1,374 results match your criteria: "Hospital Universitario San Cecilio[Affiliation]"

Article Synopsis
  • Cetuximab, a therapeutic monoclonal antibody used in cancer treatment, lacks sufficient data regarding risks of mishandling in hospital environments, prompting a need for studies on its stability under various stress conditions.* -
  • The study evaluated the impact of factors like light exposure, temperature fluctuations, and agitation on cetuximab's physical and functional properties, using advanced analytical techniques to assess its quality attributes.* -
  • Findings indicated that light exposure caused significant degradation of cetuximab, leading to harmful changes in its structure and effectiveness, suggesting that the drug should be protected from such conditions to maintain its safety and efficacy.*
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Article Synopsis
  • * In a group of 13 patients who underwent revision surgery after using ceramics, assessments showed that despite appearances of fusion on imaging, actual solid fusion was lacking according to surgical and histological evaluations.
  • * Findings indicated that biphasic ceramics did not integrate well with bone, with evidence of incomplete resorption and replacement by immature tissue, suggesting that their use should be approached with caution.
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Multiomic-based immune response profiling in migraine, vestibular migraine and Meniere's disease.

Immunology

December 2024

Meniere Disease Neuroscience Research Program, Faculty of Medicine and Health, School of Medical Sciences, The Kolling Institute, University of Sydney, Sydney, New South Wales, Australia.

Article Synopsis
  • Migraines (MI) are a common brain problem affecting about 20% of people worldwide, and some people with migraines also have balance issues, which is called vestibular migraine (VM).
  • Meniere's disease (MD) is another condition that affects the inner ear and can cause spinning sensations, ringing in the ears, and hearing loss, which sometimes overlaps with vestibular migraine symptoms.
  • A study compared blood samples from people with migraines, vestibular migraines, Meniere's disease, and healthy individuals, finding that migraines and vestibular migraines have similar immune responses, while Meniere's disease shows different immune reactions and can be divided into two types based on activity.
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Long-term benefit of ustekinumab in ulcerative colitis in clinical practice: ULISES study.

Aliment Pharmacol Ther

November 2024

Gastrointestinal Units of Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Universidad Autónoma de Madrid (UAM), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.

Article Synopsis
  • Ustekinumab is approved for treating ulcerative colitis (UC), and this study evaluated its long-term effectiveness and tolerability in real clinical settings.
  • In a multicenter analysis of 620 UC patients, 25% discontinued treatment, with baseline anemia, steroid use, and severe disease linked to higher discontinuation rates.
  • At 16 weeks, 40% of patients were in steroid-free remission, and treatment was generally safe with no adverse effects on other conditions, indicating good long-term durability for difficult-to-treat cases.
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Correction: A systematic review on the contribution of DNA methylation to hearing loss.

Clin Epigenetics

September 2024

Meniere's Disease Neuroscience Research Program, Faculty of Medicine and Health, School of Medical Sciences, The Kolling Institute, University of Sydney, Rm 611024, Level 11 Kolling Institute | 10 Westbourne St, St Leonards, Sydney, NSW, 2064, Australia.

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Snapshot of knowledge and stigma toward mental health disorders and treatment in Spain.

Front Psychol

August 2024

Deparment of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, University of Alcala, Alcala de Henares, Spain.

Background: Mental disorders significantly impact individuals and societies globally. Addressing societal stigma is crucial, as it affects help-seeking behaviors and the effectiveness of treatment for mental disorders.

Objective: This study aims to explore the knowledge and perceptions of the Spanish population toward mental disorders and their treatment, assess changes in mental health stigma over time, and examine variations across sociodemographic variables by comparing current results with previous studies.

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Introduction: A clinical dermatological research was conducted in Spain from 2005 through 2014 as part of the MaIND project with the provinces or centers with the highest number of published articles. However, a low level of evidence in scientific production was confirmed as the overall result. The aim of this study is to update the Spanish clinical dermatological research in bibliometric terms from 2015 through 2021 with comparisons between both periods of time.

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Article Synopsis
  • Recent years have seen a rise in the approval of monoclonal antibodies (mAbs) and other biological treatments, each with varied immunosuppressive effects and mechanisms that necessitate personalized vaccination schedules for patients.
  • Current vaccine recommendations for patients on mAbs are mainly based on expert opinions rather than individualized protocols, highlighting a significant gap in research addressing the diverse uses of these treatments.
  • This review aims to compile information on mAbs approved by the EMA as of January 1, 2024, and provide a practical guide for personalizing vaccination strategies for immunocompromised individuals, reflecting recent developments in vaccine technology and administration practices.
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Management of Spinal Deformities Caused by Osteoporotic Vertebral Fractures.

Rev Esp Cir Ortop Traumatol

September 2024

Unidad de Patología de Columna, Servicio de Traumatología, Fundación Jiménez Díaz, Madrid, España.

Osteoporosis and fragility play a significant role in the treatment and planning of patients with deformity secondary to osteoporotic vertebral fracture (OVF). The resulting deformity can present significant challenges for its management, both from a medical and surgical perspective. The need for a specific classification for these deformities, including the potential for the development of artificial intelligence and machine learning in predictive analysis, is emerging as a key point in the coming years.

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Background: The objectives were to evaluate the safety and immunogenicity of the nonavalent human papillomavirus (nHPV) vaccine in adult Spanish women living with HIV (WLHIV); the prevalence of anal and cervical dysplasia and nHPV vaccine genotypes in the anus and cervix; and risk factors for high-risk HPV (HR-HPV) infection in anal mucosa.

Methods: In this single-center, open-arm, non-randomized clinical trial, the nHPV vaccine was administered at 0, 2, and 6 months to WLHIV enrolled between February 2020 and November 2023, measuring vaccine antibody titers pre-vaccination and at 2, 6, and 7 months after the first dose. Cervical and anal cytology and HPV PCR genotyping studies were performed.

