Institutional experience with clofarabine and cytarabine in relapsed pediatric acute myeloid leukemia.

Cytarabine (1000 mg/m/d intravenous for 5 d) and clofarabine (40 mg/m/d intravenous for 5 d) were given every 28 days to 9 children with relapsed acute myeloid leukemia at our institution. Among 19 courses, there were 18 infectious episodes. Median hospitalization time was 13 days (7.

Genetic alterations in children and adolescents with acute myeloid leukaemia.

Acute Myeloid Leukemia is a clinically and genetically heterogeneous disease, in which cytogenetic aberrations are the most important factors to determine biological behavior and prognosis. More than 20 different chromosomal abnormalities have been identified in a high percentage of children (70-85%) with the novo AML. We reviewed the most frequently found and the impact of these aberrations on prognosis.

Solid ovarian tumours in childhood: a 35-year review in a single institution.

Purpose: Solid ovarian tumours are uncommon in childhood. Our aim is to evaluate the outcomes in a single institution over 35 years.

Methods: We reviewed their clinical presentation, management, pathology and outcomes from 1972 to 2007.

Effectiveness of the treatment with intravenous pamidronate in calcinosis in juvenile dermatomyositis.

Objective: Calcinosis is a frequent finding in up to 40% of children with juvenile dermatomyositis (JDM). Different treatments (aluminum hydroxide, diltiazem, probenecid, alendronate, etc.) have been used in an attempt to clear calcinosis and to avoid the onset of new calcium deposition, but none has been clearly effective.

[Biloma as a complication after closed abdominal trauma. Review of the literature after bile leaks].

Bile leaks are a rare complication secondary to closed liver trauma. The diagnosis is usually late, which increases the morbidity and hospital stay. We report a case of biloma secondary to severe liver injury, including a description of the diagnosis and management.

[Drug treatment with fibrinolytics (corrected) of secondary empyema secondary to complicated parapneumonic effusion].

In recent years we have observed in our country an increase in complications associated with bacterial pneumonia, such as pleural effusion and empyema. The initial treatment is an association of antibiotics, covering the potential germ involved, and the placement of a pleural drainage tube, in order to accelerate the resolution process. Formation of septa within the pleural cavity requires additional therapy (antifibrinolytic treatment, videothorascopy), but no one of these two alternatives is been demonstrated better than the other.

Posterior fossa clear cell meningioma without dural attachment in a child.

Introduction: Meningiomas are relatively uncommon in childhood. They represent 1% to 2% of all intracranial tumours of infancy and childhood and 1.5% to 1.

[Impact in our environment of a gastroschisis therapeutic management protocol].

Introduction: Continuous exposure to amniotic in fetus with gastroschisis, leads to inflammation and edema of intestinal loops, hindering intestinal return to abdomen and making staged repair necessary in many cases. Furthermore, intestinal loops are hipoperistaltic, which leads to oral toleration difficulties, large periods of parenteral nutrition and an increase of hospital stay. The objective of this study is to evaluate the results in our environment, of a new multidisciplinary management protocol in patients with a prenatal diagnosis of gastroschisis.

[Laparoscopic Kasai portoenterostom: present and future of biliary atresia treatment].

Introduction: Kasai's operation has proved its value in surgical treatment of biliary atresia (BA). Its laparoscopic approach is a new challenge for pediatric surgeons, with all the potential advantages of minimally invasive surgery. The aim of the present study has been to report our experience in laparoscopic management of five patients with biliary atresia.

[Ibuprofen versus indomethacin in the preterm persistent patent ductus arteriosus therapy: review and meta-analysis].

Introduction: Persistent patent ductus arteriosus (PDA) is a common pathology in the preterm whose traditional treatment has been indomethacin. Recently, ibuprofen has shown its effectiveness in closing the PDA with less hemodynamic effects. The objective of this paper is to review the current literature in order to determine if there is any benefit of ibuprofen versus indomethacin in the PDA therapy.

[Choledocal cyst: analysis of 29 cases and review or the literature].

Unlabelled: The aim of the present study has been to systematize the clinical presentation of the entity named choledochal cyst, in relation with its probable etiopathology and the intraoperative findings as well as its evolution after surgery, based on the revision of the literature and of our experience in 29 cases.

Material And Methods: 29 cases of cystic dilatation of the biliar duct extra and/or intrahepatic are analyzed. In 4 cases the diagnosis was prenatal and two were excluded of the study after it has been confirmed they suffered biliary atresia type I.

[Evaluation of a home care program for children with cancer].

The home care team dependent from the pediatric oncology unit in our institution started working in April, 1997. We evaluate in this paper the medical activities accomplished in seventeen month experience. The team is constituted by a pediatric oncologist, two pediatric nurses and a clinical assistant with experience in the specialty.