462 results match your criteria: "Hospital Universitario Ramón y Cajal - IRYCIS[Affiliation]"
Objectives: To evaluate the impact of hospitalisation for infectious diseases on the Health-Related Quality of life (HRQOL), multidimensional frailty, and functioning of older patients, we conducted a longitudinal matched cohort study in four European countries.
Methods: HRQOL, frailty, and functioning were assessed using validated questionnaires at inclusion, at discharge, and up to six months later (M6) in patients aged over 65 years hospitalised for severe acute respiratory or bloodstream infections, and matched controls hospitalised for non-infectious conditions. Comparative analyses employed multilevel mixed-effect linear or logistic models to assess changes from inclusion.
Geriatr Psychol Neuropsychiatr Vieil
September 2024
Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany, Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON N6A 5K8, Canada.
Rev Esp Geriatr Gerontol
January 2025
Servicio de Geriatría, Hospital Universitario Ramón y Cajal (IRYCIS), Ctra. de Colmenar Viejo, km. 9,100, 28034, Madrid C.P. 28034, Mexico.
Background And Aim: To evaluate the association between sarcopenia and metabolic syndrome.
Patients And Methods: A case-control study.
Setting: Geriatric Care Clinic of Metepec (México).
Pituitary
December 2024
Endocrinology & Nutrition Department, Hospital Universitario Germans Trias i Pujol. CIBERER U747 (ISCIII), Universitat Autònoma de Barcelona, Badalona, Spain.
Acromegaly-induced diabetes presents unique features due to the direct effects of excess growth hormone (GH) and insulin-like growth factor 1 (IGF-) on glucose metabolism, especially insulin resistance in association to low body fat content and water retention. Increased cardiovascular risk is much higher when acromegaly is complicated with diabetes, thus requiring a holistic management that addresses also these specific characteristics which differ from those of classical type 2 diabetes.The optimal management of diabetes in acromegaly requires not only an effective control of carbohydrate disturbances per se, but also the concurrent control of GH hypersecretion as it will directly impact on glucose control.
View Article and Find Full Text PDFPituitary
December 2024
Department of Endocrinology and Nutrition, Hospital Universitario de Puerta de Hierro Majadahonda, Madrid, Spain.
Purpose: Studies focused on the effects of sellar and/or perisellar (S/PS) meningiomas on pituitary function are scarce. The primary objective of the present study was to determinate the effects that S/PS meningiomas and their treatments have on pituitary function. Also, we described the clinical characteristics and therapeutic outcomes of the cohort of adult Spanish patients.
View Article and Find Full Text PDFCochrane Database Syst Rev
December 2024
NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK.
Background: Sample collection is a key driver of accuracy in the diagnosis of SARS-CoV-2 infection. Viral load may vary at different anatomical sampling sites and accuracy may be compromised by difficulties obtaining specimens and the expertise of the person taking the sample. It is important to optimise sampling accuracy within cost, safety and accessibility constraints.
View Article and Find Full Text PDFBone Marrow Transplant
December 2024
Servicio de hematologia, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS)/CSIC, Universidad de Sevilla, Sevilla, Spain.
Ruxolitinib has been approved for the treatment of adults and pediatric patients ≥12 years with steroid refractory graft-versus-host disease (GvHD). However, real-life studies are needed to confirm the results of clinical trials and further assess its efficacy in special populations. We performed a descriptive, retrospective, multi-center study of 352 adults and 42 pediatric patients treated with ruxolitinib for steroid-refractory acute or chronic GvHD.
View Article and Find Full Text PDFNeurosurgery
December 2024
Endocrinology & Nutrition Service, Germans Trias Hospital Research Institute, Badalona, Centro de Investigación Biomédica en Red de Enfermedades Raras U747, Autonomous University of Barcelona, Barcelona, Spain.
Background And Objective: Currently, the management for pituitary apoplexy (PA) has been promoted toward a more conservative approach, particularly for patients with low-grade PA scores. Our aim was to investigate trends in PA management and compare clinical presentation, therapeutic approaches, and outcomes before and after 2017, additionally to evaluate long-term outcomes in conservatively treated patients.
Methods: Spanish multicenter, retrospective study.
Rev Endocr Metab Disord
November 2024
Endocrinology & Nutrition Department, Hospital Universitario Germans Trias i Pujol, CIBERER U747 (ISCIII), Universitat Autònoma de Barcelona, Badalona, Spain.
Oncologist
November 2024
Cardiology Department, Hospital Universitario de Navarra, 31008 Pamplona (Navarra), Spain.
Background: BRCA1/2 genes play a critical role in genome stability and DNA repair. In animal models, loss of cardiomyocyte-specific BRCA1/2 is associated with DNA damage, apoptosis, cardiac dysfunction, and mortality following anthracycline exposure. However, whether these preclinical findings translate to humans remains unclear.
View Article and Find Full Text PDFEur J Endocrinol
November 2024
Endocrinology & Nutrition Department, Hospital Clinic, University of Barcelona, IDIPAS, Barcelona 08036, Spain.
Neurosurg Rev
November 2024
Department of Neurosurgery, Hospital Universitario 12 de Octubre; Departamento de Cirugía, Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigaciones Sanitarias 12 de Octubre, imas12, Madrid, 28041, Spain.
Rev Endocr Metab Disord
November 2024
Endocrinology & Nutrition Department, Hospital Universitario Germans Trias i Pujol, CIBERER U747 (ISCIII), Universitat Autònoma de Barcelona, Badalona, Spain.
