario Virgen del Rocío, CSIC, University de Seville, Seville, Spain.
Systemic neurophysiological entrainment to behaviorally relevant rhythmic stimuli.
Physiol Rep
October 2024
Department of Experimental Psychology, University of Seville, Sevilla, Spain.
Article Synopsis
- The study looks at how our brain and body's rhythms, like our heartbeat and breathing, respond to sounds in different ways.
- Researchers tested this by measuring signals from our nervous systems while people listened to sounds in three different situations: no sound, listening passively, and actively trying to tell the sounds apart.
- They found that when people actively engaged with sounds, their brain and body rhythms synchronized with the music, which helped them react quicker and better.
[Reactive infectious mucocutaneous eruption (RIME) in paediatric patients: extrapulmonary Mycoplasma pneumoniae involvement].
Rev Esp Quimioter
December 2024
Cristina González Vargas, Servicio de Pediatría General, Hospital Universitario Virgen del Rocío, Sevilla, Spain.