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Introduction And Objectives: Management in recent-onset atrial fibrillation (AF) is to achieve sinus rhythm (SR) by cardioversion (CV). However, frequently SR is spontaneously restored, making scheduled admission unnecessary and causing misutilization of healthcare resources. Emerging medical technology allows accurate heart rhythm monitoring.

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Article Synopsis
  • Diffuse alveolar hemorrhage (DAH) is a severe and uncommon complication in systemic lupus erythematosus (SLE) patients, with early diagnosis and treatment critical for improving survival rates.
  • In a study from the RELESSER register, 37 out of 4024 SLE patients experienced DAH, with notable characteristics including a high prevalence of women and links to renal issues and thrombocytopenia.
  • Factors associated with higher mortality in DAH patients included smoking, prior lupus nephritis, infections, and the use of cyclophosphamide, with a mortality rate of 35.7% observed in the cohort.
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Co-morbid sarcopenia and low bone mineral density in young paediatric cancer survivors.

J Cachexia Sarcopenia Muscle

October 2024

Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.

Background: Sarcopenia and low areal bone mineral density (aBMD) are prevalent musculoskeletal complications after paediatric cancer treatment. However, their relationship has not been examined in young paediatric cancers survivors. This study aimed to evaluate aBMD differences according to sarcopenia status and the risk of low aBMD Z-score in young paediatric cancer survivors with sarcopenia confirmed/probable.

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The One Health approach, recognizing the interconnectedness of human, animal, and environmental health, has gained significance amid emerging zoonotic diseases and antibiotic resistance concerns. This paper aims to demonstrate the utility of a collaborative tool, the SIEGA, for monitoring infectious diseases across domains, fostering a comprehensive understanding of disease dynamics and risk factors, highlighting the pivotal role of One Health surveillance systems. Raw whole-genome sequencing is processed through different species-specific open software that additionally reports the presence of genes associated to anti-microbial resistances and virulence.

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Update on the pathophysiology, diagnosis and management of Ménière's disease.

Curr Opin Otolaryngol Head Neck Surg

October 2024

Division of Otolaryngology, Department of Surgery, Instituto de Investigación Biosanitaria, ibs.GRANADA, Granada, Universidad de Granada, Granada, Spain.

Purpose Of Review: The aim of this work is to summarize the main advances on the pathophysiology, diagnosis, and treatment of Meniere's disease (MD).

Recent Findings: Different immune responses to biotic stimuli may trigger MD, with subgroups identified based on cytokine and genetic profile, suggesting potential benefits from immune therapy, including antiallergic medication. Genetic and epigenetic research, along with imaging studies, reveal the complexity of MD, involving inflammation, immunity, and metabolic processes.

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Punch grafting is a technique that can improve and accelerate the healing of hard-to-heal wounds and reduce the associated pain. It is a simple and inexpensive procedure that can be performed in the examination room. It is a technique that uses small split-thickness skin grafts (STSG) to promote the growth of epithelial tissue.

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Introduction: The increase in risky sexual behaviors among adolescent students has sparked alarm and has become an area of research interest. As adolescents prioritize confidentiality and accessibility, digital interventions are becoming increasingly relevant in sex education. We therefore posed the following research question: Are digital application interventions effective to prevent risky sexual behaviors in school adolescents?

Design: A systematic peer review was conducted between January and December 2023 in five databases (PubMed, Web of Science, Scopus, EMBASE, and PsycINFO) without restricting for language or year of publication.

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Physicochemical, microbiological, and sensory properties of healthy juices containing aloe vera gel and probiotics and their antidiabetic effects on albino rats.

Front Nutr

July 2024

Departamento de Sanidad Animal, Grupo de Investigación en Sanidad Animal y Zoonosis, Facultad de Veterinaria, Universidad de Córdoba, Córdoba, Spain.

The consumption of fruit and vegetable juices is widely recognized as a healthy choice across all age groups. Orange, carrot, and aloe vera are renowned for their functional properties and health benefits. In this study, we investigated the potential incorporation of aloe vera gel into blended orange and carrot juices.

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Detecting the association of genetic variants to the response of biological therapy represents an important advance in developing a personalized therapy. The aim of this work was to study the association of polymorphisms with an optimal response to tildrakizumab in patients with psoriasis in a real-life clinical practice. Ninety patients with plaque psoriasis recruited from-Spanish hospitals receiving tildrakizumab for at least 24 weeks were genotyped for 180 polymorphisms.

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Fluoropyrimidines (FPs) are commonly prescribed in many cancer streams. The EMA and FDA-approved drug labels for FPs recommend genotyping the *2A (rs3918290), *13 (rs55886062), *HapB3 (rs56038477), alleles, and rs67376798 before treatment starts. We implemented the genotyping in our daily clinical routine, but we still found patients showing severe adverse drug events (ADEs) to FPs.

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Fungal Head and Neck Dermatitis: Current Understanding and Management.

Clin Rev Allergy Immunol

June 2024

Department of Dermatology & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, South Korea.

Article Synopsis
  • Head and neck dermatitis (HND) is a severe form of atopic dermatitis that primarily affects seborrheic areas and significantly impacts patients’ quality of life, with treatment being complicated by the ineffectiveness of usual topical therapies and the potential for dupilumab-associated dermatitis (DAHND).
  • Research indicates that fungi, particularly Malassezia species, play a crucial role in HND development, as they activate the immune system and cause inflammation via specific immune pathways.
  • While antifungals show promise in treating HND, particularly in oral form, the long-term effects are uncertain; new therapies like Janus kinase inhibitors and OX40 inhibitors are being explored, and factors like host microbiome variations could lead to more
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