Pasireotide long-acting release (PAS-LAR) is a second-generation somatostatin receptor ligand (SRL) approved for acromegaly treatment. This meta-analysis aimed to evaluate the real-world effectiveness and safety of PAS-LAR in patients with acromegaly resistant to first-generation somatostatin receptor ligands (fgSRL). A systematic literature search was conducted in PubMed and Web of Science for real-world studies on PAS-LAR in acromegaly published between 2014 and 2023.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
October 2024
Endocrinology & Nutrition Department, Hospital Universitario de Vall d´Hebron, Barcelona, Spain.
Cochrane Database Syst Rev
October 2024
Department of Applied Health Sciences, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK.
J Am Nutr Assoc
February 2025
Nutritional Control of the Epigenome Group, Precision Nutrition and Obesity Program, IMDEA Food, CEI UAM+CSIC, Madrid, Spain.
Objective: Life expectancy and obesity prevalence are increasing worldwide, leading to an increase in the prevalence of cardiovascular disease. High-density lipoprotein (HDL) functionality and immunosenescence play key roles in cardiovascular disease, longevity, and quality of aging. Both molecular hallmarks of aging are impacted by obesity and metabolic syndrome and can be modulated by lifestyle.
View Article and Find Full Text PDFEndocrinol Diabetes Nutr (Engl Ed)
October 2024
Endocrinology & Nutrition Department, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain. Electronic address:
Primary hyperaldosteronism (PH) is the most common cause of secondary hypertension (HTN) and is associated with a higher cardiometabolic risk than essential HTN. Nevertheless, PH remains clearly underdiagnosed. An early diagnosis and adequate treatment of this disease are essential to reduce the cardiometabolic morbimortality associated with aldosterone excess.
View Article and Find Full Text PDFInt J Mol Sci
September 2024
Unidad Mixta de Investigación Cardiovascular Universidad Francisco de Vitoria, Hospital Universitario Ramón y Cajal (IRYCIS), 28034 Madrid, Spain.
Vascular aging is associated with the development of cardiovascular complications, in which endothelial cell senescence (ES) may play a critical role. Nitric oxide (NO) prevents human ES through inhibition of oxidative stress, and inflammatory signaling by mechanisms yet to be elucidated. Endothelial cells undergo an irreversible growth arrest and alter their functional state after a finite number of divisions, a phenomenon called replicative senescence.
View Article and Find Full Text PDFNat Rev Dis Primers
September 2024
Servicio de Geriatría, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain.
Sarcopenia is the accelerated loss of skeletal muscle mass and function commonly, but not exclusively, associated with advancing age. It is observed across many species including humans in whom it can lead to decline in physical function and mobility as well as to increased risk of adverse outcomes including falls, fractures and premature mortality. Although prevalence estimates vary because sarcopenia has been defined in different ways, even using a conservative approach, the prevalence is between 5% and 10% in the general population.
View Article and Find Full Text PDFEur J Obstet Gynecol Reprod Biol
November 2024
WHO Collaborating Centre for Global Women's Health, Institute of Metabolism and Systems Research, University of Birmingham, UK; NIHR Birmingham Biomedical Centre (BRC), University Hospitals Birmingham, UK.
Objective: To identify and prioritise early pregnancy risk factors for stillbirth to inform prognostic factor and model research.
Study Design: We used a modified e-Delphi method and consultation meeting to achieve consensus. Risk factors for early, late and stillbirth at any gestation identified from an umbrella review of risk factors for stillbirth were entered into a two-stage online Delphi survey with an international group of stakeholders made up of healthcare professionals and researchers.
Rev Esp Enferm Dig
December 2024
Hepatología y Trasplante Hepático, Hospital Universitario Reina Sofía. IMIBIC. CIBERehd, España.
Health Technol Assess
August 2024
WHO Collaborating Centre for Global Women's Health, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
Background: Fetal growth restriction is associated with perinatal morbidity and mortality. Early identification of women having at-risk fetuses can reduce perinatal adverse outcomes.
Objectives: To assess the predictive performance of existing models predicting fetal growth restriction and birthweight, and if needed, to develop and validate new multivariable models using individual participant data.
Age Ageing
November 2023
National Research Council, Neuroscience Section, Padova, Italy.
Aims: Literature regarding anticoagulants in older people affected by atrial fibrillation (AF) is limited to retrospective studies, poorly considering the importance of multidimensional frailty. The main objective of this study is to evaluate in hospitalised older persons with AF the benefit/risk ratio of the anticoagulant treatments, considering the severity of frailty, determined by the multidimensional prognostic index (MPI).
Methods: In this European, multicentre, prospective study, older hospitalised patients (≥65 years) with non-valvular AF were followed-up for 12 months.
JCI Insight
August 2024
Vascular Biology and Therapeutics Program.
The complexity of the mechanisms underlying metabolic dysfunction-associated steatotic liver disease (MASLD) progression remains a significant challenge for the development of effective therapeutics. miRNAs have shown great promise as regulators of biological processes and as therapeutic targets for complex diseases. Here, we study the role of hepatic miR-33, an important regulator of lipid metabolism, during the progression of MASLD and the development of hepatocellular carcinoma (HCC).
View Article and Find Full Text PDFEur Geriatr Med
October 2024
Department of Internal Medicine and Paediatrics, Ghent University, Ghent, Belgium.
Purpose: Drug-drug interactions (DDIs) are prevalent among multimorbid and polymedicated older adults and can increase the risk of adverse drug reactions (ADRs), hospital admissions, and mortality. This study describes the incidence and prevalence of 66 clinically relevant DDIs and analyses the occurrence of 12 corresponding predefined ADRs in older inpatients enrolled in the SENATOR trial.
Methods: The sub-study of the SENATOR trial that involved 1537 multimorbid older inpatients, recruited from 2016 to 2018 in six academic teaching hospitals in Belgium, Iceland, Ireland, Italy, Scotland, and Spain respectively, and analysed 66 potentially clinically significant DDIs.