[Advances in the physiopathology of epileptogenesis: molecular aspects].

Objective: We review the molecular basis of epileptogenesis and the new perspectives in the treatment of epilepsy.

Development: Epileptogenesis are the molecular and cellular events producing the disordered firing of a subpopulation of neurons resulting in periodic seizures. Epilepsies may be due to genetic and acquired factors.

[Pre and perioperative factors determining early in-hospital mortality in patients over 75 years of age undergoing cardiac surgery].

Introduction And Objectives: To know the in-hospital morbidity and mortality and the related factors in patients over 75 years old undergoing cardiac surgery.

Patients And Methods: A retrospective analysis was carried out in 252 out of 2043 consecutive patients (129 female, 123 male) over 75 years of age (mean age 77.8 years; range 75 to 89 years) undergoing open heart surgery from january 1, 1994 to november 30, 1997.