Treatment of Buerger disease (thromboangiitis obliterans) with bosentan: a case report.

Buerger disease (thromboangiitis obliterans) is a non-atherosclerotic segmental inflammatory disease strongly associated with tobacco use, and it affects small and medium-sized blood vessels in the upper and lower extremities. The only known treatment for this disease is complete discontinuation of tobacco use. This report describes the case history of a woman with Buerger disease treated with the oral dual endothelin receptor antagonist bosentan.

Direct association between C-reactive protein serum levels and endothelial dysfunction in patients with claudication.

Objectives: To evaluate the relationship between C-Reactive Protein (hsCRP), a serum marker of inflammation, and endothelial dysfunction in patients with intermittent claudication.

Design, Patients And Methods: Cross-sectional study with stratified sampling on dependent variables of age, genre, hypertension, hyperlipidemia, diabetes, smoking status and ankle-brachial index (ABI) to select 156 patients from a target population of 4,100 patients with claudication. We assessed the flow-mediated arterial dilation (FMAD) as a reporter of endothelial function and plasma levels of hsCRP and fibrinogen.

[Retrospective analysis of the carboplatin dosage and relationship with toxicity in cancer patients].

Objective: To analyse carboplatin dosage in cancer patients in order to establish whether they are over- or underdosed in comparison to the theoretical dose calculations during the first cycle of chemotherapy and to find a relationship between the dosage in the first cycle and dose reduction in subsequent cycles, as a result of adverse effects related to the same.

Method: Retrospective analysis over a one year period of prescriptions of chemotherapy with carboplatin. Patients were stratified into 4 groups according to body mass index and serum creatinine values.

[Myopia: prevalence of retinal tears and throphic holes].

Purpose: We study the prevalence of retinal tears and holes in myopia. We consider age distribution, also retinal localization, and its relationship with the different types of posterior vitreous detachment.

Material And Methods: 200 eyes from 124 myopic patients were selected.

Is trophoblastic thickness at the embryonic implantation site a new sign of negative evolution in first trimester pregnancy?

In this study a new sign to evaluate the evolution of pregnancy is described: the trophoblastic thickness at the embryonic implantation site. A prospective, observational study of 592 normal pregnancies with no known risk factors was carried out from January 1998 to February 1999. Serial ultrasound scans were performed from week 5 to week 12 of pregnancy.

Contribution of transvaginal sonography to the evaluation of benign cervical conditions.

Purpose: We evaluated the role of transvaginal sonography in imaging the normal cervix and its benign changes.

Methods: This prospective study included 512 postmenopausal women who underwent transvaginal sonography before hysterectomy and within 15 days of a colposcopy examination that showed no malignant findings. The sonographic findings were compared to the pathology report.