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Imipenem-relebactam is a novel β-lactam-β-lactamase inhibitor combination. We evaluated the activity of imipenem-relebactam and comparators against clinical isolates recovered in 8 Spanish and 11 Portuguese intensive care units (ICUs) (SUPERIOR, 2016-2017; STEP, 2017-2018). Overall, 747 isolates (378 Escherichia coli, 252 Klebsiella spp.

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